Postepy higieny i medycyny doswiadczalnej (Online)最新文献

[Somatotropin].

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2020-02-07 DOI: 10.32388/gyry3h

U. Kosmala, S. Kwiatkowski

引用次数: 1

[Immunodiffusion]. (免疫扩散)。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2020-02-02 DOI: 10.32388/hhjf1q

H. Albrycht, D. Rymkiewicz

引用次数: 144

[Pyruvate kinase]. (丙酮酸激酶)。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2020-02-02 DOI: 10.1007/springerreference_36517

J. Jedrzejak

引用次数: 156

Stigmatization in dermatology with a special focus on psoriatic patients. 皮肤病学的污名化，特别关注银屑病患者。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-12-11 DOI: 10.5604/01.3001.0010.6879

Dimitre Dimitrov, Jacek C Szepietowski

{"title":"Stigmatization in dermatology with a special focus on psoriatic patients.","authors":"Dimitre Dimitrov, Jacek C Szepietowski","doi":"10.5604/01.3001.0010.6879","DOIUrl":"https://doi.org/10.5604/01.3001.0010.6879","url":null,"abstract":"A stigma is currently defined as a discrediting mark, biological or social, that sets a person off from others and disrupts interactions with them. People who differ from social norms in some respect are often negatively labeled. A number of medical conditions are recognized at present as stigmatizing their sufferers and certain skin diseases are among them. The article aimed to analyze the current understanding about stigmatization among dermatological patients, especially those with psoriasis. We performed our search on PubMed up to November 2016 and utilized combinations of key phrases containing such words as stigmatization, skin, dermatology, names of various skin conditions (psoriasis, vitiligo, acne, etc.). Following a precise selection process, 58 articles remained. Stigmatization seems to be a common and important problem in dermatology. Psoriasis appears as the most frequently studied skin disease (37.2% of articles). It was followed by vitiligo (13.7%) and leprosy (8.6%). Mainly, the visibility of skin lesions as well as cultural factors contribute to the feeling of stigmatization. There is a need for more research in the field of stigmatization in dermatological conditions and an urgent need for the creation of special anti-stigmatization program/programs for patients suffering from dermatoses.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"1115-1122"},"PeriodicalIF":0.0,"publicationDate":"2017-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

3-Bromopyruvate as a potential pharmaceutical in the light of experimental data. 根据实验数据，3-溴丙酮酸是一种潜在的药物。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-12-08 DOI: 10.5604/01.3001.0010.6666

Izabela Szczuka, Andrzej Gamian, Grzegorz Terlecki

{"title":"3-Bromopyruvate as a potential pharmaceutical in the light of experimental data.","authors":"Izabela Szczuka, Andrzej Gamian, Grzegorz Terlecki","doi":"10.5604/01.3001.0010.6666","DOIUrl":"https://doi.org/10.5604/01.3001.0010.6666","url":null,"abstract":"3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxylic acid transporters. Increasing interest in this compound, in recent times, is mainly due to hopes associated with its anticancer action. It is based on the impairment of energy metabolism of tumor cells by inhibiting enzymes in the glycolysis pathway (hexokinase II, glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate kinase) and the oxidative phosphorylation (succinate dehydrogenase). Two cases of clinical application of this compound in the treatment of advanced cancers were reported. By using 3-BrPA, rheumatoid arthritis in SKG mice has been reduced. This compound has also antiparasitic activity: lowers cell viability of Trypanosoma brucei, decreases intracellular proliferation of Toxoplasma gondii and reduces the metabolic activity of Schistosoma mansoni. It also has antifungal properties; particularly it acts strongly on Cryptococcus neoformans, as well as Saccharomyces cerevisiae. An inhibitory effect on bacterial enzymes was also described on: isocitrate lyase from Escherichia coli, Mycobacterium tuberculosis, Pseudomonas indigofera and 2-methylisocitrate lyase, succinate dehydrogenase and acetohydroxylic acid synthase from Escherichia coli. Wherever undesirable (cancer, parasitic) cells differ from normal by more intense glycolysis and higher energy needs, there is a good chance of successful 3-BrPA use. However, this compound acts on all cells and it, therefore, seems that its future as a pharmaceutical is dependent upon the development of appropriate methods for its effective and safe application.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"988-996"},"PeriodicalIF":0.0,"publicationDate":"2017-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

SUMO proteases as potential targets for cancer therapy. SUMO蛋白酶作为癌症治疗的潜在靶点。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-12-08 DOI: 10.5604/01.3001.0010.6667

Piotr Bialik, Katarzyna Woźniak

{"title":"SUMO proteases as potential targets for cancer therapy.","authors":"Piotr Bialik, Katarzyna Woźniak","doi":"10.5604/01.3001.0010.6667","DOIUrl":"https://doi.org/10.5604/01.3001.0010.6667","url":null,"abstract":"Sumoylation is one of the post-translational modifications of proteins, responsible for the regulation of many cellular processes, such as DNA replication and repair, transcription, signal transduction and nuclear transport. During sumoylation, SUMO proteins are covalently attached to the ε-amino group of lysine in target proteins via an enzymatic cascade that requires the sequential action of E1, E2 and E3 enzymes. An important aspect of sumoylation is its reversibility, which involves SUMO-specific proteases called SENPs. SENPs (sentrin/SUMO-specific proteases) catalyze the deconjugation of SUMO proteins using their isopeptidase activity. These enzymes participate through hydrolase activity in the reaction of SUMO protein maturation, which involves the removal of a short fragment on the C-terminus of SUMO inactive form and exposure two glycine residues. SENPs are important for maintaining the balance between sumoylated and desumoylated proteins required for normal cellular physiology. Six SENP isoforms (SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7) have been identified in mammals. These SENPs can be divided into three subfamilies based on their sequence homology, substrate specificity and subcellular localization. Results of studies indicate the role of SUMO proteases in the development of human diseases including cancer, suggesting that these proteins may be attractive targets for new drugs.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"997-1004"},"PeriodicalIF":0.0,"publicationDate":"2017-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Structure of bacterial chromosome: An analysis of DNA-protein interactions in vivo. 细菌染色体结构:体内dna -蛋白质相互作用的分析。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-12-08 DOI: 10.5604/01.3001.0010.6696

Joanna Hołówka, Małgorzata Płachetka

引用次数: 2

Perspective in optimization of stem cell therapies for heart regeneration. 心脏再生干细胞治疗的优化前景。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-12-07 DOI: 10.5604/01.3001.0010.6665

Paulina Gapska, Maciej Kurpisz

{"title":"Perspective in optimization of stem cell therapies for heart regeneration.","authors":"Paulina Gapska, Maciej Kurpisz","doi":"10.5604/01.3001.0010.6665","DOIUrl":"https://doi.org/10.5604/01.3001.0010.6665","url":null,"abstract":"There is a variety of mechanisms(s) factor(s) that may influence stem cell therapies for heart regeneration. Among the best candidates for stem cell source are: mesenchymal stem cells (also those isolated from adipose tissue), cardiac cell progenitors (CPC) and descendants of iPSC cells. iPSC/s can be potentially beneficial although their pluripotent induction has been still in question due to: low propagation efficacy, danger of genomic integration/instability, biological risk of current vector system teratoma formation etc. which have been discussed in this review. Optimization protocols are required in order to enhance stem cells resistance to pathological conditions that they may encounter in pathological organ and to increase their retention. Combination between gene transfer and stem cell therapy is now more often used in pre-clinical studies with the prospect of subsequent clinical trials. Complementary substances have been contemplated to support stem cell viability (mainly anti-inflammatory and anti- apoptotic agents), which have been tested in animal models with promising results. Integration of nanotechnology both for efficient stem cell imaging as well as with the aim to provide cell supporting scaffolds seem to be inevitable for further development of cellular therapies. The whole organ (heart) reconstruction as well as biodegradable scaffolds and scaffold-free cell sheets have been also outlined.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"975-987"},"PeriodicalIF":0.0,"publicationDate":"2017-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Epigenetic modifications: An important mechanism in diabetic disturbances. 表观遗传修饰:糖尿病紊乱的重要机制。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-11-29 DOI: 10.5604/01.3001.0010.6156

Anna Rorbach-Dolata, Adriana Kubis, Agnieszka Piwowar

{"title":"Epigenetic modifications: An important mechanism in diabetic disturbances.","authors":"Anna Rorbach-Dolata, Adriana Kubis, Agnieszka Piwowar","doi":"10.5604/01.3001.0010.6156","DOIUrl":"https://doi.org/10.5604/01.3001.0010.6156","url":null,"abstract":"In the search for explanations of diabetes pathomechanisms, especially the development of its vascular complications (micro- and macrovascular ), although current, good metabolic control of diabetes, attention was drawn to the role of epigenetic inheritance associated with epigenetic modifications of histone proteins and DNA in hyperglycemia conditions. This study showed the significant role of DNA methylation and histone epigenetic modifications (a different nature and a different degree) in the transmission of information that is not connected with gene inheritance but concerns the persistent changes induced by hyperglycemia..Attention was paid to the role of DNA methylation of pancreatic cells in the pathogenesis of type 1 diabetes, but also type 2. The important role of DNA methylation changes in a so-called intrauterine growth restriction (IUGR) as reason of subsequent development of diabetes was particularly emphasized. In the pathogenesis of type 2 diabetes and its complications, especially microvascular complications, the greatest share and importance of epigenetic modifications on mitochondrial DNA metylation are the most important. The multidirectionality Complicaand complexity of epigenetic modifications of histone proteins indicate their importance in the development of diabetic disturbances. An especially important role is attributed to methylation and acetylation of histone proteins, in particular on arginine and lysine, whose changes occur most frequently. Moreover, epigenetic modifications of the enzymes, especially methylases, responsible for these processes are the underlying. It has been indicated that the identification of epigenetic differences within the DNA or histone proteins may be a useful prognostic biomarker of susceptibility to the disease development in the future. Moreover, they may become a potential target for future therapeutic interventions for clinical disorders in diabetes.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"960-974"},"PeriodicalIF":0.0,"publicationDate":"2017-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Viability and growth promotion of starter and probiotic bacteria in yogurt supplemented with whey protein hydrolysate during refrigerated storage. 添加水解乳清蛋白的酸奶冷藏期间发酵剂和益生菌的活力和生长促进作用。

Postepy higieny i medycyny doswiadczalnej (Online) Pub Date : 2017-11-22 DOI: 10.5604/01.3001.0010.5866

Anna Dąbrowska, Konrad Babij, Marek Szołtysik, Józefa Chrzanowska

{"title":"Viability and growth promotion of starter and probiotic bacteria in yogurt supplemented with whey protein hydrolysate during refrigerated storage.","authors":"Anna Dąbrowska, Konrad Babij, Marek Szołtysik, Józefa Chrzanowska","doi":"10.5604/01.3001.0010.5866","DOIUrl":"https://doi.org/10.5604/01.3001.0010.5866","url":null,"abstract":"The effect of whey protein hydrolysate (WPH) addition on growth of standard yoghurt cultures and Bifidobacterium adolescentis during co-fermentation and its viability during storage at 4ºC in yoghurts has been evaluated. WPH was obtained with the use of serine protease from Y. lipolytica yeast. Stirred probiotic yoghurts were prepared by using whole milk standardized to 16% of dry matter with the addition of either whey protein concentrate, skim milk powder (SMP), WPH-SMP (ratio 1:1), WPH. The hydrolysate increased the yoghurt culture counts at the initial stage of fermentation and significantly inhibited the decrease in population viability throughout the storage at 4ºC in comparison to the control. The post-fermentation acidification was also retarded by the addition of WPH. The hydrolysate did not increase the Bifidobacterium adolescentis counts at the initial stage. However, the WPH significantly improved its viability. After 21 days of storage, in the yogurts supplemented with WPH, the population of these bacteria oscillated around 3.04 log10 CFU/g, while in samples where SMP or whey protein concentrate was used, the bacteria were no longer detected.","PeriodicalId":87132,"journal":{"name":"Postepy higieny i medycyny doswiadczalnej (Online)","volume":"71 0","pages":"952-959"},"PeriodicalIF":0.0,"publicationDate":"2017-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35639965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9