Balkan Medical JournalPub Date : 2025-05-05Epub Date: 2025-01-17DOI: 10.4274/balkanmedj.galenos.2024.2024-11-27
Seher Bostancı, Bengü Nisa Akay, Devrim Deniz Kuşçu, Ayşe Öktem
{"title":"Imiquimod and Lentigo Maligna: Can Severe Inflammation Be the Endpoint in Short-Term Use?","authors":"Seher Bostancı, Bengü Nisa Akay, Devrim Deniz Kuşçu, Ayşe Öktem","doi":"10.4274/balkanmedj.galenos.2024.2024-11-27","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-11-27","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"279-281"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Balkan Medical JournalPub Date : 2025-05-05DOI: 10.4274/balkanmedj.galenos.2025.2024-12-37
Serkan Gönültaş, Numan Baydilli, Mehmet Solakhan, Ahmet Güzel, Sina Kardaş, Aykut Demirci, Suhejb Sulejman, Serhat Yentür, Kemal Ertaş, Mustafa Gökhan Köse, Berk Bulut, Mücahit Gelmiş, Murat Bozlu, Ateş Kadıoğlu
{"title":"Etiology of Hematospermia in Turkish Men: Multicentric Study.","authors":"Serkan Gönültaş, Numan Baydilli, Mehmet Solakhan, Ahmet Güzel, Sina Kardaş, Aykut Demirci, Suhejb Sulejman, Serhat Yentür, Kemal Ertaş, Mustafa Gökhan Köse, Berk Bulut, Mücahit Gelmiş, Murat Bozlu, Ateş Kadıoğlu","doi":"10.4274/balkanmedj.galenos.2025.2024-12-37","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2024-12-37","url":null,"abstract":"<p><strong>Background: </strong>Hematospermia is defined as the presence of blood in the semen. The data regarding its etiology and management is variable across the literature.</p><p><strong>Aims: </strong>To investigate the etiology of hematospermia in Türkiye so as to contribute to the current management strategies for hematospermia.</p><p><strong>Methods: </strong>An online study protocol was published through the Turkish Urology Association communication network, and the centers that met the criteria were included in the study. All patients who presented with hematospermia complaints in the past 1 year were subjected to detailed anamnesis, physical examination, and routine laboratory tests. Based on the results, the patients were assigned to Group 1 (patients aged < 40 years with only one episode of hematospermia in the past 6 months) or Group 2 (patients with concomitant symptoms or ≥ 40 years or ≥ 2 times in the past 6 months). Radiological imaging was performed for the patients in Group 2.</p><p><strong>Results: </strong>A total of 199 patients (Group 1: 44, Group 2: 155; mean age: 43.07 ± 14.73 years; age range: 16-73 years) from across 42 cities and 22 different centers were enrolled in this study. In the etiological classification, inflammation was identified as the most common cause (n = 76, 38.1%). Idiopathic hematospermia was higher in Group 1 than in Group 2 (70.4% vs. 112.2%, respectively), and hematospermia was associated with malignancy in 9 (5.8%) Group 2 patients. Positivity was detected in urine or semen cultures in 20 (12.9%) patients, and hematospermia occurred after COVID-19 infection in 2 patients. A significant correlation was noted between patients showing no-concomitant symptoms and those showing idiopathic hematospermia, inflammation, malignancy, varicocele, and multiple etiological factors (<i>p</i> = 0.004, <i>p</i> = 0.028, <i>p</i> = 0.002, <i>p</i> = 0.001, <i>p</i> = 0.026, <i>p</i> = 0.016). The most common radiological findings were an increase in the prostate volume (n = 48, 30.9%) and changes in the signal intensities of the seminal vesicles (n = 29, 18.7%). Despite the use of different approaches to manage idiopathic hematospermia, the patients' survey results were generally similar.</p><p><strong>Conclusion: </strong>Hematospermia in all age groups occurs generally due to self-limiting benign causes. Diagnostic imaging should therefore evaluate the elucidate etiology in patients with identified risk factors so as to avoid unnecessary treatments in idiopathic patients.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"212-221"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Efficacy and Safety of a Combination of Enteral and Parenteral Nutrition Support in the Postoperative Period for Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis”","authors":"Nosaibah Razaqi, Rachana Mehta, Shubham Kumar, Ranjana Sah","doi":"10.4274/balkanmedj.galenos.2025.2025-1-12","DOIUrl":"10.4274/balkanmedj.galenos.2025.2025-1-12","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"282-283"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Balkan Medical JournalPub Date : 2025-05-05DOI: 10.4274/balkanmedj.galenos.2025.2025.160425
Berrin Papila
{"title":"The Evolution of Axillary Surgery in Breast Cancer-Towards De-escalation.","authors":"Berrin Papila","doi":"10.4274/balkanmedj.galenos.2025.2025.160425","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025.160425","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"183-184"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Balkan Medical JournalPub Date : 2025-05-05DOI: 10.4274/balkanmedj.galenos.2025.2025-1-87
Yichuan Liu, Zongquan Wen, Nanrui Zeng
{"title":"Regulating Effect of Weekend Catch-up Sleep on Association of Hepatic Steatosis with Atherosclerotic Cardiovascular Disease.","authors":"Yichuan Liu, Zongquan Wen, Nanrui Zeng","doi":"10.4274/balkanmedj.galenos.2025.2025-1-87","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-87","url":null,"abstract":"<p><strong>Background: </strong>Both insufficient and excessive catch-up sleep durations have been implicated in influencing the risk of cardiovascular diseases (CVDs) and metabolic disorders. However, the specific impact of weekend catch-up sleep (WCS) on the relationship between hepatic steatosis (HS) and atherosclerotic cardiovascular disease (ASCVD) remains unclear.</p><p><strong>Aims: </strong>This cross-sectional study aims to examine the potential regulatory effect of WCS on the association between controlled attenuation parameter (CAP) and ASCVD.</p><p><strong>Methods: </strong>Weighted logistic regression analyses were employed to evaluate the associations of CAP and WCS with ASCVD, expressed in terms of odds ratios (ORs) and 95% confidence intervals (CIs). The study also explored the effect of WCS on the CAP-ASCVD relationship and assessed the potential regulatory role of WCS in subgroups based on age, gender, body mass index, and obesity status.</p><p><strong>Results: </strong>Eligible participants were categorized into two groups: those with an ASCVD risk < 7.5% (n = 1536) and those with an ASCVD risk ≥ 7.5% (n = 1612). After adjusting for covariates, CAP ≥ 274 dB/m was associated with a higher likelihood of ASCVD compared to the CAP < 274 dB/m (OR, 1.84, 95% CI, 1.24-2.73). When compared to a WCS duration of 0-1 hour, WCS ≥ 1 hour was found to increase the potential ASCVD risk associated with CAP (OR, 3.29, 95% CI, 1.41-7.68). Furthermore, among individuals with WCS ≥ 1 hour, CAP ≥ 274 dB/m was linked to a higher ASCVD risk than among those with CAP < 274 dB/m (OR, 3.72, 95% CI, 1.99-6.93). Additionally, in subgroups of participants aged ≥ 60 years, females, non-obese and obese individuals, WCS ≥ 1 hour was associated with an increased ASCVD risk related to CAP (all, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>A WCS duration of ≥ 1 hour may be associated with an increased ASCVD risk in adults with HS aged ≥ 40 years. However, further research is necessary to clarify the causal relationships between WCS, HS, and ASCVD.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"233-241"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic Significance of Red Blood Cell Distribution Width-to-Albumin Ratio in Predicting 1-Year Mortality for Critically Ill Chronic Obstructive Pulmonary Disease Patients.","authors":"Wei Zhao, Yongli Liu, Chenyang Hu, Yuxin Zhang, Yajie Hu, Yiqing Qu","doi":"10.4274/balkanmedj.galenos.2025.2025-1-141","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-141","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a major global healthcare challenge. To address the gap in existing prognostic research, this study examined the possibility of the red blood cell distribution width-albumin ratio (RAR) as a viable biomarker for predicting COPD outcomes.</p><p><strong>Aims: </strong>To evaluate the relationship between RAR and the one-year mortality risk in COPD patients.</p><p><strong>Study design: </strong>A retrospective cohort study.</p><p><strong>Methods: </strong>Participants were grouped based on their RAR levels. Multiple interpolations were used to address missing data. The effect of biomarkers on mortality was estimated using Kaplan-Meier survival curves and Cox risk regression models. Stratified analyses were conducted to assess the consistency of the RAR's predictive value for mortality across different subgroups. RAR was used to build a predictive model and the C-index and time-dependent receiver operating characteristic curves were used to evaluate the model's performance.</p><p><strong>Results: </strong>This study examined 2,379 patients, dividing them into three groups based on their RAR levels. According to Cox regression, RAR was correlated with the 1-year all-cause mortality of patients [model 3: HR = 1.24 (95% confidence interval 1.19-1.29) <i>p</i> < 0.001], with consistent positive correlations between subgroups. This relationship was shown to be linear via the restricted cubic spline. RAR had been demonstrated to be a potentially more effective biomarker than albumin and red blood cell distribution width for determining the one-year mortality risk in COPD patients.</p><p><strong>Conclusion: </strong>A significant association was found between RAR and the one-year mortality of COPD patients. This result implies that RAR may be an effective instrument for determining the prognosis in COPD patients.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"222-232"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}