发布求助
文献互助 智能选刊 最新文献

CellR4-- repair, replacement, regeneration, & reprogramming最新文献

筛选
英文 中文
Considerations on the harvesting site and donor derivation for mesenchymal stem cells-based strategies for diabetes. 基于间充质干细胞的糖尿病策略的收获位点和供体来源的考虑。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-09-29
L Zazzeroni, G Lanzoni, G Pasquinelli, C Ricordi
{"title":"Considerations on the harvesting site and donor derivation for mesenchymal stem cells-based strategies for diabetes.","authors":"L Zazzeroni,&nbsp;G Lanzoni,&nbsp;G Pasquinelli,&nbsp;C Ricordi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mesenchymal Stem Cells (MSCs) possess important characteristics that could be exploited in therapeutic strategies for Type 1 Diabetes (T1D) and for certain complications of Type 2 Diabetes (T2D). MSCs can inhibit autoimmune, alloimmune and inflammatory processes. Moreover, they can promote the function of endogenous and transplanted pancreatic islets. Furthermore, they can stimulate angiogenesis. MSC functions are largely mediated by their secretome, which includes growth factors, exosomes, and other extracellular vesicles. MSCs have shown a good safety profile in clinical trials. MSC-derived exosomes are emerging as an alternative to the transplantation of live MSCs. MSCs harvested from different anatomical locations (e.g. bone marrow, umbilical cord, placenta, adipose tissue, and pancreas) have shown differences in gene expression profiles and function. Data from clinical trials suggest that umbilical cord-derived MSCs could be superior to bone marrow-derived MSCs for the treatment of T1D. Autologous MSCs from diabetic patients may present abnormal functions. BM-MSCs from T1D patients exhibit gene expression differences that may impact in vivo function. BM-MSCs from T2D patients seem to be significantly impaired due to the T2D diabetic milieu. In this review, we highlight how the harvesting site and donor derivation can affect the efficacy of MSC-based treatments for T1D and T2D.</p>","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267851/pdf/nihms-994869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHPI, MPBR, Part 2A (Product Code PHPI-A-01, Islets Alone). PHPI, MPBR, Part 2A(产品代码php - a -01, Islets Alone)。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"PHPI, MPBR, Part 2A (Product Code PHPI-A-01, Islets Alone).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319354/pdf/nihms-997524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raw Material Specification, Lisofylline, 60 mg/mL. 原料规格:异茶碱，60mg /mL。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"Raw Material Specification, Lisofylline, 60 mg/mL.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319361/pdf/nihms-997516.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raw Material Specification, Exenatide, 250 μg/mL. 原料规格:艾塞那肽，250 μg/mL。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"Raw Material Specification, Exenatide, 250 <i>μ</i>g/mL.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319640/pdf/nihms-997517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHPI, MPBR, Part 2B (Product Code PHPI-L-01, Islets with Lisofylline). PHPI, MPBR, Part 2B(产品代码PHPI- l -01, Islets with Lisofylline)。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"PHPI, MPBR, Part 2B (Product Code PHPI-L-01, Islets with Lisofylline).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319645/pdf/nihms-997529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The greater omentum as a site for pancreatic islet transplantation. 大网膜作为胰岛移植的一个部位。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-06-20
M Pellicciaro, I Vella, G Lanzoni, G Tisone, C Ricordi
{"title":"The greater omentum as a site for pancreatic islet transplantation.","authors":"M Pellicciaro,&nbsp;I Vella,&nbsp;G Lanzoni,&nbsp;G Tisone,&nbsp;C Ricordi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The greater omentum is a highly vascularized anatomical structure in the peritoneal cavity. Its main components are connective, adipose and vascular cells, along with specialized immune cells. The omentum functions as a site for fat accumulation, it has adhesive properties to control traumatized and inflamed tissues, and a function in local hemostasis, immune responses, and revascularization. Other functions include the absorption of fluids, the phagocytosis of particulate matter, and foreign body reaction. The omentum is catalyzing significant interest for its potential as a site for pancreatic islet and cell transplantation. Our knowledge about this structure, its functions, and its potential as a site for transplantation is poised to grow in the coming years.</p>","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025931/pdf/nihms-1057406.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25590186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHPI, MPBR, Part 2B (Product Code PHPI-L-01 or PHPI-E-01, Islets with Lisofylline or Exenatide). PHPI, MPBR, Part 2B(产品代码PHPI- l -01或PHPI- e -01，含有异茶碱或艾塞那肽的胰岛)。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"PHPI, MPBR, Part 2B (Product Code PHPI-L-01 or PHPI-E-01, Islets with Lisofylline or Exenatide).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319632/pdf/nihms-997527.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purified Human Pancreatic Islets Master Production Batch Record, Part 1 University of Illinois, Chicago & University of Miami (Product Codes PHPI-A-01, PHPI-E-01, PHPI-L-01). 纯化人胰岛主生产批记录，第1部分，伊利诺伊大学，芝加哥大学和迈阿密大学(产品代码:PHPI-A-01, PHPI-E-01, PHPI-L-01)。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"Purified Human Pancreatic Islets Master Production Batch Record, Part 1 University of Illinois, Chicago & University of Miami (Product Codes PHPI-A-01, PHPI-E-01, PHPI-L-01).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319353/pdf/nihms-997518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purified Human Pancreatic Islets, CIT Transplant Media with Lisofylline or Exenatide. 纯化的人胰岛，CIT移植培养基与Lisofylline或艾塞那肽。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-05-26
{"title":"Purified Human Pancreatic Islets, CIT Transplant Media with Lisofylline or Exenatide.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319650/pdf/nihms-997676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purified Human Pancreatic Islets Master Production Batch Record, Part 1 University of Illinois, Chicago & University of Miami (Product Codes PHPI-A-01 & PHPI-L-01). 纯化人胰岛主生产批记录，第1部分，伊利诺伊大学，芝加哥和迈阿密大学(产品代码:PHPI-A-01和PHPI-L-01)。
CellR4-- repair, replacement, regeneration, & reprogramming Pub Date : 2017-01-01 Epub Date: 2017-04-11
{"title":"Purified Human Pancreatic Islets Master Production Batch Record, Part 1 University of Illinois, Chicago & University of Miami (Product Codes PHPI-A-01 & PHPI-L-01).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319893/pdf/nihms-994943.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36881101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信