Epidemiologic perspectives & innovations : EP+I最新文献

{"title":"Factors related to the frequency of citation of epidemiologic publications.","authors":"Kristian B Filion,&nbsp;I Barry Pless","doi":"10.1186/1742-5573-5-3","DOIUrl":"https://doi.org/10.1186/1742-5573-5-3","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated that the frequency with which a publication is cited varies greatly. Our objective was to determine whether author, country, journal, or topic were associated with the number of times an epidemiological publication is cited.</p><p><strong>Methods: </strong>We used outcome-based sampling and investigated one public health issue - child injury prevention, and one clinical topic - coronary artery disease (CAD) prevention. Using the Institute for Scientific Information's (ISI) Web of Science(R) databases, we limited searches to full articles involving humans published in English between 1998 and 2004. We calculated the citation rate and, after frequency-matching on year of publication, selected the 36 most frequently cited and 36 least frequently cited articles per year, for a total of 252 highly-cited and 252 infrequently-cited articles per topic area (child injury prevention and CAD prevention).</p><p><strong>Results: </strong>Highly-cited articles in both CAD and child injury prevention were more likely to be published in medium or high impact journals or in journals with medium or high circulations. They were also more likely to be published by authors from U.S. institutions. Among articles examining CAD prevention, the highly-cited articles often involved risk factors, and the association between topics and frequency of citation persisted after adjusting for impact factor. Among articles addressing child injury prevention, topic was not statistically associated with citation.</p><p><strong>Conclusion: </strong>Journal and country appear to be the factors most strongly associated with frequency of citation. In particular, highly-cited articles are predominantly published in high-impact, high-circulation journals. The factors, however, differ somewhat depending on the area of research the journals represent. Among CAD prevention articles, for example, topic is also an important predictor of citation whereas the same is not true for articles addressing injury prevention.</p><p><strong>Condensed abstract: </strong>Our objective was to determine whether author, country, journal, or topic were associated with the number of times an epidemiological publication is cited. We used outcome-based sampling and investigated one public health issue, child injury prevention, and one clinical topic, coronary artery disease (CAD) prevention. Using the Institute for Scientific Information (ISI) Web of Science(R) databases, we limited searches to full articles involving humans published in English between 1998 and 2004. We calculated the citation rate and, after frequency-matching on year of publication, selected the 36 most frequently cited and 36 least frequently cited articles per year, for a total of 252 highly-cited and 252 infrequently-cited articles per topic area (child injury prevention and CAD prevention). Highly-cited articles in both CAD and child injury prevention were more likely to be","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"5 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2008-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-5-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27288949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should adjustment for covariates be used in prevalence estimations?","authors":"Wenjun Li,&nbsp;Edward J Stanek,&nbsp;Elizabeth R Bertone-Johnson","doi":"10.1186/1742-5573-5-2","DOIUrl":"https://doi.org/10.1186/1742-5573-5-2","url":null,"abstract":"<p><strong>Background: </strong>Adjustment for covariates (also called auxiliary variables in survey sampling literature) is commonly applied in health surveys to reduce the variances of the prevalence estimators. In theory, adjusted prevalence estimators are more accurate when variance components are known. In practice, variance components needed to achieve the adjustment are unknown and their sample estimators are used instead. The uncertainty introduced by estimating variance components may overshadow the reduction in the variance of the prevalence estimators due to adjustment. We present empirical guidelines indicating when adjusted prevalence estimators should be considered, using gender adjusted and unadjusted smoking prevalence as an illustration.</p><p><strong>Methods: </strong>We compare the accuracy of adjusted and unadjusted prevalence estimators via simulation. We simulate simple random samples from hypothetical populations with the proportion of males ranging from 30% to 70%, the smoking prevalence ranging from 15% to 35%, and the ratio of male to female smoking prevalence ranging from 1 to 4. The ranges of gender proportions and smoking prevalences reflect the conditions in 1999-2003 Behavioral Risk Factors Surveillance System (BRFSS) data for Massachusetts. From each population, 10,000 samples are selected and the ratios of the variance of the adjusted prevalence estimators to the variance of the unadjusted (crude) ones are computed and plotted against the proportion of males by population prevalence, as well as by population and sample sizes. The prevalence ratio thresholds, above which adjusted prevalence estimators have smaller variances, are determined graphically.</p><p><strong>Results: </strong>In many practical settings, gender adjustment results in less accuracy. Whether or not there is better accuracy with adjustment depends on sample sizes, gender proportions and ratios between male and female prevalences. In populations with equal number of males and females and smoking prevalence of 20%, the adjusted prevalence estimators are more accurate when the ratios of male to female prevalences are above 2.4, 1.8, 1.6, 1.4 and 1.3 for sample sizes of 25, 50, 100, 150 and 200, respectively.</p><p><strong>Conclusion: </strong>Adjustment for covariates will not result in more accurate prevalence estimator when ratio of male to female prevalences is close to one, sample size is small and risk factor prevalence is low. For example, when reporting smoking prevalence based on simple random sampling, gender adjustment is recommended only when sample size is greater than 200.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":" ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2008-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-5-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40420306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of an automated telephone survey to enable prospective monitoring of subjects whose confidentiality is paramount: a four-week cohort study of partner violence recurrence after Emergency Department discharge.","authors":"Douglas J Wiebe,&nbsp;Brendan G Carr,&nbsp;Elizabeth M Datner,&nbsp;Michael R Elliott,&nbsp;Therese S Richmond","doi":"10.1186/1742-5573-5-1","DOIUrl":"https://doi.org/10.1186/1742-5573-5-1","url":null,"abstract":"<p><strong>Objective: </strong>A goal in intimate partner violence (IPV) research is to identify victims when they are treated in a hospital Emergency Department (ED) and predict which patients will sustain abuse again after discharge, so interventions can be targeted. Following patients to determine those prognostic factors is difficult, however, especially to study IPV given the risk to be assaulted if their partner learns of their participation. We assessed the feasibility of an automated telephone survey and a wireless incentive delivery system to follow ED patients after discharge, enabling detection of IPV recurrence.</p><p><strong>Methods: </strong>A four-week prospective cohort pilot study was conducted at an urban academic medical center ED in the U.S. Thirty patient subjects (24 women, 6 men; 18-54 years) who had sustained IPV in the past six months, 12 of whom presented for an acute IPV-related condition, were interviewed in the ED and were asked to report weekly for four weeks after discharge to a toll-free, password protected telephone survey, and answer recorded questions using the telephone keypad. A $10 convenience store debit card was provided as an incentive, and was electronically recharged with $10 for each weekly report, with a $20 bonus for making all four reports.</p><p><strong>Results: </strong>Twenty-two of 30 subjects (73.3%) made at least one report to the telephone survey during the four weeks following discharge; 14 of the 30 subjects (46.7%) made all four weekly reports. Each time the telephone survey was accessed, the subject completed all questions (i.e., no mid-survey break-offs). Eight months after follow-up ended, almost all debit cards (86.7%) had been used to make purchases.</p><p><strong>Conclusion: </strong>Approximately three of every four subjects participated in follow-up after ED discharge, and approximately two of every four subjects completed all follow-up reports, suggesting the method of an automated telephone survey and wireless incentive delivery system makes it feasible to study IPV prospectively among discharged patients. That finding, along with evidence that IPV recurrence risk is high, suggests the protocol tested is warranted for use conducting full-scale studies of IPV. The protocol could benefit efforts to study other outcomes, especially when patient confidentiality is paramount for their safety.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"5 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2008-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-5-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27209604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of neighborhood density and street connectivity on walking behavior: the Twin Cities walking study.","authors":"J Michael Oakes,&nbsp;Ann Forsyth,&nbsp;Kathryn H Schmitz","doi":"10.1186/1742-5573-4-16","DOIUrl":"https://doi.org/10.1186/1742-5573-4-16","url":null,"abstract":"<p><p>A growing body of health and policy research suggests residential neighborhood density and street connectivity affect walking and total physical activity, both of which are important risk factors for obesity and related chronic diseases. The authors report results from their methodologically novel Twin Cities Walking Study; a multilevel study which examined the relationship between built environments, walking behavior and total physical activity. In order to maximize neighborhood-level variation while maintaining the exchangeability of resident-subjects, investigators sampled 716 adult persons nested in 36 randomly selected neighborhoods across four strata defined on density and street-connectivity - a matched sampling design. Outcome measures include two types of self-reported walking (from surveys and diaries) and so-called objective 7-day accelerometry measures. While crude differences are evident across all outcomes, adjusted effects show increased odds of travel walking in higher-density areas and increased odds of leisure walking in low-connectivity areas, but neither density nor street connectivity are meaningfully related to overall mean miles walked per day or increased total physical activity. Contrary to prior research, the authors conclude that the effects of density and block size on total walking and physical activity are modest to non-existent, if not contrapositive to hypotheses. Divergent findings are attributed to this study's sampling design, which tends to mitigate residual confounding by socioeconomic status.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"4 ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2007-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-4-16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27116205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-cohort design in practice - experiences from the MORGAM Project.","authors":"Sangita Kulathinal,&nbsp;Juha Karvanen,&nbsp;Olli Saarela,&nbsp;Kari Kuulasmaa","doi":"10.1186/1742-5573-4-15","DOIUrl":"https://doi.org/10.1186/1742-5573-4-15","url":null,"abstract":"<p><p>When carefully planned and analysed, the case-cohort design is a powerful choice for follow-up studies with multiple event types of interest. While the literature is rich with analysis methods for case-cohort data, little is written about the designing of a case-cohort study. Our experiences in designing, coordinating and analysing the MORGAM case-cohort study are potentially useful for other studies with similar characteristics. The motivation for using the case-cohort design in the MORGAM genetic study is discussed and issues relevant to its planning and analysis are studied. We propose solutions for appending the earlier case-cohort selection after an extension of the follow-up period and for achieving maximum overlap between earlier designs and the case-cohort design. Approaches for statistical analysis are studied in a simulation example based on the MORGAM data.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":" ","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2007-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-4-15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41049554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults' perspectives on key domains of childhood social and economic experiences and opportunities: a first step to creating a multidimensional measure.","authors":"Irene H Yen,&nbsp;Anita L Stewart,&nbsp;Teresa Scherzer,&nbsp;Eliseo J Pérez-Stable","doi":"10.1186/1742-5573-4-14","DOIUrl":"https://doi.org/10.1186/1742-5573-4-14","url":null,"abstract":"<p><strong>Objectives: </strong>Although research has found that childhood socioeconomic status (SES) is associated with physical and mental health in mid- and later life, most of these studies used conventional, single dimension SES measures for the childhood period such as household income or educational attainment of parents. Life course and health disparities research would benefit from identification and measurement of a variety of childhood social and economic experiences and opportunities that might affect health in later life.</p><p><strong>Design: </strong>This study utilized qualitative research methods to identify key dimensions of childhood experiences related to SES. We conducted in-depth interviews with 25 adults age 55 to 80 years from diverse economic and ethnic backgrounds. Topics included home, neighborhood, school, and work experiences during early childhood and adolescence. Interviews were audio-taped and transcripts were coded to identify thematic domains.</p><p><strong>Results: </strong>We identified eight thematic domains, many of which had clear subdomains: home and family circumstances, neighborhood, work and money, potential for advancement through schooling, school quality and content, discrimination, influence and support of adults, and leisure activities. These domains highlight individual characteristics and experiences and also economic and educational opportunities.</p><p><strong>Conclusion: </strong>These domains of childhood social and economic circumstances add breadth and depth to conventional conceptualization of childhood SES. When the domains are translated into a measurement tool, it will allow for the possibility of classifying people along multiple dimensions, such as from a low economic circumstance with high levels of adult support.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":" ","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2007-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-4-14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41017778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warning: Anti-tobacco activism may be hazardous to epidemiologic science.","authors":"Carl V Phillips","doi":"10.1186/1742-5573-4-13","DOIUrl":"10.1186/1742-5573-4-13","url":null,"abstract":"<p><p>This commentary accompanies two articles submitted to Epidemiologic Perspectives & Innovations in response to a call for papers about threats to epidemiology or epidemiologists from organized political interests. Contrary to our expectations, we received no submissions that described threats from industry or government; all were about threats from anti-tobacco activists. The two we published, by James E. Enstrom and Michael Siegel, both deal with the issue of environmental tobacco smoke. This commentary adds a third story of attacks on legitimate science by anti-tobacco activists, the author's own experience. These stories suggest a willingness of influential anti-tobacco activists, including academics, to hurt legitimate scientists and turn epidemiology into junk science in order to further their agendas. The willingness of epidemiologists to embrace such anti-scientific influences bodes ill for the field's reputation as a legitimate science.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"4 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2007-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27063358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the tobacco control movement misrepresenting the acute cardiovascular health effects of secondhand smoke exposure? An analysis of the scientific evidence and commentary on the implications for tobacco control and public health practice.","authors":"Michael Siegel","doi":"10.1186/1742-5573-4-12","DOIUrl":"10.1186/1742-5573-4-12","url":null,"abstract":"<p><p>While chronic exposure to secondhand smoke has been well recognized as a cause of heart disease in nonsmokers, there has been recent speculation about the potential acute cardiovascular effects of transient exposure to secondhand smoke among nonsmokers; in particular, the possibility that such exposure could increase the risk of acute myocardial infarction even in an otherwise healthy nonsmoker. This paper reviews the claims being made by a number of anti-smoking and public health groups regarding the acute cardiovascular effects of secondhand smoke exposure among otherwise healthy adults, analyzes the validity of these claims based on a review of the scientific evidence, and discusses the implications of the findings for tobacco control and public health practice. Based on the analysis, it appears that a large number of anti-smoking organizations are making inaccurate claims that a single, acute, transient exposure to secondhand smoke can cause severe and even fatal cardiovascular events in healthy nonsmokers. The dissemination of inaccurate information by anti-smoking groups to the public in support of smoking bans is unfortunate because it may harm the tobacco control movement by undermining its credibility, reputation, and effectiveness. Disseminating inaccurate information also represents a violation of basic ethical principles that are a core value of public health practice that cannot and should not be sacrificed, even for a noble end such as protecting nonsmokers from secondhand smoke exposure. How the tobacco control movement responds to this crisis of credibility will go a long way towards determining the future effectiveness of the movement and its ability to continue to save lives and protect the public's health.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"4 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2007-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27040464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defending legitimate epidemiologic research: combating Lysenko pseudoscience.","authors":"James E Enstrom","doi":"10.1186/1742-5573-4-11","DOIUrl":"10.1186/1742-5573-4-11","url":null,"abstract":"<p><p>This analysis presents a detailed defense of my epidemiologic research in the May 17, 2003 British Medical Journal that found no significant relationship between environmental tobacco smoke (ETS) and tobacco-related mortality. In order to defend the honesty and scientific integrity of my research, I have identified and addressed in a detailed manner several unethical and erroneous attacks on this research. Specifically, I have demonstrated that this research is not \"fatally flawed,\" that I have not made \"inappropriate use\" of the underlying database, and that my findings agree with other United States results on this relationship. My research suggests, contrary to popular claims, that there is not a causal relationship between ETS and mortality in the U.S. responsible for 50,000 excess annual deaths, but rather there is a weak and inconsistent relationship. The popular claims tend to damage the credibility of epidemiology. In addition, I address the omission of my research from the 2006 Surgeon General's Report on Involuntary Smoking and the inclusion of it in a massive U.S. Department of Justice racketeering lawsuit. I refute erroneous statements made by powerful U.S. epidemiologists and activists about me and my research and I defend the funding used to conduct this research. Finally, I compare many aspect of ETS epidemiology in the U.S. with pseudoscience in the Soviet Union during the period of Trofim Denisovich Lysenko. Overall, this paper is intended to defend legitimate research against illegitimate criticism by those who have attempted to suppress and discredit it because it does not support their ideological and political agendas. Hopefully, this defense will help other scientists defend their legitimate research and combat \"Lysenko pseudoscience.\"</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"4 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2007-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27040463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing population characteristics, effect-measure modification, and cancer risk factor identification.","authors":"Martha L Slattery,&nbsp;Maureen A Murtaugh,&nbsp;Charles Quesenberry,&nbsp;Bette J Caan,&nbsp;Sandra Edwards,&nbsp;Carol Sweeney","doi":"10.1186/1742-5573-4-10","DOIUrl":"https://doi.org/10.1186/1742-5573-4-10","url":null,"abstract":"<p><p>Epidemiologic studies have identified a number of lifestyle factors, e.g. diet, obesity, and use of certain medications, which affect risk of colon cancer. However, the magnitude and significance of risk factor-disease associations differ among studies. We propose that population trends of changing prevalence of risk factors explains some of the variability between studies when factors that change prevalence also modify the effect of other risk factors. We used data collected from population-based control who were selected as study participants for two time periods, 1991-1994 and 1997-2000, along with data from the literature, to examine changes in the population prevalence of aspirin and non-steroidal anti-inflammatory medication (NSAID) use, obesity, and hormone replacement therapy (HRT) over time. Data from a population-based colon cancer case-control study were used to estimate effect-measurement modification among these factors. Sizeable changes in aspirin use, HRT use, and the proportion of the population that is obese were observed between the 1980s and 2000. Use of NSAIDs interacted with BMI and HRT; HRT use interacted with body mass index (BMI). We estimate that as the prevalence of NSAIDs use changed from 10% to almost 50%, the colon cancer relative risk associated with BMI >30 would change from 1.3 to 1.9 because of the modifying effect of NSAIDs. Similarly, the relative risk estimated for BMI would increase as the prevalence of use of HRT among post-menopausal women increased. In conclusion, as population characteristics change over time, these changes may have an influence on relative risk estimates for colon cancer for other exposures because of effect-measure modification. The impact of population changes on comparability between epidemiologic studies can be kept to a minimum if investigators assess exposure-disease associations within strata of other exposures, and present results in a manner that allows comparisons across studies. Effect-measure modification is an important component of data analysis that should be evaluated to obtain a complete understanding of disease etiology.</p>","PeriodicalId":87082,"journal":{"name":"Epidemiologic perspectives & innovations : EP+I","volume":"4 ","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-5573-4-10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27021939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}