Biosecurity and bioterrorism : biodefense strategy, practice, and science最新文献

{"title":"Federal funding for health security in FY2015.","authors":"Crystal Boddie,&nbsp;Tara Kirk Sell,&nbsp;Matthew Watson","doi":"10.1089/bsp.2014.0050","DOIUrl":"https://doi.org/10.1089/bsp.2014.0050","url":null,"abstract":"<p><p>Previous articles in this series have provided funding information for federal civilian biodefense programs and programs focused on radiological and nuclear preparedness and consequence management. This year the authors have expanded the focus of the analysis to US federal funding for health security. This article provides proposed funding amounts for FY2015, estimated amounts for FY2014, and actual amounts for FY2010 through FY2013 in 5 domains critical to health security: biodefense programs, radiological and nuclear programs, chemical programs, pandemic influenza and emerging infectious disease programs, and multiple-hazard and preparedness programs. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"163-77"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32476368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smallpox vaccines and eczema.","authors":"Julie Block","doi":"10.1089/bsp.2014.0042","DOIUrl":"https://doi.org/10.1089/bsp.2014.0042","url":null,"abstract":"","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"218"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32528277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial effects of IMVAMUNE.","authors":"Nathaly Arndtz-Wiedemann","doi":"10.1089/bsp.2014.0037","DOIUrl":"https://doi.org/10.1089/bsp.2014.0037","url":null,"abstract":"","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"217-8"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32528273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness of the local health department workforce to respond to infectious disease events: empirical, ethical, and legal considerations.","authors":"Holly A Taylor,&nbsp;Lainie Rutkow,&nbsp;Daniel J Barnett","doi":"10.1089/bsp.2014.0009","DOIUrl":"https://doi.org/10.1089/bsp.2014.0009","url":null,"abstract":"<p><p>According to the Institute of Medicine, the local health department workforce is at the hub of the public health emergency preparedness system. A growing body of research has pointed to troubling attitudinal gaps among local health department workers, a vital response cohort, regarding willingness to respond to emergent infectious disease threats, ranging from naturally occurring pandemics to bioterrorism events. A summary of relevant literature on the empirical evidence, ethical norms, and legal standards applicable to the willingness of public health professionals to respond to an infectious disease emergency is presented. Recommendations are proposed for future work to be done to bring the relevant empirical, ethical, and legal considerations together to develop practical guidance for the local response to infectious disease emergencies. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"178-85"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32453006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating 6 ricin field detection assays.","authors":"Hans-Christian Slotved,&nbsp;Nadja Sparding,&nbsp;Julia Tanas Tanassi,&nbsp;Nina R Steenhard,&nbsp;Niels H H Heegaard","doi":"10.1089/bsp.2014.0015","DOIUrl":"https://doi.org/10.1089/bsp.2014.0015","url":null,"abstract":"<p><p>This study presents data showing the performance of 6 commercial detection assays against ricin around concentrations specified as detection limits by the producers. A 2-fold dilution series of 20 ng/ml ricin was prepared and used for testing the lateral-flow kits: BADD, Pro Strips™, ENVI, RAID DX, Ricin BioThreat Alert, and IMASS™ device. Three of the 6 tested field assays (IMASS™ device, ENVI assay, and the BioThreat Alert assay) were able to detect ricin, although differences in the measured detection limits compared to the official detection limits and false-negative results were observed. We were not able to get the BADD, Pro Strips™, and RAID assays to function in our laboratory. We conclude that when purchasing a field responder assay, there is large variation in the specificity of the assays, and a number of in-house tests must be performed to ensure functionality. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"186-9"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32464768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national study examining closed points of dispensing (PODs): existence, preparedness, exercise participation, and training provided.","authors":"Terri Rebmann,&nbsp;Travis M Loux,&nbsp;Zachary Swick,&nbsp;David Reddick,&nbsp;Harlan Dolgin,&nbsp;John Anthony,&nbsp;Rohan Prasad","doi":"10.1089/bsp.2014.0014","DOIUrl":"https://doi.org/10.1089/bsp.2014.0014","url":null,"abstract":"<p><p>The Centers for Disease Control and Prevention recommends using open points of dispensing (PODs) and alternative modalities, such as closed PODs, for mass dispensing of medical countermeasures. However, closed POD existence has not been assessed. In 2013 we sent an online questionnaire to US Cities Readiness Initiative (CRI) and non-CRI public health disaster planners. Chi-square tests were used to determine differences between CRIs and non-CRIs when comparing having at least 1 closed POD, and to compare having a closed POD and perceived mass dispensing preparedness. A total of 301 disaster planners participated. Almost all (89.3%, n=218) jurisdictions have considered establishing a closed POD, and three-quarters (74.2%, n=181) currently have at least one. CRIs were more likely than non-CRIs to have a closed POD (85.0% vs 58.5%, X(2)=21.3, p<.001). Those with 1 or more closed PODs were more likely to believe their jurisdiction could distribute medical countermeasures within 48 hours compared to those without a closed POD (78.5% vs 21.5%; X(2)=10.8, p=.001). Half had a written plan and/or written standing orders (59.1% and 52.5%, respectively). Almost half (42%, n=72) have done no preevent training for POD staff in the past 2 years; almost 20% (18%, n=32) do not plan to offer any just-in-time training. Nearly 40% (n=70) have conducted no exercises in the past year. Closed PODs contribute to community preparedness; their establishment should be followed by development of written plans, worker training, and exercises. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"208-16"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32496648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Working after a tornado: a survey of hospital personnel in Joplin, Missouri.","authors":"Rachel Charney,&nbsp;Terri Rebmann,&nbsp;Robert G Flood","doi":"10.1089/bsp.2014.0010","DOIUrl":"https://doi.org/10.1089/bsp.2014.0010","url":null,"abstract":"<p><p>In 2011, an EF5 tornado hit Joplin, MO, requiring complete evacuation of 1 hospital and a patient surge to another. We sought to assess the resilience of healthcare workers in these hospitals as measured by number reporting to work, willingness to work, personal disaster preparedness, and childcare responsibilities following the disaster. In May 2013, a survey was distributed to healthcare workers at both Joplin hospitals that asked them to report their willingness to work and personal disaster preparedness following various disaster scenarios. For those with childcare responsibilities, scheduling, costs, and impact of hypothetical alternative childcare programs were considered in the analyses. A total of 1,234 healthcare workers completed the survey (response rate: 23.4%). Most (87.8%) worked the week following the Joplin tornado. Healthcare workers report more willingness to work during a future earthquake or tornado compared to their pre-Joplin tornado attitudes (86.2 vs 88.4%, t=-4.3, p<.001; 88.4 vs 90%, t=-3.1, p<.01, respectively), with no change during other scenarios. They expressed significantly higher post-tornado personal disaster preparedness, but only preevent preparedness was a significant predictor of postevent preparedness. Nearly half (48.5%, n=598) had childcare responsibilities; 61% (n=366) had childcare needs the week of the tornado, and 54% (n=198) required the use of alternative childcare. If their hospital had provided alternative childcare, 51% would have used it and 42% felt they would have been more willing to report to work. Most healthcare workers reported to work following this disaster, demonstrating true resilience. Disaster planners should be aware of these perceptions as they formulate their own emergency operation plans. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"190-200"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32496456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ebola in West Africa: a familiar pattern?","authors":"Amesh A Adalja","doi":"10.1089/bsp.2014.1563","DOIUrl":"https://doi.org/10.1089/bsp.2014.1563","url":null,"abstract":"Medicine for Policymakers is a Journal column that provides decision makers with brief explanations of the meaning and implications for biosecurity of clinical issues. The articles describe, for a nonmedical audience, hospital practices, medical challenges, healthcare delivery issues, and other topics of current interest. Readers may submit ideas to the column's editor, Amesh A. Adalja, MD, through the Journal's editorial office at jjfox@upmc.edu.","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 4","pages":"161-2"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.1563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32484083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The smallpox threat: a time to reconsider global policy.","authors":"D A Henderson,&nbsp;Isao Arita","doi":"10.1089/bsp.2014.1509.comm","DOIUrl":"https://doi.org/10.1089/bsp.2014.1509.comm","url":null,"abstract":"In May of this year, the 67th World Health Assembly will again debate the question of when the remaining specimens of smallpox virus should be destroyed. Over the past 18 years, this has been on the agenda of 5 previous Assemblies, the last being in 2011. At that time, the delegates ‘‘affirmed strongly the decisions of previous Health Assemblies that the remaining stocks of variola virus should be destroyed.’’ They asked that the date be decided by the 2014 Assembly. Inordinate amounts of time, effort, and resources have been spent in endeavoring to reach consensus on this one component of a smallpox threat strategy: whether to destroy or not destroy smallpox virus strains now being retained in the 2 World Health Organization (WHO) Collaborating Laboratories (in the United States and Russia). In both, the virus is being held under secure conditions. This year, a WHO-appointed group of international scientists concurred that there is no justification for retaining live smallpox virus. In any case, as others have pointed out, advances in genomic biology would now permit strains of virus to be replicated should someone wish to do so. Logic dictates an early date for destruction of the last laboratory strains. Meanwhile, countries and committees have substantially ignored the far more important initiatives that the global community and individual nations should take in order to be prepared to deal with smallpox outbreaks should they occur. Few have stockpiles of vaccine; not more than 8 to 10 countries have sufficient vaccine to cope with an outbreak. A WHO global emergency reserve, recommended 10 years ago, is steadily shrinking. Strategic plans for outbreak containment have been little discussed. At the same time, 2 initiatives have received special attention and resources: one to develop a vaccine that would protect without adverse reactions, and one to perfect antiviral drugs to treat cases should they occur. Both have failed to meet expectations. In writing this commentary, we have jointly drawn on our own half-century of experience with smallpox to offer a brief historic context for a better comprehension of current efforts and to critique the contemporary status of preparedness and response in coping with the unlikely return of smallpox, which has played such a dominant role throughout mankind’s history.","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 3","pages":"117-21"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2014.1509.comm","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32244544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency and effectiveness of using nonmedical staff during an urgent mass prophylaxis response.","authors":"Malaya Fletcher,&nbsp;Raymond Puerini,&nbsp;Jessica Caum,&nbsp;Steven J Alles","doi":"10.1089/bsp.2013.0087","DOIUrl":"https://doi.org/10.1089/bsp.2013.0087","url":null,"abstract":"<p><p>Using a simulated anthrax scenario, the Philadelphia Department of Public Health tested the readiness of a nonmedical closed point-of-dispensing (POD) site to see how rapidly and accurately it could provide medication to its internal population. This closed POD had developed and exercised its mass prophylaxis plan in conjunction with the local health department twice before, and the department was interested in assessing the impact of having no onsite department involvement. Two sessions were conducted as part of the overall exercise. In session 1, agency staff ran POD operations with no department involvement. During session 2, department staff provided an hour-long training session and oversaw POD operations. Mean throughput and accuracy rates of the 2 sessions were then compared to a previous health department public POD exercise staffed by department personnel and medical volunteers. The closed POD would be able to process the entire internal population in an estimated mean time of 23.9 hours. The accuracy rates for dispensing the correct medication during session 1 was 84.7% and 92.4% during session 2 (p=0.0012). Overall accuracy was significantly higher in a previous local health department public POD exercise (88.6% vs. 96.9%, p < 0.0001), as was pediatric dosing accuracy (p < 0.0001). We concluded that nonmedical closed PODs are a valuable strategy during a public health emergency that requires large segments of a population to receive medication rapidly. They must be activated judiciously, however, as their use may increase adverse events and potentially result in discontinuation of antibiotic prophylaxis should people choose not to finish the course. Local health department training and oversight reduce errors but may not always be available. </p>","PeriodicalId":87059,"journal":{"name":"Biosecurity and bioterrorism : biodefense strategy, practice, and science","volume":"12 3","pages":"151-9"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/bsp.2013.0087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32397857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}