Barcelona respiratory network reviews最新文献_第6页

The Case of Procalcitonin for Lower Respiratory Tract Infections 降钙素原治疗下呼吸道感染1例

Barcelona respiratory network reviews Pub Date : 2019-09-20 DOI: 10.23866/brnrev:2019-0017

Meropi Karakioulaki, D. Stolz

引用次数: 2

Insights into Chronic Obstructive Pulmonary Disease Epidemiology, Phenotypes and Outcomes from SPIROMICS 慢性阻塞性肺疾病流行病学，表型和SPIROMICS结果的见解

Barcelona respiratory network reviews Pub Date : 2019-09-20 DOI: 10.23866/brnrev:2018-0014

W. Labaki, F. Martinez, M. Han

{"title":"Insights into Chronic Obstructive Pulmonary Disease Epidemiology, Phenotypes and Outcomes from SPIROMICS","authors":"W. Labaki, F. Martinez, M. Han","doi":"10.23866/brnrev:2018-0014","DOIUrl":"https://doi.org/10.23866/brnrev:2018-0014","url":null,"abstract":"SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) is a multicentre National Institutes of Health funded cohort study of nearly 3000 never-smokers and ever-smokers (≥ 20 pack-years) with and without chronic obstructive pulmonary disease (COPD). It was designed to help fill gaps in our understanding of the biological complexity and clinical heterogeneity of COPD. The original goals for this study were to identify subgroups of smokers who may benefit from targeted therapies and to discover and validate intermediate biomarker endpoints. Here we review important findings from SPIROMICS over the past five years, including the impact of environmental and occupational exposures on the respiratory health of smokers, the characterisation of symptomatic smokers with preserved pulmonary function and the investigation of several diagnostic and prognostic biomarkers such as airway mucin concentration, functional small airways disease on chest computed tomography and a gene expression signature of interleukin 17A response in airway epithelium. (BRN Rev. 2019;5(4):233-48) Corresponding author: MeiLan K. Han, mrking@umich.edu","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42164663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Beyond T2-inflammation: What Does the Future Hold for Severe Asthma? 超越T2炎症：严重哮喘的未来如何？

Barcelona respiratory network reviews Pub Date : 2019-09-20 DOI: 10.23866/BRNREV:2019-0001

S. Diver, C. Brightling

引用次数: 0

Featuring Characteristics of Chronic Obstructive Pulmonary Disease, Procalcitonin and Lower Tract Infections and Inert Gas Studies 慢性阻塞性肺疾病的特征、降钙素原和下呼吸道感染及惰性气体研究

Barcelona respiratory network reviews Pub Date : 2019-09-20 DOI: 10.23866/brnrev:2019-m0064

R. Rodríguez-Roisín

{"title":"Featuring Characteristics of Chronic Obstructive Pulmonary Disease, Procalcitonin and Lower Tract Infections and Inert Gas Studies","authors":"R. Rodríguez-Roisín","doi":"10.23866/brnrev:2019-m0064","DOIUrl":"https://doi.org/10.23866/brnrev:2019-m0064","url":null,"abstract":"The last issue of BRN Reviews for the current year sets out two first-class observational studies devoted to the complexities of the natural history of chronic obstructive pulmonary disease (COPD). The first refers to SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS), a multicentre, cohort study of nearly 3000 never-smokers and ever-smokers with and without COPD. This outstanding work is reviewed by Wassim W Labaki, from University of Michigan (Ann Ar bor, MI) together with two distinguished members of the Global Initiative for Obstructive Lung Disease (GOLD) Science Committee, FJ Mar tinez, from Weill Cornell Medical College (New York, NY), and MeiLan K Han, from the same university as the first author, who leads the publication, a talented worldwide COPD researcher. This huge observational study focuses on the natural history of COPD, funded by the United States (US) National Institutes of Health (NIH), and represents a milestone in the effort to further phenotype the challenging complexity and heterogeneity of COPD. Indeed, SPIROMICS has gener ated significant knowledge on the clinical phe notypes of COPD through the identification of distinct subgroups and the investigation of various chest and imaging biomarkers. Through the description of the major findings achieved by SPIROMICS, the reader is invited to pay special attention to table 2 that includes a very thorough summary of the strengths and shortcomings of the study. I will give just one example, that one of on exposures. It is observed that second-hand smoke exposure and ever-use of e-cigarettes are associated with a higher burden of respiratory symptoms in subjects with COPD; however, a lot of work on long-term effects of e-cigarette use on respiratory health, lung function and clinical effects in individuals with COPD remains to be investigated.","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44702963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Multiple Inert Gas Elimination Technique 50 years later: Lessons Learned 50年后的多重惰性气体消除技术：经验教训

Barcelona respiratory network reviews Pub Date : 2019-09-20 DOI: 10.23866/brnrev:2019-0024

P. Wagner

引用次数: 0

Barcelona respiratory network reviews Pub Date : 2019-09-16 DOI: 10.23866/BRNREV:2018-0010

L. Sastre, M. Molina-Molina, R. P. Abellón

引用次数: 0

The Impact of the Global Initiative for Asthma (GINA): Compass, Concepts, Controversies and Challenges 全球哮喘倡议的影响：指南针、概念、争议和挑战

Barcelona respiratory network reviews Pub Date : 2019-07-18 DOI: 10.23866/BRNREV:2017-0034

H. Reddel

引用次数: 7

Usefulness of Biological Clustering Patterns in Chronic Obstructive Pulmonary Disease 生物聚类模式在慢性阻塞性肺疾病中的应用

Barcelona respiratory network reviews Pub Date : 2019-07-01 DOI: 10.23866/BRNREV:2018-0016

A. Halner, M. Bafadhel

{"title":"Usefulness of Biological Clustering Patterns in Chronic Obstructive Pulmonary Disease","authors":"A. Halner, M. Bafadhel","doi":"10.23866/BRNREV:2018-0016","DOIUrl":"https://doi.org/10.23866/BRNREV:2018-0016","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) affects millions of people worldwide. It is now clear that COPD is heterogeneous, different components of the disease being present in different patients. Yet, the diversity of COPD pathophysiology, severity and how this relates to disease prognosis and treatment outcomes is far from understood. In order to address this, mathematical techniques such as cluster analysis have been employed to identify subgroups or clusters of COPD patients with differing disease attribute profiles. However, significant methodological shortcomings call into question the validity of the COPD clusters identified in such studies. Furthermore, few published studies relate COPD clusters to underlying disease mechanisms and treatment outcomes. Where this has been addressed, progress has particularly been made for patients with an eosinophilic-predominant profile. In order to maximise the usefulness of COPD cluster analysis studies, we propose that future studies must implement more stringent methodologies and focus on COPD inflammatory biology. (BRN Rev. 2019;5(3):201-214) Corresponding author: Mona Bafadhel, mona.bafadhel@ndm.ox.ac.uk","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45387922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genes, Telomeres, Allergies and Biomarkers, Key Pathogenic Clues of Chronic Respiratory Diseases 基因、端粒、过敏和生物标志物，慢性呼吸道疾病的关键致病线索

Barcelona respiratory network reviews Pub Date : 2019-07-01 DOI: 10.23866/brnrev:2019-m0063

R. Rodríguez-Roisín

{"title":"Genes, Telomeres, Allergies and Biomarkers, Key Pathogenic Clues of Chronic Respiratory Diseases","authors":"R. Rodríguez-Roisín","doi":"10.23866/brnrev:2019-m0063","DOIUrl":"https://doi.org/10.23866/brnrev:2019-m0063","url":null,"abstract":"The first contribution of this new issue introduces a fascinating review of the role of genetics in individual susceptibility to chronic obstructive pulmonary disease (COPD) masterly written by Sarah L O’Beirne and Ronald G Crystal, from the prestigious Department of Genetic Medicine and Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York. Under the senior authorship of Ron Crystal, a legend in respiratory research since the nineteen seventies1, this paper focuses on the complex genetic architecture in COPD resulting from multifaceted interactions between environmental exposures, genetic susceptibility and gene-by-environment interactions. Although the most important risk factor for the development of COPD continues to be long-term cigarette smoking, environmental factors cannot be ignored. Only 15-20% of ever smokers develop COPD and not all of the patients with COPD have a history of tobacco smoking, which points to an individual susceptibility to environmental stress and/or factors independent of environment exposures, including genetic susceptibility and gene-by-environment interactions. All in all this backdrop contributes to disease development along with the familial aggregation observed in COPD and in monogenetic conditions, such as alpha-1 antitrypsin deficiency, hence supporting a role for genetic susceptibility in disease pathogenesis. Within this context, key issues such as exome sequencing, expression quantitative trait loci, genome-wide association study (GWAS) and single nucleotide polymorphism (SNP), along with epigenetic and integrative approaches, are attractively exposed to provide a more thorough picture of COPD hereditability.","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44353416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases 变态反应发展机制（MeDALL）研究：了解变态反应性疾病的系统医学方法

Barcelona respiratory network reviews Pub Date : 2019-07-01 DOI: 10.23866/BRNREV:2018-0011

J. Anto, J. Bousquet

{"title":"Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases","authors":"J. Anto, J. Bousquet","doi":"10.23866/BRNREV:2018-0011","DOIUrl":"https://doi.org/10.23866/BRNREV:2018-0011","url":null,"abstract":"Mechanisms of the Development of Allergy (MeDALL) was a European Union-Seventh Framework Programme for Research and Technological Development project aimed to apply the systems medicine approach to improve the understanding of allergic diseases. It was based on existing birth cohorts to redefine classical phenotypes and identify novel phenotypes of immunoglobulin (Ig)E-associated asthma, allergic rhinitis and dermatitis. The project included a wide range of population-based, clinical and mechanistic studies applying systems medicine. MeDALL demonstrated the existence of the multimorbidity of eczema, rhinitis, and asthma both in IgE-sensitized and non-sensitized children and integrated the evidence on multimorbidities and polysensitization in a new framework of allergic diseases. Innovative approaches included unsupervised statistical modelling, computational analysis of the topology of the protein interaction network and the IgE MeDALL allergen-chip. Mechanistic studies included testing candidate biomarkers, epigenetics, and transcriptomics. Assessment of individual and environmental factors included puberty, maternal smoking and pregnancy. (BRN Rev. 2019;5(3):169-83) Corresponding author: Josep M. Antó, Josepm.anto@isglobal.org","PeriodicalId":87223,"journal":{"name":"Barcelona respiratory network reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41894359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0