CellR4-- repair, replacement, regeneration, & reprogramming最新文献

{"title":"Purified Human Pancreatic Islets, CIT Wash Solution: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319646/pdf/nihms-996200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets, Supplementary Purification, Biocoll Procedure & Record: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319639/pdf/nihms-996210.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets, CIT Purification Solution: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319619/pdf/nihms-996208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets, CIT Purification Density Gradients: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319662/pdf/nihms-996205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets, CIT Digestion Solution: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319879/pdf/nihms-995430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cardiac regenerative potential of myoblasts remains limited despite improving their survival via antioxidant treatment.","authors":"Sarah A Beckman,&nbsp;Naosumi Sekiya,&nbsp;William C W Chen,&nbsp;Logan Mlakar,&nbsp;Kimimassa Tobita,&nbsp;Johnny Huard","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Since myoblasts have been limited by poor cell survival after cellular myoplasty, the major goal of the current study was to determine whether improving myoblast survival with an antioxidant could improve cardiac function after the transplantation of the myoblasts into an acute myocardial infarction.</p><p><strong>Background: </strong>We previously demonstrated that early myogenic progenitors such as muscle-derived stem cells (MDSCs) exhibited superior cell survival and improved cardiac repair after transplantation into infarcted hearts compared to myoblasts, which we partially attributed to MDSC's higher antioxidant levels.</p><p><strong>Aim: </strong>To determine if antioxidant treatment could increase myoblast survival, subsequently improving cardiac function after myoblast transplantation into infarcted hearts.</p><p><strong>Materials and methods: </strong>Myoblasts were pre-treated with the antioxidant N-acetylcysteine (NAC) or the glutathione depleter, diethyl maleate (DEM), and injected into infarcted murine hearts. Regenerative potential was monitored by cell survival and cardiac function.</p><p><strong>Results: </strong>At early time points, hearts injected with NAC-treated myoblasts exhibited increased donor cell survival, greater cell proliferation, and decreased cellular apoptosis, compared to untreated myoblasts. NAC-treated myoblasts significantly improved cardiac contractility, reduced fibrosis, and increased vascular density compared to DEM-treated myoblasts, but compared to untreated myoblasts, no difference was noted.</p><p><strong>Discussion: </strong>While early survival of myoblasts transplanted into infarcted hearts was augmented by NAC pre-treatment, cardiac function remained unchanged compared to non-treated myoblasts.</p><p><strong>Conclusion: </strong>Despite improving cell survival with NAC treated myoblast transplantation in a MI heart, cardiac function remained similar to untreated myoblasts. These results suggest that the reduced cardiac regenerative potential of myoblasts, when compared to MDSCs, is not only attributable to cell survival but is probably also related to the secretion of paracrine factors by the MDSCs.</p>","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627517/pdf/nihms855248.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35582656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Composition and Fractional β-Cell Viability Assay.","authors":"H Ichii,&nbsp;A Pileggi,&nbsp;R D Molano,&nbsp;E Linetsky,&nbsp;R Alejandro,&nbsp;L Inverardi,&nbsp;C Ricordi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319378/pdf/nihms-996223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36837579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes in the Pathogenesis, Diagnosis and Treatment of Pancreatic Diseases.","authors":"M Garcia-Contreras,&nbsp;C Ricordi,&nbsp;P D Robbins,&nbsp;E Oltra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exosomes (EXOs) are small vesicles (30-200 nm) of endocytic origin, which are released by many different cell types into the extracellular space. They may play a key role in facilitating cell-cell communication, under both physiological and pathological conditions. EXOs contain a wide range of RNA molecules and proteins. Their specific molecular signatures make them promising candidates in early diagnosis and prognosis of pancreatic diseases. EXOs could also provide a new method to monitor treatment response in patients suffering from pancreatic cancer and other diseases of the pancreas. Additionally they may help to improve current treatments via personalized medicine approaches using them as therapeutic vehicles themselves.</p>","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048207/pdf/nihms-1059485.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38885683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets, CIT Culture Media: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343843/pdf/nihms-995427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36978352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purified Human Pancreatic Islets (PHPI) Master Production Batch Record: A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87230,"journal":{"name":"CellR4-- repair, replacement, regeneration, & reprogramming","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300133/pdf/nihms-995419.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36812089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}