Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-10-30DOI: 10.1177/10398562241291335
Antoine Sawares, James Olver, Marco Morcos, Trevor Norman
{"title":"Oxytocin in old age psychiatry: A systematic review of the safety of using intranasal oxytocin in older adults.","authors":"Antoine Sawares, James Olver, Marco Morcos, Trevor Norman","doi":"10.1177/10398562241291335","DOIUrl":"10.1177/10398562241291335","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the literature for evidence of adverse events associated with the use of intranasal oxytocin in older adults (60+).</p><p><strong>Methods: </strong>A systematic review was undertaken according to PRISMA guidelines. Peer-reviewed literature was searched for studies involving intranasal oxytocin use in older populations. The Joanna Briggs Institute's (JBI) critical appraisal tool was used to assess the quality of included studies.</p><p><strong>Results: </strong>The search identified nine randomized controlled trials (RCTs) that investigated the effects of intranasal oxytocin on a total sample size of 331 older participants. Adverse effects associated with oxytocin administration were predominantly mild and varied inconsistently between studies. Compared to placebo intranasal oxytocin was not significantly associated with severe adverse outcomes in doses ranging from 24 to 72 IU after single dose and or repeated doses in the short-term.</p><p><strong>Conclusion: </strong>In a population of older adults, intranasal oxytocin is devoid of serious adverse events. Although this review offers valuable insights, it may not fully reflect the potential adverse events associated with the long-term administration of intranasal oxytocin such as would be expected in its clinical application if approved for the treatment of dementia.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"33-44"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-11-21DOI: 10.1177/10398562241302200
Katie Jones, Carolyn Gillespie, Sarah J Wilson
{"title":"Victorian Collaborative Centre for Mental Health and Wellbeing's response to <i>The corrosion of adult mental healthcare in Australia: Can we meet the needs of those who need the most?</i>","authors":"Katie Jones, Carolyn Gillespie, Sarah J Wilson","doi":"10.1177/10398562241302200","DOIUrl":"10.1177/10398562241302200","url":null,"abstract":"","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"171-173"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-10-14DOI: 10.1177/10398562241292209
John Kasinathan, Annie Parsons
{"title":"Radicalisation in adolescents: mental health considerations for violent extremism.","authors":"John Kasinathan, Annie Parsons","doi":"10.1177/10398562241292209","DOIUrl":"10.1177/10398562241292209","url":null,"abstract":"<p><strong>Objective: </strong>To outline current understanding and recommended mental health and psychiatric considerations for radicalisation and violent extremism among adolescents.</p><p><strong>Method: </strong>Overview of recent research regarding violent extremism in adolescents and relationships with mental illness and other psychosocial determinants. Relevant international and Australasian research is outlined, with an emphasis on adolescents. Psychiatric considerations, intervention and policy implications will be explored.</p><p><strong>Results: </strong>Adolescents who become radicalised form a heterogenous group with complex, multifaceted needs from mental disorder, familial, societal and/or environmental contributions. Thus, assessment and management need to be individualised. Mental health clinicians working with at-risk and radicalised adolescents should maintain a high index of suspicion for mental illness (particularly psychosis and depressive disorder) and neurodevelopmental disorder. Identified psychiatric conditions warrant prioritised mental health treatment. There may be a relationship between specific psychopathology and certain ideological beliefs and behaviours.</p><p><strong>Conclusions: </strong>Radicalised adolescents pose challenges with risk of serious harm to others, presentation complexity, multifactorial contributors and associations with varied psychopathology. All adolescents at risk of radicalisation or who are radicalised, should receive comprehensive mental health assessment and prompt assertive treatment of identified psychiatric conditions.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"57-63"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-08-31DOI: 10.1177/10398562241278959
Melanie Hurley, Angela Komiti, Malcolm Hopwood
{"title":"Describing the burden of disease amongst inpatients with treatment resistant major depressive disorder in Australia.","authors":"Melanie Hurley, Angela Komiti, Malcolm Hopwood","doi":"10.1177/10398562241278959","DOIUrl":"10.1177/10398562241278959","url":null,"abstract":"<p><strong>Objective: </strong>To describe the quality of life and clinical characteristics of treatment-resistant depression (TRD) patients in an Australian patient cohort recruited cross-sectionally during admission.</p><p><strong>Method: </strong>Inpatients admitted for TRD treatment completed a quality of life questionnaire (AQoL-8D) and a depression severity assessment (HAM-D). A chart review and patient interview occurred for demographic and patient characteristics. Comparisons between the mean AQoL-8D scores of the study population and Australian population norms occurred.</p><p><strong>Results: </strong>79 TRD inpatients (70.9% female), mean age of 44.8 ± 14.9 years, were recruited, with 78.5% having an anxiety disorder, 48.1% post-traumatic stress disorder, and 30.4% a personality disorder. Adjunctive to antidepressants, 92.4% were taking antipsychotics and 55.7% were taking mood stabilisers. Approximately 42% of patients received transcranial magnetic stimulation, and 35.4% received electroconvulsive therapy. Mean HAM-D score was 20.3 ± 5.2, and AQoL-8D score (120.1 ± 16.5) was significantly higher than Australian population norms (<i>p</i> < .001) indicating reduced quality of life.</p><p><strong>Conclusions: </strong>Personal and clinical characteristics of patients hospitalised for TRD were similar to TRD globally with impaired quality of life relative to the general Australian population. TRD patients on average presented with moderate/severe depression, highlighting the need for greater support for these individuals.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"128-133"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Thought Broadcast: The importance of psychiatric journal clubs.","authors":"","doi":"10.1177/10398562241282377a","DOIUrl":"https://doi.org/10.1177/10398562241282377a","url":null,"abstract":"","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":"33 1","pages":"17"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Naturalistic outcomes of patients discharged from a community treatment order: QA project.","authors":"Manpreet Kaur Dhawan, Ramanathan Ganapathy, Anoop Sankaranarayanan, Ricardo Maldonado","doi":"10.1177/10398562241286669","DOIUrl":"10.1177/10398562241286669","url":null,"abstract":"<p><strong>Objective: </strong>To study outcomes for patients after they are discharged from Community treatment orders (CTO) including rate of relapse, median time to relapse and to identify the risk factors associated with relapse.</p><p><strong>Method: </strong>The study population included patients discharged from CTO from July 2017 to December 2021, managed by a major metropolitan* case management team (CMT). The data were collected from electronic medical records (EMR). Descriptive analysis was conducted to study the sample characteristics. Logistic regression using univariate and multivariate analysis was performed to examine the associations between factors related to relapse.</p><p><strong>Results: </strong>A total of 128 patients were studied. The relapse rate was 27.4% with median time to relapse of 72 days. Poor insight, poor treatment compliance, duration of CTO and number of CMT contacts were significantly associated with relapse while substance use, psychiatric comorbidities and psychosocial factors were not.</p><p><strong>Conclusions: </strong>The findings suggest that people who relapsed had poor insight and poor medication adherence, had CTO for a longer period and had frequent contact from CMT even after discharge from CTO.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"140-143"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-09-06DOI: 10.1177/10398562241282377
Jeffrey Cl Looi, Stephen Allison, Tarun Bastiampillai, Steve Kisely, Paul A Maguire, Luke S-C Woon, Katrina Anderson, Gin S Malhi
{"title":"Deprescribing antidepressants for depression - what is the evidence for and against?","authors":"Jeffrey Cl Looi, Stephen Allison, Tarun Bastiampillai, Steve Kisely, Paul A Maguire, Luke S-C Woon, Katrina Anderson, Gin S Malhi","doi":"10.1177/10398562241282377","DOIUrl":"10.1177/10398562241282377","url":null,"abstract":"<p><strong>Objective: </strong>Recent guidelines suggest that the overall quantity and duration of antidepressant prescriptions should be reduced. In this paper, we comment on the evidence both for and against this view.</p><p><strong>Methods: </strong>We critically review the arguments proposed by proponents of antidepressant deprescribing in the context of the evidence-base for the treatment of depression.</p><p><strong>Results: </strong>Proponents of deprescribing do not address the substantive issues of whether inappropriate prescribing has been demonstrated, and when prescribing is needed. Their arguments for deprescribing are rebutted in this context.</p><p><strong>Conclusions: </strong>Whether or not to deprescribe antidepressant medication needs to take into consideration the risk-benefit profile of the decision, the responsibility for which needs to be shared and based on the context of the patient's depression, their preferences, experiences and perspectives.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"12-17"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Australasian PsychiatryPub Date : 2025-02-01Epub Date: 2024-08-31DOI: 10.1177/10398562241276335
Alison Clayton, Andrew James Amos, Jillian Spencer, Patrick Clarke
{"title":"Implications of the Cass Review for health policy governing gender medicine for Australian minors.","authors":"Alison Clayton, Andrew James Amos, Jillian Spencer, Patrick Clarke","doi":"10.1177/10398562241276335","DOIUrl":"10.1177/10398562241276335","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the key recommendations of England's independent inquiry into gender identity services for children and young people (the Cass Review) and to evaluate their relevance to Australian health policy.</p><p><strong>Conclusions: </strong>The Cass Review's findings and recommendations have clear applicability to Australian health policy. As a matter of priority, Australian health authorities need to seriously engage with the Cass Review's findings and recommendations. To not do so will put the health and well-being of vulnerable children and young people at risk.</p>","PeriodicalId":8630,"journal":{"name":"Australasian Psychiatry","volume":" ","pages":"89-95"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}