The Glaxo volume; an occasional contribution to the science and art of medicine最新文献

{"title":"MONITORING ASSESSMENT OF THE EFFECT OF TRANSCRANIAL ELECTRICAL STIMULATION ON THE PSYCHO-EMOTIONAL STATE IN THE WOUND PROCESS AFTER SURGICAL INTERVENTIONS IN THE ORAL CAVITY","authors":"M. Y. Domishche, D. V. Krulko","doi":"10.21802/artm.2022.4.24.44","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.44","url":null,"abstract":"The Goal is evaluation of the analgesic effect and psychoemotional state of patients against the background of the use of TES therapy in the wound process after dental interventions in patients. \u0000Materials and methods We selected two representative clinical groups by age, medical and social status, and the nature of the pathology. The first group (main) included 105 patients, where after primary radical operations; treatment of the wound process was carried out comprehensively with the use of transcranial electrical stimulation (TES). Group II (comparison) consisted of 128 patients who received traditional therapy according to the clinical protocol. In all patients with open wounds, pain syndrome, psychoemotional state, and clinical course of the wound process were evaluated by generally accepted methods. \u0000Research results It has been established that long-term pathological processes in stomatological pathology increase both depression and contribute to the development of psychological dysfunction (Table 2). The assessment of the pain syndrome in a comparative aspect was carried out in the main and comparison groups starting from the second day, since the residual effect of painkillers can be observed on the first day. The results are shown in Table 3 \u0000It follows from our data that a significant decrease in pain syndrome was observed in patients on the background of TES therapy already on the 2nd day after surgical interventions (p < 0.001). And starting from the 3rd day, the pain syndrome had a pronounced tendency to decrease, and on the 5th day in the II and III main groups it was (2.78 ± 0.32 and 1.13 ± 0.08) points. and on the 8th day (1.62 ± 0.08 and 0.80 ± 0.02) points, respectively, which is significantly higher than the comparison group (р < 0.05). \u0000The analysis of the psychological state indicates that against the background of TES-therapy, there is a more significant decrease in the level of reactive anxiety, as well as situational and personal anxiety compared to the comparison group, which has a positive effect, as evidenced by clinical observations, on the course of the wound process and wound healing. \u0000From the data in Table 4, on the background of TES therapy, there is only a significant decrease in the level of reactive anxiety both in patients of the 1st group, and in the 2nd and 3rd groups compared to patients on the background of traditional treatment. \u0000In addition, in the II and III groups, compared to the comparison group, the level of situational anxiety decreased to (31.4 ± 2.3 and 35.0 ± 2.4) points, which almost corresponds to the level of the control group \u0000(p > 0.05). Personal anxiety in these groups was at the level of (37.5 ± 4.3 and 39.6 ± 4.1) points, which is significantly higher than the control group (p < 0.05). In the comparison groups, both situational and personal anxiety even on the 5th day of postoperative intervention was significantly higher than the control group (p < 0.05). \u0000Conclusions: \u0000 \u0000Timely assess","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77811185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECTIVENESS OF PHARMACOLOGIC TREATMENT FOR REGRESSION OF CLINICAL SYMPTOMS AND INDICATIONS FOR SURGICAL TREATMENT OF CHRONIC NASOPHARYNGITIS ASSOCIATED WITH EPSTEIN-BARR VIRUS","authors":"I. Koshel, O. I. Leta","doi":"10.21802/artm.2022.4.24.72","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.72","url":null,"abstract":"Chronic nasopharyngitis (CNP) associated with Epstein-Barr virus (EBV) is etiopathogenetically based on the virus-induced chronic inflammation of the pharyngeal tonsil. Studies using immunological methods have shown that EBV is involved in the hypertrophy of the lymphoid tissue of the pharynx in children and adolescents, since the lymphoid tissue of the pharyngeal tonsil is the site of primary infection and persistence of the virus. The surgery does not often resolve the problem in 19-26% of patients. Therefore, there are many questions regarding the choice of the adequate therapy that would show its effectiveness. \u0000Objective: to evaluate the effect of treatment of CNP associated with Epstein-Barr virus with the phytoneering extract BNO 1030 on the dynamics of the main clinical symptoms and associated indications for surgery. \u0000Material and methods. A total of 108 outpatients divided into two groups: experimental (n-54) and control (n-54). Verification of EBV was carried out according to the ELISA reaction profile: IgM-VCA/IgG-EA/IgG-EBNA. All the patients were prescribed a background treatment and the experimental group additionally received BNO 1030. The evaluation of the effectiveness of treatment was based on the analysis of the dynamics of clinical symptoms, the degree of hypertrophy of the pharyngeal tonsil, and the existence of indications for surgical treatment. Symptom assessment was performed on V1 (day 0), V2 (day 51), V3 (day 101), V4 (day 141). Indications for surgical intervention (adenotomy) were determined on V4 together with the patient's parents. \u0000Results. Clinical symptoms of CNP include runny or stuffy nose, postnasal drip, nasal voice, posterior cervical lymphadenopathy. Symptoms were rated, on average, from 0 to 3 points on a 4-point MSS scale that corresponds to the moderate course of CNP. At V1, both groups showed comparable symptom scores. \u0000The use of the phytoneering extract BNO 1030 in addition to background therapy in patients of the main group proved its clinical efficacy. At V3 and V4, in patients of the main group, there was observed a clinically significant decrease in the severity of nasal congestion, nasality, enlarged cervical lymph nodes (p<0.05). There was insignificant difference between the groups in the dynamics of nasal discharge and postnasal drip symptoms at all visits (р> 0,05). \u0000The analysis of the dynamics of indicators of pharyngeal tonsil hypertrophy in both groups of patients was carried out before the operation. There are significant differences between hypertrophy indicators between V1 and V4 (p<0.05). After eliminating the operated patients, there were no differences between the groups in the degree of hypertrophy (p> 0.05). The need for surgery decreased in patients of the main group. A 14.8% decrease in adenotomy rate was observed: from 53.7% in the control group to 38.9% in the main group (p<0.05). Conservative treatment was prolonged in 61.1% of patients in the main group and 46.3% of pati","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88988947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF EXTRACTS OF GENTIANA ASСLEPIADEA IN THE ACUTE TETRACHLOROMETHANE HEPATITIS MODEL","authors":"N. Hrytsyk, H. Ersteniuk","doi":"10.21802/artm.2022.4.24.21","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.21","url":null,"abstract":"Nowadays, diseases of the hepatobiliary system occupy a special place among diseases of internal organs and systems. At present, the most commonly used hepatoprotectors are herbal remedies. Due to the content of flavonoids, polyphenols, trace elements and other groups of biologically active substances, herbal preparations have antioxidant, antiviral, membrane-stabilizing and choleretic effects. Species of the genus Gentiana, whose underground and above-ground parts contain biologically active substances of various chemical structures, are promising for research. \u0000The aim: to study the hepatoprotective activity of Gentiana аsсlepiadea root extracts on the model of acute tetrachloromethane hepatitis. \u0000Materials and methods. Hepatoprotective activity was studied on the model of acute tetrachloromethane hepatitis. Experiments were performed on 36 white non-linear sexually mature rats weighing 170-240 g. Animals are divided into 6 groups: 1st group – intact animals; 2nd group – control pathology; groups 3-5 - animals treated with thick and liquid extracts of Gentiana аsсlepiadea; 6th group - animals that received the comparative drug Silymarin. The effectiveness of the hepatoprotective action of the studied extracts was determined by the survival rate of animals, the Liver Mass Coefficient, biochemical parameters of blood serum and liver homogenate. \u0000Research results. The results of biochemical studies show that a single injection of tetrachloromethane was accompanied by the development of acute toxic damage to the liver in a group of animals with a control pathology, as evidenced by a 3.5 times increase in the activity of alanine aminotransferase (ALT) in blood serum, a 2.45 times increase in the activity of aspartate aminotransferase (AST) and 1.6 times increase in the activity of alkaline phosphatase (ALP), the level of TBK-reactants in blood serum and liver homogenate - 1.8 and 2.5 times, respectively, compared to the indicators of the group of intact animals. The use of extracts of the roots of Gentiana asslepiadea and the comparative drug Silymarin in experimental hepatitis was accompanied by a noticeable decrease in pathological manifestations and led to a significant decrease in the studied parameters relative to the values in animals with control pathology. The most pronounced hepatoprotective activity was established when using thick and liquid extracts of the roots of Gentiana asslepiadea at a dose of 25 mg/kg of animal body weight, as evidenced by a decrease in the activity of the studied enzymes in the blood serum of the experimental animals: by 2.42 and 2.08 times of ALT, by 2.05 and 1.92 times of AST, by 1.44 and 1.37 times of ALP, the level of TBC-reactants in blood serum by 1.75 and 1.58 times, and in the liver homogenate by 1.90 and 1.78 times, respectively. Silymarin had a slightly lower effect on the development of cytolysis syndrome, reducing the activity of ALT by 1.92 times, AST by 1.81 times, ALP by 1.32 times, the level of TBC","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91408954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEVEL OF KNOWLEDGE OF WOMEN ABOUT THE RISKS ASSOCIATED WITH OVERWEIGHT DURING PREGNANCY","authors":"L. Maksymenko","doi":"10.21802/artm.2022.4.24.90","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.90","url":null,"abstract":"Worldwide half of women start pregnancy with overweight/obese, which greatly increases the risk of pregnancy and birth complications. Recommendations to improve preconception care emphasize the need to ensure that women of reproductive age understand factors that increase the obstetric and perinatal risks connected with high body mass index (BMI). \u0000Aim. Study whether women who start pregnancy with overweight were known of the increased risks of the gestational complications associated with a high (BMI) and the barriers and limitations that women had to optimize their body weight before conception. \u0000Materials and methods. total of 117 pregnant were enrolled in the research. The first group included 68 overweight women (BMI 25.0-29.9 kg/m2), the second - 49 normal body weight women (BMI 18.5-24.9 kg/m2) before pregnancy. Two questionnaires were used: \"Questionnaire on the assessment of the level of knowledge of women about the risks associated with overweight during pregnancy\" and \"Barriers and limitations that women had to optimize body weight before conception\". Patients filled out the presented questionnaires individually during the first antenatal visit (9-12 weeks). The results were statistically analyzed using Statistica 10.0 program pack (StatSoft Inc., USA) and Microsoft Excel statistical analysis package. The differences between the groups were considered statistically significant at p<0.05. \u0000Results. It was shown that the majority of women knew that overweight increased the general risk of pregnancy complications regardless of the woman's BMI. However, the chances of underestimating the high risk of operative delivery in overweight patients were (OR=3.80; 95% CI: 1.83-7.87; p<0.001 and OR=3.69; 95% CI: 1.58 -8.64; p=0.004), premature birth (OR=2.96; 95% CI: 1.47-5.95; p=0.003 and OR=2.99; 95% CI: 1.31-6 .83; p=0.015), adverse neonatal outcomes (OR=2.96; 95% CI: 1.47-5.95; p=0.0031), and especially fetal congenital anomalies of development (OR=5.50; 95 % CI: 2.62-11.54; p<0.001 and OR=12.38; 95% CI: 4.56-33.58; p<0.001) among patients of the first and second groups, respectively. An underestimation of the risk of diabetes, caesarean section, premature birth, and negative perinatal outcomes, and especially congenital fetal abnormalities, has been confirmed if weight loss occurs before conception. The main barriers and limitations for women to optimize their weight before pregnancy were insufficient basic knowledge about the risk of gestational, especially perinatal complications during pregnancy and childbirth associated with overweight, family culture and habits, unsuccessful repeated irregular attempts to weight lose, lack of information and consulting medical professionals on this issue. Only 14.7 % of women reported that they were satisfied with their appearance and health and did not need to lose weight. \u0000Conclusions. Being overweight, usually caused by incorrect lifestyle, including dietary choices and lack of physical activity, has l","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91204403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN THE BIOELECTRIC ACTIVITY OF MUSCULUS MASSETER IN CASE OF MANDIBLE EDENTULOUSNESS TREATMENT","authors":"B. Pelekhan, M. Rozhko","doi":"10.21802/artm.2022.4.24.128","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.128","url":null,"abstract":"The objective of the research: to define the dynamics of changes in bioelectric activity of mm. masseter dexter et sinister in patients with mandible edentulousness treated by means of four implant-supported dental prostheses of various types. \u0000105 patients were examined at the premises of the Center of Dentistry of the University Clinic of Ivano-Frankivsk National Medical University. 30 individuals out of 105 at the age of 23-28 with intact dentition, without somatic pathology were included in the control group. \u000075 patients with mandible edentulousness underwent clinical examination, prosthodontic treatment, and follow-up. 3 clinical groups (Group I; II; III) were formed from this cohort of patients depending on the structural features of the manufactured dental prostheses. \u0000We conducted electromyography of mm. masseter dexter et sinister to the patients of the examination groups (n = 75) and the control group (n = 30) in order to achieve the objective of the research. The examination was performed by means of two-channel electroneuromyographic complex “Neuro-EMG-Micro” (“Neurosoft”) in the functional diagnostics office at the premises of the Department of Dentistry of Postgraduate Study Faculty at IFNMU. \u0000Quantitative indicators of bioelectrical activity of the right and left masticatory muscles were analyzed. Namely, the average values of the maximum amplitudes (μV) when performing the test of maximum bite force were analyzed. Recording of electromyographic indicators was performed before the prosthodontic treatment, 14 days after the fixation of the dental prosthesis, in 6 months and 12 months after the dental prosthesis functioning in order to study the dynamics of changes in the indicators of the examination groups. \u0000Electromyography recording and analysis of the findings in the individuals of the control group was performed once. \u0000Analyzing quantitative indicators of electromyographic examination significant differences in the dynamics of an increase in the indicators in 12 months compared to the initial indicators depending on the type of fixed dental prosthesis (subgroup A рІ-ІІІ<0.001; subgroup B рІ-ІІІ<0.001) and the order of prosthodontic treatment (рА-Б <0.001 for all groups of patients) were observed. \u0000 \u0000Despite the fact that bioelectric indicators of mm. masseter dexter et sinister activity in the patients of the examination groups approximated to the indices of the control group, the dynamics of change was not equivalent and depended on the type of the dental prosthesis. \u0000The dynamics of an increase in the indicators of the patients in the examination groups differed by growth, however, the greatest increase was recorded in the period of “14 days” – “6 months” after the fixation of the dental prosthesis. \u0000On performing the test of maximum bite, the indicators of the masticatory muscles bioelectrical activity increased during the period named “before the treatment” – “12 months of functioning” most of all in IIIA examination group","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89793664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF MOBILIZATION TECHNIQUES IN THE PHYSICAL THERAPY OF PATIENTS WITH ADHESIVE CAPSULITIS OF THE SHOULDER JOINT","authors":"A. P. Rusanov, V. Vitomskyi, M. Vitomska","doi":"10.21802/artm.2022.4.24.181","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.181","url":null,"abstract":"The purpose of the study: to analyze the results of studies devoted to the study of the effectiveness of the use of mobilization techniques in patients with adhesive capsulitis of the shoulder joint. \u0000Materials and methods. This work is the result of an analysis of studies devoted to the study of the effect of mobilization techniques as monotherapy and as part of a complex physical therapy on the range of motion in the shoulder joint, pain on the visual analog scale, and the shoulder pain and disability index. \u0000Results. Stretching exercises, pendulum exercises, various manual therapies, proprioceptive neuromuscular facilitation techniques, and muscle energy techniques are used in physical therapy for adhesive capsulitis. Analysis of the literature confirmed that mobilization is widely used in the therapy of patients with adhesive capsulitis of the shoulder joint. At the same time, the number of mobilization techniques, which are used in the form of monotherapy or part of complex treatment, is significant. There are quite a few types of mobilization techniques for adhesive capsulitis of the shoulder joint: angular mobilization; progressive mobilization; mobilization of the spine in combination with scapular stretching, angular and translational mobilization; high-intensity techniques based on the pain threshold; the Cyriax approach; Mulligan technique; Maitland technique. There are research results that indicate an immediate effect of intensive mobilization on the amplitude of passive abduction. A number of studies have established the advantages of end-range and intensive mobilization compared to mid-range mobilization. At the same time, studies were found that did not establish the advantages of mobilization over therapeutic exercises, and also established the advantages of therapeutic exercises without pain compared to a complex intervention that included exercises and mobilization with exceeding the pain threshold. Thus, the question of the intensity of mobilization, the level of pain during mobilization remains relevant. Results of literature reviews noted that the Kaltenborn technique shows better results after 2-6 weeks of therapy in reducing pain, improving range of motion and functional activity; that there is moderate evidence of effectiveness of mobilization methods in the short and long term; that the Maitland technique and combined mobilization are recommended for use. In the aspect of mobilization with adhesive capsulitis, there is a question of its direction (anterior or posterior) to improve the amplitude of external rotation. At the same time, the conclusions of the last systematic review of the effectiveness of conservative methods of treatment of adhesive capsulitis indicate that there is no reliable evidence that would convincingly testify to the superiority of one method of treatment of adhesive capsulitis over another. \u0000Conclusions. The results of scientific studies indicate different conclusions regarding the effectiveness o","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74524616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAUSES OF INGUINAL HERNIAS RECURRENCE DURING THE LIECHTENSTEIN OPERATION","authors":"M. G. Honchar, Y. M. Kuchirka, I. Melnyk, I. Churpiy","doi":"10.21802/artm.2022.4.24.170","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.170","url":null,"abstract":"Numerous methods of plastic surgery of inguinal hernias with own tissues, which were developed by surgeons, gave relapses up to 35%. A large number of relapses in the treatment of inguinal hernias with tension methods forced surgeons to look for new ways to solve this problem. \u0000Without pathological changes in the deep inguinal ring, a hernia cannot occur, and this leads to the conclusion that all existing methods, which are aimed at strengthening only the front wall of the inguinal canal, are pathogenetically unfounded and often a recurrence of the hernia can be expected. \u0000Therefore, a justified operation for various types of inguinal hernia is the strengthening of the deep ring and the back wall of the inguinal canal. \u0000Changing the concept of the approach to the treatment of inguinal hernias should be aimed at minimizing trauma and take into account the pathogenetic features of the development of hernias. \u0000The reason for the development of inguinal hernias is expansion, destruction, functional insufficiency of deep inguinal openings: medial and lateral. \u0000The back wall of the inguinal canal does not have a protective function when intraperitoneal pressure increases and cannot resist hernia formation. At the same time, its weakening, destruction can contribute to the increase of the internal inguinal opening. Although we did not come across any publication that gave an example of a hernia exiting directly through the back wall of the inguinal canal. \u0000Based on our own clinical experience, as well as the processing of a large number of literary sources, we offer a modified type of Lichtenstein's operation in the following interpretation: a typical incision of the skin and subcutaneous tissue with the opening of the aponeurosis of the external oblique abdominal muscle; mobilization of the spermatic cord; mobilization of the hernia sac, its opening, stitching at the base and removal. With a direct inguinal hernia, if the bag is small, there is no need to remove it. Revision of the internal inguinal ring in case of an oblique hernia and, if necessary, sewing it to the required size (the tip of the little finger should pass between the cord and the ring). \u0000Revision of the medial deep ring in direct inguinal hernia and its suturing \"tightly\" over the hernial protrusion. \u0000Prepare a mesh implant so that its dimensions cover both deep holes, dissect it according to our proposed method. Fix the net to the deep ring using the described method. Sew the lower part of the mesh with an overlap of 1-1.5 cm to the pubic bone, fix the lateral edge of the implant to the pubic ligament with a wrapping suture or knotted single sutures. \u0000Above the spermatic cord, the legs of the dissected implant are sewn together and sewn to the aponeurosis of the external oblique muscle of the abdomen from below. \u0000The medial edge of the mesh is sewn to the internal oblique muscle and to the aponeurosis of the external oblique muscle in the manner described above. \u0000The middle part of t","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76344925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF THE FORM OF VENOUS HYPERTENSION IN PATIENTS WITH DECOMPENSATED CHRONIC VENOUS INSUFFICIENCY WITH VARICOSE DISEASE AND POSTTHROMBOTIC SYNDROME","authors":"F. M. Pavuk, V. Rusyn, V. Y. Fedusyak","doi":"10.21802/artm.2022.4.24.121","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.121","url":null,"abstract":"Aim. Improve the results of treatment of patients with decompensated forms of chronic venous insufficiency by determining the main forms of venous hypertension inherent in varicose veins and postthrombotic syndrome. \u0000Materials and methods. From 2018 to 2022, 147 patients with chronic venous insufficiency (CVI) C6 according to CEAP, aged from 38 to 69 years (on average, 55±5.3 years), were treated in the surgical clinic of the Communal non-commercial enterprise «Transcarpathian Regional Hospital» of the Transcarpathian Regional Council from 2018 to 2022. According to the etiopathogenesis of decompensated CVI, 76 (51.7%) patients were diagnosed with varicose veins of the lower extremities, and 71 (48.3%) patients with postthrombotic syndrome (PTS). Research of venous hemodynamics began with the determination of vertical reflux in the system of the large saphenous vein, then in the system of the small saphenous vein, then the presence of vertical reflux in the system of deep veins of the lower extremities and horizontal reflux in the thigh and lower leg. At the same time, isolated and combined forms of horizontal and vertical refluxes were distinguished. \u0000Research results. Based on the complex ultrasonographic examination (USG) and the etiopathogenesis of chronic venous insufficiency, 76 (51.7%) patients with varicose veins (VC) had superficial venous hypertension. In decompensated forms of PTPS, 71 (48.3%) in 68 (95.8%) patients had deep venous hypertension, and in 3 (4.2%) a mixed form of venous hypertension. According to USG studies, the diameter of the large saphenous vein (LSV) in patients of the 1st group was on average 10.3±0.2 mm, the small saphenous vein (SSV) was 5.3±0.1 mm. In patients of the second group, the diameter of the LSV was 11.1±0.5 mm, the SSV was 6.5±0.2 mm. Failure of penetrating veins in the first group was found in 14 (18.4%), and only in 12 (15.8%) cases horizontal reflux was single. The average diameter of penetrating veins was 5.1±0.5 mm \u0000In the second group of patients, horizontal reflux in penetrating veins was found in all patients, and in 56 (78.9%) of them, it was multiple. At the same time, the average diameter of penetrating veins was 5.8±0.9 mm. \u0000The size of trophic ulcers was larger in the second group of patients. With a diameter of a trophic ulcer up to 10 cm in patients with superficial hypertension, 42.1% had the IIst depth of the lesion, and with deep venous hypertension, the IIIst depth of the lesion was observed in 51.4% of cases. 34.2% of patients with superficial hypertension had trophic ulcers with a diameter of up to 5 cm and a depth of lesions of the IIst, then patients with deep venous hypertension had trophic ulcers of up to 5 cm in diameter with a depth of lesions of the IIst in only 5.8% of cases. IV st. of lesion depth was observed only in three patients with a mixed form of venous hypertension. \u0000Conclusions. In decompensated forms of varicose veins, superficial venous hypertension is observed i","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83082606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF OCCUPATIONAL THERAPY AND SENSORY INTEGRATION ON THE LEVEL OF SELF-CARE OF CHILDREN WITH AUTISTIC SPECTRUM DISORDERS","authors":"M. Vitomska","doi":"10.21802/artm.2022.4.24.14","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.14","url":null,"abstract":"The purpose to assess the effectiveness of occupational therapy and sensory integration on the level of self-care of children with autism spectrum disorders in early childhood. \u0000Materials and methods 60 patients (from 3 to 5 years) participated in the study. The control group (CG) underwent a standard correction program with the consultation of an occupational therapist for 6 months. The first main group (OG1) additionally received occupational therapy sessions 3 times a week, which were aimed at forming self-care skills. Children of the second main group (OG2) received sessions on sensory integration (2 times a week) in addition to OG1 therapy. In sessions on sensory integration, children formed and improved imitation abilities, orientation in space, coordination, and sensory perception. The study used a questionnaire for the assessment of children's disability. The self-care domain was used for the analysis. Evaluation was carried out by occupational therapists before the start of the intervention and after completion of the program. \u0000Results Initial results revealed a rather low level of self-care in the patient groups. In all groups, the worst scores were obtained in the item that is responsible for fastening and unfastening fittings, and the best in the item that is responsible for the awareness of defecation. As for the final indicators, the item \"fastening\" remained with the lowest score in CG and OG1. The best score remained in the item \"awareness of defecation\". Analysis of the distribution of groups by gender did not establish differences between groups. The average age of the children was 3.85±0.63 years. The groups did not differ in age. Initial results revealed a fairly low level of self-care, but the groups were not statistically different. Indicators х̅±SD of the total domain score were 24.35±6.34 points in CG, 26.10±7.70 points in OG1, and 25.85±5.65 points in OG2. Comparison of the three groups according to the final results of the total score of the self-care domain established statistical differences. Conducted a posteriori test established the presence of statistical differences in all pairs of groups (p<0.001). Statistical indicators х̅±SD in CG were 30.85±6.71 points, in OG1 – 42.20±5.14 points, and in OG2 – 53.05±5.85 points. The results of the repeated assessment were statistically different from the initial ones in CG (t = -11.156, p<0.001), OG1 (t = -20.794, p<0.001) and OG2 (t = -23.875, p<0.001). These results are a consequence of the fact that statistically significant dynamics were observed in CG only in five points, namely those responsible for: consistency of food consumed, use of drinking vessels, nose care, hand hygiene, fasteners. On the other hand, among groups OG1 and OG2, statistically significant changes were found in all items of the domain, however, a pairwise comparison of the final results in the items of groups OG1 and OG2 revealed statistical advantages of the second in five items. At the same time, a ","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"324 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76302002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF AMINOCAPRONIC ACID ON THE REGRESSION OF NASAL POLYPS AND NASAL CONGESTION IN PATIENTS WITH POLYPOUS RHINOSINUSITIS","authors":"I. Koshel, Yaroslav R. Maksymenko","doi":"10.21802/artm.2022.4.24.66","DOIUrl":"https://doi.org/10.21802/artm.2022.4.24.66","url":null,"abstract":"Chronic rhinosinusitis with nasal polyposis (CRS with NP) is a clinical syndrome including several clinical phenotypes and endotypes with differences in pathophysiology and is divided into neutrophilic (non-type 2) and eosinophilic (type 2) according to the dominant endotype, which is the most severe variant associated with therapy resistance and frequent recurrence. Such pheno-endotype requires personalized treatment, and pharmacotherapy based on endotyping is prospective. Aminocapronic acid (ACA) competitively inhibits plasminogen and plasmin formation, inhibits C3a and C5a, which can affect the pathophysiological mechanisms of eosinophilic inflammation and polypous growth, since, in addition to hemostatic properties, it also has desensitizing, anti-enzymatic, and anti-proliferative properties. \u0000The aim of the research: to evaluate the influence of additional administration of aminocapronic acid on the degree of regression of nasal polyps in comparison with patients receiving standard therapy of Chronic rhinosinusitis with nasal polyposis according to clinical recommendations. \u0000Material and methods. The study included 120 outpatients, divided into two groups: the main (n - 60) and control (n - 60) ones. The average age of the main group was 45.8 years; the control group was 47.0 years. Patients were prescribed basic treatment (irrigation therapy with saline solutions and mometasone furoate), and in the main group – additionally aminocapronic acid (ACA). The evaluation of treatment effectiveness was based on the analysis of the dynamics of nasal congestion and the regression of nasal polyps at V2 (day 5±1), V3 (day 10±1), V4 (day 20±1) and V5 (day 30±1) compared to V0. Indications for surgical treatment were determined at V3. \u0000Results. The use of aminocapronic acid in Chronic rhinosinusitis with nasal polyposis contributes to a reliable reduction in the severity of the main clinical symptoms (rhinorrhea, postnasal drip, nasal congestion, reduced sense of smell), nasal congestion starting from V2, regression of polyps – from V3 compared to patients of the control group. This ensured a statistically significant 25% reduction in the number of operated patients: 56.7% in the main group versus 81.7% in the control (p<0.05). Conservative treatment was continued by 43.3% of patients of the main group and by 18.3% of patients of the control group (p<0.05). After the operated patients were removed from the groups, they did not significantly differ in the dynamics of regression of nasal congestion and nasal polyps at V4 and V5 (p>0.05). Differences in the results of treatment are attributed to the clinical effects of Aminocapronic acid (ACA), since the group characteristics of the patients were commensurable. \u0000Conclusions: \u0000 \u0000the additional appointment of Aminocapronic acid (ACA) to patients with Chronic rhinosinusitis with nasal polyposis contributes to a faster regression of nasal congestion associated with edematous changes of the mucous membrane of th","PeriodicalId":86625,"journal":{"name":"The Glaxo volume; an occasional contribution to the science and art of medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82508399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}