Balkan Medical Journal最新文献

{"title":"Cystic Bronchiectasis due to AIDS: Case and References.","authors":"Songyang Pan, Miao Chen, Tianyang Dai","doi":"10.4274/balkanmedj.galenos.2025.2025-8-80","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-8-80","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"212-213"},"PeriodicalIF":4.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-Oncology in 2025: From Molecular Mechanisms to Clinical Practice.","authors":"Kalliopi Keramida","doi":"10.4274/balkanmedj.galenos.2026.2026-1-183","DOIUrl":"10.4274/balkanmedj.galenos.2026.2026-1-183","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"43 4","pages":"171-173"},"PeriodicalIF":4.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ARID4B</i> Promotes Lung Adenocarcinoma Malignancy by Activating <i>GPRC5C</i> transcription via Histone H1 Displacement.","authors":"Guangnan Huang, Lei Gao, Shu Fang, Likun Xu, Xiaowei Zhao","doi":"10.4274/balkanmedj.galenos.2026.2025-10-260","DOIUrl":"10.4274/balkanmedj.galenos.2026.2025-10-260","url":null,"abstract":"<p><strong>Background: </strong>Epithelial–mesenchymal transition and cancer cell stemness (CSC) are critical processes that driving the invasion and lethality of lung adenocarcinoma (LUAD). The chromatin remodeler <i>ARID4B</i> has been implicated in other cancers; however, its specific role and underlying mechanism in LUAD progression remain unclear.</p><p><strong>Aims: </strong>To elucidate the function of <i>ARID4B</i> in LUAD.</p><p><strong>Study design: </strong>This study integrated bioinformatics analysis, <i>in vitro</i> cellular functional assays, and in vivo orthotopic lung cancer models to investigate the oncogenic role of <i>ARID4B</i>.</p><p><strong>Methods: </strong><i>ARID4B</i> expression and its correlation with patient prognosis were analyzed using public databases. <i>ARID4B</i> was silenced using two independent short hairpin RNAs in A549 and H1650 LUAD cell lines, and subsequent changes in invasion, migration, and stemness markers were assessed. Tumor metastasis was evaluated using orthotopic and tail-vein injection mouse models. The regulatory mechanism by which <i>ARID4B</i> controls <i>GPRC5C</i> expression was investigated using dual-luciferase reporter and chromatin immunoprecipitation assays.</p><p><strong>Results: </strong><i>ARID4B</i> was significantly upregulated in LUAD and was associated with poor patient prognosis. Silencing <i>ARID4B</i> in LUAD cells significantly reduced their invasion and migration capabilities (adj. <i>p</i> < 0.01). Furthermore, <i>ARID4B</i> knockdown resulted in downregulation of SNAIL, upregulation of E-cadherin, and impairment of stem-like characteristics, as demonstrated by decreased CSC marker expression and reduced sphere-forming ability (adj. <i>p</i> < 0.05). In the orthotopic model, <i>ARID4B</i> deficiency markedly inhibited tumor metastasis (adj. <i>p</i> < 0.001). Mechanistically, <i>ARID4B</i> transcriptionally activated <i>GPRC5C</i> (adj. <i>p</i> < 0.01). Furthermore, <i>ARID4B</i> knockdown increased histone H1 occupancy at the <i>GPRC5C</i> promoter (adj. <i>p</i> < 0.01), indicating that <i>ARID4B</i> facilitates an open chromatin state. Rescue experiments further confirmed that <i>GPRC5C</i> is required for <i>ARID4B</i>-mediated maintenance of tumor invasiveness and cancer stemness.</p><p><strong>Conclusion: </strong><i>ARID4B</i> promotes LUAD malignancy by transcriptionally activating <i>GPRC5C</i>, thereby driving EMT and cancer stemness.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunodeficiency-Associated Childhood Interstitial Lung Diseases: Data from the Türkiye chILD Registry.","authors":"Handan Kekeç, Tuğba Şişmanlar Eyüboğlu, Ayşe Tana Aslan, Volkan Medeni, Fazılcan Zirek, Mervenur Tekin, Figen Gülen, İsmail Güzelkaş, Sanem Eryılmaz Polat, Ayça Kıykım, Sinem Can Oksay, Abdurrahman Erdem Başaran, Ali Ersoy, Ela Erdem Eralp, Gökçen Ünal, Beste Özsezen, Gökçen Kartal Öztürk, Melih Hangül, Mina Hızal, Cansu Yılmaz Yeğit, Halime Nayır Büyükşahin, Füsün Ünal, Tuğba Ramaslı Gürsoy, Ayşe Ayzıt Kılınç Sakallı, Sevgi Pekcan, Nazan Çobanoğlu, Güzin Cinel, Yasemin Gökdemir, Saniye Girit, Ebru Yalçın, Nagehan Emiralioğlu, Ahmet Cevdet Ceylan, Diclehan Orhan, Berna Oğuz, Nural Kiper","doi":"10.4274/balkanmedj.galenos.2025.2025-10-42","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-10-42","url":null,"abstract":"<p><strong>Background: </strong>Childhood interstitial lung diseases (chILD) and immunodeficiencies are rare, heterogeneous, and clinically challenging disorders.</p><p><strong>Aims: </strong>To evaluate the clinical and radiological characteristics of immunodeficiency-related chILD using data from the Türkiye chILD Registry (chILD-TR).</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Patients registered with the B3 code, according to the chILD-European classification, from 18 participating centers were included. Patients were classified into primary immunodeficiency (PID) and secondary immunodeficiency (SID) groups. Demographic, clinical, and radiological variables were compared between the two groups.</p><p><strong>Results: </strong>Among 667 patients registered in the chILD-TR, 114 (17%) had immunodeficiency-related chILD, including 53 (47%) females. The median current age was 156 months (range: 23-357), the age at symptom onset was 60 months (range: 0-215), and the age at chILD diagnosis was 85 months (range: 2-217). PID was identified in 77 patients (67.6%) and SID in 37 patients (32.4%). The PID group had significantly lower median current age, age at first symptom, and age at chILD diagnosis compared with the SID group (<i>p</i> < 0.05). No significant differences were observed in growth z-scores between the groups (<i>p</i> > 0.05). A history of hematopoietic stem cell transplantation (HSCT) and a diagnosis of bronchiolitis obliterans (BO) were more frequent in the SID group (<i>p</i> < 0.05). The most common computed tomography findings were ground-glass opacities in PID and mosaic perfusion in SID. During follow-up, 14 patients (12.3%) died.</p><p><strong>Conclusion: </strong>Immunodeficiency-associated chILD encompasses a heterogeneous spectrum of disorders and is associated with increased mortality. Distinct clinical and radiological patterns were observed between PID and SID. These findings underscore the importance of early detection, individualized diagnostic strategies, and ongoing follow-up to improve outcomes in this high-risk population. Recognition of post-infectious BO and following HSCT is critical for timely intervention.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"125-135"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Tocolytic Agents for Successful External Cephalic Version: A Bayesian Network Meta-Analysis of Sixteen Randomized Controlled Trials.","authors":"Yunyun Xiao, Jinhe Shi, Yan Dong, Lu Han","doi":"10.4274/balkanmedj.galenos.2025.2025-10-205","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-10-205","url":null,"abstract":"<p><strong>Background: </strong>Cesarean section is frequently performed for breech presentation; however, external cephalic version (ECV) is recommended as an alternative strategy to increase the likelihood of vaginal birth. Tocolytic agents are commonly administrated to improve ECV success, yet the comparative effectiveness of different regimens remains inadequately characterized.</p><p><strong>Aims: </strong>To systematically evaluate and compare the efficacy and safety of various tocolytic agents in facilitating successful ECV through a Bayesian network meta-analysis.</p><p><strong>Study design: </strong>Bayesian network meta-analysis.</p><p><strong>Methods: </strong>Bayesian network meta-analysis was performed using the \"gemtc\" package in R 4.1.1. Treatment effects were quantified by calculating odds ratios (ORs) with corresponding 95% credible intervals (CrIs). Surface under the cumulative ranking curve values were used to rank tocolytic agents according to ECV success rates, maternal outcomes, and adverse events.</p><p><strong>Results: </strong>A total of sixteen RCTs encompassing 2,817 participants and six distinct tocolytic agents met the inclusion criteria. Compared with placebo, terbutaline (OR: 2.7, 95% CrI: 1.1-6.4) and ritodrine (OR: 2.2, 95% CrI: 1.4-3.9) were associated with significantly higher ECV success rates. Additionally, terbutaline was linked to an increased likelihood of vaginal delivery (OR: 2.0, 95% CrI: 1.0-2.9). Maternal adverse effects, including tachycardia, palpitations, hypotension, nausea, dizziness, and flushing, were more frequently reported with terbutaline, nifedipine, and nitroglycerin than with placebo. No statistically significant differences in fetal heart rate abnormalities were detected among the elevated interventions.</p><p><strong>Conclusion: </strong>Terbutaline and ritodrine appear to offer superior efficacy in improving ECV success compared with alternative tocolytic agents, albeit with a higher incidence of maternal side effects. Consequently, clinical decision-making regarding tocolytic use should be informed by a comprehensive assessment of the associated benefits and potential risks.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"115-124"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel SHOX Variant in Léri-Weill Dyschondrosteosis with Madelung Deformity.","authors":"Jing Luo, Xiaoli Wang","doi":"10.4274/balkanmedj.galenos.2025.2025-9-241","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-9-241","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"43 3","pages":"163-165"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical and Main Portal Venous Blood-Flows of Fetal Liver in Normal and Growth Restricted Fetuses and the Impact of the Type of Umbilicoportal Anastomosis on the Main Portal Vein Blood-Flow.","authors":"Görkem Arıca, İsmail Yılmaz, Doğu Küçüksüleymanoğlu, Didem Kaymak, Ebru Alıcı Davutoğlu, Rıza Madazlı","doi":"10.4274/balkanmedj.galenos.2025.2025-9-168","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-9-168","url":null,"abstract":"<p><strong>Background: </strong>The fetal liver is perfused by the umbilical vein (UV) and the main portal vein (MPV), both of which are crucial for nutrient delivery. The configuration of the umbilicoportal anastomosis may influence MPV blood flow and potentially affect fetal liver perfusion in fetuses with fetal growth restriction (FGR).</p><p><strong>Aims: </strong>To evaluate absolute and normalized UV and MPV blood flows in fetuses with normal growth and FGR, and to investigate the effect of umbilicoportal anastomosis type on MPV flow.</p><p><strong>Study design: </strong>Prospective case–control study.</p><p><strong>Methods: </strong>Ultrasound was used to measure UV and MPV diameters, while Doppler ultrasound assessed time-averaged maximum velocities. Flow volumes were calculated as time-averaged maximum velocity volume and normalized to estimated fetal weight (TAMXVVN) and abdominal circumference. Anastomoses were categorized as T-, X-, or H-shaped. Z-scores were derived from AGA nomograms.</p><p><strong>Results: </strong>Compared with AGA fetuses, FGR fetuses exhibited significantly smaller UV diameters, lower absolute UV flow, UV-TAMXVVN, and UVTAMXVV/ AC (<i>p</i> < 0.05), but higher MPV-TAMXVVN (<i>p</i> < 0.05), suggesting compensatory redistribution. Both UV and MPV flows showed strong correlations with gestational age (r > 0.7, <i>p</i> < 0.001). UV-TAMXVVN Z-scores decreased with gestation, whereas MPV-TAMXVVN Z-scores increased until 32 weeks before plateauing. Blood flow parameters did not differ significantly across anastomosis types in either group.</p><p><strong>Conclusion: </strong>FGR fetuses demonstrate reduced UV perfusion with compensatory increases in MPV flow. The type of umbilicoportal anastomosis does not significantly affect MPV blood flow.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"151-158"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echoes of the Past: Are E-Cigarettes the New \"Light\" Cigarettes?","authors":"Ethem Yıldız, Oğuz Kılınç, Çağlar Çuhadaroğlu","doi":"10.4274/balkanmedj.galenos.2026.2026.090126","DOIUrl":"10.4274/balkanmedj.galenos.2026.2026.090126","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"113-114"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Beach to the Emergency Room: Sea Anemone Sting.","authors":"Rocío Egido García-Comendador, Elena Sánchez Marcos","doi":"10.4274/balkanmedj.galenos.2025.2025-11-24","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-11-24","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"159-160"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 40 Hz Auditory Stimulation on Postoperative Delirium: A Prospective Single-Arm Study.","authors":"Jiayong Hu, Yuyao Zhu, Jianhui Liu","doi":"10.4274/balkanmedj.galenos.2025.2025-8-98","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-8-98","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"166-167"},"PeriodicalIF":4.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}