Balkan Medical Journal最新文献

{"title":"The Evolution of Axillary Surgery in Breast Cancer-Towards De-escalation.","authors":"Berrin Papila","doi":"10.4274/balkanmedj.galenos.2025.2025.160425","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025.160425","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"183-184"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEXAS Syndrome: An Overlooked Threat.","authors":"Serdal Uğurlu, Berkay Kılıç","doi":"10.4274/balkanmedj.galenos.2025.2025-170425","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-170425","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"185-187"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating Effect of Weekend Catch-up Sleep on Association of Hepatic Steatosis with Atherosclerotic Cardiovascular Disease.","authors":"Yichuan Liu, Zongquan Wen, Nanrui Zeng","doi":"10.4274/balkanmedj.galenos.2025.2025-1-87","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-87","url":null,"abstract":"<p><strong>Background: </strong>Both insufficient and excessive catch-up sleep durations have been implicated in influencing the risk of cardiovascular diseases (CVDs) and metabolic disorders. However, the specific impact of weekend catch-up sleep (WCS) on the relationship between hepatic steatosis (HS) and atherosclerotic cardiovascular disease (ASCVD) remains unclear.</p><p><strong>Aims: </strong>This cross-sectional study aims to examine the potential regulatory effect of WCS on the association between controlled attenuation parameter (CAP) and ASCVD.</p><p><strong>Methods: </strong>Weighted logistic regression analyses were employed to evaluate the associations of CAP and WCS with ASCVD, expressed in terms of odds ratios (ORs) and 95% confidence intervals (CIs). The study also explored the effect of WCS on the CAP-ASCVD relationship and assessed the potential regulatory role of WCS in subgroups based on age, gender, body mass index, and obesity status.</p><p><strong>Results: </strong>Eligible participants were categorized into two groups: those with an ASCVD risk < 7.5% (n = 1536) and those with an ASCVD risk ≥ 7.5% (n = 1612). After adjusting for covariates, CAP ≥ 274 dB/m was associated with a higher likelihood of ASCVD compared to the CAP < 274 dB/m (OR, 1.84, 95% CI, 1.24-2.73). When compared to a WCS duration of 0-1 hour, WCS ≥ 1 hour was found to increase the potential ASCVD risk associated with CAP (OR, 3.29, 95% CI, 1.41-7.68). Furthermore, among individuals with WCS ≥ 1 hour, CAP ≥ 274 dB/m was linked to a higher ASCVD risk than among those with CAP < 274 dB/m (OR, 3.72, 95% CI, 1.99-6.93). Additionally, in subgroups of participants aged ≥ 60 years, females, non-obese and obese individuals, WCS ≥ 1 hour was associated with an increased ASCVD risk related to CAP (all, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>A WCS duration of ≥ 1 hour may be associated with an increased ASCVD risk in adults with HS aged ≥ 40 years. However, further research is necessary to clarify the causal relationships between WCS, HS, and ASCVD.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"233-241"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Red Blood Cell Distribution Width-to-Albumin Ratio in Predicting 1-Year Mortality for Critically Ill Chronic Obstructive Pulmonary Disease Patients.","authors":"Wei Zhao, Yongli Liu, Chenyang Hu, Yuxin Zhang, Yajie Hu, Yiqing Qu","doi":"10.4274/balkanmedj.galenos.2025.2025-1-141","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-141","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a major global healthcare challenge. To address the gap in existing prognostic research, this study examined the possibility of the red blood cell distribution width-albumin ratio (RAR) as a viable biomarker for predicting COPD outcomes.</p><p><strong>Aims: </strong>To evaluate the relationship between RAR and the one-year mortality risk in COPD patients.</p><p><strong>Study design: </strong>A retrospective cohort study.</p><p><strong>Methods: </strong>Participants were grouped based on their RAR levels. Multiple interpolations were used to address missing data. The effect of biomarkers on mortality was estimated using Kaplan-Meier survival curves and Cox risk regression models. Stratified analyses were conducted to assess the consistency of the RAR's predictive value for mortality across different subgroups. RAR was used to build a predictive model and the C-index and time-dependent receiver operating characteristic curves were used to evaluate the model's performance.</p><p><strong>Results: </strong>This study examined 2,379 patients, dividing them into three groups based on their RAR levels. According to Cox regression, RAR was correlated with the 1-year all-cause mortality of patients [model 3: HR = 1.24 (95% confidence interval 1.19-1.29) <i>p</i> < 0.001], with consistent positive correlations between subgroups. This relationship was shown to be linear via the restricted cubic spline. RAR had been demonstrated to be a potentially more effective biomarker than albumin and red blood cell distribution width for determining the one-year mortality risk in COPD patients.</p><p><strong>Conclusion: </strong>A significant association was found between RAR and the one-year mortality of COPD patients. This result implies that RAR may be an effective instrument for determining the prognosis in COPD patients.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"222-232"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is MINOCA Syndrome Causing Fatal Left Ventricular Aneurysms Less Innocent than It Appears?","authors":"Cihan Öztürk, Gökay Taylan, Fethi Emre Ustabaşıoğlu, Turan Ege","doi":"10.4274/balkanmedj.galenos.2024.2024-7-116","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2024.2024-7-116","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"274-275"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of Introduction of Machine Learning into Patient-Controlled Anesthesia in Chronic Obstructive Pulmonary Disease and Congestive Heart Failure","authors":"Saim Mahmood Khan, Syed Ali Hassan, Faiza Rubab","doi":"10.4274/balkanmedj.galenos.2024.2024-10-64","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2024.2024-10-64","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"272-273"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perineal Approach for Female Epispadias Repair and Providing Continence","authors":"Dinçer Avlan, Sadettin Yıldız, İrem İnanç","doi":"10.4274/balkanmedj.galenos.2024.2024-8-138","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-8-138","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"269-271"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and Significance of MicroRNAs in the Relationship Between Obesity and Cancer.","authors":"Ahmed S Doghish, Reda M Mansour, Sherif S Abdel Mageed, Hebatallah Ahmed Mohamed Moustafa, Osama A Mohammed, Ahmed E Elesawy, Nehal I Rizk","doi":"10.4274/balkanmedj.galenos.2025.2025-3-60","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-3-60","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are small, noncoding RNAs that are essential for regulating gene expression at the posttranscriptional stage. Recent research shows that miRNAs are crucial in the development of two major global health issues: obesity and cancer, two significant health issues worldwide. This study examines the complex mechanisms by which miRNAs govern vital biological processes, including adipogenesis, cancer, and metabolic dysregulation. We highlight the dual function of miRNAs as oncogenes and tumor suppressors in obesity-related malignancies and investigate their potential as prognostic and diagnostic markers. To demonstrate their varied roles, specific examples of vital miRNAs are underscored, such as miR-21, which promotes adipogenesis and is overexpressed in various cancers, and miR-34a, a tumor suppressor involved in cell cycle arrest and apoptosis. In addition, we examined the recent developments in miRNA-based therapies, which include miRNA inhibitors, mimics, and novel delivery vehicles and have the potential for treating obesity-related malignancies. This review aims to clarify, within the framework of miRNA biology, the therapeutic potential of miRNAs in addressing the interrelation between obesity and cancer.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"188-200"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans-visceral Migration of Retained Gauze: A Rare Cause of Intestinal Obstruction","authors":"Slobodan Todorovic, Nikola Tesic, Filip Lukic, Jasna Gacic, Borislav Toskovic","doi":"10.4274/balkanmedj.galenos.2024.2024-12-20","DOIUrl":"10.4274/balkanmedj.galenos.2024.2024-12-20","url":null,"abstract":"","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"262-263"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Parvovirus B19 in Türkiye: A Descriptive Analysis of National Surveillance Data (2020-2024).","authors":"Kamer Kalip, Melik Toptaş, Gönül Çulha, Mehmet Balcı, Erdoğan Öz, Muhammed Emin Demirkol","doi":"10.4274/balkanmedj.galenos.2025.2025-1-50","DOIUrl":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-50","url":null,"abstract":"<p><strong>Background: </strong>Parvovirus B19 (B19V) infection occurs worldwide seasonally, especially in school-age children. Due to limited surveillance, clinicians report an increase of cases to identify outbreaks, while labs determine seropositivity rates. In 2024, B19V outbreak occurred in Türkiye and many other countries.</p><p><strong>Aims: </strong>To estimate incidences of B19V infection in Türkiye from 2020 to 2024 using National Infectious Disease Surveillance and Early Warning System (IZCI) and to determine case fatality rate (CFR) during the 2024 outbreak period.</p><p><strong>Study design: </strong>Retrospective descriptive study.</p><p><strong>Methods: </strong>The number of cases was obtained from the syndromic surveillance of rash diseases in national database. All notifications with International Classification of Diseases, 10th Revision diagnosis code \"erythema infectiosum\" within the syndromic surveillance were included in the study. All age groups were included in the study and no specific group was excluded. Annual estimated incidences were calculated for past 5 years. The distribution of cumulative incidence for the outbreak by age group and geographical regions was analysed. CFR was calculated for the outbreak period by using the proportion of people who have been diagnosed with B19V. Disease indicators were calculated as crude rates.</p><p><strong>Results: </strong>The estimated incidence in 2024 was 15.24 per 100,000. The peak of the outbreak was in May. The regions with the highest cumulative incidences during the outbreak period were the Black Sea, Marmara, and Central Anatolia. The highest cumulative incidence was 102.64 per 100,000 in 5-9 age group. The CFR was calculated as 0.0184% in the outbreak with 2 deaths out of 10,898 cases.</p><p><strong>Conclusion: </strong>Türkiye has experienced the largest B19V outbreak between February and June 2024. This study showed the unusual scale of B19V post-pandemic, suggesting that such outbreaks can be expected after pandemics. The establishment of syndromic surveillance has proved critical for early outbreak detection and response.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":"42 3","pages":"254-261"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}