Behavior Genetics最新文献_第8页

Awards Presented at the 53rd Annual Meeting of the Behavior Genetics Association, June 24 2023, Murcia, Spain. 2023年6月24日在西班牙穆尔西亚举行的行为遗传学协会第53届年会上颁发的奖项。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-11-01 DOI: 10.1007/s10519-023-10158-7

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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. 下采样GWAS汇总统计的可比性评估指南。

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Behavior Genetics Pub Date : 2023-11-01 Epub Date: 2023-09-15 DOI: 10.1007/s10519-023-10152-z

Camille M Williams, Holly Poore, Peter T Tanksley, Hyeokmoon Kweon, Natasia S Courchesne-Krak, Diego Londono-Correa, Travis T Mallard, Peter Barr, Philipp D Koellinger, Irwin D Waldman, Sandra Sanchez-Roige, K Paige Harden, Abraham A Palmer, Danielle M Dick, Richard Karlsson Linnér

{"title":"Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics.","authors":"Camille M Williams, Holly Poore, Peter T Tanksley, Hyeokmoon Kweon, Natasia S Courchesne-Krak, Diego Londono-Correa, Travis T Mallard, Peter Barr, Philipp D Koellinger, Irwin D Waldman, Sandra Sanchez-Roige, K Paige Harden, Abraham A Palmer, Danielle M Dick, Richard Karlsson Linnér","doi":"10.1007/s10519-023-10152-z","DOIUrl":"10.1007/s10519-023-10152-z","url":null,"abstract":"Proprietary genetic datasets are valuable for boosting the statistical power of genome-wide association studies (GWASs), but their use can restrict investigators from publicly sharing the resulting summary statistics. Although researchers can resort to sharing down-sampled versions that exclude restricted data, down-sampling reduces power and might change the genetic etiology of the phenotype being studied. These problems are further complicated when using multivariate GWAS methods, such as genomic structural equation modeling (Genomic SEM), that model genetic correlations across multiple traits. Here, we propose a systematic approach to assess the comparability of GWAS summary statistics that include versus exclude restricted data. Illustrating this approach with a multivariate GWAS of an externalizing factor, we assessed the impact of down-sampling on (1) the strength of the genetic signal in univariate GWASs, (2) the factor loadings and model fit in multivariate Genomic SEM, (3) the strength of the genetic signal at the factor level, (4) insights from gene-property analyses, (5) the pattern of genetic correlations with other traits, and (6) polygenic score analyses in independent samples. For the externalizing GWAS, although down-sampling resulted in a loss of genetic signal and fewer genome-wide significant loci; the factor loadings and model fit, gene-property analyses, genetic correlations, and polygenic score analyses were found robust. Given the importance of data sharing for the advancement of open science, we recommend that investigators who generate and share down-sampled summary statistics report these analyses as accompanying documentation to support other researchers' use of the summary statistics.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"404-415"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10244326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Minutes of the Annual Business Meeting of the Members of the Behavior Genetics Association : June 24, 2023, 12:15-13:30, Venue 'Auditorium and Conference Centre' Murcia (Spain). 行为遗传学协会成员年度商业会议记录：2023年6月24日，12:15-13:30，地点“礼堂和会议中心”穆尔西亚（西班牙）。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-11-01 DOI: 10.1007/s10519-023-10157-8

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Announcement of the Fulker Award for a Paper Published in Behavior Genetics, Volume 52, 2022. 富尔克奖发表在《行为遗传学》2022年第52卷的论文公告。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-11-01 DOI: 10.1007/s10519-023-10159-6

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Nonlinear Catch-Up Growth in Height, Weight, and Head Circumference from Birth to Adolescence: A Longitudinal Twin Study. 从出生到青春期身高、体重和头围的非线性追赶增长：一项纵向双胞胎研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-11-01 Epub Date: 2023-08-27 DOI: 10.1007/s10519-023-10151-0

Sean R Womack, Christopher R Beam, Evan J Giangrande, Rebecca J Scharf, Xin Tong, Medha Ponnapalli, Deborah W Davis, Eric Turkheimer

{"title":"Nonlinear Catch-Up Growth in Height, Weight, and Head Circumference from Birth to Adolescence: A Longitudinal Twin Study.","authors":"Sean R Womack, Christopher R Beam, Evan J Giangrande, Rebecca J Scharf, Xin Tong, Medha Ponnapalli, Deborah W Davis, Eric Turkheimer","doi":"10.1007/s10519-023-10151-0","DOIUrl":"10.1007/s10519-023-10151-0","url":null,"abstract":"Owing to high rates of prenatal complications, twins are, on average, substantially smaller than population norms on physical measurements including height, weight, and head circumference at birth. By early childhood, twins are physically average. This study is the first to explore the process of catch-up growth by fitting asymptotic growth models to age-standardized height, weight, and head circumference measurements in a community sample of twins (n = 1281, 52.3% female) followed at up to 17 time points from birth to 15 years. Catch-up growth was rapid over the first year and plateaued around the population mean by early childhood. Shared environmental factors accounted for the majority of individual differences in initial physical size (57.7-65.5%), whereas additive genetic factors accounted for the majority of individual differences in the upper asymptotes of height, weight, and head circumference (73.4-92.6%). Both additive genetic and shared environmental factors were associated with variance in how quickly twins caught up. Gestational age and family SES emerged as important environmental correlates of physical catch-up growth.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"385-403"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Reviewers for Volume 53. 第53卷的评审员。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-10-12 DOI: 10.1007/s10519-023-10163-w

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Behavior Genetics Association 53rd Annual Meeting Abstracts. 行为遗传学协会第53届年会摘要。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-10-12 DOI: 10.1007/s10519-023-10156-9

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Gay Fathers, Twin Sons: The Citizenship Case that Captured the World by Nancy Segal : Aug 8-2023, Roman & Littlefield, ISBN-13 978-1538171257. 同性恋父亲，双胞胎儿子:占领世界的公民案件，南希·西格尔:8月8日-2023，罗曼和利特菲尔德，ISBN-13 978-1538171257。

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Behavior Genetics Pub Date : 2023-09-19 DOI: 10.1007/s10519-023-10160-z

Gareth Richards

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Bias in Gene-by-Environment Interaction Effects with Sum Scores; An Application to Well-being Phenotypes. 总分的基因与环境交互效应中的偏差；在幸福表型中的应用》（Gene-by-Environment Interaction Effects with Sum Scores Bias; An Application to Well-being Phenotypes）。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-07-01 Epub Date: 2023-03-01 DOI: 10.1007/s10519-023-10137-y

Dirk H M Pelt, Inga Schwabe, Meike Bartels

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A Longitudinal Analysis of Gene x Environment Interaction on Verbal Intelligence Across Adolescence and Early Adulthood. 对青春期和成年早期语言智能基因与环境相互作用的纵向分析。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-07-01 Epub Date: 2023-05-12 DOI: 10.1007/s10519-023-10145-y

LiChen Dong, Evan J Giangrande, Sean R Womack, Kristy Yoo, Christopher R Beam, Kristen C Jacobson, Eric Turkheimer

{"title":"A Longitudinal Analysis of Gene x Environment Interaction on Verbal Intelligence Across Adolescence and Early Adulthood.","authors":"LiChen Dong, Evan J Giangrande, Sean R Womack, Kristy Yoo, Christopher R Beam, Kristen C Jacobson, Eric Turkheimer","doi":"10.1007/s10519-023-10145-y","DOIUrl":"10.1007/s10519-023-10145-y","url":null,"abstract":"The Scarr-Rowe hypothesis proposes that the heritability of intelligence is higher in more advantaged socioeconomic contexts. An early demonstration of this hypothesis was Rowe and colleagues (Rowe et al., Child Dev 70:1151-1162, 1999), where an interaction between the heritability of verbal intelligence and parental education was identified in adolescent siblings in Wave I of the National Longitudinal Study of Adolescent to Adult Health. The present study repeated their original analysis at Wave I using contemporary methods, replicated the finding during young adulthood at Wave III, and analyzed the interaction longitudinally utilizing multiple measurements. We examined parental education, family income, and peer academic environment as potential moderators. Results indicated increased heritability and decreased shared environmental variance of verbal intelligence at higher levels of parental education and peer academic environment in adolescence. Moreover, moderation by peer academic environment persisted into adulthood with its effect partially attributable to novel gene-environment interactions that arose in the process of cognitive development.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 4","pages":"311-330"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10023858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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