Bangabandhu Sheikh Mujib Medical University Journal最新文献_第9页

Stunting and its associated factors in under-five children: evidence from Bangladesh Demographic and Health Survey 2014 5岁以下儿童发育迟缓及其相关因素:来自2014年孟加拉国人口与健康调查的证据

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-02-05 DOI: 10.3329/bsmmuj.v15i4.63893

Md. Sahidul Islam, M. S. Islam, R. Chowdhury, M. M. Zaman

{"title":"Stunting and its associated factors in under-five children: evidence from Bangladesh Demographic and Health Survey 2014","authors":"Md. Sahidul Islam, M. S. Islam, R. Chowdhury, M. M. Zaman","doi":"10.3329/bsmmuj.v15i4.63893","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i4.63893","url":null,"abstract":"Impaired growth and development experienced by children, referred to as stunting, is a major impediment to human development. Although the Bangladesh economy has experienced high growth in recent decades, malnutrition still remains a public health problem. This study assesses the prevalence and risk factors associated with stunting among children under-five in Bangladesh. This analysis uses data from the Bangladesh Demographic and Health Survey 2014, a community-based cross-sectional study. A total of 6,965 children were enrolled in the study. The prevalence of stunting was 36.5% [95% confidence interval (CI): 34.8-38.3%] and 40.2% [95% CI: 37.4-43.1%] for children aged 0-59 months and 0-23 months respectively. Multivariate logistic regression revealed that the significant factors for stunting for children aged 0-59 months and 0-23 months were maternal working status, mother education, mothers age at childbirth, birth order, delivery mode, receiving antenatal clinic visit, media habits, perceived size of child at birth, child sex, children having had diarrhea in last two weeks, wealth and geographical region. In order to meet the nutrition indicators under zero hunger sustainable development goal and 2025 target of World Health Assembly, policy interventions are needed to reduce stunting specially focusing on eastern region of Bangladesh.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):22-31","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46051385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutation in the beta-myosin heavy chain (β-MHC) gene of adult Bangladeshi patients with hypertrophic cardiomyopathy 孟加拉国成年肥厚性心肌病患者β-肌球蛋白重链(β-MHC)基因突变

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-02-05 DOI: 10.3329/bsmmuj.v15i4.64154

L. Banu, M. Masum, Susmita Rahman, Sultana Mahbuba, Mahmud Hosasain, M. J. Hosen, Toufiq Ahmed, S. Banerjee, Dipal Krisna Adhikary, S. Habib, G. Sultana, M. Islam

{"title":"Mutation in the beta-myosin heavy chain (β-MHC) gene of adult Bangladeshi patients with hypertrophic cardiomyopathy","authors":"L. Banu, M. Masum, Susmita Rahman, Sultana Mahbuba, Mahmud Hosasain, M. J. Hosen, Toufiq Ahmed, S. Banerjee, Dipal Krisna Adhikary, S. Habib, G. Sultana, M. Islam","doi":"10.3329/bsmmuj.v15i4.64154","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i4.64154","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiomyopathy characterized by sudden cardiac death. HCM is caused by the mutation in several genes that encode sarcomere proteins. Beta-Myosin Heavy Chain (β-MHC) gene is the one of the most mutated genes responsible for HCM. Studies on mutation spectrum of β-MHC gene are lacking in the Asian population including Bangladeshi patients. This study was intended to mutational analysis of β-MHC gene in Bangladeshi HCM patients. A cross-sectional study was conducted for mutation analysis of the β-MHC gene on 70 Bengali Bangladeshi HCM probands using nextgeneration sequencing at the Genetic Research Lab of Bangabandhu Sheikh Mujib Medical University. Structural and functional impact of the mutations were further analyzed by in-silico process. Thirty-nine nucleotide variants were found in both exonic (36%, n= 14) and intronic regions (64%, n=25) of β-MHC gene. We found 14 missense mutations, including the p.Glu965Lys, p.Arg941Pro, p.Lys940Met, p.Glu935Lys, and p.Met922Lys that are associated with inherited HCM. Most variants were heterozygous and one homozygous (p.Val919Leu) was found. The variant with most evidence of causing the disease was p.Glu935Lys. Among the missense variants, nine were not noted in ClinVar, dbSNP, GenomeAD databases. These unreported variants located between myosin head and tail domains might be novel mutations for Bangladeshi population. We found nine novel variants in the β-MHC gene. Findings of this research will help to developing a genetic database of HCM for early diagnosis and proper management of HCM patients in Bangladesh.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):2-7","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47988084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Declining trend of tobacco use in a rural community of Bangladesh: Results of eight years of community interventions 孟加拉国农村社区烟草使用下降趋势：八年社区干预的结果

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i3.62939

M. Zaman, Ananna Zaman, Palash Chandra Banik, S. Numan, Md. Sadekul Islam, J. Ahmed, S. Choudhury, Tanvir Turin Choudhury

{"title":"Declining trend of tobacco use in a rural community of Bangladesh: Results of eight years of community interventions","authors":"M. Zaman, Ananna Zaman, Palash Chandra Banik, S. Numan, Md. Sadekul Islam, J. Ahmed, S. Choudhury, Tanvir Turin Choudhury","doi":"10.3329/bsmmuj.v15i3.62939","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62939","url":null,"abstract":"Tobacco use in Bangladesh has been high, but there is no report on community-level intervention to reduce tobacco use. The aim of this article is to report the experience of eight years of community intervention to reduce tobacco use in a rural area of Bangladesh. We have done four householdbased surveys (2006, 2008, 2012, and 2014) in Ekhlaspur village of Chandpur district. One man and one woman aged ≥18 years from each of 600 households were selected for each survey randomly to monitor tobacco use in this village concomitant with community interventions. The intervention package included yard meetings, health facility-based counselling, observance of the world no-tobacco days, and periodic lectures in schools. Chi-square for linear trend analysis was done to examine declining trends of prevalence of tobacco use. There were 953 to 1015 participants, approximately half being men in each survey. Their mean age was 44 to 45 years in all surveys. A decline in tobacco use has been observed from 58.8 in 2006 to 43.4% in 2014 (Ptrend=0.000). There has not been any perceivable change in smoking in women because it was either zero or close to zero across surveys. A similar trend was observed in age groups, educational achievements, and hypertension (Ptrend=0.000). Smoking in men declined from 58.3 to 35.2% (Ptrend= 0.000). Community interventions in a sustainable manner can reduce tobacco use in rural communities of Bangladesh.\u0000BSMMU J 2022; 15(3): 157-161","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49307631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of graft uptake in underlay myringoplasty using dry and wet temporalis fascia graft 干、湿颞筋膜下膜成形术中移植物摄取的评价

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i2.60860

Md Hasanul Haque, A. Huq, Nigar Sultana, Tanvir Ahmed, Abirvab Naha, Md. Abdur Razzak, Mohammad Jahidur Rahman Khan, Md Jaber Al Sayied

{"title":"Evaluation of graft uptake in underlay myringoplasty using dry and wet temporalis fascia graft","authors":"Md Hasanul Haque, A. Huq, Nigar Sultana, Tanvir Ahmed, Abirvab Naha, Md. Abdur Razzak, Mohammad Jahidur Rahman Khan, Md Jaber Al Sayied","doi":"10.3329/bsmmuj.v15i2.60860","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60860","url":null,"abstract":"Chronic otitis media (COM) is a vital cause of deafness worldwide. Myringoplasty is one of the best treatment options for COM (inactive mucosal variety). Temporalis Fascia is the most favored grafting material among various autografts, which can be used as dry or wet depending upon the Surgeon's choice. The main focus of this study is to compare the graft uptake rate by using dry and wet temporalis fascia by underlay technique. This cross-sectional comparative study was directed from January 2018 to June 2019 at the Department of Otolaryngology-Head & Neck Surgery of BSMMU, Dhaka. All consecutive cases of COM (inactive mucosal) who underwent surgery were randomly assigned either into the dry (Group-A) or wet temporalis fascia group (Group-B). At 12 weeks follow-up, the density of graft failure (4.4% vs. 8.8%) and retraction pocket (0% vs. 2.2%) were higher in the wet procedure. However anterior blunting (2.2% vs. 2.2%) were the same in both procedures, and medialization (2.2% vs. 0%) were more in the dry procedure. Air Bone Gap (ABG) improved significantly in both groups following operation but reduced in Group-A more significantly than Group-B. On the other hand, there was no remarkable difference in successful graft uptake between the groups (Dry group-91.12% vs. wet group-84.44%, p>0.05). No graft material is superior to others in terms of graft uptake.\u0000BSMMU J 2022; 15(2): 84-89","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41333079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency and outcome of thrombocytopenia in neonates who are at risk of developing thrombocytopenia - a prospective observational study 新生儿发生血小板减少的频率和结果——一项前瞻性观察性研究

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i2.60866

Sarbari Saha, D. Roy, I. Jahan, Mohammad Kamrul Hassan Shabuj, Sadeka Choudhury, M. Mannan, M. Shahidullah, S. Dey

{"title":"Frequency and outcome of thrombocytopenia in neonates who are at risk of developing thrombocytopenia - a prospective observational study","authors":"Sarbari Saha, D. Roy, I. Jahan, Mohammad Kamrul Hassan Shabuj, Sadeka Choudhury, M. Mannan, M. Shahidullah, S. Dey","doi":"10.3329/bsmmuj.v15i2.60866","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60866","url":null,"abstract":"Thrombocytopenia is the commonest hematological abnormality encountered in the neonatal intensive care unit (NICU). This prospective, observational study was conducted among 78 consecutive at-risk neonates admitted in NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from September 2016 to August 2017. Platelet count was measured in all at risk neonates at enrollment and less than 1,50,000/cmm was consiered as the cut off point for determining thrombocytopenia. Platelet count was measured every alternate day till discharge or normalisation of platelet count if the initial platelet count was low. If initial platelet count revealed normal, then the babies were followed up clinically if they develop any further risk condition for developing thrombocytopenia. During the period from enrollment to discharge, if any baby develops thrombocytopenia at any time then baby was defined as thrombocytopenic. Overall 39.7%patients found to be thrombocytopenic among 78 at-risk neonates. Pregnancy induced hypertension (PIH), neonatal sepsis and small for gestational age (SGA), intra uterine growth restriction(IUGR), prematurity, necrotizing enterocolitis (NEC) were significantly associated with thrombocytopenia. Sepsis and NEC were found to be independent risk factor for thrombocytopenia. Regarding outcome, length of hospital stay was significantly more in thrombocytopenic patients than non-thrombocytopenic patients. Death rate was also higher in thrombocytopenic patients in comparison to non-thrombocytopenic patients.\u0000BSMMU J 2022; 15(2): 115-120","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41373054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niemann Pick disease: a rare lysosomal storage disease 尼曼匹克病:一种罕见的溶酶体贮积病

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i2.60871

G. Kundu, Sk Serjina Anwar, Noor-A-Sabah Liza, S. T. Alam, Sanjida Ahmed, Mohammad Arbab Sarker, Meher Nigar Nishi, Sharmina Afrin, M. Quddus

引用次数: 0

A 15-year-old boy with an unerupted tooth enclosed by dentigerous cyst associated with odontome 一个15岁的男孩，有一颗未出牙的牙齿被牙切开术相关的含牙囊肿包围

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i3.62930

A. H. Z. H. Shikder, Muhiuddin Mahmud Galib, Fahmida Siddiqua, Dilara Jahan

引用次数: 0

Application of toluidine blue stain and neuron specific enolase immunohistochemical stain in the diagnosis of hirschsprung disease 甲苯胺蓝染色和神经元特异性烯醇化酶免疫组化染色在巨结肠病诊断中的应用

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i2.60863

Tasmia Islam, S. G. Banu, B. P. Dey, M. M. Rahman, Papiya Rahman, Ummey Salma Shabnam, Syeeda Shiraj Um Mahmuda

{"title":"Application of toluidine blue stain and neuron specific enolase immunohistochemical stain in the diagnosis of hirschsprung disease","authors":"Tasmia Islam, S. G. Banu, B. P. Dey, M. M. Rahman, Papiya Rahman, Ummey Salma Shabnam, Syeeda Shiraj Um Mahmuda","doi":"10.3329/bsmmuj.v15i2.60863","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60863","url":null,"abstract":"Hirschsprung disease is one of the most common and problematic infancy and childhood maladies. Early and accurate diagnosis is a fundamental step in proper management and prevention of complications. The most reliable method for diagnosis is the histopathological analysis of colorectal biopsies and the typical finding of Hirschsprung disease is the absence of ganglion cells. Toluidine blue stain can act as a double check along with conventional H&E stain for ganglion cell detection. Neuron-specific enolase is an immune-histochemical marker that can also aid in better identifying ganglion cells, especially for small and immature ones. This study aimed to evaluate Toluidine blue stain and Neuron specific enolase immunostain along with conventional H&E stain as a panel for the diagnosis of Hirschsprung disease. This cross-sectional study was conducted from September 2019 to August 2021, involving 55 clinically suspected Hirschsprung disease cases. Paraffin blocks of colorectal biopsy samples were collected from the Department of Pathology, BSMMU. Hematoxylin & Eosin, Toluidine blue stain, and Neuron specific enolase immunohistochemical stain for Hirschsprung disease detection were performed on the sections from the paraffin blocks. Then the sections were examined and an evaluation of the stains was done. Statistical analysis was performed on the tabulated data by chi-square test. Among 55 cases, conventional H&E stain detected ganglion cells in 31 cases, that is 56.4%. Later, Toluidine blue stain and Neuron specific enolase immu- nohistochemical stain detected ganglion cells in 35 cases, that is 63.6%. So, these two addition- al stains were able to detect ganglion cells in four more cases compared to conventional H&E stain. In conclusion, conventional H&E stain, Toluidine blue stain, and NSE immunohisto- chemical stain can improve the diagnostic accuracy of Hirschsprung disease.\u0000BSMMU J 2022; 15(2): 102-106","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43563685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prothrombin time and activated partial thromboplastin time in women with gestational diabetes mellitus 妊娠期糖尿病妇女凝血酶原时间和活化部分凝血活酶时间

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i3.62929

Samira Mahjabeen, S. Selim, M. Mustari

引用次数: 0

A 19-year-old boy with intra-oral discharging sinus for 28 days 一个19岁的男孩，口腔内鼻窦排出28天

Bangabandhu Sheikh Mujib Medical University Journal Pub Date : 2023-01-16 DOI: 10.3329/bsmmuj.v15i2.60870

P. Das, Mozammal Hosain, Shuvendu Saha, Md Ali Asgor Moral

引用次数: 0