Australasian Psychiatry最新文献_第7页

Real-world safety profile of trazodone: Evidence from FAERS pharmacovigilance data (2004-2024). 曲唑酮的实际安全性：来自FAERS药物警戒数据的证据（2004-2024）。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-21 DOI: 10.1177/10398562261479289

Junyin Zhou, Lijuan Xu, Yaqin Sun

{"title":"Real-world safety profile of trazodone: Evidence from FAERS pharmacovigilance data (2004-2024).","authors":"Junyin Zhou, Lijuan Xu, Yaqin Sun","doi":"10.1177/10398562261479289","DOIUrl":"https://doi.org/10.1177/10398562261479289","url":null,"abstract":"ObjectiveTrazodone has shown good efficacy in patients with major depressive disorder accompanied by insomnia and anxiety symptoms. However, real-world data on its long-term adverse effects remain limited. This study analyzes a large dataset to assess the relationship between trazodone and specific adverse events (AEs).MethodsData from the FAERS database covering the period from the first quarter of 2004 to the third quarter of 2024 were collected, standardized, and analyzed. Signal detection was performed using the ROR, PRR, BCPNN, and MGPS algorithms.ResultA total of 5172 reports were collected, covering 27 system organ classes and 1616 preferred terms (PTs). Contrary to the official drug label, reproductive system and breast disorders exhibited the highest correlation, with involved PTs including priapism, clitoral engorgement, and penile vein thrombosis. Surprisingly, trazodone showed the highest signal strength in association with penile amputation. The detection of wandering pacemaker and electrocardiogram PR prolongation emphasized the cardiovascular event risk. Notably, completed suicide and serotonin syndrome exhibited relatively high occurrence rates. Other uncommon but significant AEs, such as wound infection fungal, hypervigilance, and hangover, were also detected. Additionally, new and clinically significant rare AEs, such as hyper IgE syndrome and acute myopia, were identified.ConclusionsThis study provides valuable data on the AEs of trazodone, particularly its potential reproductive system adverse effects, cardiovascular risks, and other rare events. Our findings lay the foundation for further safety assessments of trazodone.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261479289"},"PeriodicalIF":1.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benzodiazepine prescribing at discharge from adult and older persons psychiatric inpatient units: A systematic review and meta-analysis. 成人和老年人精神科住院病房出院时苯二氮卓类药物处方：系统回顾和荟萃分析。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-18 DOI: 10.1177/10398562261474431

Justin McMahon, John McMaster, David Maletsky, Hesitha Abeysundera

{"title":"Benzodiazepine prescribing at discharge from adult and older persons psychiatric inpatient units: A systematic review and meta-analysis.","authors":"Justin McMahon, John McMaster, David Maletsky, Hesitha Abeysundera","doi":"10.1177/10398562261474431","DOIUrl":"https://doi.org/10.1177/10398562261474431","url":null,"abstract":"ObjectivePsychiatric inpatient discharge is a prescribing transition at which benzodiazepines initiated for short-term symptom control may unintentionally continue beyond discharge. Existing guidance is limited for prescribing decisions. We aimed to estimate benzodiazepine discharge prevalence from adult and older persons psychiatric inpatient units and examine between-study heterogeneity.MethodsWe searched five databases from inception to 31 December 2022, updated the search on 27 November 2025 (PROSPERO: CRD42022368986), and included studies reporting benzodiazepine prescribing at discharge from adult and older persons psychiatric inpatient units.ResultsTwenty-five studies contributed 28 cohorts and 15,517 discharge observations. Pooled discharge prevalence was 50% (95% CI: 37-62) in acute adult cohorts and 27% (95% CI: 18-38) in older persons cohorts, with substantial heterogeneity and very low certainty of evidence. Admission-to-discharge change was small and non-significant across 11 paired cohorts.ConclusionBenzodiazepine prescribing at psychiatric inpatient discharge was common and highly variable. Marked setting-level variation, lower prevalence in older persons settings, and divergent admission-to-discharge trajectories suggest modifiable systemic influences beyond patient-level factors. Although continuation may support community transition after inpatient stabilisation, its downstream impact remains unclear because post-discharge patient-centred outcomes were not reported. Future research should clarify the risk-benefit profile of continuation to inform transition-specific prescribing guidance.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261474431"},"PeriodicalIF":1.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contribution of rare genetic variation to psychiatric presentations: An overlooked curricular topic in residency training. 罕见遗传变异对精神病学表现的贡献：住院医师培训中一个被忽视的课程主题。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-18 DOI: 10.1177/10398562261479310

Mark Ainsley Colijn

引用次数: 0

Institutional and home living status in schizophrenia: Associations with functioning, childhood trauma, and symptom severity. 精神分裂症患者的机构和家庭生活状况：与功能、童年创伤和症状严重程度的关系

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-11 DOI: 10.1177/10398562261476921

Alper Mert, Selim Çiftçioğlu, Esra Soylu, Zinar Çiftçi, Mehmet Furkan Soylu

{"title":"Institutional and home living status in schizophrenia: Associations with functioning, childhood trauma, and symptom severity.","authors":"Alper Mert, Selim Çiftçioğlu, Esra Soylu, Zinar Çiftçi, Mehmet Furkan Soylu","doi":"10.1177/10398562261476921","DOIUrl":"https://doi.org/10.1177/10398562261476921","url":null,"abstract":"IntroductionResidential status has been associated with clinical and functional outcomes in schizophrenia, yet its interaction with childhood trauma (CT) remains unclear. We examined the associations between residential status, CT, and clinical outcomes in schizophrenia.MethodsIn this cross-sectional study conducted in Türkiye, clinically stable patients with schizophrenia (n = 68) were included, comprising 34 institutionalized and 34 home living. Positive and Negative Syndrome Scale (PANSS), Functioning Assessment Short Test (FAST), Childhood Trauma Questionnaire (CTQ-28), Calgary Depression Scale for Schizophrenia (CDSS), and Beck Scale for Suicidal Ideation (BSSI) were administered. Group comparisons, correlation analyses, and multivariable regression models were conducted.ResultsInstitutionalized patients exhibited poorer functioning and higher PANSS scores (all p < 0.05). Notably, suicide risk was higher in home living patients (p = 0.014), despite similar depressive symptoms across groups. CT severity did not differ by residential status. Regression models revealed that residential status was an independent predictor for both functioning and suicide risk, while CT severity independently predicted overall symptom severity.ConclusionResidential status plays a divergent role in schizophrenia, where home living is linked to higher suicide risk and institutional care to functional decline. CT appears to represent a background risk factor influencing clinical severity.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261476921"},"PeriodicalIF":1.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A co-design in a regional Australian mental health service: Defining a Scope of Practice for peer workers. 澳大利亚区域精神卫生服务的共同设计：确定同行工作者的实践范围。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-11 DOI: 10.1177/10398562261475969

James McLure, Jacqueline M Kirkman, Melinda Watt, Rachel M Tindall

{"title":"A co-design in a regional Australian mental health service: Defining a Scope of Practice for peer workers.","authors":"James McLure, Jacqueline M Kirkman, Melinda Watt, Rachel M Tindall","doi":"10.1177/10398562261475969","DOIUrl":"https://doi.org/10.1177/10398562261475969","url":null,"abstract":"ObjectiveTo describe a Scope of Practice for mental health peer workers including values, practice principles and ethical guidelines. Secondly to identify the functions, activities and responsibilities pertaining to peer workers.MethodsA co-design approach was utilized to inform the design of the Scope of Practice. The team provided differing perspectives and consisted of senior peer workers, lived experience project officers and a service development manager. After reviewing existing literature, key concepts were grouped into themes. These domains were discussed, deliberated, defined and refined in the creation of a Scope of Practice.ResultsThe co-design process resulted in five core values: courage; mutuality; humanity; hope, purpose and growing-self; and wisdom. Six principles of practice: engages in companionship - being with; shares experience intentionally; walks beside during challenging situations; optimism for peers; understands individual worldviews and how this may impact others; and engages in collaborative best-practice, mutual learning and continued development. And five foundational and ethical guidelines were developed: personal/professional boundaries; peer worker/clinical boundaries; gifts; duty of care; and confidentiality and transparency.ConclusionThis Scope of Practice framework provides a structure for widespread understanding and acceptance of the role of peer workers within mental health services in Australia. The framework described aims to elevate peer work as a unique professional discipline.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261475969"},"PeriodicalIF":1.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More TMS is needed in Public Mental Health Services. 公共精神卫生服务需要更多的经颅磁刺激。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-10 DOI: 10.1177/10398562261476928

Madeleine Leung, Truong Hieu Pham, Osama Ali

引用次数: 0

Narcissism re-framed as a superiority motive: unifying evolutionary and clinical perspectives. 自恋被重新定义为一种优越感动机：统一进化和临床观点。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-07 DOI: 10.1177/10398562261477361

Kevin Rourke, John Kasinathan

引用次数: 0

Mood symptoms as mediators of the impulsivity-ADHD link in adolescents. 情绪症状作为青少年冲动- adhd联系的中介。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-06 DOI: 10.1177/10398562261476908

Mustafa Tolga Tunagur, Betül Hakyemezoglu, Aybüke Cirakoglu, Enes Sarigedik, Elif Merve Kurt Tunagur

{"title":"Mood symptoms as mediators of the impulsivity-ADHD link in adolescents.","authors":"Mustafa Tolga Tunagur, Betül Hakyemezoglu, Aybüke Cirakoglu, Enes Sarigedik, Elif Merve Kurt Tunagur","doi":"10.1177/10398562261476908","DOIUrl":"https://doi.org/10.1177/10398562261476908","url":null,"abstract":"BackgroundThe study investigated whether manic/hypomanic symptoms mediate the link between impulsivity dimensions and ADHD severity.MethodsInitially, 175 adolescents aged 12-18 years were recruited; following three exclusions due to incomplete records, the final sample comprised 62 adolescents with ADHD and 110 controls. Participants and parents completed the Barratt Impulsivity Scale-Short Form (BIS), Conners-Wells Adolescent Self-Report Scale-Short Form (CASS-S), Mood Disorder Questionnaire-Parent Form (MDQ), and DSM-IV-Based Disruptive Behavior Disorders Rating Scale-Parent Form. Mediation analyses were estimated via generalized linear modeling (identity link) with bias-corrected bootstrap confidence intervals (5000 resamples) to evaluate parent-reported mood symptoms (MDQ) as a mediator between self-reported BIS dimensions and CASS-S ADHD Index scores.ResultsThe ADHD group scored significantly higher across all impulsivity, mood, and ADHD dimensions than controls (p ≤ .05). Additionally, MDQ scores significantly mediated the relationships between nonplanning, motor, attentional, and total impulsivity scores and ADHD severity across all models (p ≤ .01). Direct paths remained robust, indicating partial mediation.ConclusionsManic/hypomanic symptoms partially mediate the relationship between trait impulsivity and ADHD severity dimensionally. Clinically, screening for subthreshold affective symptoms is clinically vital to limit diagnostic overshadowing and differentiate core neurodevelopmental deficits from emerging bipolar spectrum features.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261476908"},"PeriodicalIF":1.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When clinician-rated measures reflect the assessment: HoNOS, clinical judgement, and organisational risk. 当临床医生评价的措施反映了评估：HoNOS，临床判断和组织风险。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-04 DOI: 10.1177/10398562261476918

Allen Morris-Yates, Tim Coombs, Christine Gee Am

{"title":"When clinician-rated measures reflect the assessment: HoNOS, clinical judgement, and organisational risk.","authors":"Allen Morris-Yates, Tim Coombs, Christine Gee Am","doi":"10.1177/10398562261476918","DOIUrl":"https://doi.org/10.1177/10398562261476918","url":null,"abstract":"ObjectivesTo examine the clinical governance implications of Health of the Nation Outcome Scales (HoNOS) rating quality in Australian mental health services. The paper argues that HoNOS occupies a distinctive position among clinician-rated measures because it requires clinicians to translate the overall clinical assessment into structured ratings across domains of behaviour, symptoms, impairment, and social functioning. It considers why poor-quality HoNOS ratings should not be treated as a narrow technical or training problem, but as a signal of potential risk in assessment practice, documentation quality, organisational reporting, and service credibility.ConclusionsHoNOS rating quality should be understood as a clinical governance responsibility. Because HoNOS data are embedded in routine outcomes and casemix infrastructure, unreliable or invalid ratings can compromise clinical interpretation, service monitoring, benchmarking, system reporting, and funding-related classification processes. Maintaining rating quality therefore requires more than individual clinician training. Health service organisations need structured implementation protocols, supervision, periodic calibration, documentation standards, and routine monitoring of rating patterns. HoNOS should be treated not simply as a clinical instrument, but as a governed clinical data asset whose integrity is necessary for accountable mental health service delivery.","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"10398562261476918"},"PeriodicalIF":1.7,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Fellowship Program Taskforce update. 新的奖学金计划工作组更新。

IF 1.7 4区医学

Australasian Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-07-30 DOI: 10.1177/10398562261463922c

引用次数: 0