Basic & Clinical Cancer Research最新文献

Effects of Gold Nanoparticles on Proton Therapy for Breast Cancer 金纳米颗粒在乳腺癌质子治疗中的作用

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8831

Elham Ariyabod, S. N. Hosseini Motlagh, S. Mohammadi

{"title":"Effects of Gold Nanoparticles on Proton Therapy for Breast Cancer","authors":"Elham Ariyabod, S. N. Hosseini Motlagh, S. Mohammadi","doi":"10.18502/bccr.v13i1.8831","DOIUrl":"https://doi.org/10.18502/bccr.v13i1.8831","url":null,"abstract":"Background: Beam therapy, the most common and successful treatment used after surgery, plays an important role in treating cancer. In proton therapy, proton beam (PB) particles irradiate the tumor. To enhance the treatment of breast tumors, gold nanoparticles (GNPS) can be injected into the tumor simultaneously as irradiating the PB. \u0000Methods: This paper aims to simulate the treatment of breast tumors by using PBs and injecting GNPs with different concentrations simultaneously. We introduced the breast phantom (BP), then we irradiated it with a proton pencil beam, which is also injected with GNPs simultaneously. We used the GEANT4/ GATE7 (G4/G7) code to show the enhancement of the absorbed dose in the tumor. \u0000Results: The findings of our simulations show that the location of the Bragg peak within the tumor shifts to higher depths with increasing energy. Also, by injecting GNPs in different amounts of 10, 25, 50, and 75 mg/ml with simultaneous irradiation of the PB, the rate of absorbed dose increases up to 1.75% compared to the non-injected state. Our results also show that the optimal range of proton energy that creates the Bragg peaks within the tumor is between 28 to 35 MeV, which causes the spread out of the Bragg peak. It should be noted that the amount of absorbed dose is affected by quantities such as total stopping power, average Coulomb scattering angle, CSDA range, and straggling range. \u0000Conclusion: This work offers new insights based on the use of GNPS in the treatment of breast cancer through proton therapy and indicates that adding GNPS is a promising strategy to increase the killing of cancer cells while irradiating fast PBs. In fact, the results of this study confirm the ability of GNPs to enhance treatment by increasing the absorbed dose in breast tumors using proton therapy.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84418086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-Reacting Material 197, a Specific Inhibitor of HB-EGF, and Its Anticancer Effects HB-EGF特异性抑制剂-交叉反应物质197及其抗癌作用

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8828

M. Tanhapour, A. Golestani, A. Vaisi-Raygani, M. Aminian

引用次数: 0

Cancer has an Independent Association with Death in Hospitalized Patients with COVID-19: A Single-center Study in Iran 在伊朗进行的一项单中心研究中，2019冠状病毒病住院患者的癌症与死亡有独立关联

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8830

R. Ghalehtaki, Kasra Kolahdouzan, Saeed Rezaei, Farzaneh Bagheri, F. Jafari, Mohammadreza Chavoshi, Negin Mohammadi, M. S. Seyyedsalehi, A. Nahvijou, Nima Mousavi Darzikolaee, Samaneh Salarvand, A. Kazemian, M. Aghili, K. Zendehdel

{"title":"Cancer has an Independent Association with Death in Hospitalized Patients with COVID-19: A Single-center Study in Iran","authors":"R. Ghalehtaki, Kasra Kolahdouzan, Saeed Rezaei, Farzaneh Bagheri, F. Jafari, Mohammadreza Chavoshi, Negin Mohammadi, M. S. Seyyedsalehi, A. Nahvijou, Nima Mousavi Darzikolaee, Samaneh Salarvand, A. Kazemian, M. Aghili, K. Zendehdel","doi":"10.18502/bccr.v13i1.8830","DOIUrl":"https://doi.org/10.18502/bccr.v13i1.8830","url":null,"abstract":"Background: COVID-19 could cause severe complications in those with pre-existing conditions such as cancer. Here, we aimed to assess the outcome of COVID-19 in hospitalized patients with a history of cancer. \u0000Methods: In this retrospective cohort study, we extracted medical records of patients with any cancer history among hospitalized patients with COVID-19. Our patients were admitted between February 20th and July 15th, 2020. The primary outcome was death, and the secondary outcomes were overall survival, COVID-19-specific mortality, admission to intensive care unit (ICU), and hospital stay. A group of individuals without cancer history was selected from the COVID-19 cohort and matched for age, gender, and pre-existing conditions. We utilized univariate and multivariate logistic regression to analyze the association between studied variables and primary outcomes. \u0000Results: We identified 46 patients with cancer and COVID-19. The median age was 63, and 54.3% were male. According to the univariate logistic regression analysis, death was 5.3 (CI95%: 1.75-15.85) times more probable in cancer patients than controls (p=0.003). The multivariate analysis adjusted for having cancer and sex, age, and having any comorbidity showing this figure was 5.5 (CI95%:1.8-16.8) (p=0.003). The 30- and 90-day COVID-19 specific mortality was 30% (CI95%:17-43) and 33% (CI95%: 20-46), respectively. \u0000Conclusion: Patients with COVID-19 with a history of cancer have a considerably higher risk of death irrespective of age, gender, and other pre-existing conditions. Patients with advanced cancers and concurrent bacterial infections need the most vigorous care.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85241386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Knowledge, Attitude, nutritional Practice and physical activity and its relation with quality of life in patients with breast cancer 乳腺癌患者的知识、态度、营养实践和身体活动的评估及其与生活质量的关系

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8832

N. Abdous, P. NazarAli, A. Ramezankhani, F. Fallah

{"title":"Assessment of Knowledge, Attitude, nutritional Practice and physical activity and its relation with quality of life in patients with breast cancer","authors":"N. Abdous, P. NazarAli, A. Ramezankhani, F. Fallah","doi":"10.18502/bccr.v13i1.8832","DOIUrl":"https://doi.org/10.18502/bccr.v13i1.8832","url":null,"abstract":"Background: The aim of this study was to assess the correlation between nutritional knowledge, Attitude, and Practice (KAP) and physical activity (PA) on the quality of life (QOL) in women with breast cancer (BC). \u0000Methods: This cross-sectional study involved all women with BC who referred to Imam Khomeini Hospital in Tehran during the years 2018-2019 that by using Cochran formula, 220 of them were selected by convenience sampling and answered the questionnaire including Global Physical Activity Questionnaire (GPAQ), Nutritional Knowledge, Attitude, Practice Survey (KAP) and Quality of life Questionnaire for breast cancer patients (QLQ-30). To determine the share of nutritional variables and physical activity (PA) in predicting QOL, standard multiple regression was used by SPSS 22 software. \u0000Results: The findings of the study showed that the BC patients’ PA (109.61±110.831), QOL (49.805±16.830) and KAP (K= 46.028±11.879; A=45.540±19.754; P=46.870±12.362) were not in a good condition.The best functional outcomes of QLQ-30 questionnaire were found for social functioning (73.560±26.873) and role functioning (73.560±26.873) subscales whereas emotional functioning was found lowest (58.257±24.298).Also, the results showed thatNutrition-RelatedKnowledge (β=144; P=0.036), Attitudes (β=160; P=0.038), and Practice (β=0.596; P=0.045) and PA (β=0.042; P=0.001) were significant factorsinpredictingcancer patients’ quality of life. \u0000Conclusion: The study showed that active patients have a good QOL, also, right nutritional choices and performance by the patients can result in better quality of life, therefore, the patients should receive special interventions at this time.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88222043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transarterial Chemoembolization Of Hepatocellular Carcinoma: Can Early Diffusion Weighted Imaging Predict Response? 肝细胞癌经动脉化疗栓塞:早期弥散加权成像能预测疗效吗?

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8834

Gulzar Asma, Shera Tahleel, Shah Omair, Choh Naseer, Gojwari Tariq, Bhat Mudaisr, Maqsood Shadab

{"title":"Transarterial Chemoembolization Of Hepatocellular Carcinoma: Can Early Diffusion Weighted Imaging Predict Response?","authors":"Gulzar Asma, Shera Tahleel, Shah Omair, Choh Naseer, Gojwari Tariq, Bhat Mudaisr, Maqsood Shadab","doi":"10.18502/bccr.v13i1.8834","DOIUrl":"https://doi.org/10.18502/bccr.v13i1.8834","url":null,"abstract":"PURPOSE: We evaluated the role of early diffusion weighted imaging (DWI) in predicting response to TACE in patients with HCC and compare the results with contrast enhanced magnetic resonance imaging. Methods: 24 patients with documented HCC were taken up for TACE after a pre-procedural contrast CT and MRI. Post procedural DWI was taken on day 5-7 and the mean ADC values were documented and compared to pre procedural values. The change in ADC values was grouped into 4 categories: group 1- <25%, group 2 26-50%, group 3- 51-75% and group 4- >75%. The increase in ADC values signifying response was correlated with 5 week CEMRI scan (which has been the traditional gold standard for response evaluation) and a threshold ADC increase signifying response in majority of the cases was calculated. Results: The mean ADC of the lesions changed from 1.21× 10-3 (pre TACE) to 2.02× 10-3 mm2/sec (post TACE) [p<0.001]. Taking CE MRI as gold standard, DWI imaging had a sensitivity of 80%, specificity of 94.7% with a positive predictive value of 80%, negative predictive value of 94.7% and overall accuracy of 91.7%. Complete response was seen in19 (79%) and incomplete in 5 (21%) patients in our study. The change in ADC was significantly higher in responders (884.15 ± 161.60) as compared to non responders (564.80 ± 221.05) [p =0.001]. Conclusion: Early DWI after TACE can predict response of a HCC lesion to chemoembolization. The change in ADC values can earmark responders from non-responders. Early DWI results are concordant with CEMRI results in most of the cases. DWI can act as a substitute to CEMRI when contrast administration is not advised.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89663416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain 慢性髓性白血病1例年轻男性，异常表现为体重减轻、骨痛和腹痛

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8833

Niloufar Mohamadian, Mehdi Seyedmoradi, B. Izadi, F. Amirian, M. Ramezani

引用次数: 0

The Effect of Ursodeoxycholic acid and N-acetyl cysteine on Lymphoblast Viability 熊去氧胆酸和n -乙酰半胱氨酸对淋巴细胞活力的影响

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8829

A. Ayçiçek, T. Tahtakesen, Cengiz Bayram

{"title":"The Effect of Ursodeoxycholic acid and N-acetyl cysteine on Lymphoblast Viability","authors":"A. Ayçiçek, T. Tahtakesen, Cengiz Bayram","doi":"10.18502/bccr.v13i1.8829","DOIUrl":"https://doi.org/10.18502/bccr.v13i1.8829","url":null,"abstract":"Aim: To investigate invitro ursodeoxycholic acid (UDCA) and N-acetyl cysteine (NAC) effect on blast cell viability in children newly diagnosed with acute lymphoblastic leukemia (ALL). \u0000Patients and Methods: Samples were obtained from 52 newly diagnosed ALL patients aged 1 to 17 years. UDCA and NAC were added at clinically relevant concentrations (0-300 micrograms) onto 5x10^5 cells treated at room temperature in a dark place. Untreated and treated cells were stained with 7-amino-actinomycin D (7AAD PE) and analyzed by flow cytometry \u0000Results: Median (interquartile range; IQR) blast percentage and incubation time were 90% (11) and 18 (1.5) hours, respectively. The dead/live blast cells ratio (7AAD+) was lower in lymphoblasts treated with all NAC concentrations than untreated controls (P < 0.001). The use of NAC was noted to, regardless of concentration, contribute to lymphoblasts viability. On the contrary, the dead/live blast cells ratio in samples treated with UDCA at the abovementioned concentrations was relatively high, suggesting the protective role for both hepatotoxicities and against leukemia. However, the difference was not statistically significant (P >0.05). There was also no correlation between different doses of UCDA and NAC regarding blast cell viability (P > 0.232). \u0000Conclusion: The present study showed that in vitro NAC use had a protective effect on lymphoblast viability in newly diagnosed ALL patients before starting chemotherapy. Patient-derived ALL cells can be successfully analyzed ex vivo in a short and different period without loss of blasts.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74189201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Combination of Genistein and Imatinib has an Increased Effect on Cell Proliferation Inhibition in Philadelphia Positive Leukemia Cell Lines 染料木素联合伊马替尼对费城阳性白血病细胞增殖抑制作用增强

Basic & Clinical Cancer Research Pub Date : 2022-02-23 DOI: 10.18502/bccr.v13i1.8827

E. Azizi, A. Biglari, Ali Kian Saei, S. Amanpour, S. Muhammadnejad, Mahnaz Haddadi, M. Saffari, R. Shirkoohi

引用次数: 0

Fibrolamellar Hepatocellular Carcinoma: Report of a Rare Case with Rapid Progression and Unusual Metastatic Sites 纤维层状肝细胞癌:报告一例进展迅速且转移部位异常的罕见病例

Basic & Clinical Cancer Research Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7980

Adeleh Rezagholizadeh Shirvan, S. Sotoudeh, M. Tahmasebi

引用次数: 0

Cancer Statistics in I.R. Iran in 2020 2020年伊朗癌症统计数据

Basic & Clinical Cancer Research Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7985

K. Zendehdel

引用次数: 2