Atherosclerosis最新文献

{"title":"Dietary vitamin K intakes and atherosclerotic cardiovascular disease incidence: Findings from the UK biobank","authors":"Montana Dupuy,&nbsp;Chengfeng Li,&nbsp;Pratik Pokharel,&nbsp;Liezhou Zhong,&nbsp;Benjamin H. Parmenter,&nbsp;Simone Radavelli-Bagatini,&nbsp;Jack Dalla Via,&nbsp;Allan Linneberg,&nbsp;Jette Jakobsen,&nbsp;Tilman Kühn,&nbsp;Aedín Cassidy,&nbsp;Jonathan M. Hodgson,&nbsp;Joshua R. Lewis,&nbsp;Marc Sim,&nbsp;Nicola P. Bondonno","doi":"10.1016/j.atherosclerosis.2026.120837","DOIUrl":"10.1016/j.atherosclerosis.2026.120837","url":null,"abstract":"<div><h3>Background and aims</h3><div>Vitamin K is essential for processes that inhibit vascular and valvular calcification, attributes of atherosclerotic cardiovascular diseases (ASCVDs) and aortic stenosis (AS). Relationships between dietary vitamin K1 and K2 intakes, ASCVD and AS were explored.</div></div><div><h3>Methods</h3><div>In 112,111 participants from the UK Biobank without ASCVD or AS (median age 59.7 years, 57.3% female), dietary vitamin K1 (μg/day) and K2 (μgPKeq/day) intakes were calculated from Oxford WebQ 24-h dietary questionnaires, using vitamin K food composition databases. Associations with incident ASCVD, ASCVD subtypes and AS, obtained from self-reports, primary care data, hospital records and death registries, were examined using restricted cubic splines within multivariable-adjusted Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Over a median follow-up of 10.5 years, 8696 ASCVD cases were recorded. Non-linear associations between vitamin K1 intakes and ASCVD were observed within multivariable-adjusted models (p_{non-linearity}≤0.01). Higher vitamin K1 intakes were associated with a 7-10% lower risk of ASCVD, with no advantage observed beyond moderate intakes (HR_Q3vsQ1 0.90 [0.85-0.95]). Lower risk relationships were also found for ischemic heart disease (IHD), ischemic stroke and peripheral arterial disease but not AS. The highest vitamin K2 intakes were associated with a greater risk of incident ASCVD (HR_Q5vsQ1 1.07 [1.01-1.14]), IHD and AS.</div></div><div><h3>Conclusions</h3><div>Among adults without prevalent ASCVD, those with higher dietary vitamin K1, but not K2, intakes had lower ASCVD risk. Positive associations with vitamin K2 may reflect food source confounding warranting further investigation. These findings reinforce the promotion of vitamin K1-rich vegetable consumption (e.g. spinach and broccoli) to support cardiovascular health.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120837"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE LONG-TERM EFFICACY AND SAFETY OF LERODALCIBEP IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLAEMIA","authors":"Frederick Raal,&nbsp;Meral Kayikcioglu,&nbsp;Dirk Blom,&nbsp;Jeffrey Vest,&nbsp;Miriam Anderson,&nbsp;David Kallend,&nbsp;Evan Stein","doi":"10.1016/j.atherosclerosis.2026.120852","DOIUrl":"10.1016/j.atherosclerosis.2026.120852","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120852"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148924400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEMAGLUTIDE AND EXERCISE SYNERGY IN OBESITY: PRESERVING MUSCLE MASS AND UNCOVERING ORGAN CROSSTALK","authors":"Jose Inia,&nbsp;Simone Droog,&nbsp;Jessica Snabel,&nbsp;Aswin Menke,&nbsp;Martien Caspers,&nbsp;Jelle De Jong,&nbsp;J. Wouter Jukema,&nbsp;Hans Princen,&nbsp;Anita Van Den Hoek","doi":"10.1016/j.atherosclerosis.2026.120902","DOIUrl":"10.1016/j.atherosclerosis.2026.120902","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120902"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF IL-13 ON EXPRESSION OF ENDOGLIN AND ADHESION MOLECULES IN AORTIC ENDOTHELIAL CELLS","authors":"Adéla Diepoltová,&nbsp;Katarina Tripska,&nbsp;Martina Vašinová,&nbsp;Petra Fikrova,&nbsp;Petr Nachtigal","doi":"10.1016/j.atherosclerosis.2026.120932","DOIUrl":"10.1016/j.atherosclerosis.2026.120932","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120932"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CASE OF ATORVASTATIN-ASSOCIATED NECROTIZING AUTOIMMUNE MYOPATHY","authors":"Chrysoula Boutari,&nbsp;Maria Boutel,&nbsp;Magdalini Kolaza,&nbsp;Christos Leonida,&nbsp;Theodoros Dimitroulas,&nbsp;Ioannis Goulis","doi":"10.1016/j.atherosclerosis.2026.120854","DOIUrl":"10.1016/j.atherosclerosis.2026.120854","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120854"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOLUBLE TREM2 IS AN LXR-DEPENDENT SECRETED PROTEIN THAT PROTECTS AGAINST ATHEROSCLEROSIS","authors":"Sarah Shawky,&nbsp;Adil Rasheed,&nbsp;Michael Saikali,&nbsp;Dide Yurtal,&nbsp;Yangyushuang Xu,&nbsp;Andria Henry,&nbsp;Alexia Chiodo,&nbsp;Warren Lee,&nbsp;Carolyn Cummins","doi":"10.1016/j.atherosclerosis.2026.120871","DOIUrl":"10.1016/j.atherosclerosis.2026.120871","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120871"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORE CHOLESTEROL THAN APOB: A STRIKING TOTAL CHOLESTEROL–TO–APOB RATIO REVEALS LIPOPROTEIN X–MEDIATED HYPERCHOLESTEROLEMIA IN CHOLESTATIC LIVER DISEASE","authors":"Nicolas Francisco Goldfarb,&nbsp;Augusto Lavalle Cobo","doi":"10.1016/j.atherosclerosis.2026.120873","DOIUrl":"10.1016/j.atherosclerosis.2026.120873","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120873"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COLCHICINE REVERSES INFLAMMATORY SIGNATURES IN CHIP-POSITIVE CORONARY DISEASE: THE COLCHIP TRIAL","authors":"Moritz Von Scheidt,&nbsp;Marius Schwab,&nbsp;Johannes Krefting,&nbsp;Fabian Starnecker,&nbsp;Judith Hecker,&nbsp;Christian Graesser,&nbsp;Stephan Baumann,&nbsp;Lena Piermeier,&nbsp;Victoria Sander,&nbsp;Florian Bassermann,&nbsp;Irina Pugach,&nbsp;Christian Friess,&nbsp;Gregor Hoermann,&nbsp;Manja Meggendorfer,&nbsp;Stefan Holdenrieder,&nbsp;Michaela Sander,&nbsp;J. Heimlich,&nbsp;Gerard Pasterkamp,&nbsp;Michal Mokry,&nbsp;Zhifen Chen,&nbsp;Wolfgang Koenig","doi":"10.1016/j.atherosclerosis.2026.120876","DOIUrl":"10.1016/j.atherosclerosis.2026.120876","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120876"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVING CARE FOR HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLAEMIA (HOFH): KEY INSIGHTS AND FUTURE DIRECTIONS FROM THE GLOBAL HICC REGISTRY","authors":"Willemijn Schonck,&nbsp;Janneke Mulder,&nbsp;Marina Cuchel,&nbsp;Laurens F. Reeskamp,&nbsp;Fahad Alnouri,&nbsp;Iulia Iatan,&nbsp;Tomas Freiberger,&nbsp;Meral Kayikcioglu,&nbsp;Tycho Tromp,&nbsp;Doortje Reijman,&nbsp;Albert Wiegman,&nbsp;G. Hovingh,&nbsp;Jeanine Roeters Van Lennep,&nbsp;Frederick Raal,&nbsp;Dirk Blom,&nbsp;Alberico Catapano","doi":"10.1016/j.atherosclerosis.2026.120923","DOIUrl":"10.1016/j.atherosclerosis.2026.120923","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120923"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148916677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREMATURE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE DURING A LOW AND VERY-LOW CARBOHYDRATE HIGH-FAT DIET: A CASE SERIES","authors":"Iulia Iatan,&nbsp;Navid Saleh,&nbsp;Nicol Vaizman,&nbsp;Shubhika Ranjan,&nbsp;Lubomira Cermakova,&nbsp;Liam Brunham","doi":"10.1016/j.atherosclerosis.2026.120842","DOIUrl":"10.1016/j.atherosclerosis.2026.120842","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"419 ","pages":"Article 120842"},"PeriodicalIF":7.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148924398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}