IEEE life sciences letters最新文献

Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum. 阿尔茨海默氏症谱系中的叙事障碍、白质损伤和脑脊液生物标志物。

IEEE life sciences letters Pub Date : 2019-10-31 DOI: 10.18632/aging.102391

Claudia Drummond, Gabriel Coutinho, Marina Carneiro Monteiro, Naima Assuncao, Alina Teldeschi, Andrea Silveira de Souza, Natalia Oliveira, Ivanei Bramati, Felipe Kenji Sudo, Bart Vanderboght, Carlos Otavio Brandao, Rochele Paz Fonseca, Ricardo de Oliveira-Souza, Jorge Moll, Paulo Mattos, Fernanda Tovar-Moll

{"title":"Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum.","authors":"Claudia Drummond, Gabriel Coutinho, Marina Carneiro Monteiro, Naima Assuncao, Alina Teldeschi, Andrea Silveira de Souza, Natalia Oliveira, Ivanei Bramati, Felipe Kenji Sudo, Bart Vanderboght, Carlos Otavio Brandao, Rochele Paz Fonseca, Ricardo de Oliveira-Souza, Jorge Moll, Paulo Mattos, Fernanda Tovar-Moll","doi":"10.18632/aging.102391","DOIUrl":"10.18632/aging.102391","url":null,"abstract":"Background: Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied.Objectives: We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum.Results: Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p<0.01). ROIs DTI assessment distinguished the three groups. Mean Diffusivity (MD) in the uncinate, bilateral parahippocampal cingulate and left inferior occipitofrontal fasciculi negatively correlated with NProd. Changes in specific tracts correlated with T-tau/Aβ1-42 ratio in CSF.Conclusions: AD and aMCI patients presented more ND impairments than controls. Those findings were associated with changes in ventral language-associated and in the inferior parahippocampal pathways. The latest were correlated with biomarkers' levels in the CSF.Methods: AD (N=14), aMCI (N=31) and Control (N=39) groups were compared for whole brain (WB) and regions of interest (ROI) DTI parameters, ND and AD CSF biomarkers.","PeriodicalId":87271,"journal":{"name":"IEEE life sciences letters","volume":"2 4","pages":"9188-9208"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72568691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE life sciences letters Pub Date : 2017-10-25 DOI: 10.1109/LLS.2017.2756835

Pinar Kanlikilicer;Andrei Dragomir;Die Zhang;Yasemin Akay;Metin Akay

{"title":"The Age-Related Effect of Nicotine on the Expression of Neuroprotective Genes in Ventral Tegmental Area and Substantia Nigra","authors":"Pinar Kanlikilicer;Andrei Dragomir;Die Zhang;Yasemin Akay;Metin Akay","doi":"10.1109/LLS.2017.2756835","DOIUrl":"10.1109/LLS.2017.2756835","url":null,"abstract":"Selective degeneration of dopaminergic neurons, which are predominantly located in the substantia nigra (SN) of the midbrain, is one of the hallmarks of Parkinson's disease (PD). Large-scale microarray experimental data revealed several genes with significantly differential expression between the ventral tegmental area (VTA) and the SN dopamine (DA) neurons. Several epidemiological studies have additionally indicated nicotine-mediated neuroprotection in PD patients. Based on the strong evidence implicating lipoprotein lipase (LPL), pituitary adenylate cyclase-activating polypeptide and gastrin-releasing peptide genes in neuroprotection, this letter investigates areaand age-specific nicotine regulation of these genes' expression in the VTA and SN of different age groups (3 months, 12 months, and 24 months) in an in vivo animal model. Our in vivo rat model results suggest that out of these genes, only the LPL gene has significantly differential expression between the VTA and SN in the senior age group (24 months). Nicotine treatment did not upregulate the neuroprotective genes in adult and senior groups (12 and 24 months). Differential expression of the LPL gene in the senior population may contribute to the different survival rates of DA neurons within the VTA and SN. However, downregulation by nicotine suggests that these genes may not be related to the nicotine-mediated neuroprotection known to reduce the risks of PD. Our results suggest that nicotine may not play an important role in the regulation of neuroprotective gene expressions, while providing new insights into the role of nicotine in PD.","PeriodicalId":87271,"journal":{"name":"IEEE life sciences letters","volume":"3 4","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/LLS.2017.2756835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41457675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Delay-Based Sustained Chemical Oscillator: Qualitative Analysis of Oregonator-Based Models 基于延迟的持续化学振荡器：基于Oregonator模型的定性分析

IEEE life sciences letters Pub Date : 2017-09-26 DOI: 10.1109/LLS.2017.2756834

Hakki Ulaş Ünal;Islam Boussaada;Silviu-Iulian Niculescu

引用次数: 3

Automatic Optimization Method for Segmentation and Surface Model Generation in Electron Tomography 电子层析成像中分割和表面模型生成的自动优化方法

IEEE life sciences letters Pub Date : 2017-06-01 DOI: 10.1109/LLS.2017.2756886

Jae Hoon Jung;Joseph Szule

引用次数: 5

ON–OFF Feedback Control of Plug-Flow Crystallization: A Case of Quality-by-Control in Continuous Manufacturing 塞流结晶的开-关反馈控制——以连续生产中的质量控制为例

IEEE life sciences letters Pub Date : 2017-01-31 DOI: 10.1109/LLS.2017.2661981

Andy Koswara;Zoltan K. Nagy

引用次数: 7

Conditions for Cell Size Homeostasis: A Stochastic Hybrid System Approach 细胞大小稳态的条件:一种随机混合系统方法

IEEE life sciences letters Pub Date : 2016-12-29 DOI: 10.1109/LLS.2016.2646383

Cesar Augusto Vargas-Garcia;Mohammad Soltani;Abhyudai Singh

{"title":"Conditions for Cell Size Homeostasis: A Stochastic Hybrid System Approach","authors":"Cesar Augusto Vargas-Garcia;Mohammad Soltani;Abhyudai Singh","doi":"10.1109/LLS.2016.2646383","DOIUrl":"https://doi.org/10.1109/LLS.2016.2646383","url":null,"abstract":"How isogenic cell populations maintain size homeostasis, i.e., a narrow distribution of cell size, is an intriguing fundamental problem. We model cell size using a stochastic hybrid system, where a cell grows exponentially in size (volume) over time and probabilistic division events are triggered at discretetime intervals. Moreover, whenever division occurs, size is randomly partitioned among daughter cells. We first consider a scenario where a timer (cell-cycle clock) that measures the time elapsed since the last division event regulates both the cellular growth and division rates. The analysis reveals that such a timer-controlled system cannot achieve size homeostasis, in the sense that the cell-to-cell size variation grows unboundedly with time. To explore biologically meaningful mechanisms for controlling size, we consider two classes of regulation: a size-dependent growth rate and a size-dependent division rate. Our results show that these strategies can provide bounded intercellular variation in cell size and exact mathematical conditions on the form of regulation needed for size homeostasis are derived. Different known forms of size control strategies, such as the adder and the sizer, are shown to be consistent with these results. Finally, we discuss how organisms ranging from bacteria to mammalian cells have adopted different control approaches for maintaining size homeostasis.","PeriodicalId":87271,"journal":{"name":"IEEE life sciences letters","volume":"2 4","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2016-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/LLS.2016.2646383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49986485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Proportional–Integral Degradation Control Allows Accurate Tracking of Biomolecular Concentrations With Fewer Chemical Reactions 比例积分降解控制允许精确跟踪生物分子浓度与较少的化学反应

IEEE life sciences letters Pub Date : 2016-12-23 DOI: 10.1109/LLS.2016.2644652

Mathias Foo, Jongrae Kim, Jongmin Kim, D. Bates

{"title":"Proportional–Integral Degradation Control Allows Accurate Tracking of Biomolecular Concentrations With Fewer Chemical Reactions","authors":"Mathias Foo, Jongrae Kim, Jongmin Kim, D. Bates","doi":"10.1109/LLS.2016.2644652","DOIUrl":"https://doi.org/10.1109/LLS.2016.2644652","url":null,"abstract":"We consider the design of synthetic embedded feedback circuits that can implement desired changes in the concentration of the output of a biomolecular process (reference tracking in control terminology). Such systems require the use of a “subtractor” to generate an error signal that captures the difference between the current and desired values of the process output. Unfortunately, standard implementations of the subtraction operator using chemical reaction networks are one sided, i.e., they cannot produce negative error signals. Previous attempts to deal with this problem by representing signals as the difference in concentrations of two different biomolecular species lead to a doubling of the number of chemical reactions required to generate the circuit, hence sharply increasing the difficulty of experimental implementations and limiting the complexity of potential designs. Here, we propose an alternative approach that introduces a degradation term into the classical proportion–integral (PI) control scheme. The extra tuning flexibility of the PI degradation controller compensates for the limitations of the one-sided subtraction operator, providing robust high-performance tracking of concentration changes with a minimal number of chemical reactions.","PeriodicalId":87271,"journal":{"name":"IEEE life sciences letters","volume":"2 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2016-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/LLS.2016.2644652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62509668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effective Dynamic Models of Metabolic Networks 代谢网络的有效动态模型

IEEE life sciences letters Pub Date : 2016-12-23 DOI: 10.1109/LLS.2016.2644649

Michael Vilkhovoy;Mason Minot;Jeffrey D. Varner

引用次数: 0

Proportional–Integral Degradation Control Allows Accurate Tracking of Biomolecular Concentrations With Fewer Chemical Reactions 比例积分降解控制允许精确跟踪生物分子浓度与较少的化学反应

IEEE life sciences letters Pub Date : 2016-12-23 DOI: 10.1109/LLS.2016.2644652

Mathias Foo;Jongrae Kim;Jongmin Kim;Declan G. Bates

{"title":"Proportional–Integral Degradation Control Allows Accurate Tracking of Biomolecular Concentrations With Fewer Chemical Reactions","authors":"Mathias Foo;Jongrae Kim;Jongmin Kim;Declan G. Bates","doi":"10.1109/LLS.2016.2644652","DOIUrl":"https://doi.org/10.1109/LLS.2016.2644652","url":null,"abstract":"We consider the design of synthetic embedded feedback circuits that can implement desired changes in the concentration of the output of a biomolecular process (\u0000<italic>reference tracking\u0000 in control terminology). Such systems require the use of a “subtractor” to generate an error signal that captures the difference between the current and desired values of the process output. Unfortunately, standard implementations of the subtraction operator using chemical reaction networks are one sided, i.e., they cannot produce negative error signals. Previous attempts to deal with this problem by representing signals as the difference in concentrations of two different biomolecular species lead to a doubling of the number of chemical reactions required to generate the circuit, hence sharply increasing the difficulty of experimental implementations and limiting the complexity of potential designs. Here, we propose an alternative approach that introduces a degradation term into the classical proportion–integral (PI) control scheme. The extra tuning flexibility of the PI degradation controller compensates for the limitations of the one-sided subtraction operator, providing robust high-performance tracking of concentration changes with a minimal number of chemical reactions.","PeriodicalId":87271,"journal":{"name":"IEEE life sciences letters","volume":"2 4","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2016-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/LLS.2016.2644652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49986487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Cell as a Decision-Making Unit 作为决策单位的细胞

IEEE life sciences letters Pub Date : 2016-12-23 DOI: 10.1109/LLS.2016.2644648

L. Castelli, R. Pesenti, D. Segrè

引用次数: 4