The Glaxo volume; an occasional contribution to the science and art of medicine最新文献

{"title":"CLINICAL CASE OF CUTIS VERTICIS GYRATA","authors":"V. Tkach, O. Aleksandruk, M. Voloshynovych, G. Girnyk, N. Kozak","doi":"10.21802/artm.2023.1.25.111","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.111","url":null,"abstract":"Cutis verticis gyrata (CVG) is a descriptive term for a rare benign skin condition characterized by the formation of tortuous folds and deep furrows that mimic the gyri of the brain because of excessive skin growth. It is observed mainly in men. The first clinical case of the disease was described in 1837 by Alibert J. \u0000There are primary and secondary forms of CVG. Among the cases of primary CVG in 1984, Garden JM and Robinson JK further distinguished the essential and combined subtypes. The reason for the appearance of the essential form is not known. Primary combined CVG can accompany neuropsychiatric disorders, cerebral palsy, epilepsy, seizures, and ophthalmological abnormalities, most commonly cataracts. Secondary CVG occurs as a result of chronic inflammation, such as hysteria, lymphostasis, elephantiasis, eczema, psoriasis, folliculitis, atopic dermatitis, etc. In case of secondary CVG, the lower extremities are more often affected, the skin is congested-red, cyanotic, dense, swollen. Papillomatous growths, layering of crusts and scales are often visible against the background of changed skin. \u0000Given the rarity of this disease (it was diagnosed for the first time in our more than 50 years of dermatological practice), we report a clinical case of CVG. \u0000Case Presentation. Patient P., 27 years old, complained of wrinkles and increased mobility of the skin of the scalp. He noticed the first manifestations of the disease at the age of 17, but did not pay attention, believing that these were individual features of the skin structure. For the last 3-4 years in a row, he noticed a thickening and increase in the size of the folds of the skin on the scalp, growing mobility. The skin, according to the patient, had the appearance of ribs. \u0000During the dermatological examination, the skin is of normal color, turgor and elasticity are preserved, sweat and sebum secretion is moderate. Skin appendages are without pathological changes. The skin of the scalp is uniformly covered with thick hair, hyperelastic, pronounced transverse deep linear furrows resembling brain convolutions are visible. \u0000When using dermoscopy without a light-conducting liquid, the vascular pattern is hardly visible, on the surface there is small lamellar peeling. However, after its application, areas of clearly visible vessels of the superficial vascular plexus of the skin, which coincide with the location of the furrows, are determined. \u0000The patient was examined; no pathology was detected on the part of internal organs and heart. The results of ultrasound of the thyroid gland and organs of the abdominal cavity were without pathological changes. General analysis of blood, urine, blood sugar within the normal range. Biochemical indicators of liver and kidney function without deviations. The patient is recommended to have a periodic examination by a dermatologist. With increasing clinical manifestations - surgical removal of skin folds. \u0000Conclusions. The described clinical case of CVG is","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87741104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROSTRUCTURAL ORGANIZATION OF THE SUBMANDULAR GLAND UNDER CONDITIONS OF 5-WEEK OPIOID INFLUENCE","authors":"","doi":"10.21802/artm.2023.1.25.48","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.48","url":null,"abstract":"The use of opioids is an effective method of treatment for severe and acute pain; however, when they used inappropriately, in addition to their powerful pain-relieving properties, opioids cause significant side effects. The initial changes in the human body caused by the use of narcotic substances (opiates) are detected in the oral cavity, in particular, in the salivary glands. The earliest manifestations of pathological changes in the oral cavity are caries, stomatitis, gingivitis, periodontitis and xerostomia. Based on the results of our research and the study of the effect of opioids on other organs, we can conclude that long-term use of opioids has a significant negative effect on the structure of the submandibular gland and homeostasis of the oral cavity as a whole. The presence of a number of unsolved questions regarding the problems of structural reconstruction of the salivary glands during the use of narcotic agents, as well as the possibility of selecting the most effective methods of treatment and prevention of salivary gland diseases determined the choice of this research topic. \u0000Materials and methods. The research was performed on 15 mature, white, male rats with body weight 200–220 g, aged 4.5–6 months, which were kept under standard conditions at the vivarium of the Danylo Halytsky Lviv National Medical University. Animals were divided into two groups: experimental and control. In the experimental group, animals (10 rats) were daily administered an opioid analgesic (nalbuphine) intramuscularly according to the following schedule: 1st week – 8 mg/kg, 2nd week – 15 mg/kg, 3rd week – 20 mg/kg, 4th week – 25 mg/kg, V week – 30 mg/kg. Controls were 5 rats that were injected with 0.9% sodium chloride solution in a volume of 1 ml for 5 weeks. We used the histological method to conduct the research. \u0000Results. Damage to the organs of the oral cavity and the submandibular gland, in particular, is an element of comorbid pathology caused by long-term use of opioids. During the 5-week administration of the opioid, we observed irreversible destructive changes in the structural organization of the submandibular gland, which was characterized by the dilation of the vessels of the microcirculation, dystrophic and necrotic changes of the final serous and mucous secretory acini, necrosis of serocytes. Such pathological processes in the structural organization of the submandibular gland can cause an imbalance in the quantitative and qualitative composition of saliva and, as a result, a violation of the homeostasis of the oral cavity and the upper parts of the gastrointestinal tract. \u0000Conclusions. The results of the research demonstrate the negative impact of long-term opioid exposure on the structural organization of the submandibular gland and are similar to changes in other organs and body systems during long-term opioid exposure. The damage to microcirculation vessels is the starting and primary mechanisms in this process with the subsequent increas","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82229197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STATE OF THE REPRODUCTIVE SYSTEM AFTER COVID-19 (LITERATURE REVIEW)","authors":"","doi":"10.21802/artm.2023.1.25.88","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.88","url":null,"abstract":"The first case of a coronavirus infection called SARS CoV-2 and the disease caused by this virus, COVID-19, was recorded on December 8, 2019 in the city of Wuhan, Hubei Province, China. On December 31, 2019, a death from a respiratory disease of unknown origin was registered and reported to WHO. The outbreak of this infection has reached pandemic proportions. \u0000Information available in the available literature about the impact of coronavirus infection on the female and male reproductive system is limited and contradictory. \u0000Research rationale. That the available data on the effect of SARS-CoV 2 on the female and male reproductive system are few and contradictory, which requires further study of the problem \u0000The purpose of the research. Conduct a systematic analysis of available modern literature on the impact of COVID-19 on the reproductive system of women and men. \u0000The materials and methods. The literature analysis was carried out on the basis of available scientific sources of the last years 2019-2023. The search strategy was related articles related to the impact of the transmitted SARS-CoV-2 infection on the female reproductive system by manual search in Pub-Med and Google Scholar databases. \u0000Research results. To date, there is no reliable data on the infection of ovarian tissue and endometrium, which affects oogenesis, embryo implantation processes, early embryogenesis, pregnancy in natural cycles and DRT programs. When infected with the SARS-CoV-2 virus, the following mechanisms are possible: damage to the female reproductive system: damage to the ovarian tissue with a violation of ovulatory function, damage to the oocytes with the formation of aneuploid oocytes, damage to the endometrium with a violation of the embryo implantation process. In the available sources of literature at the moment, there are no reliable data confirming infection of ovarian tissues or endometrium affecting oogenesis, embryo implantation processes, early embryogenesis, onset of pregnancy in a natural cycle or DRT programs. Long-term follow-up of patients with COVID-19 is necessary to obtain reliable data. On the basis of experimental studies, it is possible to assume the possibility of the SARS CoV-2 virus affecting the reproductive system of a woman as follows: infection of ovarian tissue, violation of ovulatory function, and the formation of infected oocytes with reduced fertilization potential. Infection of oocytes with the SSARS CoV-2 virus affects the female reproductive system in the following ways: infection of ovarian tissues, violation of ovulatory function, formation of infected oocytes with reduced fertilization potential. Infection of oocytes with the SARS CoV-2 virus can contribute to the formation of aneuploid oocytes incapable of fertilization. Infection of the endometrium with the SARS CoV-2 virus can contribute to the disruption of embryo implantation processes. Despite the significant lack of publications on the effects of the SARS CoV-2 virus on ","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"51 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72576026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SODIUM GLUTAMATE: MECHANISMS OF INFLUENCE ON DIFFERENT ORGANS AND BODY SYSTEMS (LITERATURE REVIEW)","authors":"M. I. Vashcheniuk","doi":"10.21802/artm.2023.1.25.101","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.101","url":null,"abstract":"There are lots of reports about the negative impact of monosodium glutamate on the structural organization of organs, in particular, the nervous, digestive, immune and other systems in the medical literature. The hypothalamus is a part of the midbrain that receives impulses, coordinates and regulates the activity of the entire body, the gray hump is the higher vegetative center of thermoregulation and metabolism, so the study of morphological changes in the structural elements of the gray hump of the hypothalamus will make it possible to understand the cause and method of obesity correction. Although the US Food and Drug Administration (FDA) recommends that monosodium glutamate is not harmful in safe doses, and no adverse effects have been observed when monosodium glutamate is taken with food, it is virtually impossible to establish a safe dose because most common foods today contain monosodium glutamate. \u0000Goal. To analyze the data of modern scientific literature regarding the influence of monosodium glutamate on the morpho-functional state of the body's organs and systems. \u0000Research rationale. Analyzing the modern scientific literature, it can be said that, despite the large-scale study of the problems of the effects of monosodium glutamate on various organs, many issues remain insufficiently studied. Most of the works are devoted to the study of the effect of monosodium glutamate on the liver, pancreas, reproductive and immune systems, but the issue of the effect on the brain and its structures remains poorly studied. There is no information about research in the area of the gray hump of the hypothalamus. \u0000The aim of the study. To establish the features of the structural organization of the gray humerus of the hypothalamus in normal conditions and under the influence of monosodium glutamate. \u0000Materials and methods. The research was performed among publications in Google Scholar, PUBMED and Web of Science (according to the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis), published no more than 10 years ago. Individual older works that are fundamental to understanding this problem are also taken into account. \u0000The results. Monosodium glutamate is a food additive that has been known as a «taste enhancer» for more than 100 years. In Japan, it is the fifth type of taste – «umami», after sour, bitter, salty and sweet. According to US Food and Drug Administration (FDA) guidelines, monosodium glutamate is not harmful in safe doses. No significant side effects have been observed during taking monosodium glutamate with food. It is virtually impossible to establish a safe dose, because most common foods today contain glutamate. Today, there is no unequivocal answer regarding the safety of this food supplement, so the analysis of literature is required. \u0000Conclusions. Analyzing current information, it can be argued that glutamate-induced damage is manifested by metabolic and dystrophic changes, as well as impaired beha","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79818640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF CONNECTIVE TISSUE METABOLISM IN PATIENTS WITH POST-INFARCTION REMODELING AND REPERFUSION SYNDROME","authors":"N. Seredyuk, I. Vakaliuk, Y. Vandzhura, R. Denina, I.Yu. Vandzhura, P. Zvonar","doi":"10.21802/artm.2023.1.25.66","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.66","url":null,"abstract":"Early restoration of coronary blood flow in acute myocardial infarction with elevation helps reduce the area of myocardial necrosis, prevent dilatation of the ventricular cavity, and reduce the development of arrhythmias and mortality. However, despite modern technologies in STEMI treatment, the development of reperfusion syndrome, in particular, arrhythmias, is possible after the restoration of blood flow in the infarct-related artery, which is a consequence of acute cellular, metabolic and local electrophysiological changes in the myocardium. \u0000The aim: is to investigate the long-term effects of reperfusion syndrome on the catabolic/anabolic activity of connective tissue and the processes of connective tissue framework formation in the post-infarction period in patients with myocardial infarction. \u0000Materials and methods. The study involved 156 patients with acute myocardial infarction with ST segment elevation (STEMI), and 15 apparently healthy individuals (control of laboratory parameters). The average age of the patients was (57.8±1.2) years. The percent of male patients prevailed (76 %). \u0000All MI patients were divided into two groups: Group I (98 people) – MI patients without clinical signs of reperfusion syndrome during revascularization, Group II (58 people) – MI patients with the signs of reperfusion syndrome in the form of rhythm and conductivity disturbances during revascularization of coronary arteries by percutaneous coronarography intervention (PCI) with prolonged stenting of the infarct-dependent coronary artery. \u0000Peculiarities of connective tissue metabolism were studied by the content of free and bound oxyproline, glycosaminoglycans, and antibodies to atypical collagens (Ig M and Ig G) in blood serum. \u0000Results. The recovery period after myocardial infarction showed an increase in collagen catabolism over collagen synthesizing processes in patients with MI who had reperfusion syndrome. The described patterns were also established by changes in glycosaminoglycans. The study showed an increase in the level of antibodies to atypical collagens. Particularly, the level of Ig M, which was within the norm (0.43±0.18) ng/ml, in patients with MI without reperfusion manifestations was three times higher (p<0.001), and in cases of  combination of MI and reperfusion syndrome – the highest (p<0.001). \u0000Conclusions: \u0000 \u0000Changes in collagen-synthesizing processes are observed in patients with MI, with a tendency to increase the processes of catabolism of the connective tissue matrix. \u0000The presence of reperfusion syndrome manifestations in MI patients after revascularization aggravates the processes of catabolism, even in the recovery period after MI. \u0000Increase in the activity of catabolic processes stimulates fibrosis and formation of rigid matrix and atypical collagen, to which antibodies are synthesized, thus blocking the pathological circuit of restructuring of the heart connective tissue framework, and accordingly its pathological remodeling. \u0000Th","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"54 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87707766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFLUENCE OF MOBILIZATION AND ISCHEMIC COMPRESSION ON PAIN AND DISABILITY IN ADHESIVE CAPSULITIS AND MYOFASCIAL PAIN SYNDROME","authors":"A. P. Rusanov, N. Borzykh, I. V. Roi, A. Kudrin, V. Vitomskyi, M. Vitomska","doi":"10.21802/artm.2023.1.25.60","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.60","url":null,"abstract":"The purpose of the study: to investigate the effect of end-range mobilization and ischemic compression on pain and disability scores among patients with adhesive capsulitis of the shoulder joint and myofascial pain syndrome in the thoracic region. \u0000Materials and methods. Goniometry of the shoulder joint, assessment of pain at the end points of the range of motion and trigger points (when applying a pressure of 2.5 kg×cm-2), as well as the Shoulder Pain and Disability Index questionnaire were used before the intervention and after physical therapy. \u0000Physical therapy began after an examination and consultation with an orthopedic traumatologist. The majority of patients received 15 planned procedures of end-range mobilization performed by a physical therapist within 3 weeks, only two patients received 14 and 16 procedures. Mobilization from I to V degrees of intensity according to the Maitland classification was used. The patient performed ischemic compression independently after instruction (determination of the localization of trigger points, formation of their map, training in exposure techniques). Compression was performed with an average level of pain or more than average; duration of 30 seconds for each point. \u0000Results. The proportion of male patients was 20.8%. In the examined group of patients, the values of Me (25%; 75%) for age were 53.5 (48.25; 58.5) years, and for the duration of symptoms 4 (2; 5.5) months. Localization of adhesive capsulitis on the right side was observed in 9 patients (37.5%), and on the dominant upper limb in 8 (33.3%) patients. In five patients, the lesion was on the dominant right limb. The evaluation of the transfer of end-range mobilization procedures at the end of the first, sixth, eleventh and last procedure established that the maximum pain on a 10-point scale during mobilization was, respectively: 10 (9; 10) points, 8 (7.25; 9) points, 7 (5 ; 8) points and 4 (3; 5) points. In the course of physical therapy, the indicators of amplitudes of movements and pain at maximum amplitude, as well as at trigger points, improved statistically. The median value for active abduction increased by 74.5° and for active flexion increased by 116.5°. The median value for active internal rotation increased by 77.5°, and for active external rotation, flexion increased by 75°. The median value of pain when reaching the maximum amplitude of active abduction decreased by 6 points, and for active flexion, internal and external rotation, the median dynamics indicator was similar. It should be noted that the pain index at the trigeminal point at the first assessment was 9 (9; 9) points, and at the final assessment it statistically improved and was 4 (3; 4) points (Z = -4.340; p<0.001). All items of the Shoulder Pain and Disability Index questionnaire improved statistically, leading to improvements in domain values and the index itself. Іndicators Me (25%; 75%) of the pain domain decreased from 93 (63; 100) points to 16 (6.5; 20) points (","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88896116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF CARDIOPROTECTIVE THERAPY ON INFLAMMATION AND FIBROSIS FORMATION IN PATIENTS WITH MYOCARDIAL INFARCTION IN COMBINATION WITH TYPE 2 DIABETES MELLITUS","authors":"","doi":"10.21802/artm.2023.1.25.18","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.18","url":null,"abstract":"Myocardial infarction, especially ST-elevation myocardial infarction (STEMI), is the leading cause of death worldwide. Rapid detection and treatment of patients with STEMI is essential to minimize heart muscle damage and improve patient outcomes. Type 2 diabetes mellitus (T2DM) is a common metabolic disorder that is associated with various cardiovascular diseases, including STEMI. Patients with T2DM have a higher risk of developing STEMI, and this relationship is explained by factors such as insulin resistance, oxidative stress, and low-grade inflammation. Low-grade inflammation is now considered a characteristic feature of T2DM associated with the development of cardiovascular disease. \u0000Aim: to evaluate the effect of quercetin and adenosine-containing drug Advocard on inflammation and myocardial remodeling in patients with STEMI and concomitant T2DM. \u0000Materials and methods. This study involved 97 patients  who were diagnosed with STEMI and T2DM who were inpatients at the Ivano-Frankivsk Regional Clinical Cardiology Center. The patients were divided into three separate groups. The first group included 34 patients who received only standard treatment as prescribed by current protocols for STEMI and T2D. The second group consisted of 29 patients who received the same basic therapy, but with the addition of quercetin (4.5 g intravenously for 5 days) to the treatment complex. The third group included 34 patients who received quercetin and Advocard (adenosine -29.25 mg in combination with molsidomine - 0.3 mg and folic acid - 0.45 mg in one half tablet) 2 tablets 3 times a day for 3 weeks against the background of similar basic therapy. \u0000Results. After analyzing the data of the three groups, it was found that the mean fibronectin level before treatment was 2.92±0.11 ng/ml in group 1, 2.67±0.39 ng/ml in group 2 and 2.68±0.38 ng/ml in group 3 (group 1 vs. group 2 p=0.892, group 1 vs. group 3 p=0.12). After treatment, the average fibronectin level decreased to 1.82±0.35 ng/ml in group 1, 1.11±0.26 ng/ml in group 2, and 0.82±0.28 ng/ml in group 3 (group 1 vs. group 2 p<0.001, group 1 vs. group 3 p<0.001). The difference between pre- and post-treatment levels (Δ fibronectin) was 0.86 ng/ml in group 1, 1.57 ng/ml in group 2, and 2.10 ng/ml in group 3. The mean level of sST2 before treatment was 23.08±1.39 ng/ml in the first group, 22.96±1.13 ng/ml in the second group and 23.11±1.05 ng/ml in the third group (group 1 vs. group 2, p=0.705, group 1 vs. group 3, p=0.916). After treatment, the mean level of sST2 decreased to 15.88±1.76 ng/mL in the first group, 10.06±1.77 ng/mL in the second group, and 7.11±1.65 ng/mL in the third group (group 1 vs. group 2 p<0.001, group 1 vs. group 3 p<0.001). The difference between the pre- and post-treatment levels, or Δ sST2, was 7.21 ng/mL in the first group, 12.90 ng/mL in the second group, and 16.00 ng/mL in the third group. \u0000Conclusions: \u0000The use of quercetin and advocard in the pharmacological management of patients wit","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83006628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYSICAL THERAPY OF PREGNANT WOMEN WITH PRIMARY MANIFESTATIONS OF VARICOSE DISEASE OF THE LOWER EXTREMITIES","authors":"Yu.L. Tonkopei, T. Buhaienko, O. Bespalova, Yu.M. Maliarova, O. Prysiazhniuk","doi":"10.21802/artm.2023.1.25.71","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.71","url":null,"abstract":"As a result of the generalization of clinical experience, it has been proved that varicose disease of the lower extremities of pregnant women is defined as a polyetiological disease of the venous system. \u0000The high pathological incidence of varicose veins among pregnant women is caused by a number of factors. The consequence of such changes may be stagnation in the venous bed of the lower extremities. Therefore, women who have a history of primary manifestations of varicose veins of the lower extremities often have got problems during pregnancy and the postpartum period in the form of complications of symptoms leading to thrombophlebitis (inflammation of superficial veins). \u0000Timely started and implemented physical therapy allows relieving or completely eliminating the above symptoms of the disease of pregnant women, significantly improves the properties of blood circulation and the condition of the inner walls of vessels. \u0000The aim of the study is to assess the functional state of the body of women in the second and third trimester of pregnancy with primary manifestations of varicose veins of the lower extremities and the effectiveness of the physical therapy program. \u0000Methods and materials. 19 pregnant women with varicose veins, aged 22 to 29 years, from the second to third trimester of pregnancy participated in the study. Two groups were formed: the main number of 10 women (implemented measures of the developed physical therapy program, which included kinesiotherapy, therapeutic and electrophoresis) and a comparison group – 9 women (implemented standard physical therapy technique). \u0000The following methods were used during the research: 1) anthropometric examination; 2) physiological monitoring of functional indicators of the state of the cardiovascular system of women (pulsometry and tonometry with systematic registration of the indicators of systolic and diastolic blood pressure, heart rate; 3) functional diagnostics (active orthostatic test, spirometry); 4) clinical somatoscopy with participation; 5) assessment of the quality of life. \u0000Conclusions. In the process of different periods of pregnancy, the examined patients were diagnosed with primary varicose veins of the lower extremities. Pregnant women with varicose veins had an intensive increase of body weight in the last trimester of pregnancy. \u0000The inconsistency of the actual blood pressure indicators towards hypertension compared to the physiological norms was revealed. After the implementation of the developed physical therapy program, the following dynamics of changes were exposed: the average value of systolic and diastolic pressure and heart rate indicators of the main group decreased in contrast to the comparison group (p>0.05). Among the women of the main group, the vital capacity of the lungs increased by 7.56%. The normalization of the regulation and type of reaction of the orthostatic test with a change of body position from horizontal to vertical was observed among pregnant women o","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86519191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF BURNOUT SYNDROME AMONG MEDICAL PROFESSIONALS IN UKRAINE FROM 2018 TO 2022","authors":"V. Botiakova","doi":"10.21802/artm.2023.1.25.92","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.92","url":null,"abstract":"The article examines issues related to the prevalence of burnout syndrome among medical professionals in Ukraine from 2018 to 2022. For this purpose, a number of scientific sources related to the subject of the study were analyzed. \u0000It should be mentioned that in the conditions of modern society there are increased requirements for the qualification of specialists (medical professionals), their productivity and the quality of providing medical care. This may affect the professional competence of the specialists, his/her physical/mental health and stress resistance to the formation of negative states caused by the nature of the job, for example, such as burnout syndrome. \u0000Burnout syndrome is one of the most urgent problems in the world. In recent decades, scientists from various countries have been actively researching this phenomenon. The issues concerning the prevalence of burnout syndrome among medical professionals in Ukraine from 2018 to 2022 have not been sufficiently clarified and require more detailed research. \u0000Based on the conducted research, it is possible to reach the following conclusions: preserving the life and health of any person, in particular, a medical professional (including the family doctor), who provides high-quality, qualified, timely medical/rehabilitation assistance to the sick person is an extremely important task of the state. Taking into account the above-mentioned thesis it should be noted that of great importance is the prevention of burnout syndrome as burnout may occur as a possible complication due to the performance of the professional duties by medical professionals. Medical professionals with specialization in \"General Practice – Family Medicine\", \"Therapy\" (Internal Medicine), \"Pediatrics\", \"Emergency Medicine\", \"Psychiatry\", \"Neurology\", and \"Surgery\" are special categories of specialists who have a high risk of developing burnout syndrome due to the specific of their work. These professional categories spend a significant amount of time in close contact with patients. Burnout syndrome can be manifested by emotional exhaustion, dissatisfaction with oneself, feeling of experiencing psychotraumatic circumstances, inadequate selective emotional response, reduction of professional duties, expansion of the sphere of emotions economy, emotional and/or personal detachment, as well as psychosomatic and psychovegetative disorders, a feeling of lack of energy, a desire to be alone, exhaustion, disappointment in professional activity, being on the edge of one’s opportunities, insensitivity to the patients' needs and their objectification, as well as by the loss of interest, indifference to job, physical and emotional fatigue, increased irritability regarding minor events, dizziness, rapid fatigue, headache, etc. Moreover, factors associated with burnout syndrome among Ukrainian medical professionals were analyzed, including those that were studied during the COVID-19 pandemic and factors of the combat environment, whic","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80704205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVING THE METHODOLOGY OF PHYSICAL THERAPY IN ATHLETES WITH INJURIES OF THE KNEE JOINT CONNECTIVE APPARATUS","authors":"","doi":"10.21802/artm.2023.1.25.23","DOIUrl":"https://doi.org/10.21802/artm.2023.1.25.23","url":null,"abstract":"Description and results of the action developed programs of kinesiotherapy with a combination of kinesiotape to restore impaired locomotor functions of the knee joint and the possibility of continuation playing sports after arthroscopic operations for damage to the ligamentous apparatus. \u0000Injuries of the musculoskeletal system (MS) are quite common, especially in athletes. According to statistics, up to 50-70% of all ORA injuries occur in the knee joint. Most often, this type of injury is received by athletes, representatives of complex coordination sports and martial arts. Among injuries to the knee joint, injuries to the ligaments, which later cause post-traumatic instability, take second place after damage to the menisci. \u000035 patients with injuries of the ligamentous apparatus of the CS (12 women and 23 men) who underwent arthroscopic surgery took part in our study. The patients were active athletes in various sports, in particular game sports. Patients were divided into two groups (the main group and the comparison group) depending on the kind of restorative treatment program. The main group included 23 people whose average age was (24.3±3.0) years. Patients of this group received a rehabilitation program in the conditions of an educational and scientific center Department of Physical Therapy, Occupational Therapy of PNU named after Vasyl Stefanyk. The comparison group (CP) consisted of 12 people, the average age of which was (23.8±3.1) years, who underwent rehabilitation in the polyclinic department of the 1st city polyclinic. \u0000The individual program of physical therapy for OG patients included kinesiotherapy and massage muscles of the lower limb, physiotherapeutic procedures and the use of kinesiotape. Kinesiotherapy included therapeutic gymnastics of independent classes, massage for the prevention of contracture of the CS and atrophy of the thigh muscles. Various types of massage were used - classic manual massage with passive movements in the joints, self-massage and hydro massage. Physiotherapy procedures were aimed at reducing swelling and pain, preventing the development of the inflammatory process. Patients were prescribed electrophoresis of painkillers, UV irradiation, and UHF or laser therapy, applications of ozokerite or paraffin. These procedures contribute to the stimulation of lymph and blood circulation, trophic processes in the joints, increasing the amplitude of movements and restoring the strength of the muscles of the limb. \u0000In order to objectify the results of the restorative treatment, the functional ability of the lower limb was assessed using the Lovett muscle test (six-point assessment of muscle strength), the amplitude of movements in the knee joint (goniometry) and the visual analog pain scale (VAS) on the 14th day, 1.5 months, 3 and 5 months after the operation. This part of the study showed the advantages of the developed rehabilitation program using elements of kinesiotaping, as only a few patients with functional","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88998681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}