Blood and genomics最新文献_第2页

HLA-A, -B, -C, -DRB1 and -DQB1 alleles associated with different hematological diseases in Chinese population HLA-A、-B、-C、-DRB1和-DQB1等位基因与中国人群不同血液病的相关性

Blood and genomics Pub Date : 2021-01-01 DOI: 10.46701/bg.2021022021116

Lijun Wang, Dongmei Li, Jie Wang, Y. Jing, Zhongmei Wang, Yanjun Jia

引用次数: 0

The combination of DNA methyltransferase inhibitor therapy and immunotherapy for acute myeloid leukemia DNA甲基转移酶抑制剂联合免疫治疗急性髓性白血病

Blood and genomics Pub Date : 2021-01-01 DOI: 10.46701/bg.2021022021132

Yuxuan Wu, Z. Xiang

引用次数: 0

The progress and perspectives of CAR-T cell therapy CAR-T细胞治疗的进展与展望

Blood and genomics Pub Date : 2021-01-01 DOI: 10.46701/bg.2021022021126

Yan Peng, Zhenqing Feng

引用次数: 0

Identification and analysis of a rare CisAB group 一个罕见的CisAB群的鉴定和分析

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020012019133

Ziyi He, Ying-xin Hu, Si-Xing Cui

引用次数: 0

Genetic predisposition to multiple myeloma 多发性骨髓瘤的遗传易感性

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020012020103

Yan Cheng, Fumou Sun, X. Cui, S. Janz

{"title":"Genetic predisposition to multiple myeloma","authors":"Yan Cheng, Fumou Sun, X. Cui, S. Janz","doi":"10.46701/bg.2020012020103","DOIUrl":"https://doi.org/10.46701/bg.2020012020103","url":null,"abstract":"Genetic myeloma risk research relied on genome - wide association studies to identify 24 common but low-impact germline predisposition alleles that account for an estimated one eighth of the heritable myeloma risk in Caucasians. Next - generation sequencing, particularly whole - exome sequencing, uncovered a handful of rare but high - impact myeloma risk loci that convey intriguing clues about etiology. The recent discovery of NCOA1 as a myeloma susceptibility gene in Han Chinese has set the stage for the more complete elucidation of the genetic myeloma risk across ethnic barriers. Validating individual myeloma risk loci at the functional level and integrat-ing predisposition genes in genetic networks and biological pathways are important research tasks going forward. Candidate pathways that are currently emerging include plasma cell development, autophagy, telomere maintenance, and cell cycle regulation. An outstanding knowledge gap in the area of gene - environment interaction con-cerns the possibility that tumor - promoting effects of myeloma susceptibility alleles depend on specific environmental or occupational exposures. An implicit promise of myeloma risk research is the detection of new molecular targets for myeloma treatments and preventions. A related outcome is new biomarkers for patient stratification, prognostication, and development of individualized treatment plans.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89318216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological and genetic analysis of ABO ambiguous blood group samples ABO歧义血型样本的血清学和遗传学分析

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020022020112

Ying Li, Jinming Xu, Yongliang Zhu, Ting Xiong, Ling Zhao, Yunnan Yao, Xiaoyu Zhou

{"title":"Serological and genetic analysis of ABO ambiguous blood group samples","authors":"Ying Li, Jinming Xu, Yongliang Zhu, Ting Xiong, Ling Zhao, Yunnan Yao, Xiaoyu Zhou","doi":"10.46701/bg.2020022020112","DOIUrl":"https://doi.org/10.46701/bg.2020022020112","url":null,"abstract":"The accuracy of regular serum methods to detect ABO blood groups can be negatively affected by some factors, such as irregular antibodies, autoantibodies or effects of diseases leading to false or weak agglutination. This study aimed to accurately identify ambiguous ABO blood groups by serological and gene detection methods. The samples were collected in the First Affiliated Hospital of Nanjing Medical University from December 2018 to December 2019. ABO genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP) method in 20 samples, and ABO exons 6 and 7 or FUT1 and FUT2 genes were sequenced in 5 samples. The genes detected in the 21 specimens included 4 cases of A/B, 2 cases of A205/O01, 3 cases of A/O01, 3 cases of A/O02, 1 case of O01/O01, 1 case of O01/O02, 1 case of B/O01, 1 case of B/O02, 1 case of Bel/O01, 1 case of Cisab01/O01, 1 case of rare B/O04, 1 case of Bombay-like Bmh, 1 case of new gene showing c.261del G of exon 6, c.579 T>C of exon 7 and B new/O01. This study suggests that ABO blood group genotyping technology combined with serological typing can be used for accurately typing ambiguous blood groups.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83050004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rare B(A)02/O01 was found in Sichuan again: a case report 四川再次发现罕见B(A)02/O01 1例

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020022020117

Jie Wang, lin gui, Wei-xin Zhou, Jianbo Yang, Yuanshuai Huang

引用次数: 0

Prevalence and specificity of some rare red cell pan-reactive alloantibodies against high frequency red cell antigens among hospitalized Saudi patients 沙特住院患者中一些罕见的针对高频红细胞抗原的泛反应性异体抗体的患病率和特异性

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020022020126

Samy M Attallah, Tarek Hakeem, Ebrahim Hamdy, Zyiad AlHarby, Faisal Althubiani, Ershad Dade, Abdulla Al Harbi

{"title":"Prevalence and specificity of some rare red cell pan-reactive alloantibodies against high frequency red cell antigens among hospitalized Saudi patients","authors":"Samy M Attallah, Tarek Hakeem, Ebrahim Hamdy, Zyiad AlHarby, Faisal Althubiani, Ershad Dade, Abdulla Al Harbi","doi":"10.46701/bg.2020022020126","DOIUrl":"https://doi.org/10.46701/bg.2020022020126","url":null,"abstract":"Some patients' sera react with all available donors' red cells and a compatible donor is difficult or impossible to be found. These may either be due to a complex mixture of antibodies or the presence of alloantibodies against high-frequency antigens (HFAs). The aim of this study is to identify the prevalence and characteristics of antibodies to HFAs in Saudi Arabian patients. A total of 23 out of 172 000 patients who received blood transfusions had rare alloantibodies to HFAs at an incidence of 0.013%. Twenty-three patients suspected with pan-reactive alloantibodies against HFAs had their red cells tested using antisera to HFAs, while their plasma was tested against a selected panel of red blood cells with rare phenotypes. Anti-Ge2 antibody was found in the highest number of patients (56.5%), whereas anti-U, anti JK3, anti H, anti-RH 29, anti-hr, anti-Kn, anti-Ch, anti-Rg, anti-Yt, and anti-Cr antibodies were found in the remaining patients (43.5%). This study suggests that although antibodies such as anti-Ge2, antiKn, anti-Ch, anti-Rg, anti-Yt , and anti-Cr are not clinically significant, they cause a delay in the provision of compatible blood. Whereas, anti-U, anti JK3, anti H, anti-RH29 and anti-hr are clinically significant antibodies. An understanding of antibody characteristics to HFAs and the widespread use of the extended red cell phenotype and antibody identification panel will both be helpful for the diagnosis of these HFAs.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84463599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronavirus disease 2019 (COVID-19): diagnosis and prognosis. 冠状病毒病 2019（COVID-19）：诊断与预后。

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/BG.2020022020120

Xueying Wang, Yang Zhou, Linlin Liu, Jinmin Ma, Honglong Wu, Lijian Zhao, Weijun Chen, Shengwen Calvin Li, Qian Ran, Zhongjun Li

引用次数: 0

B para-Bombay phenotype in China caused by homozygous mutation for site 328 G>A of FUT1 gene: a case report FUT1基因328 G>A位点纯合突变引起的中国B类孟买表型1例

Blood and genomics Pub Date : 2020-01-01 DOI: 10.46701/bg.2020022020116

Z. Gu, Chun Li, Hua-Dong Lu

引用次数: 0