Behavior Genetics最新文献_第6页

Introduction to IDEA Special Issue. IDEA 特刊简介。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 DOI: 10.1007/s10519-023-10173-8

Deborah Finkel, Sara R Jaffee

引用次数: 0

The Challenges and Opportunities for Mental Health Twin Research in Nigeria. 尼日利亚心理健康双胞胎研究的挑战和机遇。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-09-21 DOI: 10.1007/s10519-023-10153-y

Olakunle Ayokunmi Oginni, Ayoyinka Ayorinde, Kehinde Dorcas Ayodele, Onyedikachi Joseph Opara, Boladale Mapayi, Kolawole Mosaku

{"title":"The Challenges and Opportunities for Mental Health Twin Research in Nigeria.","authors":"Olakunle Ayokunmi Oginni, Ayoyinka Ayorinde, Kehinde Dorcas Ayodele, Onyedikachi Joseph Opara, Boladale Mapayi, Kolawole Mosaku","doi":"10.1007/s10519-023-10153-y","DOIUrl":"10.1007/s10519-023-10153-y","url":null,"abstract":"The recent interest in increasing diversity in genetic research can be useful in uncovering novel insights into the genetic architecture of mental health disorders - globally and in previously unexplored settings such as low- and middle-income settings like Nigeria. Genetic research into mental health is potentially promising in Nigeria and we reflect on the challenges and opportunities for twin research which may be particularly suited to Nigeria. The higher rates of twinning in Africa and Nigeria specifically, make the twin design an affordable and readily maintainable approach for genetic research in the country. Despite potential challenges with recruitment, data collection, data analysis and dissemination; the success of current efforts suggest that the twin design can tapped even further for greater impact in the country. We highlight some ways in which the scope of twin research can be increased and suggest some ways in which existing challenges can be overcome including recent Patient Participant Involve and Engagement activities.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"42-50"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol Use Disorder Polygenic Risk Scores and Trajectories of Early Adolescent Externalizing Behaviors: Examining the Role of Parenting and Family Conflict in the Racially/Ethnically Diverse ABCD Sample. 酒精使用障碍的多因素风险评分和早期青少年外部化行为的轨迹：在种族/民族多样性ABCD样本中检验父母关系和家庭冲突的作用。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-10-04 DOI: 10.1007/s10519-023-10155-w

Angel D Trevino, Belal Jamil, Jinni Su, Fazil Aliev, Kit K Elam, Kathryn Lemery-Chalfant

{"title":"Alcohol Use Disorder Polygenic Risk Scores and Trajectories of Early Adolescent Externalizing Behaviors: Examining the Role of Parenting and Family Conflict in the Racially/Ethnically Diverse ABCD Sample.","authors":"Angel D Trevino, Belal Jamil, Jinni Su, Fazil Aliev, Kit K Elam, Kathryn Lemery-Chalfant","doi":"10.1007/s10519-023-10155-w","DOIUrl":"10.1007/s10519-023-10155-w","url":null,"abstract":"This study examined the independent and interactive effects of alcohol use disorder genome-wide polygenic scores (AUD-PGS) and parenting and family conflict on early adolescent externalizing behaviors. Data were drawn from White (N = 6181, 46.9% female), Black/African American (N = 1784, 50.1% female), and Hispanic/Latinx (N = 2410, 48.0% female) youth from the adolescent brain cognitive development Study (ABCD). Parents reported on youth externalizing behaviors at baseline (T1, age 9/10), 1-year (T2, age 10/11) and 2-year (T3, age 11/12) assessments. Youth reported on parenting and family environment at T1 and provided saliva or blood samples for genotyping. Results from latent growth models indicated that in general externalizing behaviors decreased from T1 to T3. Across all groups, higher family conflict was associated with more externalizing behaviors at T1, and we did not find significant associations between parental monitoring and early adolescent externalizing behaviors. Parental acceptance was associated with lower externalizing behaviors among White and Hispanic youth, but not among Black youth. Results indicated no significant main effect of AUD-PGS nor interaction effect between AUD-PGS and family variables on early adolescent externalizing behaviors. Post hoc exploratory analysis uncovered an interaction between AUD-PGS and parental acceptance such that AUD-PGS was positively associated with externalizing rule-breaking behaviors among Hispanic youth, but only when parental acceptance was very low. Findings highlight the important role of family conflict and parental acceptance in externalizing behaviors among early adolescents, and emphasize the need to examine other developmental pathways underlying genetic risk for AUD across diverse populations.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"101-118"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations, Caveats, and Suggestions for the Use of Polygenic Scores for Social and Behavioral Traits. 社会和行为特征多基因评分的使用注意事项、注意事项和建议。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-10-06 DOI: 10.1007/s10519-023-10162-x

Amy L Non, Jessica P Cerdeña

引用次数: 0

Parental Nurturance Moderates the Etiology of Youth Resilience. 父母的养育调节了青年韧性的病因。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-08-29 DOI: 10.1007/s10519-023-10150-1

Alexandra Y Vazquez, Elizabeth A Shewark, Luke W Hyde, Kelly L Klump, S Alexandra Burt

{"title":"Parental Nurturance Moderates the Etiology of Youth Resilience.","authors":"Alexandra Y Vazquez, Elizabeth A Shewark, Luke W Hyde, Kelly L Klump, S Alexandra Burt","doi":"10.1007/s10519-023-10150-1","DOIUrl":"10.1007/s10519-023-10150-1","url":null,"abstract":"Parenting behaviors are among the most robust predictors of youth resilience to adversity. Critically, however, very few studies examining these effects have been genetically-informed, and none have considered parenting as an etiologic moderator of resilience. What's more, despite the multidimensionality of resilience, extant etiologic literature has largely focused on a single domain. The current study sought to fill these respective gaps in the literature by examining whether and how parental nurturance shapes the etiology of academic, social, and psychological resilience, respectively. We employed a unique sample of twins (N = 426 pairs; ages 6-11) exposed to moderate-to-severe levels of environmental adversity (i.e., family poverty, neighborhood poverty, community violence) from the Twin Study of Behavioral and Emotional Development in Children. As expected, parental nurturance was positively correlated with all forms of resilience. Extended univariate genotype-by-environment interaction models revealed that parental nurturance significantly moderated genetic influences on all three domains of resilience (academic resilience A1= -0.53, psychological resilience A1= -1.22, social resilience A1= -0.63; all p < .05), such that as parental nurturance increased, genetic influences on youth resilience decreased. Put another way, children experiencing high levels of parental nurturance were more resilient to disadvantage, regardless of their genetic predisposition towards resilience. In the absence of nurturing parenting, however, genetic influences played an outsized role in the origins of resilience. Such findings indicate that parental nurturance may serve as a malleable protective factor that increases youth resilience regardless of genetic influences.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"137-149"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10840741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Diversity in Behavior Genetics: Strategies for Incorporating Undergraduates into Student-Driven Research. 促进行为遗传学的多样性：将本科生纳入学生驱动型研究的策略。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.1007/s10519-023-10172-9

S Mason Garrison, Emma E Webster, Rachel Good

引用次数: 0

The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins. 科伦坡双胞胎和单胎研究（COTASS）：试验收集营养数据的可行性并将样本扩大到双胞胎子女。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2024-01-07 DOI: 10.1007/s10519-023-10171-w

Lasith Dissanayake, Binoli Herath, Janani Opatha, Sameeha Jabir, Rajindra Siriwardana, Kavish Sirisena, Malmi Wickramasinghe, Manouri Wimalasekera, Ruvini Liyanage, G N Duminda Guruge, Kaushalya Jayaweera, Ranil Jayawardena, Helena M S Zavos, Athula Sumathipala, Frühling Rijsdijk

{"title":"The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins.","authors":"Lasith Dissanayake, Binoli Herath, Janani Opatha, Sameeha Jabir, Rajindra Siriwardana, Kavish Sirisena, Malmi Wickramasinghe, Manouri Wimalasekera, Ruvini Liyanage, G N Duminda Guruge, Kaushalya Jayaweera, Ranil Jayawardena, Helena M S Zavos, Athula Sumathipala, Frühling Rijsdijk","doi":"10.1007/s10519-023-10171-w","DOIUrl":"10.1007/s10519-023-10171-w","url":null,"abstract":"Nutrition and diet are key modifiable risk factors for the rising burden of non-communicable diseases like cardio-vascular diseases and diabetes in low- and middle- income countries (LMICs). The nutritional transition in dietary behaviours in LMICs has most likely contributed to this problem. Although traditionally assumed to be environmental, dietary choices are also genetically influenced. Twin study designs can be used to investigate the relative influence of genes and environment on nutrition intake, eating behaviours and associated psychological health. The overall aim of this project is to: provide proof-of-concept for the feasibility of using dietary (biomarker) data within the Children-of-Twin design in nutrition studies, develop laboratory skills and statistical genetic skills and establish a Sri Lankan-specific food composition database. Currently, a pilot study is being conducted with 304 individuals (38 Monozygotic twin pairs, 38 Dizygotic twin pairs and their male or female adult offspring). Questionnaire data on nutritional intake, eating behaviours, psychological well-being, physical health, and bio-specimens are being collected. A Sri Lankan-specific food composition database was developed, training sessions on macro and micro element analysis in biological samples and statistical genetics skills development were conducted and Community Engagement and Involvement programs were carried out in two districts of Sri Lanka.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"63-72"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139110736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

South Asia: The Missing Diverse in Diversity. 南亚：多样性中缺失的多样性。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-11-02 DOI: 10.1007/s10519-023-10161-y

Deepika R Dokuru, Tanya B Horwitz, Samantha M Freis, Michael C Stallings, Marissa A Ehringer

引用次数: 0

Reinvigoration of a Diversity, Equity, and Inclusion Committee at the Institute for Behavioral Genetics: Student-driven Progress. 振兴行为遗传学研究所的多样性、公平和包容委员会：学生推动进步。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-08-21 DOI: 10.1007/s10519-023-10149-8

Katie N Paulich, Tanya B Horwitz, Samantha M Freis, Pamela N Romero Villela, Sidney Aki, Michael C Stallings, Marissa A Ehringer

{"title":"Reinvigoration of a Diversity, Equity, and Inclusion Committee at the Institute for Behavioral Genetics: Student-driven Progress.","authors":"Katie N Paulich, Tanya B Horwitz, Samantha M Freis, Pamela N Romero Villela, Sidney Aki, Michael C Stallings, Marissa A Ehringer","doi":"10.1007/s10519-023-10149-8","DOIUrl":"10.1007/s10519-023-10149-8","url":null,"abstract":"Extremist far-right ideologies, including scientifically inaccurate beliefs about race, are on the rise (Mieriņa and Koroļeva 2015; Youngblood 2020); individuals perpetuating such ideologies occasionally cite genetics research, including behavioral genetics research. This highlights the need for behavioral geneticists to actively confront extremist ideology and promote anti-racism. We emphasize the need for Diversity, Equity and Inclusion (DEI) committees within behavioral genetics institutions. DEI committees can lead to: greater awareness of ways in which behavioral genetics has been misused (historically and currently) to harm minoritized communities, increased discussions on conducting ethical behavioral genetics research, and increased collaboration for conducting more diverse behavioral genetics research. We discuss the activities and goals of the student-driven DEI committee at the Institute for Behavior Genetics (IBG). At the same time, we acknowledge we have a long way to go, both as a committee and as a field. Our committee is still in its early stages; we discuss challenges to increasing DEI in the field and present future goals for both IBG and the behavioral genetics community as we explore the process of implementing DEI work.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"24-33"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10032997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka. 各类食物的食用频率与心血管代谢风险因素：斯里兰卡基因信息双胞胎研究》。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI: 10.1007/s10519-023-10165-8

Helena M S Zavos, Laura Riddleston, Kaushalya Jayaweera, Lasith Dissanayake, Sameeha Jabir, Gayani Pannala, Matthew Hotopf, Sisira Siribaddana, Athula Sumathipala, Frühling V Rijsdijk

{"title":"Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka.","authors":"Helena M S Zavos, Laura Riddleston, Kaushalya Jayaweera, Lasith Dissanayake, Sameeha Jabir, Gayani Pannala, Matthew Hotopf, Sisira Siribaddana, Athula Sumathipala, Frühling V Rijsdijk","doi":"10.1007/s10519-023-10165-8","DOIUrl":"10.1007/s10519-023-10165-8","url":null,"abstract":"Low- and middle-income countries (LMICs) globally have undergone rapid urbanisation, and changes in demography and health behaviours. In Sri Lanka, cardio-vascular disease and diabetes are now leading causes of mortality. High prevalence of their risk factors, including hypertension, dysglycaemia and obesity have also been observed. Diet is a key modifiable risk factor for both cardio-vascular disease and diabetes as well as their risk factors. Although typically thought of as an environmental risk factor, dietary choice has been shown to be genetically influenced, and genes associated with this behaviour correlate with metabolic risk indicators. We used Structural Equation Model fitting to investigate the aetiology of dietary choices and cardio-metabolic phenotypes in COTASS, a population-based twin and singleton sample in Colombo, Sri Lanka. Participants completed a Food Frequency Questionnaire (N = 3934) which assessed frequency of intake of 14 food groups including meat, vegetables and dessert or sweet snacks. Anthropometric (N = 3675) and cardio-metabolic (N = 3477) phenotypes were also collected including weight, blood pressure, cholesterol, fasting plasma glucose and triglycerides. Frequency of consumption of most food items was found to be largely environmental in origin with both the shared and non-shared environmental influences indicated. Modest genetic influences were observed for some food groups (e.g. fruits and leafy greens). Cardio-metabolic phenotypes showed moderate genetic influences with some shared environmental influence for Body Mass Index, blood pressure and triglycerides. Overall, it seemed that shared environmental effects were more important for both dietary choices and cardio-metabolic phenotypes compared to populations in the Global North.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"73-85"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138884069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0