Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum.

IEEE life sciences letters Pub Date : 2019-10-31 DOI:10.18632/aging.102391

Claudia Drummond, Gabriel Coutinho, Marina Carneiro Monteiro, Naima Assuncao, Alina Teldeschi, Andrea Silveira de Souza, Natalia Oliveira, Ivanei Bramati, Felipe Kenji Sudo, Bart Vanderboght, Carlos Otavio Brandao, Rochele Paz Fonseca, Ricardo de Oliveira-Souza, Jorge Moll, Paulo Mattos, Fernanda Tovar-Moll

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Abstract

Background: Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied.

Objectives: We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum.

Results: Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p<0.01). ROIs DTI assessment distinguished the three groups. Mean Diffusivity (MD) in the uncinate, bilateral parahippocampal cingulate and left inferior occipitofrontal fasciculi negatively correlated with NProd. Changes in specific tracts correlated with T-tau/Aβ1-42 ratio in CSF.

Conclusions: AD and aMCI patients presented more ND impairments than controls. Those findings were associated with changes in ventral language-associated and in the inferior parahippocampal pathways. The latest were correlated with biomarkers' levels in the CSF.

Methods: AD (N=14), aMCI (N=31) and Control (N=39) groups were compared for whole brain (WB) and regions of interest (ROI) DTI parameters, ND and AD CSF biomarkers.

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阿尔茨海默氏症谱系中的叙事障碍、白质损伤和脑脊液生物标志物。

背景：叙述性话语（ND）是指一个人口头再现一连串有时间和逻辑联系的事件的能力。患有失忆性轻度认知功能障碍（aMCI）和阿尔茨海默病（AD）的受试者可能会出现 ND 功能障碍，但这种功能、神经影像学和脑脊液（CSF）AD 生物标志物之间的相关性仍未得到充分研究：我们试图测量AD谱系内患者的ND、弥散张量成像（DTI）指数和AD CSF生物标志物之间的相关性：aMCI 和注意力缺失症患者的推理能力比对照组差。在 WB 方面，AD 受试者比对照组和 aMCI 受试者的能力更差（p 结论：AD 和 aMCI 患者的 WB 能力比对照组和 aMCI 更强：与对照组相比，AD 和 aMCI 患者的 ND 能力受损更严重。这些发现与腹侧语言相关通路和下海马旁通路的变化有关。最新结果与脑脊液中的生物标志物水平相关：方法：比较AD组（14人）、aMCI组（31人）和对照组（39人）的全脑（WB）和感兴趣区（ROI）DTI参数、ND和AD CSF生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IEEE life sciences letters

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