Atherosclerosis最新文献

{"title":"Global deletion of the LXR-regulated gene EEPD1 reveals macrophage-specific changes in lipid metabolism and cholesterol efflux","authors":"Suzanne A.E. van Wouw ,&nbsp;Melanie Loix ,&nbsp;Roelof Ottenhoff ,&nbsp;Jenina Kingma ,&nbsp;Aldo Jongejan ,&nbsp;Jeroen Bogie ,&nbsp;Menno Hoekstra ,&nbsp;Noam Zelcer","doi":"10.1016/j.atherosclerosis.2025.119163","DOIUrl":"10.1016/j.atherosclerosis.2025.119163","url":null,"abstract":"<div><h3>Background and aims</h3><div>We recently reported that Endonuclease/Exonuclease/Phosphatase family Domain containing 1 (EEPD1) is a transcriptional target of the sterol-responsive nuclear Liver X Receptors (LXR) in macrophages. The aim of this study is to clarify the <em>in vivo</em> role of EEPD1 in whole-body and macrophage lipid handling, and in the development of atherosclerosis.</div></div><div><h3>Methods</h3><div>We developed mice with global deletion of <em>Eepd1</em> and challenged them with a high-fat- and a Western-type diet. Bone marrow-derived macrophages (BMDM) were used for profiling transcriptomic and lipidomic changes, and evaluating cholesterol efflux in the absence of <em>Eepd1</em>. We transplanted bone marrow from wildtype and <em>Eepd1</em>^<em>KO</em> mice into <em>Ldlr</em>^<em>KO</em> recipients to assess the role of myeloid-specific EEPD1 in atherogenesis.</div></div><div><h3>Results</h3><div><em>Eepd1</em>^<em>KO</em> mice were indistinguishable from wildtype controls when fed a low-fat diet. However, when challenged with a high-fat diet or a cholesterol-containing western diet, <em>Eepd1</em>^<em>KO</em> displayed enhanced weight gain, with no evident changes in plasma and hepatic lipid levels observed. Consistent with our earlier report, BMDM isolated from <em>Eepd1</em>^<em>KO</em> mice had attenuated LXR-stimulated cholesterol efflux to high density lipoprotein and Apolipoprotein A1 when compared to wildtype cells. The transcriptomic and lipidomic landscape of these cells revealed a small reduction in expression of cholesterol biosynthetic genes in LXR-stimulated <em>Eepd1</em>^<em>KO</em> cells, and prominent changes in diacylglycerol and hexosylceramides level and species. Changes were also observed in triglyceride and cholesterol-ester species. Myeloid-specific loss of <em>Eepd1</em> did not alter atherosclerotic plaque size and collagen content in bone marrow-transplanted <em>Ldlr</em>^<em>KO</em> recipients.</div></div><div><h3>Conclusions</h3><div>Loss of <em>Eepd1</em> results in an altered lipidomic landscape and reduced LXR-stimulated cholesterol efflux in BMDM, but myeloid-specific loss of <em>Eepd1</em> does not influence atherogenesis in mice.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"403 ","pages":"Article 119163"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver and atherosclerotic risk of alcohol consumption in patients with metabolic dysfunction-associated Steatotic Liver Disease","authors":"Shao-Wen Wang ,&nbsp;Ching Wang ,&nbsp;Yu-Ming Cheng ,&nbsp;Tsung-Han Hsieh ,&nbsp;Chia-Chi Wang ,&nbsp;Jia-Horng Kao","doi":"10.1016/j.atherosclerosis.2025.119161","DOIUrl":"10.1016/j.atherosclerosis.2025.119161","url":null,"abstract":"<div><h3>Background/purpose</h3><div>A new disease name, \"Steatotic Liver Disease (SLD)\" was proposed in 2023. Within this algorithm, combined metabolic and alcoholic liver disease (MetALD) was named as a new specific subgroup. The clinical profiles and outcomes of MetALD patients are unknown.</div></div><div><h3>Methods</h3><div>Participants from Taiwan Biobank database after exclusion those with positive for HBsAg, anti-HCV, and former drinkers were selected. MASLD was diagnosed if having hepatic steatosis on ultrasound plus at least one of cardiometabolic criteria. Increased or moderate alcohol intake was defined as continuous drinkers with alcohol consumption exceeding 210 g for men and 140 g for women weekly or below the levels, respectively. The fibrosis 4 (FIB-4) score was used to assess the severity of liver fibrosis, and carotid plaques on duplex ultrasound were employed to diagnose atherosclerosis.</div></div><div><h3>Results</h3><div>In a total of 18,160 (mean age 55.28 ± 10.41; 33.2 % males) participants, there were 7316 (40.3 %) MASLD patients and 209 (1.2 %) MetALD patients. The participants with MetALD were younger and male predominant. After propensity score matching for age and gender, MetALD patients had higher AST, GGT, fatty liver index (FLI), and FIB-4 score and tended to have a higher proportion of carotid plaques than MASLD patients. Among MASLD patients, those with moderate alcohol intake had higher values of GGT, FLI, and FIB-4 score and a higher proportion of carotid plaques than those with no or social alcohol intake.</div></div><div><h3>Conclusions</h3><div>MetALD patients have a higher risk of liver injury than those with MASLD. Moreover, moderatet alcohol intake also increases the risk of liver injury and atherosclerotic in MASLD patients, suggesting MASLD patients should refrain from alcohol intake.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"403 ","pages":"Article 119161"},"PeriodicalIF":4.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericoronary adipose tissue attenuation on coronary computed tomography angiography: Possibilities and challenges","authors":"Alexander C. Razavi ,&nbsp;Seamus P. Whelton ,&nbsp;Mouaz H. Al-Mallah","doi":"10.1016/j.atherosclerosis.2025.119105","DOIUrl":"10.1016/j.atherosclerosis.2025.119105","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"402 ","pages":"Article 119105"},"PeriodicalIF":4.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental prognostic value of pericoronary adipose tissue attenuation beyond conventional features in patients with nonobstructive coronary artery disease","authors":"Nan Zheng ,&nbsp;Zinuan Liu ,&nbsp;Yipu Ding ,&nbsp;Xi Wang ,&nbsp;Jing Li ,&nbsp;Guanhua Dou ,&nbsp;Ran Xin ,&nbsp;Ziqiang Guo ,&nbsp;Guanxi Chen ,&nbsp;Jing Jing ,&nbsp;Bai He ,&nbsp;Dongkai Shan ,&nbsp;Junjie Yang","doi":"10.1016/j.atherosclerosis.2024.119075","DOIUrl":"10.1016/j.atherosclerosis.2024.119075","url":null,"abstract":"<div><h3>Background and aims</h3><div>It remains uncertain whether pericoronary adipose tissue attenuation (PCATa) is associated with clinical outcome in patients with nonobstructive coronary artery disease (CAD). We aim to investigate the incremental prognostic value of PCATa beyond clinical and coronary computed tomographic angiography (CCTA) features in patients with nonobstructive CAD.</div></div><div><h3>Methods</h3><div>Consecutive patients with chest pain suspected of CAD referred for CCTA from January 2017 to December 2018 were prospectively included. Multivariable Cox proportional hazard regression analysis was employed to identify the predictive factors for major adverse cardiovascular events (MACE), while the receiver operating characteristics (ROC) curve was utilized to assess the discriminatory capacity of PCATa. Kaplan-Meier curves were ultilized to visually represent event-free survival and were compared using Log-rank tests among groups stratified by high-risk plaque (HRP) and PCATa.</div></div><div><h3>Results</h3><div>Of the 1614 patients (mean age 59.0 years, 55.6 % male) with nonobstructive CAD, 68 (4.2 %) suffered MACE during a median follow-up of 28.6 months. After multivariable adjustment, PCATa was identified as an independent predictor (HR: 1.060, 95%CI: 1.025–1.096, <em>p</em> = 0.001). The inclusion of PCATa significantly enhanced the discrimination capacity [AUC:0.72 (0.66–0.78), <em>p</em> = 0.041] and risk reclassification (NRI = 1.99, <em>p</em> &lt; 0.001; IDI = 0.93, <em>p</em> &lt; 0.001) beyond the influence of clinical and CCTA factors. In the presence of HRP, a higher PCATa was found to be associated with a relatively higher risk of MACE compared to a lower PCATa (HR: 2.45, 95%CI: 1.09–5.52, <em>p</em> = 0.031).</div></div><div><h3>Conclusions</h3><div>PCATa is positively correlated with adverse outcome in patients with nonobstructive CAD, and it offers incremental predictive value beyond clinical variables and CCTA characteristics.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"402 ","pages":"Article 119075"},"PeriodicalIF":4.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis: A novel paradigm in the pathophysiology of MINOCA","authors":"Uğur Özkan ,&nbsp;Meral Kayıkçıoğlu ,&nbsp;Servet Altay","doi":"10.1016/j.atherosclerosis.2024.119097","DOIUrl":"10.1016/j.atherosclerosis.2024.119097","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"402 ","pages":"Article 119097"},"PeriodicalIF":4.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial infarction in second-generation immigrants compared to native-born Swedes in the total population of Sweden","authors":"Per Wändell ,&nbsp;Xinjun Li ,&nbsp;Axel C. Carlsson ,&nbsp;Jan Sundquist ,&nbsp;Kristina Sundquist","doi":"10.1016/j.atherosclerosis.2024.119102","DOIUrl":"10.1016/j.atherosclerosis.2024.119102","url":null,"abstract":"<div><h3>Background and aims</h3><div>Environmental and genetic factors predispose to cardiovascular disease. Some first-generation immigrants have a higher cardiovascular risk in Sweden, while less is known about second-generation immigrants. We aimed to analyze the risk of acute myocardial infarction (AMI) among second-generation immigrants in Sweden.</div></div><div><h3>Methods</h3><div>We included all individuals 18 years of age and older in Sweden, n = 4,580,967. AMI was defined as at least one registered diagnosis in the National Patient Register between January 1, 1998, and December 31, 2018. Cox regression analysis was used to estimate the relative risk (hazard ratio = HR) with 99 % confidence interval (CI) of incident AMI with adjustments made for age, sociodemographics, and comorbidities, and also subdivided into two age groups, i.e., 18–54 years and ≥55 years.</div></div><div><h3>Results</h3><div>A total of 158,815 AMI events were registered. Fully adjusted models showed HRs (99 % CI) in second-generation immigrants for men 1.05 (1.01–1.08), and for women 0.99 (0.94–1.05). A marginally higher MI risk was found only among men with parents from the Nordic countries in the fully adjusted model, HR 1.05 (1.01–1.10), and a lower risk only among women with parents from Asian countries, HR 0.47 (0.30–0.75). No significant overall differences in AMI risk were seen in older and younger second-generation immigrants.</div></div><div><h3>Conclusions</h3><div>The overall risk of AMI was similar for most groups of men and women with foreign-born parents compared to native-born Swedes. Our findings suggest that environmental factors may be more important than genetic factors, but further studies are needed to quantify these risks concerning AMI.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"402 ","pages":"Article 119102"},"PeriodicalIF":4.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fgf23 expression increases atherosclerotic plaque burden in male ApoE deficient mice","authors":"Karolina Lindberg ,&nbsp;Olga Ovchinnikova ,&nbsp;Matthias B. Moor ,&nbsp;John Pirault ,&nbsp;Daniel FJ. Ketelhuth ,&nbsp;Hannes Olauson ,&nbsp;Göran K. Hansson ,&nbsp;Tobias E. Larsson","doi":"10.1016/j.atherosclerosis.2025.119158","DOIUrl":"10.1016/j.atherosclerosis.2025.119158","url":null,"abstract":"<div><h3>Introduction</h3><div>Components of both the innate and adaptive immune system impact on arterial walls in atherosclerosis. Fibroblast growth factor-23 (FGF23) is a phosphate regulating hormone linked to cardiovascular disease (CVD) in patients with and without chronic renal disease. However, it remains controversial whether FGF23 is merely a biomarker or contributes to CVD. Here, we overexpressed <em>Fgf23</em> in <em>ApoE</em>^{<em>−/−</em>}mice to delineate the role of FGF23 in atherogenesis.</div></div><div><h3>Methods and results</h3><div>10-week old <em>ApoE</em>^{<em>−/−</em>} mice received a hydrodynamic tail vein with a plasmid encoding for <em>Fgf23</em>, and were sacrificed 10 weeks later. FGF23 concentrations increased more than 400-fold in the <em>Fgf23</em> treated group, remaining high throughout the experiment. Mice in the Fgf23 group developed hypophosphatemia, secondary hyperparathyroidism and a moderate increase in plasma creatinine concentrations. Male <em>ApoE</em>^{<em>−/−</em>} mice exposed to high Fgf23 developed larger atherosclerotic lesions compared to controls, in two different locations of aorta, whereas no differences in plaque burden were seen between female <em>ApoE</em>^{<em>−/−</em>} mice and controls. Serum IL-6 concentrations were increased in the Fgf23 group, associated with a vascular inflammatory response of recruited macrophages and neutrophils, and with a shift of CD4⁺ T effector cells from Th1 to Th17 and migration of lymphocytes to the spleen.</div></div><div><h3>Conclusion</h3><div><em>Fgf23</em> overexpression increases the atherosclerotic burden in male <em>ApoE</em>^{<em>−/−</em>} mice and alters both the innate immune system and T cell subpopulations, generating an inflammatory environment that may promote adverse clinical outcomes associated with FGF23 excess.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"403 ","pages":"Article 119158"},"PeriodicalIF":4.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear associations of serum lipid levels with cognitive decline: Findings from the ELSA-Brasil cohort","authors":"Naomi Vidal Ferreira ,&nbsp;Marcio Sommer Bittencourt ,&nbsp;Giuliano Generoso ,&nbsp;Natalia Gomes-Gonçalves ,&nbsp;Sandhi Maria Barreto ,&nbsp;Luana Giatti ,&nbsp;Raul D. Santos ,&nbsp;Paulo A. Lotufo ,&nbsp;Isabela Martins Bensenor ,&nbsp;Claudia Kimie Suemoto","doi":"10.1016/j.atherosclerosis.2025.119159","DOIUrl":"10.1016/j.atherosclerosis.2025.119159","url":null,"abstract":"<div><h3>Background and aims</h3><div>Elevated low-density lipoprotein-cholesterol (LDL-C) is a modifiable risk factor for dementia, but evidence on other lipids is inconsistent, particularly in studies from low and middle-income countries. This study aimed to assess the association between lipid levels and cognitive decline in the ELSA-Brasil cohort.</div></div><div><h3>Methods</h3><div>In this prospective study, baseline serum lipid profile [total cholesterol (TC), LDL-C, high-density lipoprotein-cholesterol (HDL-C), triglycerides, and non-high-density lipoprotein-cholesterol (Non-HDL-C)] was analyzed. Cognition was assessed in three waves four years apart using the CERAD Word List, the semantic and phonemic verbal fluency, Trail Making Test B (TMT-B), and a global score.</div></div><div><h3>Results</h3><div>ln 12,870 individuals at baseline, the mean (SD) age was 51.4 (8.9) years old, 55.4 % were women, and 53.4 % White. Over eight years of follow-up, inverted U-shape associations of TC with memory [Effective Degrees of Freedom (EDF) = 2.975; P = 0.006] and global cognitive decline (EDF = 2.957; P = 0.014), LDL-C with memory (EDF = 2.976; P = 0.021), verbal fluency (EDF = 2.973; P = 0.041), and global cognitive decline (EDF = 2.962; P = 0.030), and Non-HDL-C with memory (EDF = 2.975; P = 0.012) and global cognitive decline (EDF = 2.963; P = 0.035) were observed. A cubic-shaped association with TMT-B (EDF = 2.981; P = 0.005) was observed for HDL-C. Inverted U-shape associations of TC (EDF = 2.946; P &lt; 0.001), LDL-C (EDF = 2.956; P = 0.007), and Non-HDL-C (EDF = 2.951; P = 0.006) in participants aged less than 60 years and inverted U-shape associations of TC (EDF = 2.882; P = 0.044) in women were observed for global cognitive decline.</div></div><div><h3>Conclusions</h3><div>Non-linear associations of baseline serum lipids with a decline in different cognitive domains over eight years of follow-up were observed, particularly in individuals younger than 60 years and in women.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"403 ","pages":"Article 119159"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma polyamines levels and post-stroke depression in ischemic stroke patients: A multicenter prospective study","authors":"Yu He ,&nbsp;Xinyue Chang ,&nbsp;Yi Liu ,&nbsp;Jiawen Fei ,&nbsp;Xiaoli Qin ,&nbsp;Beiping Song ,&nbsp;Quan Yu ,&nbsp;Pinni Yang ,&nbsp;Mengyao Shi ,&nbsp;Daoxia Guo ,&nbsp;Yanbo Peng ,&nbsp;Jing Chen ,&nbsp;Aili Wang ,&nbsp;Tan Xu ,&nbsp;Jiang He ,&nbsp;Yonghong Zhang ,&nbsp;Zhengbao Zhu","doi":"10.1016/j.atherosclerosis.2025.119150","DOIUrl":"10.1016/j.atherosclerosis.2025.119150","url":null,"abstract":"<div><h3>Background and aims</h3><div>Polyamines have been suggested to implicated in inflammation, ischemic stroke, and mental disorders, but the associations of polyamines with post-stroke depression (PSD) remain unclear. We aimed to prospectively investigate the associations of plasma putrescine, spermidine and spermine with PSD among ischemic stroke patients in a multicenter cohort study.</div></div><div><h3>Methods</h3><div>We measured plasma putrescine, spermidine and spermine levels at baseline among 635 ischemic stroke patients from a preplanned ancillary study of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3-month follow-up after ischemic stroke.</div></div><div><h3>Results</h3><div>Plasma putrescine and spermidine were positively associated with the risk of PSD. The adjusted odds ratios of PSD for the highest versus lowest tertile of putrescine and spermidine were 1.77 (95 % CI, 1.13–2.78; <em>p</em>_trend = 0.014) and 1.77 (95 % CI, 1.11–2.82; <em>p</em>_trend = 0.013), respectively. Multivariable-adjusted spline regression analyses showed linear associations of plasma putrescine (<em>p</em> = 0.002 for linearity) and spermidine (<em>p</em> = 0.008 for linearity) with PSD. In addition, plasma putrescine (continuous net reclassification improvement [NRI]: 26.33 %, <em>p</em> = 0.002; integrated discrimination improvement [IDI]: 1.06 %, <em>p</em> = 0.009) and spermidine (continuous NRI: 20.72 %, <em>p</em> = 0.013; IDI: 1.04 %, <em>p</em> = 0.010) could significantly improve the risk reclassification of PSD beyond the established risk factors.</div></div><div><h3>Conclusions</h3><div>High plasma putrescine and spermidine levels were associated with increased risk of PSD among ischemic stroke patients. Our findings suggest that plasma polyamines should be implicated in the pathophysiologic processes of PSD and may be the potential intervention targets for PSD.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"403 ","pages":"Article 119150"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden and national health inequity of ischemic heart disease attributed to kidney dysfunction from 1990 to 2021: Findings from the global burden of disease study 2021.","authors":"Yue Zhang, Jinyi Wu, Na Wang, Junjie Zhu, Ping Zhang, Xin Wang, Yingying Zhang, Nawi Ng, Lijian Lei","doi":"10.1016/j.atherosclerosis.2025.119140","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2025.119140","url":null,"abstract":"<p><strong>Background and aims: </strong>To estimate the global disease burden and cross-national inequalities in the distribution of ischemic heart disease attributable to kidney dysfunction (KI-IHD) from 1990 to 2021.</p><p><strong>Methods: </strong>The estimates for age-standardized death rates (ASDR) and age-standardized disability-adjusted life-years rates (ASDAR) of KI-IHD were obtained from the Global Burden of Disease Study (GBD) 2021. Data for gross domestic product (GDP) and GDP growth rates were extracted from World Bank database. The average annual percent change (AAPC) was calculated to analyze temporal trends of ASDR and ASDAR by Joinpoint regression model. Slope index of inequality and concentration index were generated to quantify the cross-national socioeconomic inequality of KI-IHD burden.</p><p><strong>Results: </strong>From 1990 to 2021, the ASDR and ASDAR of KI-IHD has shown downward trend globally; with AAPC values of -1.384 % and -1.204 %. The ASDR and ASDAR of KI-IHD was higher in males than females, with increasing age, the burden gradually increased. The concentration index showed 0.02 (95%CI: 0.02, 0.06) in 1990 and -0.11 (95%CI: 0.15, -0.07) in 2021. The slope index of inequality showed that an excess of 170 ASDR per 100,000 existed between countries with the lowest and the highest SDI in 1990, however, in 2021, the results are reversed, a reduction of 159 per 100,000. GDP growth rate and GDP per capita might be associated with the health inequality of KI-IHD.</p><p><strong>Conclusion: </strong>The burden of KI-IHD has decreased in almost 70 % of countries over the past three decades. Disproportional distribution of health inequalities was concentrated in poor countries.</p>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"119140"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}