Avicenna journal of medical biotechnology最新文献_第6页

Novel Osteoporosis Therapeutic Targets Derived from Medical Biotechnology 源自医学生物技术的新型骨质疏松症治疗靶点

Avicenna journal of medical biotechnology Pub Date : 2023-11-27 DOI: 10.18502/ajmb.v16i1.14164

Sepideh Hajivalizadeh, S. Akhondzadeh

引用次数: 0

Recombinant Production of TP4-LYC1, A New Chimeric Peptide with Targeted Cytotoxicity to HeLa Cells 重组生产对 HeLa 细胞具有靶向细胞毒性的新型嵌合肽 TP4-LYC1

Avicenna journal of medical biotechnology Pub Date : 2023-11-27 DOI: 10.18502/ajmb.v16i1.14166

Hanieh Mohammad Pour, A. Jahanian-Najafabadi, F. Shafiee

{"title":"Recombinant Production of TP4-LYC1, A New Chimeric Peptide with Targeted Cytotoxicity to HeLa Cells","authors":"Hanieh Mohammad Pour, A. Jahanian-Najafabadi, F. Shafiee","doi":"10.18502/ajmb.v16i1.14166","DOIUrl":"https://doi.org/10.18502/ajmb.v16i1.14166","url":null,"abstract":"Background: Tilapia Piscidin 4 (TP4) showed potential anti-tumor effects against various cancer cells. Lycosine-1 (LYC1), is another Antimicrobial Peptides (AMP) from spider venom with targeted penetration to cancer cells without any adverse effects on normal cells. The aim of this study was to produce a soluble recombinant fusion peptide in order to diminish the cytotoxicity of TP4 against normal cells. Methods: In order to express of TP4-LYC-1, TP4, and LYC1 in fusion to the inteins1/2 of pTWIN-1 vector, induction condition was optimized to earn soluble peptides. Auto-cleavage induction of inteins1/2 was performed based on IMPACT® manual and their effect on cell viability of HeLa and HUVEC cells was surveyed by MTT assay. Results: The best condition for accessing the most soluble peptide in fusion to the inteins was approximately similar for all three peptides (0.1 mM of IPTG, at 22°C). After the induction of self-cleavage of inteins, a band in 3, 3, and 6 kDa was observed on tricine-SDS-PAGE. The IC50 values of TP4-LYC1 and TP4 against HeLa cells were calculated as 0.83, and 2.75 µM, respectively. Conclusion: In the present study, a novel chimeric peptide, TP4-LYC1, was successfully produced. This fusion protein can act as a safe bio-molecule with potent cytotoxic effects against cancer cells, but the penetration ability and determination of cell death mechanism must be performed in order to have more precise view on the apoptosis induction of this recombinant peptide.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139228426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers 雌性泽西母牛卵巢内注射间充质干细胞或其条件培养基对重复 OPU-IVEP 结果的影响及其与卵泡液炎症标志物的关系

Avicenna journal of medical biotechnology Pub Date : 2023-11-27 DOI: 10.18502/ajmb.v16i1.14167

A. Sarvari, Amir Niasari-Naslaji, Abolfazl Shirazi, B. Heidari, Sara Borjian Boroujeni, Mohammad Hossein Moradi, M. Naderi, Bahareh Behzadi, M. Mehrazar, Mohammad Mehdi Dehghan

{"title":"Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers","authors":"A. Sarvari, Amir Niasari-Naslaji, Abolfazl Shirazi, B. Heidari, Sara Borjian Boroujeni, Mohammad Hossein Moradi, M. Naderi, Bahareh Behzadi, M. Mehrazar, Mohammad Mehdi Dehghan","doi":"10.18502/ajmb.v16i1.14167","DOIUrl":"https://doi.org/10.18502/ajmb.v16i1.14167","url":null,"abstract":"Background: Repeated Ovum Pick Up (OPU) could have a detrimental effect on ovarian function, reducing In Vitro Embryo Production (IVEP). The present study examined the therapeutic effect of adipose–derived Mesenchymal Stem Cells (MSCs) or its Conditioned Medium (ConM) on ovarian trauma following repeated OPU. Resolvin E1 (RvE1) and Interleukin-12 (IL-12) were investigated as biomarkers. Methods: Jersey heifers (n=8) experienced 11 OPU sessions including 5 pre-treatment and 6 treatment sessions. Heifers received intra-ovarian administration of MSCs or ConM (right ovary) and Dulbecco’s Modified Phosphate Buffer Saline (DMPBS; left ovary) after OPU in sessions 5 and 8 and 2 weeks after session 11. The concentrations of RvE1 and IL-12 in follicular fluid was evaluated on sessions 1, 5, 6, 9, and 4 weeks after session 11. Following each OPU session, the IVEP parameters were recorded. Results: Intra-ovarian administration of MSCs, ConM, and DMPBS did not affect IVEP parameters (p>0.05). The concentration of IL-12 in follicular fluid increased at the last session of pre-treatment (Session 5; p<0.05) and remained elevated throughout the treatment period. There was no correlation between IL-12 and IVEP parameters (p>0.05). However, RvE1 remained relatively high during the pre-treatment and decreased toward the end of treatment period (p<0.05). This in turn was associated with decline in some IVEP parameters (p<0.05). Conclusion: Intra-ovarian administration of MSCs or ConM during repeated OPU did not enhance IVEP outcomes in Bos taurus heifers. The positive association between RvE1 and some of IVEP parameters could nominate RvE1 as a promising biomarker to predict IVEP parameters following repeated OPU.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Quorum Sensing and Anti-Biofilm Activity of Ginger (Zingiber officinale) Rhizomes against Multidrug-Resistant Clinical Isolates of Pseudomonas aeruginosa 生姜（Zingiber officinale）根茎对耐多药铜绿假单胞菌临床分离株的抗法定量感知和抗生物膜活性

Avicenna journal of medical biotechnology Pub Date : 2023-11-27 DOI: 10.18502/ajmb.v16i1.14171

Pankaj Kumar Sagar, Poonam Sharma, Rambir Singh

{"title":"Anti-Quorum Sensing and Anti-Biofilm Activity of Ginger (Zingiber officinale) Rhizomes against Multidrug-Resistant Clinical Isolates of Pseudomonas aeruginosa","authors":"Pankaj Kumar Sagar, Poonam Sharma, Rambir Singh","doi":"10.18502/ajmb.v16i1.14171","DOIUrl":"https://doi.org/10.18502/ajmb.v16i1.14171","url":null,"abstract":"Background: The aim of this study was to determination of Anti-Quorum Sensing (AQS) and anti-biofilm potential of the methanol extract of ginger (Zingiber officinale) rhizomes against multidrug-resistant clinical isolates of Pseudomonas aeruginosa (P. aeruginosa). Methods: The AQS activity of ginger was determined against Chromobacterium violaceum (C. violaceum) ATCC 12472 (CV12472), a biosensor strain, in qualitative manner using the agar well diffusion method. The violacein pigment inhibition was assessed to confirm AQS activity of ginger. The AQS potential of sub-minimum Inhibitory Concentrations (sub-MICs) of the ginger extract was determined by targeting different QS regulated virulence factors, including swarming motility (using swarm diameter measurement method), pyocyanin pigment (using chloroform extraction method), Exopolysaccharide (EPS) (using phenol-sulphuric acid method), and biofilm formation (using microtiter plate assay), against clinical isolates (CIs 2, 3, and 4) and standard reference strain of P. aeruginosa (PA01). Results: The AQS activity of methanol extract of ginger was confirmed against C. violaceum (CV12472) as inhibition of violacein pigment formation without effecting the growth of CIs and PA01 of P. aeruginosa. The ginger extract exhibited concentration-dependent inhibition of virulence factors and biofilm formation. The maximum reduction was found in swarming motility, pyocyanin, EPS and biofilm formation against PA01 (51.38%), CI3 (57.91%), PA01 (63.29%) and CI2 (64.37%), respectively at 1/2 MIC of ginger extract. Conclusion: The results of present study revealed the effective AQS and anti-biofilm potential of Zingiber officinale rhizome methanol extract at a reduced dose (sub-MICs). The extract may be explored further for its antibiotic potential and also for reducing the chances of emergence of resistance in P. aeruginosa.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139228873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-step and Rapid Identification of SARS-CoV-2 using Real-Time Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) 利用实时反转录环路介导等温扩增技术（RT-LAMP）一步快速鉴定 SARS-CoV-2

Avicenna journal of medical biotechnology Pub Date : 2023-11-27 DOI: 10.18502/ajmb.v16i1.14165

Mohammad Shoushtari, Mehdi Zeinoddini, Javad Fathi, Hani Keshavarz Alikhani, Fatemeh Shiekhi

{"title":"One-step and Rapid Identification of SARS-CoV-2 using Real-Time Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP)","authors":"Mohammad Shoushtari, Mehdi Zeinoddini, Javad Fathi, Hani Keshavarz Alikhani, Fatemeh Shiekhi","doi":"10.18502/ajmb.v16i1.14165","DOIUrl":"https://doi.org/10.18502/ajmb.v16i1.14165","url":null,"abstract":"Background: SARS-CoV-2 as the cause of novel coronavirus disease (COVID-19) is a member of the family Coronaviridea that has generated an emerging global health concern. Controlling and preventing the spread of the disease requires a simple, portable, and rapid diagnostic method. Today, a standard method for detecting SARS-CoV-2 is quantitative real-time reverse transcription PCR, which is time-consuming and needs an advanced device. The aim of this study was to evaluate a faster and more cost-effective field-based testing method at the point of risk. We utilized a one-step RT-LAMP assay and developed, for the first time, a simple and rapid screening detection assay targeting the Envelope (E) gene, using specific primers. Methods: For this, the total RNA was extracted from respiratory samples of COVID-19 infected patients and applied to one-step a RT-LAMP reaction. The LAMP products were visualized using green fluorescence (SYBR Green I). Sensitivity testing was conducted using different concentrations of the designed recombinant plasmid (TA-E) as positive control constructs. Additionally, selectivity testing was performed using the influenza H1N1 genome. Finally, the results were compared using with conventional real time RT-PCR. Results: It was shown that the RT-LAMP assay has a sensitivity of approximately 15 ng for the E gene of SARS-CoV-2 when using extracted total RNA. Additionally, a sensitivity of 112 pg was achieved when using an artificially prepared TA-E plasmid. Accordingly, for the detection of SARS-CoV-2 infection, the RT-LAMP had high sensitivity and specificity and also could be an alternative method for real-time RT-PCR. Conclusion: Overall, this method can be used as a portable, rapid, and easy method for detecting SARS-CoV-2 in the field and clinical laboratories.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiotherapy Combination: Insight from Tumor Immune Microenvironment (TIME). 放疗联合:来自肿瘤免疫微环境的洞察(TIME)

Avicenna journal of medical biotechnology Pub Date : 2023-10-01 DOI: 10.18502/ajmb.v15i4.13490

Masoumeh Alimohammadi, Haniyeh Ghaffari-Nazari, Reza Alimohammadi, Mohsen Bakhshandeh, Seyed Amir Jalali, Nima Rezaei

{"title":"Radiotherapy Combination: Insight from Tumor Immune Microenvironment (TIME).","authors":"Masoumeh Alimohammadi, Haniyeh Ghaffari-Nazari, Reza Alimohammadi, Mohsen Bakhshandeh, Seyed Amir Jalali, Nima Rezaei","doi":"10.18502/ajmb.v15i4.13490","DOIUrl":"10.18502/ajmb.v15i4.13490","url":null,"abstract":"The view of Radiotherapy (RT) as a simple inducer of DNA damage resulting in tumor cell death has dramatically changed in recent years, and it is now widely accepted that RT can trigger an immune response which provides a sound basis for combining RT with immunotherapy. Given that, radiation can be delivered with different regimens, its effect on immune responses and Tumor Immune Microenvironment (TIME) may vary with dose and fractionation schedule. This fractional dose dependency may need to be more considered because of recent developments in RT delivery techniques making it possible to deliver precisely higher dosages per fraction (hypofractionation) while reducing exposure to normal tissues. Although combining radiotherapy with immunotherapy could be a promising strategy for synergistic enhancement of treatment efficacy, the selection of the best-matched combination of immunotherapy with each radiotherapy scheme remains to be addressed. Thus, for designing better therapeutic combinations, it is necessary to understand the immunological effects of RT. Here, we review the impact of conventional and different hypofractionation radiation schedules on the TIME. Subsequently, we highlight how knowing about these interactions may have implications for choosing a rational combination with targeted therapies.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":" ","pages":"209-215"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44344211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Catechol-O-Methyl-Transferase and Estrogen Receptors polymorphism with Severity of Temporomandibular Disorder in Iranian Patients. 儿茶酚- o -甲基转移酶和雌激素受体多态性与伊朗患者颞下颌疾病严重程度的关系

Avicenna journal of medical biotechnology Pub Date : 2023-10-01 DOI: 10.18502/ajmb.v15i4.13498

Hassan Roudgari, Shamsoulmolouk Najafi, Sheyda Khalilian, Zahra Ghafarzadeh, Aida Hahakzadeh, Sheida Behazin, Nafiseh Sheykhbahaei

{"title":"Association of Catechol-O-Methyl-Transferase and Estrogen Receptors polymorphism with Severity of Temporomandibular Disorder in Iranian Patients.","authors":"Hassan Roudgari, Shamsoulmolouk Najafi, Sheyda Khalilian, Zahra Ghafarzadeh, Aida Hahakzadeh, Sheida Behazin, Nafiseh Sheykhbahaei","doi":"10.18502/ajmb.v15i4.13498","DOIUrl":"10.18502/ajmb.v15i4.13498","url":null,"abstract":"Background: There are many studies which strongly suggest that the pathophysiology of Temporomandibular joint Disorder (TMD) may also be influenced by genetic conditions. The current study was aimed to evaluate the hypothesis that the polymorphism of estrogen receptor genes, estrogen receptor 1 and 2 (ESR1 and ESR2), and the gene Catechol-O-Methyl-Transferase (COMT) could be Predisposing factor for TMD.Methods: In this case-control study, blood sample were taken from 100 TMD diagnosed patients based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 103 healthy individuals as the control group. Tetra ARMS-PCR method was used to amplify and identify COMT rs4680, ESR1 rs1643821, and ESR2 rs1676303 gene polymorphism.Results: ESR1 genotype AA and GA showed significantly increase probability (OR= 4.80, OR=2.98, respectively) of TMD. ESR2 T/T homozygosity was associated with decreased risk for TMD (OR=0.41). The relationship between COMT and TMD was not statistically significant (p>00.05). The relationship between the severity of TMD and ESR1 was significant (p=0.003). According to the inheritance pattern the COMT and ESR1 gene, in the dominant pattern can be susceptible to TMD and in ESR2 gene, in the recessive pattern can be protective to TMD.Conclusion: It seems that SNPs of ESR1 rs1643821 has a susceptible role and ESR2 rs1676303 has a protective role against TMD. Also, we add evidences that various genotype of COMT rs4680 were not statistically different between case and control, but allele A in the dominant inherence pattern can be susceptible to TMD.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":" ","pages":"245-252"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47873154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Seroconversion Rate Following SARS COV 2 Vaccination in Health Care Workers at Shahid Beheshti University of Medical Sciences. 沙希德·贝赫什蒂医科大学医护人员接种SARS冠状病毒疫苗后血清转换率的评价

Avicenna journal of medical biotechnology Pub Date : 2023-10-01 DOI: 10.18502/ajmb.v15i4.13501

Masoud Alavi, Mohammad Mousavi, Mohammad Jazayeri, Asghar Ebadifar

{"title":"Evaluation of Seroconversion Rate Following SARS COV 2 Vaccination in Health Care Workers at Shahid Beheshti University of Medical Sciences.","authors":"Masoud Alavi, Mohammad Mousavi, Mohammad Jazayeri, Asghar Ebadifar","doi":"10.18502/ajmb.v15i4.13501","DOIUrl":"10.18502/ajmb.v15i4.13501","url":null,"abstract":"Background: Vaccines are the most effective way to prevent Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2). This study examines and compares the efficiency of AstraZeneca, Sinopharm, and Sputnik vaccines and the correlation of antibody response with age, sex, and history of corona disease in employees of Shahid Beheshti University of Medical Sciences.Methods: 202 participants were included, of which 82 were administered the Astra-Zeneca, 59 were given the Sinopharm, and 61 were given the Sputnik vaccine. SARSCoV-2 IgM and IgG antibody levels were checked four weeks after passing the second dose of all three vaccines using the enzyme-linked immunosorbent assay (ELISA) technique.Results: There was no significant difference between the amount of IgM and IgG antibodies among three vaccines (p=0.056). For all three vaccines, gender and age did not significantly affect the amount of IgM and IgG antibodies. The history of infection with COVID-19 increased the antibody response (p>0.5).Conclusion: The titer of IgM and IgG antibodies were not statistically significantly different. The IgM and IgG antibodies produced by vector-based vaccines are higher than the Sinopharm vaccine. Gender did not affect the produced antibody titer. No significant linear relationship was found between age and antibody titer. In people from this study who received two doses of the AstraZeneca vaccine and had a corona history, the average amount of both IgM and IgG antibodies was measured more than the other participants.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":"1 1","pages":"258-263"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41719582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats. 枳壳和狭叶对雄性Wistar大鼠阿尔茨海默病症状的影响

Avicenna journal of medical biotechnology Pub Date : 2023-10-01 DOI: 10.18502/ajmb.v15i4.13492

Amir Arasteh, Morteza Karimpour, Faezeh Fallah, Sara Kiani, Maedeh Kakavan

{"title":"Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats.","authors":"Amir Arasteh, Morteza Karimpour, Faezeh Fallah, Sara Kiani, Maedeh Kakavan","doi":"10.18502/ajmb.v15i4.13492","DOIUrl":"10.18502/ajmb.v15i4.13492","url":null,"abstract":"Background: Alzheimer's Disease (AD) is one of the most prevalent chronic neurodegenerative disorders. The present study aims to better understand the mechanism by which Citrus aurantium (C. aurantium) and Lavandula angustifolia (L. angustifolia) hydro-alcoholic extracts were used to treat AD and anti-oxidant issues in a laboratory model.Methods: 15 male Wistar rats, weighing 250±20 gr, aged 6-8 weeks, were used. Amyloids in the brain were found and identified using the shuttle box and Congo red test. ELISA testing for norepinephrine and serotonin, Superoxide Dismutase (SOD), Malondialdehyde (MDA), and Real-time PCR for expression of the APP and GLT1 genes were done.Results: The shuttle box test demonstrated that AD produces behavioral harm, since it significantly reduces passive avoidance learning. The Congo red test revealed that the AD models had much more amyloid beta in their brain tissue than the control. Norepinephrine levels were also decreased by using both extracts in test group. Treatment with both extracts led to a substantial rise in SOD activity and fall in MDA concentration.Conclusion: The gene expression data indicated that the relative expression of the APP and GLT1 genes was shown to be lower in the groups treated with both extracts. C. aurantium and L. angustifolia may therefore offer a multi-target treatment strategy for AD, which calls for more research in this area.","PeriodicalId":8669,"journal":{"name":"Avicenna journal of medical biotechnology","volume":" ","pages":"223-231"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49662897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Considerations in Antidepressant Use. 使用抗抑郁药时的心血管注意事项

Avicenna journal of medical biotechnology Pub Date : 2023-10-01 DOI: 10.18502/ajmb.v15i4.13489

Fateme Taghavi Zanjani, Saeed Nateghi

引用次数: 0