慢性髓性白血病1例年轻男性,异常表现为体重减轻、骨痛和腹痛

Niloufar Mohamadian, Mehdi Seyedmoradi, B. Izadi, F. Amirian, M. Ramezani
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引用次数: 0

摘要

慢性髓系白血病(Chronic myeloid leukemia, CML)是一种克隆性骨髓增殖性肿瘤,是主要发生于成人的白血病的主要亚型之一。CML的发病率随着年龄的增长缓慢增加,直到40岁中期,然后迅速上升。贫血、脾肿大和体质症状是最常见的症状和体征。这里我们报告一个27岁的男性骨痛和广泛性腹痛。由于厌食症和容易饱腹感,他的体重也有所下降。定量探针实时荧光定量PCR (qRT-PCR)检测BCR-ABL1 (t9:22) P210突变阳性。患者接受CML标准一线治疗伊马替尼治疗,临床改善。他的疼痛也减轻了,出院时情况良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. The incidence of CML increases slowly with age until the middle of the fourth decade, and then it rises rapidly. Anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man with bone pain and generalized abdominal pain. He also had weight loss because of anorexia and easy satiety. The qualitative probe-based real-time PCR (qRT-PCR) result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with Imatinib, the standard first-line treatment for CML, and showed clinical improvement. His pain also decreased, and he was discharged in good condition.
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