S. K. Ghose, Kazi Gias Uddin Ahmed, A. Chowdhury, A. Hasan, K. Saha, H. Sina, M. Arifuzzaman, Iftikher Alam, Amit Wazib, Asm Rezaul Karim, Md. Rafiqul Islam, M. Habib, Q. Mohammad
{"title":"Serum Lead Level and Polyneuropathy among Bangladeshi Patients","authors":"S. K. Ghose, Kazi Gias Uddin Ahmed, A. Chowdhury, A. Hasan, K. Saha, H. Sina, M. Arifuzzaman, Iftikher Alam, Amit Wazib, Asm Rezaul Karim, Md. Rafiqul Islam, M. Habib, Q. Mohammad","doi":"10.3329/bjn.v31i2.57380","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57380","url":null,"abstract":"Background: Heavy metals may produce various symptoms among the exposed, of which polyneuropathy is a matter of real concern. Our aim was to determine the pattern and association between polyneuropathy and blood lead level. \u0000Methods: This case control study was done in the department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka in collaboration with Bangladesh Atomic Energy Centre from July 2001 to June 2002. The lead concentration in the blood was detected by Xray fluorescence (XRF) technique. Nerve conduction study and CSF examination were done among the cases. \u0000Result: Data were collected from 92 respondents, of whom cases and controls were equal in number with a male to female ratio of 8.17:1. Mean age of the cases and controls were 30.87 +14.53 years and 30.91+ 12.03 years respectively. Among the cases, 55% had sub acute type of polyneuropathy, followed by acute and chronic type of polyneuropathy among 30% and 15% respondants respectively. The mean CSF protein level was 112.00 + 65.04 gm/L. The mean CSF protein was higher in acute polyneuropathy than in subacute and chronic cases (p<.001). The mean blood lead level among cases was 45.5587 with a standard deviation (SD) of +35.2625 and among control were 33.2065 with a SD of +5.6793. The difference was statistically significant (p= 0.021). \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 65-69","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77227568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Abdul Momen Khan, Mohammad Bahadur Ali Miah, M. Shahidullah, Md. Rafiqul Islam, Subash Kanti Day, J. Ferdous, Md Amir Hossain
{"title":"Efficacy of low-dose Topiramate in Migraine Prophylaxis","authors":"Muhammad Abdul Momen Khan, Mohammad Bahadur Ali Miah, M. Shahidullah, Md. Rafiqul Islam, Subash Kanti Day, J. Ferdous, Md Amir Hossain","doi":"10.3329/bjn.v31i2.57381","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57381","url":null,"abstract":"Background: Anticonvulsants are now commonly used for migraine prophylaxis, among them topiramate, one of the newer anticonvulsants, recently has been demonstrated to be effective as mono-therapy for migraine prophylaxis. \u0000Objectives: To observe the efficacy and safety of low dose topiramate in migraine prophylaxis. \u0000Methods: This prospective trial was carried out in the Out Patient Department (OPD) & Headache Clinic, Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka. Total 60 patients around the age range of 18 to 50 years diagnosed as migraine (with aura or without aura) according to ICHD-3 criteria, were recruited as the study population. Total 60 patients were administered by Tab.Topiramate 50 mg/ day. Out of them, total 47 patients had completed the study due to drop out of 13 patients. During trial, three follow up visits were taken, 1st follow up after 4 weeks of baseline information (Before starting prophylactic medication), 2nd follow up after 4 weeks of treatment, 3rd follow up after 8 weeks of treatment. Efficacy of treatment was measured by headache frequency, duration and severity as measured by the VAS. Effectiveness was assessed by comparing baseline & on-treatment migraine status. \u0000Results: The mean (SD) age of patients were found 29.72 (9.58) years. Female sex was predominant. The mean (SD) value of frequency of migraine at baseline level with 1st and 2nd follow up were statistically significant [Baseline 9.28 (2.39) vs. 1st FU 7.55 (3.07), p=0.001; Baseline 9.28 (2.39) vs. 2nd FU 4.72 (2.80), p<0.001]. Duration of each episode of migraine ,comparing the mean (SD) value of duration of migraine of baseline level with 1st and 2nd follow up were statistically significant [Baseline 10.85 (5.26) vs. 1st FU 8.06 (4.11) hr, p<0.001; Baseline 10.85 (5.26) vs. 2nd FU 5.53 (2.98) hr, p<0.001]. According to severity of migraine based on VAS in base line period all patients had experienced moderate & severe headache but in 1st follow up, few patients had experienced mild headache from moderate headache, few patients had experienced moderate headache from severe headache & in 2nd follow up, patients had better condition and had experienced mild and moderate headache, no patient had experienced severe headache. In this study, 23.4% patients developed adverse effects. Among the adverse effects, 8.5% develop dizziness, 6.3% drowsiness, 4.2% anorexia & blurring of vision. \u0000Conclusion: The present study suggest that low dose topiramate are effective for migraine prophylaxis in reduction of frequency, severity and duration of migraine headache . \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 70-75","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91341384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Selective Rehabilitation on Neck Pain due to Cervical Spondylosis - A Clinical Trial","authors":"Md Abdus Shakoor, -. Shamsunnahar, Nayeem Anwar, Md Muhibbur Rahman, Fatema Zohra, M. Moyeenuzzaman","doi":"10.3329/bjn.v31i2.57387","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57387","url":null,"abstract":"Background:Pain in the neck is a common complaint of the patients attending the hospital. In clinical practice, neck pain is seen frequently as a presenting symptom and sometimes it becomes disabling and compromises the working capacity. One of the most common causes of pain in the neck is cervical spondylosis. Rehabilitation treatment may play an important role to improve the condition of the patients. For this purpose, the study was done to find out the effects of rehabilitation treatment on chronic neck pain to improve the present situation regarding treatment. \u0000Methodology: A randomized clinical trial was conducted in the department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. A total of 150 patients were included and they were divided into two groups: group-A and group-B. Group-A was treated with selective rehabilitation and Group –B was treated with NSAID only. History, clinical examination and relevant investigations were done. The findings were recorded at first attendance and follow up was done weekly for six weeks. The results were expressed as mean ± SD and the level of significance was expressed by p-value unless otherwise stated. Student’s ‘t’ tests was done to test the hypothesis. \u0000Results: Among the study subjects 48(32 %)were male and 102 (68 %) were female. The male female ratio was 1: 2.12. There was significant improvement in both the group after treatment ( P= 0.001). But in comparison between two groups, all the baseline criteria were identical. There was no significant improvement between two groups up to 5th weak( P>05) but significant improvement was seen in Group-B than Group-A after six weeks treatment (P= 0.03). This results indicates that the improvement of the patient with cervical spondylosis was seen in selective rehabilitation group and in NSAIDs group. And improvementwas same in both the group up to 5th week and after six weeks more improvement was found in NSAIDs group. \u0000Conclusions: By this study, it may be concluded that to reduce symptom and disability, rehabilitation treatment can be used effectively for the treatment of chronic neck pain without analgesics and by this way nephropathy due to NSAIDs can be avoided. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 102-109","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"203 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83562605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shamsul Alam, A. Uddin, M. Majumder, M. Hasan, A. Ahmed
{"title":"Intraventricular Tumor: An Analysis of 18 Cases","authors":"Shamsul Alam, A. Uddin, M. Majumder, M. Hasan, A. Ahmed","doi":"10.3126/NJN.V13I1.15908","DOIUrl":"https://doi.org/10.3126/NJN.V13I1.15908","url":null,"abstract":"Objective: To describe the transcallosal and transcortical approach to deal with intraventricular tumors. \u0000Methods: Details of the transcallosal and transcortical approach to intraventricular tumors of the lateral and third ventricles were presented. \u0000Results: Intraventricular tumors are ideal indications for microscopic neurosurgery. They often cause cerebrospinal fluid (CSF) pathway obstruction, resulting in ventricular dilatation. The general principle of removal of intraventricular tumors was interruption of the blood supply to the tumor and subsequent tumor debulking. In general, a piecemeal resection was performed; however, in some tumors such as meningioma, it was possible to detach the lesion from the surrounding brain tissue and remove it in toto. When the tumor found in the anterior part of the third ventricle, the craniotomy was done at the coronal suture. When the tumor was located in the posterior part, the entry craniotomy was selected more anteriorly in order to pass the foramen of Monro in a straight line. \u0000Conclusion: Intraventricular tumors and related CSF pathway obstructions can be safely and effectively treated with micro neurosurgical techniques, either by transcallosal or transcortical approach. The aim should be the total extraction of the tumor with minimum damage and the chosen operative corridor should optimize tumor access and the protection of vulnerable neurovascular structures. Lateral ventricle tumors can be removed via transcortical approach when having hydrocephalus which provides a wider and more direct approach to the tumor than the transcallosal one. It allows the surgeon to achieve good functional outcome and maximum excision of the tumor. Transcallosal is an excellent midline exposure with preserving the callosomerginal and pericallosal arteriesto the midline tumor of lateral and 3rd ventricles. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 94-101","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82868106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Salam, Md. Rafiqul Islam, H. Z. Rahman, A. Ahmed, M. R. Quddus
{"title":"Epilepsy Patients in Bangladesh - The Experience of a Referral Hospital","authors":"A. Salam, Md. Rafiqul Islam, H. Z. Rahman, A. Ahmed, M. R. Quddus","doi":"10.3329/bjn.v31i2.57382","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57382","url":null,"abstract":"Purpose: To analyze the socio-demographic and electro-clinical data of Epilepsy patients presenting in the ‘Epilepsy Clinic’ of a referral hospital. \u0000Method: Epilepsy patients came to this weekly clinic after referral from this hospital OPD, other hospitals and from private practitioners. All the patients were enrolled from November, 2012 to December, 2015. Then clinical diagnosis was established by the chief investigator. Routine EEG was done. MRI was advised in appropriate cases. Finally the clinical findings and investigation reports were correlated. \u0000Results: Among 331 patients, 63% were male and 37% were female. 86% patients were in the younger age group (0- 29years). 75% patients were suffering from various forms of LRE, 19% from Generalized Epilepsy Syndrome, 2.7% were unclassified and 2.7% had pseudo-seizure. Total 224 EEG could be done. Among them 118 (52.7%) had different types of abnormalities. Among total 158 MRI, 120 (76%) were abnormal. 6.3% patients could not go to school, 3.3% left study and 12.7% patients remain unemployed due to the disease burden. \u0000Conclusion: This is a hospital based study. In this study LRE comprises 75% of total patients which is relatively higher than other reports. Males were predominating and younger people were affected more with epilepsy. Due to this disease various social problems were occurring regarding study and employment. This result demands community based larger study in our country. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 83-93","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"65 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72600581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hosen, Md. Rafiqul Islam, A. N. Rizvi, M. Bhuyian
{"title":"Association of Dyslipidaemia in Young Patients with Recent Ischaemic Stroke","authors":"M. Hosen, Md. Rafiqul Islam, A. N. Rizvi, M. Bhuyian","doi":"10.3329/bjn.v31i2.57379","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57379","url":null,"abstract":"Background: The relation between serum lipids and ischemic stroke remains controversial in young patients. The aim was to determine the serum lipid profile and the vascular risk factors for ischaemic stroke in a series of patients under 45 with an ischemic stroke and to compare them with a series of controls of the same age. \u0000Material and method: This case-control study was conducted in the Department of Neurology and Department of Biochemistry of BSMMU, Dhaka, between the period of July 2007 and June 2009 for duration of two years. A total number of 50 patients presented with recent ischemic stroke and 50 control person were enrolled in this study. All patients of both sexes, aged between 15 to 45 years presented with ischemic stroke, from 0 day to 1 month that was confirmed by CT scan of head/MRI of brain. Vascular risk factors were recorded and blood sample was collected from the cases and the controls and analyzed at the Dept. of Biochemistry, BSMMU for estimation of serum fasting lipid profile. \u0000Result: Multivariate analyses showed that other than serum lipids- family history of dyslipidaemia, family history of stroke or TIA, history of HTN and smoking habit are found significant risks for stroke in young adult. \u0000Conclusion: The present study does not confirm the role of serum lipids as risk factors for ischemic stroke in young adult. Other than serum lipids- family history of dyslipidaemia, family history of stroke or TIA, history of HTN and smoking habit are found significant risks for stroke in young adult. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 56-64","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82420486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sarcopenia, A Booming Concern of Ageing World: A Review","authors":"M. Rahman","doi":"10.3329/bjn.v31i2.57383","DOIUrl":"https://doi.org/10.3329/bjn.v31i2.57383","url":null,"abstract":"Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life and death. With the onset of advancing age, muscle tissue is gradually lost, resulting in diminished mass and strength, a condition referred to as sarcopenia. The sequelae of sarcopenia often contribute to frailty, decreased independence, and subsequently increased health care costs. This review article will introduce potential mechanisms that may contribute to sarcopenia, although no one mechanism has yet, and may not completely, define this process. Despite sarcopenia is an inevitable process of life, prevention and treatments are absolutely needed in order to improve the quality of life and quality adjusted life years. Adequate nutrition and structured exercises are essential components of treatment and prevention. However, even those individuals who maintain their fitness through exercise do not appear to be immune to sarcopenia. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 110-115","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81559465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Habib, M. Islam, Aminur Rahman, N. B. Bhowmik, Md Amirul Haque
{"title":"Myasthenia gravis as a presenting feature in a patient with SCLC: A case report","authors":"R. Habib, M. Islam, Aminur Rahman, N. B. Bhowmik, Md Amirul Haque","doi":"10.3329/bjn.v31i1.57375","DOIUrl":"https://doi.org/10.3329/bjn.v31i1.57375","url":null,"abstract":"Small cell lung cancer (SCLC) is the most frequent cancer histology associated with paraneoplastic syndromes. These syndromes are typically caused by ectopic hormone production or immune-mediated tissue destruction caused by neural antigen expression from cancer cells. Lambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC).Only a few cases of myasthenia gravis (MG) and SCLC were previously reported. The causal association between lung cancer and non-thymomatous myasthenia gravis has not been clarified yet. To date, there has been no evidence supporting the speculation that association of myasthenia gravis with lung cancer might be one of the phenotypes of paraneoplastic syndrome. We present a case of a 47-year-old male ex-smoker with SCLC associated with myasthenia gravis evidenced by the clinical findings of ptosis, dysphagia, proximal weakness, and positive repetitive nerve stimulation (RNS) test. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 50-55","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81368522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Imran Sarker, M. R. K. Khan, A. Haque, Md Rafiqul Islam
{"title":"Cerebrospinal Fluid Biomarkers for Diagnosis of Alzheimer’s Disease","authors":"Imran Sarker, M. R. K. Khan, A. Haque, Md Rafiqul Islam","doi":"10.3329/bjn.v31i1.57373","DOIUrl":"https://doi.org/10.3329/bjn.v31i1.57373","url":null,"abstract":"Alzheimer’s disease is the most common cause of dementia among elderly people. The major pathological hallmarks of AD are the loss of neurons, occurrence of extracellular senile plaques as well as intracellular neurofibrillary tangles (NFT). Biochemical changes in the brain are reflected in the cerebrospinal fluid (CSF), and intense research efforts have been made to develop biomarkers for the central pathogenic processes in AD that can be used as diagnostic tools. Biomarkers are essential part of disease management as they are essential for diagnosis, monitoring the disease progression, detecting early onset of the disease, monitoring the effect of therapeutic intervention, and also avoiding false diagnosis of the disease. Unfortunately, none of the biomarkers presently available are able to accomplish the disease diagnosis single-handedly. Three CSF biomarkers, Aâ42, Total-tau (t-tau), and phosphorylated-tau (p-tau), have been found to have the highest diagnostic potential. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 34-41","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72892027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Abdul Alim, M. Hannan, SK Abdul Kader, Abu Jafor Md Salauddin, -. Kabiruzzaman, M. Rana, K. Patwary, Nuruddin Mohammad Eusuf, Rashed Immam Jahid, S. Hasan, H. Kabir, Akm Golam Kabir
{"title":"Association Between Serum C- Reactive Protein With Migraine: A Case Control Study","authors":"Md Abdul Alim, M. Hannan, SK Abdul Kader, Abu Jafor Md Salauddin, -. Kabiruzzaman, M. Rana, K. Patwary, Nuruddin Mohammad Eusuf, Rashed Immam Jahid, S. Hasan, H. Kabir, Akm Golam Kabir","doi":"10.3329/bjn.v31i1.57370","DOIUrl":"https://doi.org/10.3329/bjn.v31i1.57370","url":null,"abstract":"Objective: The present case-control study was undertaken to find the association between serum level of CRP and attack of migraine. \u0000Methods: The study was carried out at the Headache Clinic and Outpatient Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka over a period of 2 years from January 2010 to December 2011. Migraine patients attending at the above mentioned places were enrolled as cases, while apparently healthy attendants of cases and other healthy persons, who did not have any history of migraine, were included as control. Based on predefined enrollment criteria, a total of 163 subjects were included in the study. Of them 87 were cases and 76 were controls. The serum levels of CRP of both cases and controls were measured and a serum level of > 6 mg/L was considered as raised/ elevated CRP. Levels of CRP were compared between groups (case and control) using appropriate statistical tests. \u0000Result: The findings of the study showed that the age and sex distribution of case and control groups were almost comparable. The behavioral factors like food or smoking habit and tobacco leaf chewing had no difference between the groups. Over 20% of migraine patients had abnormally high CRP as compared to 7.9% in the control group (p = 0.021). The migraine patients were 3(95% CI = 1.1 - 8.1) times more likely to be associated with raised CRP (> 6 mg/L) than their healthy counterparts. There were 7 migraine patients with aura and 80 without aura. The level of CRP was not found to be associated with type of migraine (with or without aura) (p = 0.960). \u0000Conclusion: Every one in five patients exhibits abnormally high CRP. The level of CRP does not vary whether the migraine is being associated with or without aura. The migraineurs carry higher risk of developing elevated CRP than their normal counterparts. \u0000Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 1-8","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81429677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}