发布求助
文献互助 智能选刊 最新文献

Barcelona respiratory network reviews最新文献

筛选
英文 中文
Physical Activity and Underlying Muscle Biology in Chronic Obstructive Pulmonary Disease (COPD) 慢性阻塞性肺疾病（COPD）的体力活动和基础肌肉生物学
Barcelona respiratory network reviews Pub Date : 2019-07-01 DOI: 10.23866/BRNREV:2018-0013
L. Mantoani, H. Silva, R. Rabinovich
{"title":"Physical Activity and Underlying Muscle Biology in Chronic Obstructive Pulmonary Disease (COPD)","authors":"L. Mantoani, H. Silva, R. Rabinovich","doi":"10.23866/BRNREV:2018-0013","DOIUrl":"https://doi.org/10.23866/BRNREV:2018-0013","url":null,"abstract":"Muscle dysfunction is one of the most studied systemic effects in patients with chronic obstructive pulmonary disease (COPD) and a predictor of mortality. It can be caused by sedentary habit due to muscle underuse. Conversely, muscle dysfunction also contributes to inactivity in COPD. To date, the underlying mechanisms of muscle dysfunction and their impacts on physical activity (PA) levels in COPD were not explored in a literature review. The aims of this review are to summarise and discuss the link between muscle dysfunction and biology with reduced levels of daily PA in patients with COPD. This manuscript covers the many aspects of physical inactivity in COPD, the relationship between muscle dysfunction and muscle biology with physical inactivity in this population, as well as the strategies used to tackle muscle impairment with a possible positive impact on activity levels in COPD and other complementary strategies to increase PA in this population. (BRN Rev. 2019;5(3):215-29) Corresponding author: Roberto A Rabinovich, Roberto.Rabinovich@ed.ac.uk","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46727801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Risk for Developing Chronic Obstructive Pulmonary Disease 慢性阻塞性肺疾病的遗传风险
Barcelona respiratory network reviews Pub Date : 2019-07-01 DOI: 10.23866/BRNREV:2018-0018
S. O'Beirne, R. Crystal
{"title":"Genetic Risk for Developing Chronic Obstructive Pulmonary Disease","authors":"S. O'Beirne, R. Crystal","doi":"10.23866/BRNREV:2018-0018","DOIUrl":"https://doi.org/10.23866/BRNREV:2018-0018","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD), a disorder characterised by chronic airway inflammation and the development of emphysema, results from complex interaction between genetic and environmental factors, most importantly cigarette smoke. Linkage analysis, candidate gene studies, genome-wide association studies, and more recently exome and whole genome sequencing have identified numerous genes and variants linked to COPD susceptibility, smoking behaviour and determinants of lung function. This has led to insights into disease pathogenesis and has the potential to result in novel therapies for the condition. However, the genetic architecture of COPD is complex, and though many susceptibility loci have been identified, they only explain a fraction of disease heritability. Newer methodologies including exome sequencing and whole genome sequencing, and the study of epigenetic and gene-by-environment interactions may uncover some of this missing heritability. The focus of this review will be to assess the role of genetics in individual susceptibility to COPD. (BRN Rev. 2019;5(3):154-68) Corresponding author: Ronald G. Crystal, geneticmedicine@med.cornell.edu","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44233027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demystifying Inhaler Use in Chronic Obstructive Airways Disease 揭开慢性阻塞性呼吸道疾病吸入器使用的神秘面纱
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/brnrev:2018-0009
M. Bonini, O. Usmani
{"title":"Demystifying Inhaler Use in Chronic Obstructive Airways Disease","authors":"M. Bonini, O. Usmani","doi":"10.23866/brnrev:2018-0009","DOIUrl":"https://doi.org/10.23866/brnrev:2018-0009","url":null,"abstract":"Chronic obstructive airways diseases afflict millions of people worldwide, being responsible for significant morbidity and mortality. Despite progresses in the understanding of the pathophysiological mechanisms and advances in the therapeutic interventions, neither asthma nor chronic obstructive pulmonary disease (COPD) can be cured as yet, although both diseases can be optimally controlled. Inhaler therapy plays a crucial role in achieving this and allows personalised treatment strategies to patients. However, satisfactory adherence and correct technique in the use of inhaler devices can be particularly challenging. The present review aims to present updated and evidence-based literature findings to shed light on the role and relevance of inhaler devices in chronic obstructive airways diseases and provide readers with clear information and advice about the use of inhalers in the variety of options available, to recognise the crucial inhaler errors and gain an insight with respect to recent innovation addressing the unmet needs in the field. (BRN Rev. 2018;4(4):304-18) Corresponding author: Matteo Bonini, m.bonini@imperial.ac.uk","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41404749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asthma-Chronic Obstructive Pulmonary Disease Overlap in Spain: Anything Special? 西班牙哮喘和慢性阻塞性肺病重叠：有什么特别的吗？
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/brnrev:2017-0035
B. Cosío, Luis Pérez de Llano
{"title":"Asthma-Chronic Obstructive Pulmonary Disease Overlap in Spain: Anything Special?","authors":"B. Cosío, Luis Pérez de Llano","doi":"10.23866/brnrev:2017-0035","DOIUrl":"https://doi.org/10.23866/brnrev:2017-0035","url":null,"abstract":"The asthma-chronic obstructive pulmonary disease overlap (ACO) has recently attracted attention and triggered debate as evidenced by the proliferation of articles, reviews and editorials dedicated to this topic. Most of this debate is based on the lack of a consistent definition and the scarce knowledge of its underlying mechanisms. Spain has been very active in pursuing a better understanding of this topic and in developing a clearer definition to help clinicians identify and treat this condition correctly. This paper reviews the current evidence supporting its existence and the latest findings related to its mechanisms and it points out the limitations of using the classic labels to classify chronic airways diseases. (BRN Rev. 2018;4(4):245-57) Corresponding author: Borja G. Cosío, borja.cosio@ssib.es","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45213600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double or Triple Therapy in Chronic Obstructive Pulmonary Disease 慢性阻塞性肺疾病的双重或三重治疗
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/BRNREV:2017-0029
M. Cazzola, P. Rogliani, M. Matera
{"title":"Double or Triple Therapy in Chronic Obstructive Pulmonary Disease","authors":"M. Cazzola, P. Rogliani, M. Matera","doi":"10.23866/BRNREV:2017-0029","DOIUrl":"https://doi.org/10.23866/BRNREV:2017-0029","url":null,"abstract":"Although the Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy recommends triple therapy involving long-acting muscarinic antagonists (LAMAs), long-acting β2-agonists (LABAs) and inhaled corticosteroids (ICS) only for further advanced patients, particularly for those at a high risk for exacerbation (GOLD D), triple therapy is widely prescribed in real-life management of chronic obstructive pulmonary disease (COPD), even in patients with mild or moderate COPD severity, likely because physicians prefer to prescribe a full treatment to ensure the best care to their patients. While the available clinical evidence on triple therapy has greatly increased in recent years, there is still no solid evidence to indicate whether and when addition of an ICS to the LABA/LAMA combination provides additional clinical value. Therefore, a strong recommendation can still not be generated but the results of four recent pivotal triple therapy studies support the possibility that this treatment option should be considered also for GOLD B patients. (BRN Rev. 2018;4(4):287-303) Corresponding author: Mario Cazzola, mario.cazzola@uniroma2.it","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68917111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Clinical Relevance of Periostin in Asthma 骨膜素在哮喘中的临床意义
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/brnrev:2017-0028
I. Braithwaite, Ruth Semprini, R. Beasley
{"title":"The Clinical Relevance of Periostin in Asthma","authors":"I. Braithwaite, Ruth Semprini, R. Beasley","doi":"10.23866/brnrev:2017-0028","DOIUrl":"https://doi.org/10.23866/brnrev:2017-0028","url":null,"abstract":"Periostin is a matricellular protein which is generated by airway epithelial cells in response to interleukin (IL)-4 and IL-13. Serum periostin levels have been proposed as a biomarker of type-2 inflammation with clinical utility in severe asthma. Normal reference ranges have been established in a predominant Caucasian population using the Elecsys® Periostin immunoassay. Periostin levels do not differentiate asthma from non-asthma, or mild-to-moderate asthma from severe asthma, although they are higher in adults with asthma who have raised levels of blood eosinophils and fractional exhaled nitric oxide (FeNO). Periostin status can predict response to monoclonal antibody therapy directed against IL-13 and immunoglobulin E (IgE), such that adults with severe asthma and a periostin level ≥ 50 ng/ml (designated ”periostin-high”) have a greater therapeutic response than “periostin-low” patients. The clinical relevance of these findings is uncertain, due to the similar predictive ability of the more commonly available biomarkers blood eosinophils and/or FeNO. (BRN Rev. 2018;4(4):258-73) Corresponding author: Richard Beasley, richard.beasley@mrinz.ac.nz","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42721300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Exercise testing to evaluate therapeutic interventions in chronic respiratory diseases 运动试验评价慢性呼吸系统疾病的治疗干预措施
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/BRNREV:2017-0024
L. Puente-Maestu, W. Stringer, R. Casaburi
{"title":"Exercise testing to evaluate therapeutic interventions in chronic respiratory diseases","authors":"L. Puente-Maestu, W. Stringer, R. Casaburi","doi":"10.23866/BRNREV:2017-0024","DOIUrl":"https://doi.org/10.23866/BRNREV:2017-0024","url":null,"abstract":"From an evidence-based perspective, performance during standardised exercise testing is of considerable importance in the multidimensional evaluation of most respiratory diseases. In this review we aim to summarise the available evidence on the responsiveness of exercise tests to various pharmacological and non-pharmacological therapeutic interventions, as well as the underlying mechanisms associated with the improvements. A standard test to evaluate interventions has not yet been defined and therefore there are several available formats with different types of responsiveness to interventions. Thresholds for clinically important changes are available for several tests. The mechanism of improvement is different depending on the disease process: when moderate or severe airflow limitation is present, as in chronic obstructive pulmonary disease (COPD), the primary mechanisms are reduced ventilatory requirement and/or enhanced ventilatory capacity via reduction of dynamic hyperinflation; in pulmonary arterial hypertension the effect of treatment is typically associated to haemodynamic improvement, while in interstitial lung diseases, the amelioration of arterial oxygen desaturation seems to be the predominant physiological factor. (BRN Rev. 2018;4(4):274-86) Corresponding author: Luis Puente-Maestu, lpuente@separ.es","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44505356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The Copenhagen City Heart Study Experience and its Key Contributions to Chronic Obstructive Pulmonary Disease 哥本哈根城市心脏研究经验及其对慢性阻塞性肺疾病的重要贡献
Barcelona respiratory network reviews Pub Date : 2018-10-01 DOI: 10.23866/brnrev:2017-0022
P. Lange, J. Vestbo
{"title":"The Copenhagen City Heart Study Experience and its Key Contributions to Chronic Obstructive Pulmonary Disease","authors":"P. Lange, J. Vestbo","doi":"10.23866/brnrev:2017-0022","DOIUrl":"https://doi.org/10.23866/brnrev:2017-0022","url":null,"abstract":"Although the principal aim of the Copenhagen City Heart Study (CCHS) was to investigate risk factors for ischaemic heart disease, it already started including spirometry and a questionnaire on respiratory symptoms from its start in 1976. Longitudinal design including five examination rounds and follow-up of hospitalisations, mortality and medically treated exacerbations of chronic obstructive pulmonary disease (COPD) gave a great opportunity to study different aspects of the natural history of COPD. Since 1988, more than 100 papers on different aspects of obstructive lung diseases have been published. Among the most quoted are publications on lung function decline in asthma, trajectories leading to COPD, analyses describing positive association between physical activity and COPD, role of nutritional status for prognosis of COPD, and a nested intervention study showing no effect of an inhaled corticosteroid (ICS) on lung function decline among individuals with mild COPD. The present review describes some of these studies. (BRN Rev.","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48439824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and Future Respiratory Medicine Challenges: Insights from a Barcelona Respiratory Network Foundation Retreat in Barcelona in 2017 当前和未来的呼吸医学挑战:来自2017年巴塞罗那呼吸网络基金会静修的见解
Barcelona respiratory network reviews Pub Date : 2018-07-01 DOI: 10.23866/brnrev:2018-0002
J. Dorca, A. Agustí, E. Monso
{"title":"Current and Future Respiratory Medicine Challenges: Insights from a Barcelona Respiratory Network Foundation Retreat in Barcelona in 2017","authors":"J. Dorca, A. Agustí, E. Monso","doi":"10.23866/brnrev:2018-0002","DOIUrl":"https://doi.org/10.23866/brnrev:2018-0002","url":null,"abstract":"On a global level, respiratory diseases impose a major worldwide health burden affecting millions of people. Respiratory diseases are not only very common but present a great challenge to human health and a productive economy. Prevention, control and cure of these conditions are among the most cost-effective interventions to be taken within a healthcare system and must be a priority for researchers as well as for health authorities. Today, many novel technologies can potentially improve the diagnosis and control of numerous diseases, and the present challenge is how they can be quickly developed and implemented. This review summarises the main conclusions of a Barcelona Respiratory Network (BRN) Foundation Retreat held last year in Barcelona. The debate was structured around four distinct sections: 1) trends that impact current society; 2) foreseeable changes in the field of respiratory health; 3) challenges for the future of healthcare systems; and, 4) future biomedical research trends in respiratory medicine. (BRN Rev. 2018;4(3):214-27) Corresponding author: Dr. Jordi Dorca, jodorca@bellvitgehospital.cat","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43789284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction Models in Chronic Obstructive Pulmonary Disease - Informing Practice and Improving Research 慢性阻塞性肺疾病的预测模型——为实践提供信息并改进研究
Barcelona respiratory network reviews Pub Date : 2018-07-01 DOI: 10.23866/BRNREV:2017-0018
M. Puhan, G. Riet
{"title":"Prediction Models in Chronic Obstructive Pulmonary Disease - Informing Practice and Improving Research","authors":"M. Puhan, G. Riet","doi":"10.23866/BRNREV:2017-0018","DOIUrl":"https://doi.org/10.23866/BRNREV:2017-0018","url":null,"abstract":"Prediction models have the potential to advance personalised medicine through risk-stratified management, which optimises the benefits and harms of preventive and therapeutic interventions for individuals. Thereby, the risk that patients are either underor over-treated can be minimised. In research, prediction models can be used to efficiently identify study subjects, to control for confounding and to study subgroup effects. In the area of chronic obstructive pulmonary disease (COPD), many prediction models have been developed to predict the risk of early death or exacerbations, the course of disease or for other outcomes. A prerequisite for their use is a careful development and external validation, which is, however, often lacking. This article describes the purposes of prediction models as well as their development and validation including novel approaches like multiple score comparison meta-analysis. It also describes research needs like the need for developing accurate and valid prediction models for exacerbations that support risk-stratified prevention of exacerbations. (BRN Rev. 2018;4(3):156-68) Corresponding author: Milo Puhan, miloalan.puhan@uzh.ch","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68917104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书