Behavior Genetics最新文献_第6页

The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model. 岔路花园：重新诠释基因型-环境模型的 Haseman-Elston 回归。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1007/s10519-024-10184-z

Guo-Bo Chen

引用次数: 0

Using Alternative Definitions of Controls to Increase Statistical Power in GWAS. 使用对照组的替代定义来提高 GWAS 的统计功率。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-07-01 Epub Date: 2024-06-13 DOI: 10.1007/s10519-024-10187-w

Sarah E Benstock, Katherine Weaver, John M Hettema, Brad Verhulst

{"title":"Using Alternative Definitions of Controls to Increase Statistical Power in GWAS.","authors":"Sarah E Benstock, Katherine Weaver, John M Hettema, Brad Verhulst","doi":"10.1007/s10519-024-10187-w","DOIUrl":"10.1007/s10519-024-10187-w","url":null,"abstract":"Genome-wide association studies (GWAS) are often underpowered due to small effect sizes of common single nucleotide polymorphisms (SNPs) on phenotypes and extreme multiple testing thresholds. The most common approach for increasing statistical power is to increase sample size. We propose an alternative strategy of redefining case-control outcomes into ordinal case-subthreshold-asymptomatic variables. While maintaining the clinical case threshold, we subdivide controls into two groups: individuals who are symptomatic but do not meet the clinical criteria for diagnosis (subthreshold) and individuals who are effectively asymptomatic. We conducted a simulation study to examine the impact of effect size, minor allele frequency, population prevalence, and the prevalence of the subthreshold group on statistical power to detect genetic associations in three scenarios: a standard case-control, an ordinal, and a case-asymptomatic control analysis. Our results suggest the ordinal model consistently provides the greatest statistical power while the case-control model the least. Power in the case-asymptomatic control model reflects the case-control or ordinal model depending on the population prevalence and size of the subthreshold category. We then analyzed a major depression phenotype from the UK Biobank to corroborate our simulation results. Overall, the ordinal model improves statistical power in GWAS consistent with increasing the sample size by approximately 10%.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"353-366"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attachment and Political Personality are Heritable and Distinct Systems, and Both Share Genetics with Interpersonal Trust and Altruism. 依恋和政治人格是可遗传的独特系统，二者与人际信任和利他主义共享遗传学。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1007/s10519-024-10185-y

Thomas Haarklau Kleppesto, Nikolai Olavi Czajkowski, Olav Vassend, Espen Roysamb, Nikolai Haahjem Eftedal, Jennifer Sheehy-Skeffington, Eivind Ystrom, Jonas R Kunst, Line C Gjerde, Lotte Thomsen

{"title":"Attachment and Political Personality are Heritable and Distinct Systems, and Both Share Genetics with Interpersonal Trust and Altruism.","authors":"Thomas Haarklau Kleppesto, Nikolai Olavi Czajkowski, Olav Vassend, Espen Roysamb, Nikolai Haahjem Eftedal, Jennifer Sheehy-Skeffington, Eivind Ystrom, Jonas R Kunst, Line C Gjerde, Lotte Thomsen","doi":"10.1007/s10519-024-10185-y","DOIUrl":"10.1007/s10519-024-10185-y","url":null,"abstract":"The attachment and caregiving domains maintain proximity and care-giving behavior between parents and offspring, in a way that has been argued to shape people's mental models of how relationships work, resulting in secure, anxious or avoidant interpersonal styles in adulthood. Several theorists have suggested that the attachment system is closely connected to orientations and behaviors in social and political domains, which should be grounded in the same set of familial experiences as are the different attachment styles. We use a sample of Norwegian twins (N = 1987) to assess the genetic and environmental relationship between attachment, trust, altruism, right-wing authoritarianism (RWA), and social dominance orientation (SDO). Results indicate no shared environmental overlap between attachment and ideology, nor even between the attachment styles or between the ideological traits, challenging conventional wisdom in developmental, social, and political psychology. Rather, evidence supports two functionally distinct systems, one for navigating intimate relationships (attachment) and one for navigating social hierarchies (RWA/SDO), with genetic overlap between traits within each system, and two distinct genetic linkages to trust and altruism. This is counter-posed to theoretical perspectives that link attachment, ideology, and interpersonal orientations through early relational experiences.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"321-332"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical and Machine Learning Analysis in Brain-Imaging Genetics: A Review of Methods. 脑成像遗传学中的统计和机器学习分析：方法综述》。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-05-01 Epub Date: 2024-02-10 DOI: 10.1007/s10519-024-10177-y

Connor L Cheek, Peggy Lindner, Elena L Grigorenko

引用次数: 0

Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study. 智力低于平均水平的儿童的精神病理学遗传和环境风险因素是否会放大？一项基于人口的双胞胎研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI: 10.1007/s10519-023-10174-7

Susanne Bruins, Elsje van Bergen, Maurits W Masselink, Stefania A Barzeva, Catharina A Hartman, Roy Otten, Nanda N J Rommelse, Conor V Dolan, Dorret I Boomsma

{"title":"Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study.","authors":"Susanne Bruins, Elsje van Bergen, Maurits W Masselink, Stefania A Barzeva, Catharina A Hartman, Roy Otten, Nanda N J Rommelse, Conor V Dolan, Dorret I Boomsma","doi":"10.1007/s10519-023-10174-7","DOIUrl":"10.1007/s10519-023-10174-7","url":null,"abstract":"There is a negative association between intelligence and psychopathology. We analyzed data on intelligence and psychopathology to assess this association in seven-year-old Dutch twin pairs (ranging from 616 to 14,150 depending on the phenotype) and estimated the degree to which genetic and environmental factors common to intelligence and psychopathology explain the association. Secondly, we examined whether genetic and environmental effects on psychopathology are moderated by intelligence. We found that intelligence, as assessed by psychometric IQ tests, correlated negatively with childhood psychopathology, as assessed by the DSM-oriented scales of the Child Behavior Check List (CBCL). The correlations ranged between - .09 and - .15 and were mainly explained by common genetic factors. Intelligence moderated genetic and environmental effects on anxiety and negative affect, but not those on ADHD, ODD, and autism. The heritability of anxiety and negative affect was greatest in individuals with below-average intelligence. We discuss mechanisms through which this effect could arise, and we end with some recommendations for future research.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"278-289"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Genetically Informed Study of the Association Between Perceived Stress and Loneliness. 关于感知到的压力与孤独之间关系的基因信息研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-05-01 Epub Date: 2024-02-11 DOI: 10.1007/s10519-023-10176-5

Ryan Moshtael, Morgan E Lynch, Glen E Duncan, Christopher R Beam

{"title":"A Genetically Informed Study of the Association Between Perceived Stress and Loneliness.","authors":"Ryan Moshtael, Morgan E Lynch, Glen E Duncan, Christopher R Beam","doi":"10.1007/s10519-023-10176-5","DOIUrl":"10.1007/s10519-023-10176-5","url":null,"abstract":"Although research shows a strong positive association between perceived stress and loneliness, the genetic and environmental etiology underlying their association remains unknown. People with a genetic predisposition to perceived stress, for example, may be more prone to feeling lonely and vice versa. Conversely, unique factors in people's lives may explain differences in perceived stress levels that, in turn, affect feelings of loneliness. We tested whether genetic factors, environmental factors, or both account for the association between perceived stress and loneliness. Participants were 3,066 individual twins (nFemale = 2,154, 70.3%) from the Washington State Twin Registry who completed a survey during April-May, 2020. Structural equation modeling was used to analyze the item-level perceived stress and loneliness measures. The correlation between latent perceived stress and latent loneliness was .68. Genetic and nonshared environmental variance components underlying perceived stress accounted for 3.71% and 23.26% of the total variance in loneliness, respectively. The genetic correlation between loneliness and perceived stress was .45 and did not differ significantly between men and women. The nonshared environmental correlation was .54 and also did not differ between men and women. Findings suggest that holding constant the strong genetic association between perceived stress and loneliness, unique life experiences underlying people's perceived stress account for individual differences in loneliness.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"268-277"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Grooming Cycles in Transgenic Drosophila. 转基因果蝇新陈代谢周期的改变

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-05-01 Epub Date: 2024-03-27 DOI: 10.1007/s10519-024-10180-3

John M Ringo, Daniel Segal

{"title":"Altered Grooming Cycles in Transgenic Drosophila.","authors":"John M Ringo, Daniel Segal","doi":"10.1007/s10519-024-10180-3","DOIUrl":"10.1007/s10519-024-10180-3","url":null,"abstract":"Head grooming in Drosophila consists of repeated sweeps of the legs across the head, comprising regular cycles. We used the GAL4-UAS system to study the effects of overexpressing shibirets1 and of Adar knockdown via RNA interference, on the period of head-grooming cycles in Drosophila. Overexpressing shibirets1 interferes with synaptic vesicle recycling and thus with cell communication, while Adar knockdown reduces RNA editing of neuronal transcripts for a large number of genes. All transgenic flies and their controls were tested at 22° to avoid temperature effects; in wild type, cycle frequency varied with temperature with a Q10 of 1.3. Two experiments were performed with transgenic shibirets1: (1) each fly was heat-shocked for 10 min at 30° immediately before testing at 22° and (2) flies were not heat shocked. In both experiments, cycle period was increased when shibirets1 was overexpressed in all neurons, but was not increased when shibirets1 was overexpressed in motoneurons alone. We hypothesize that grooming cycles in flies overexpressing shibirets1 are lengthened because of synaptic impairment in neural circuits that control head-grooming cycles. In flies with constitutive, pan-neuronal Adar knockdown, cycle period was more variable within individuals, but mean cycle period was not significantly altered. We conclude that RNA editing is essential for the maintenance of within-individual stereotypy of head-grooming cycles.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"290-301"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140304558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peter Driscoll (1938-2024): A Generous, Honest and Humble Man in Science. 彼得-德里斯科（1938-2024 年）：科学界慷慨、诚实和谦逊的人

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-04-25 DOI: 10.1007/s10519-024-10181-2

A. Fernández-Teruel

引用次数: 0

The Detection of Environmental Influences on Academic Achievement Appears to Depend on the Analytic Approach 环境对学习成绩影响的检测似乎取决于分析方法

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-04-08 DOI: 10.1007/s10519-024-10179-w

S. Alexandra Burt, Patrick O’Keefe, Wendy Johnson, Daniel Thaler, Leslie D. Leve, Misaki N. Natsuaki, David Reiss, Daniel S. Shaw, Jody M. Ganiban, Jenae M. Neiderhiser

{"title":"The Detection of Environmental Influences on Academic Achievement Appears to Depend on the Analytic Approach","authors":"S. Alexandra Burt, Patrick O’Keefe, Wendy Johnson, Daniel Thaler, Leslie D. Leve, Misaki N. Natsuaki, David Reiss, Daniel S. Shaw, Jody M. Ganiban, Jenae M. Neiderhiser","doi":"10.1007/s10519-024-10179-w","DOIUrl":"https://doi.org/10.1007/s10519-024-10179-w","url":null,"abstract":"One long-standing analytic approach in adoption studies is to examine correlations between features of adoptive homes and outcomes of adopted children (hereafter termed ‘measured environment correlations’) to illuminate environmental influences on those associations. Although results from such studies have almost uniformly suggested modest environmental influences on adopted children’s academic achievement, other work has indicated that adopted children’s achievement is routinely higher than that of their reared-apart family members, often substantially so. We sought to understand this discrepancy. We examined academic achievement and literacy-promotive features of the home in 424 yoked adoptive/biological families participating in the Early Growth and Development Study (EGDS; i.e., adopted children, adoptive mothers, birth mothers, and biological siblings of the adopted children remaining in the birth homes) using an exhaustive modeling approach. Results indicated that, as anticipated, adopted children scored up to a full standard deviation higher on standardized achievement tests relative to their birth mothers and reared-apart biological siblings. Moreover, these achievement differences were associated with differences in the literacy-promotive features of the adoptive and birth family homes, despite minimal measured environment correlations within adoptive families. A subsequent simulation study highlighted noise in measured environmental variables as an explanation for the decreased utility of measured environment correlations. We conclude that the field’s heavy focus on measured environment correlations within adoptive families may have obscured detection of specific environmental effects on youth outcomes, and that future adoption studies should supplement their measured environment analyses with mean differences between reared-apart relatives.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"99 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140579744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peter McGuffin CBE (February 4, 1949–January 30, 2024) 彼得-麦克格芬 CBE（1949 年 2 月 4 日-2024 年 1 月 30 日）

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-03-19 DOI: 10.1007/s10519-024-10178-x

Anita Thapar

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