Balkan Medical Journal最新文献

{"title":"Comment on “Exploring Regional Disparities in Heart Failure Epidemiology and Outcomes: A Comprehensive Study Across Geographical Regions in Türkiye”","authors":"Levent Pay","doi":"10.4274/balkanmedj.galenos.2024.2024-7-96","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-7-96","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"516-517"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Hypofibrinogenemia is a Potential Risk Factor for Ischemic Stroke","authors":"Demet Bölükbaşı, Şerife Gökbulut Bektaş, Duygu Kayar Çalılı, Şeval İzdeş","doi":"10.4274/balkanmedj.galenos.2024.2024-6-9","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-6-9","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"514-515"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mpox 2024 Outbreak: The Main Challenges.","authors":"Şiran Keske, Hüseyin Güdücüoğlu, Önder Ergönül","doi":"10.4274/balkanmedj.galenos.2024.2024-240924","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-240924","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"41 6","pages":"416-418"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenosynovial Giant Cell Tumor in the Gruberi Bursa","authors":"Fábio Ferreira, Diana Baptista, Miguel Castro","doi":"10.4274/balkanmedj.galenos.2024.2024-4-120","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-4-120","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"499-500"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesencephalic Developmental Venous Anomaly Causing Obstructive Hydrocephalus Due to Aqueductal Stenosis","authors":"Gökhan Aytekin, Merve Tuna, Serdar Solak","doi":"10.4274/balkanmedj.galenos.2024.2024-7-37","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-7-37","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"503-504"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Effect of Dienogest on Endometrium Mesenchymal Stem Cells Derived from Healthy and Endometriosis Tissues","authors":"Hayal Uzelli Şimşek, Turgay Şimşek, Gökhan Duruksu, Selenay Furat Rençber, Yusufhan Yazır","doi":"10.4274/balkanmedj.galenos.2024.2024-6-95","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-6-95","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis (EM) is an inflammatory condition in which the endometrium is observed to develop outside the uterine cavity. Endometrium has conventionally been recognized as a rich source of endometrial mesenchymal stem cells (E-MSCs). The influence of dienogest, a medication frequently prescribed for EM, on E-MSCs has not been extensively investigated.</p><p><strong>Aims: </strong>To explore effects of dienogest on the E-MSCs derived from healthy (E-MSCs-control) and diseased (E-MSCs-endometriosis) endometrial tissue samples in vitro.</p><p><strong>Study design: </strong>In vitro study.</p><p><strong>Methods: </strong>We collected samples from healthy and diseased endometrial tissues. E-MSCs were derived from both healthy and EM tissues. The effect of dienogest (VISANNE) on E-MSCs was assessed by examining cell proliferation, telomerase activity, cell migration, and estrogen secretion levels after the isolation and characterization of E-MSCs.</p><p><strong>Results: </strong>We discovered that cellular proliferation rate was higher in the E-MSCs derived from EM tissues compared to those derived from healthy tissue. The proliferation rate and telomerase activity were both suppressed by dienogest treatment, particularly in E-MSCs-endometriosis. The drug treatment also resulted in a decrease in the migration capacity of E-MSCs-endometriosis, from 60.4% to 59.2%. The expression of CXCL12, Ki67, and beta-catenin was analyzed in both E-MSCs-endometriosis and E-MSCs-control. The CXCL12 and Ki67 expressions were quite elevated in the E-MSCs-endometriosis without drug treatment compared to the E-MSCs-control. Following the treatment, these levels declined drastically to the levels close to E-MSCs-control. Similarly, this decrease in gene expression was accompanied by a decrease in estrogen secretion into the medium.</p><p><strong>Conclusion: </strong>This research demonstrates that dienogest exerts a substantial impact on both stromal and stem cells, as it effectively controls the disease by reversing EM markers, despite the absence of progesterone receptors on endometrial stem cells.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"484-490"},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Wheat (<i>Triticum aestivum</i> Linn.) Diet on the Testes of Sprague-Dawley Rats","authors":"Chika Anna Idaguko, Gladys Agoreyo","doi":"10.4274/balkanmedj.galenos.2024.2024-2-67","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-2-67","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"404-406"},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance Genes and Mortality in Carbapenem-resistant <i>Klebsiella pneumoniae</i> Bacteremias: Effects of the COVID-19 Pandemic","authors":"Ahmet Furkan Kurt, Elif Seren Tanrıverdi, Metin Yalçın, Osman Faruk Bayramlar, Sibel Yıldız Kaya, Rıdvan Karaali, Mert Ahmet Kuşkucu, Fatma Köksal Çakırlar, Barış Otlu, İlker İnanç Balkan, Bilgül Mete, Gökhan Aygün, Fehmi Tabak, Neşe Saltoğlu","doi":"10.4274/balkanmedj.galenos.2024.2024-5-99","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-5-99","url":null,"abstract":"<p><strong>Background: </strong>Emerging carbapenem-resistant <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) (CRKP) bacteremias are presenting significant public health risks due to limited treatment options and increased mortality. <i>K. pneumoniae</i> isolates exhibit carbapenem resistance rates that vary from 25% to 50% throughout the European continent, including our country.</p><p><strong>Aims: </strong>To assess the characteristics of CRKP bacteremia, a condition that has recently demonstrated an increasing prevalence in our center. We sought to ascertain the resistance rates of isolated strains to antibiotics other than carbapenems, identify the responsible carbapenemase genes, evaluate the efficacy of antibiotics, determine mortality rates, explore clonality among strains, and investigate the influence of the COVID-19 pandemic on all these factors.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This study included patients aged 18 and older who had experienced meropenem-resistant <i>K. pneumoniae</i> bacteremia. Meropenem resistance was confirmed by employing the Kirby-Bauer disk diffusion method. Meropenem minimum inhibitory concentration (MIC) levels were determined using the gradient test, while colistin MIC levels were ascertained using the disk elution technique. Carbapenemase genes were evaluated via colony polymerase chain reaction (PCR), and clonality analysis was performed using the arbitrarily primed PCR technique.</p><p><strong>Results: </strong>The study comprised 230 patients, with a mean age of 63.1 ± 15.9 years, of whom 58.7% were male. Oxacillinase-48 (OXA-48) was detected in 74.8% of the patients, New Delhi metallo-beta-lactamase (NDM) in 12.6%, OXA-48 + NDM in 7.8%, and KPC in 4.8%. The 14-day and 30-day mortality rates were 57% and 69.6%, respectively. Multivariate analysis of the 30-day mortality revealed several crucial factors, including bacteremia development in the intensive care unit, the occurrence of bacteremia during the COVID-19 pandemic, polymicrobial bacteremia, the use of indwelling intravenous catheters, a platelet count of ≤ 140,000/μl, procalcitonin levels of ≥ 6 μg/l, and a Charlson comorbidity score ≥ 3. Notably, the <i>OXA-48</i> and <i>KPC</i> genes were upregulated significantly during the COVID-19 pandemic, while the <i>NDM</i> gene groups were downregulated. Additionally, both 14-day and 30-day mortality rates increased significantly.</p><p><strong>Conclusion: </strong>In this study, the most prevalent carbapenemase gene was OXA-48; however, there has been a recent increase in <i>KPC</i> genes. No dominant epidemic strain was identified through clonality analysis. The clustering rate was 68% before the pandemic, increasing to 85.7% during the pandemic. The significance of infection control measures is underscored by the rise in both clustering and mortality rates during the COVID-19 pandemic.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"357-368"},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Alarming Emergence of Measles in Europe: Gaps and Future Directions","authors":"Şiran Keske, Yasemin Özsürekci, Önder Ergönül","doi":"10.4274/balkanmedj.galenos.2024.060824","DOIUrl":"10.4274/balkanmedj.galenos.2024.060824","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"321-323"},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Normolipemic Plane Xanthoma: Remarkable Dermatological Findings Observed in a Series of Patients","authors":"Can Baykal, Yasemin Erdem, Fatma Kübra Gül Çiftçi, Ahmet Alperen Çevik, Şule Öztürk Sarı, Nesimi Büyükbabani","doi":"10.4274/balkanmedj.galenos.2024.2024-3-72","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-3-72","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"407-410"},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}