Asia‐Pacific Psychiatry最新文献

{"title":"Cotard delusion in a depressed patient: “My throat is missing!”","authors":"Wen Yi Huan MBBS,&nbsp;Wan Asyikin Wan Azlan MB BCh BAO, Dr. Psych,&nbsp;Yee Tieng Lee MBBS, MMed (Psych)","doi":"10.1111/appy.12524","DOIUrl":"10.1111/appy.12524","url":null,"abstract":"<p>Cotard's syndrome is a rare neuropsychiatric disorder characterized by marked nihilistic delusions. This report describes an Indonesian woman from a small town in Malaysia who was diagnosed with depression and Cotard's delusion. The diagnosis was confirmed after thorough history-taking, clinical examination, and relevant laboratory tests. Herein, we highlight the unique psychopathology of a possible Cotard's syndrome subtype and efficacy of pharmacological combination strategies, rather than monotherapy and electroconvulsive therapy, for its treatment.</p>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"15 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Family Integrated Care on maternal stress in preterm infants in the Neonatal Intensive Care Unit: A bi-center experience","authors":"Yuan Zhang MD,&nbsp;Min Jiang MD,&nbsp;Xiying Xiang MD,&nbsp;Wenwen He MD,&nbsp;Juan Du MD,&nbsp;Mingyan Hei MD, PhD","doi":"10.1111/appy.12521","DOIUrl":"10.1111/appy.12521","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the effect of family integrated care (FICare) on maternal stress in preterm infants with traditional non-parent neonatal intensive care unit (NICU) care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We continuously enrolled mothers and their preterm infants from two NICUs between August 2014 and April 2017; while one NICU applied the FICare model (FICare group) and the other performed standard non-parent care model (control group). Maternal stress was evaluated by the Parental Stress Scale: NICU (PSS: NICU) on admission and right before the discharge. A generalized linear model to adjust for potential confounders. Subgroup analysis was also performed for comparisons between two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 215 mothers with preterm infants were included in this study, among whom 118 (54.88%) were in FICare group and 97 (45.12%) were in control group. The mean PSS: NICU score was 117.36 ± 26.27 on admission with no difference between two groups. Before being discharged home, the PSS: NICU score of parents in both groups was significantly reduced, with the score of FICare group was significantly lower than that of control group. In all sub-domains of PSS: NICU score as sights and sounds, baby looks and behavior score, and parental role, the scores of FICare group were significantly lower than control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was a simultaneous decrease of maternal stress for NICU preterm infants. FICare further facilitates reducing the maternal stress. It shall be encouraged to apply FICare model in NICUs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"15 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10658063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The silent epidemic: Death by suicide among physicians","authors":"Gayatri Bhatia MD, DM,&nbsp;Pawan Sharma MD,&nbsp;Arghya Pal MD,&nbsp;Arpit Parmar MD, DM","doi":"10.1111/appy.12522","DOIUrl":"10.1111/appy.12522","url":null,"abstract":"<p>Suicidal deaths among physicians have been on a steady rise in the past few decades, despite being a part of the healthcare system, training for early identification and easy access to treatment services. While there is no doubt that this warrants concern at individual, institutional, and community levels, physician suicide remains an under-researched topic. We examine the correlates of suicidal deaths among physicians along with risks and protective factors conferred to physicians as a population and emphasize the need for preventive and risk-reduction initiatives that are specifically tailored for physicians and the healthcare provider community.</p>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"15 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9219795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low mental health literacy and its association with depression, anxiety and poor sleep quality in Chinese elderly","authors":"Kai-Rong Ding MSc,&nbsp;Shi-Bin Wang PhD,&nbsp;Wen-Qi Xu MSc,&nbsp;Li-Hua Lin MSc,&nbsp;Dan-Dan Liao MSc,&nbsp;Hong-Bei Chen MSc,&nbsp;Wen-Yan Tan MSc,&nbsp;Jia-Hao Huang MSc,&nbsp;Cai-Lan Hou PhD,&nbsp;Fu-Jun Jia PhD","doi":"10.1111/appy.12520","DOIUrl":"10.1111/appy.12520","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mental health literacy (MHL) is rarely reported in the Chinese elderly. This study explored the pattern of MHL in the Chinese elderly in relation to depression, anxiety and poor sleep quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted among older adults in Guangzhou, south China. Participants were investigated face-to-face using the Chinese National Mental Health Literacy Scale, the Patient Health Questionnaire-9 item (PHQ-9), the 7-item Generalized Anxiety Disorder (GAD-7) and the Pittsburgh Sleep Quality Index (PSQI). Mental Health Literacy Scale contains three dimensions: mental health knowledge, mental health skills (such as social support, cognitive reappraisal and attentional distraction) and mental health awareness. Multivariate logistic regression was used for examining the association between MHL and mental health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 506 older adults were recruited. The percentage of depression, anxiety, and poor sleep quality were 16.6%, 7.9% and 40.9%, respectively. MHL dimensions independently associated with depression included cognitive reappraisal (OR = 1.95, <i>p</i> &lt; .001), attentional distraction (OR = 0.61, <i>p</i> = 0.044) and awareness (OR = 0.56, <i>p</i> = 0.027). MHL dimensions independently associated with anxiety symptoms included cognitive reappraisal (OR = 1.90, <i>p</i> = 0.011) and attentional distraction (OR = 0.44, <i>p</i> = 0.016). MHL dimensions independently associated with poor sleep quality included social support (OR = 0.75, <i>p</i> = 0.022), cognitive reappraisal (OR = 1.55, <i>p</i> = 0.003) and attentional distraction (OR = 0.65, <i>p</i> = 0.016).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Given the low MHL and its association with poor mental health in the Chinese elderly, policymakers and health professionals should improve the older adults' MHL, which could be conducive to the prevention and control of their mental health problems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33514672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 5-year community program in Singapore to prevent cognitive decline","authors":"Ted Kheng Siang Ng,&nbsp;Lei Feng,&nbsp;Ru Yuan Chua,&nbsp;Lee Gan Goh,&nbsp;Ee Heok Kua,&nbsp;Rathi Mahendran","doi":"10.1111/appy.12518","DOIUrl":"10.1111/appy.12518","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>There is a scarcity of naturalistic follow-up studies on cognitive stimulating activities (CSAs), particularly in a real-world setting and over long-term. We thus investigated a pooled novel CSA intervention to prevent cognitive decline amongst community-dwelling older adults without dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nested within a community-based longitudinal follow-up cohort study of community-dwelling and multi-ethnic older adults (<i>N</i> = 991), a subset of the cohort (<i>n</i> = 264) underwent four single-blinded randomized controlled trials involving four novel CSAs, including mindfulness, horticulture, art therapy, and choral singing. At the cohort's 5-year follow-up, we examined if involvements in the CSAs improved cognition, compared to controls (<i>n</i> = 727). The primary outcomes were changes in global cognition and specific cognitive domain scores measured by the mini-mental state examination (MMSE). Exploratory subgroup analyses stratified by baseline cognitive status and the number of CSAs were also conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to the control group, there was a small improvement in the CSA group on the total MMSE score (<i>d</i> = 0.108) and MMSE-immediate recall score (<i>d</i> = 0.199). Furthermore, subgroup analyses revealed medium effect sizes of improvements (<i>d</i> = 0.420) in cognitive domains in mild cognitive impairment (MCI) (vs. cognitively healthy) and those involved in two CSAs (vs. one CSA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>In summary, a CSA intervention improved cognition. MCI and those involved in two CSAs gained greater benefits from the CSAs. These sustained improvements in cognitive functions could have a significant impact on delaying or preventing dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40580490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“It seemed like my fault for wanting to become a mother …”—Experiences and perceptions related to motherhood in women with severe mental illness","authors":"Debanjan Banerjee MD, DM,&nbsp;Rashmi Arasappa MD,&nbsp;Prabha S. Chandra MD, FRCPsych,&nbsp;Geetha Desai MD, DNB, PhD","doi":"10.1111/appy.12519","DOIUrl":"10.1111/appy.12519","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Women with mental illness experience unique challenges during their motherhood. However, little is known about their own perceptions and unmet needs in the process of childbearing. A qualitative study design with a social constructivist paradigm was used to explore lived experiences of mothers with severe mental illness (SMI) during the childbearing period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Semi-structured in-depth interviews were conducted with 30 mothers recruited through purposive sampling. This was followed by inductive thematic analysis. Rigor was established through triangulation and respondent validation. This paper focuses on the perceptions during the pre-conception and pregnancy period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Emergent categories (themes) were thoughts/feelings about childbearing (ambivalence about being a mother/having a baby, fantasies about childbearing/rearing, guilt about pregnancy), the impact of mental illness (stigma, effect of symptoms on their self-care including healthcare, concerns about effect of medications on fetus), unmet needs (lack of emotional support, unanswered doubts about effects of illness on pregnancy, child and motherhood, wanting to be considered as “potential mothers”), and caregivers' reactions (discrimination, anger/abuse, selective support). The centrality of motherhood and balancing the “dual role” of a patient and mother were the overarching categories after analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Mothers with SMI prize motherhood but navigate through it with various adverse experiences. The results of this study, grounded in their voices, provide critical insights for service and policy provisions in perinatal psychiatry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40569246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative review of the epidemiology of mental disorders in Australia and India","authors":"Nagesh Pai,&nbsp;Shae-Leigh Vella,&nbsp;David Castle","doi":"10.1111/appy.12517","DOIUrl":"10.1111/appy.12517","url":null,"abstract":"<p>Mental illness and substance use disorders have been increasing worldwide. Mental illness has a significant impact upon the lives of the individual as well as their loved ones. Mental disorders are known to result in a high level of disability. This article provides a comparative review of the epidemiology of mental disorders in Australia and India, summarizing and comparing prevalence rates in both countries based upon available data. Overall, it is evident that Australia has higher prevalence rates of mental disorders than India, across most diagnostic groups. Australia has the highest prevalence of anxiety disorders whereas India has the highest prevalence of substance use disorders; including tobacco use disorders. The next most prevalent mental disorders in India are depressive disorders. However, there are demographic parameters such as gender and age as well as service-provision differences across the countries that need to be factored into any interpretation of the data. There are also problems associated with different diagnostic instruments with language and cultural nuances that may impact comparisons. We suggest that a joint epidemiological survey between the two countries would help better understand and delineate the key similarities pertaining to the epidemiology of mental disorders in Australia and India. This will in turn assist with the development of policy and treatment of mental disorders.</p>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Replication of the abnormal niacin response in first episode psychosis measured using laser Doppler flowmeter","authors":"RanPiao Gan MD,&nbsp;YuanQiao Zhao MD,&nbsp;GuiSen Wu MD,&nbsp;JiaHui Zeng MD,&nbsp;YeGang Hu PhD,&nbsp;LiHua Xu MD, PhD,&nbsp;YanYan Wei PhD,&nbsp;XiaoChen Tang PhD,&nbsp;XiaoHua Liu MD, PhD,&nbsp;HaiChun Liu PhD,&nbsp;Tao Chen PhD,&nbsp;JiJun Wang MD, PhD,&nbsp;TianHong Zhang MD, PhD","doi":"10.1111/appy.12516","DOIUrl":"10.1111/appy.12516","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Impaired sensitivity of the skin flush response to niacin is found in approximately 30% of patients with schizophrenia. Although the niacin response abnormality (NRA) may serve as a useful endophenotype for schizophrenia, few studies have directly replicated NRA in patients with first-episode psychosis (FEP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In total, 204 patients with FEP, 16 with psychotic mood disorder (PMD), and 68 healthy controls (HC) were included. The log₁₀(EC₅₀) values represent the concentration of methyl nicotinate required to elicit a half-maximal blood flow (MBF) response, and the MBF value was calculated. The NRA was defined as having log₁₀(EC₅₀) molar value above the 90% and an MBF value below the 60% of those in the HC group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 13.7% of the FEP, 12.5% of the PMD, and 7.4% of the HC group met the definition of NRA. Significant differences were found in the log₁₀(EC₅₀) values between the FEP and HC groups (<i>p</i> = .014) and in the MBF between the FEP and PMD groups (<i>p</i> = .011). Patients with FEP and NRA had more severe negative symptoms than those with a normal niacin response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These data represent the NRA in patients with FEP, defining a small subgroup of patients with early-phase psychosis possessing a clinically significant phospholipid-signaling defect.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79407410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A century of Morita therapy: What has and has not changed","authors":"Mitsuhiro Nakamura MD, MPH,&nbsp;Hidehito Niimura MD, PhD,&nbsp;Kenji Kitanishi MD, PhD","doi":"10.1111/appy.12511","DOIUrl":"10.1111/appy.12511","url":null,"abstract":"<p>We review the history of Morita therapy (MT), which has existed for over 100 years, and examine what has changed over that period and what has not. Classic MT, which was dependent on a highly strict therapeutic approach, gradually lost its pre-eminence, but at the same time, the fundamental theory of MT was refined. This theory came to be applied to current outpatient MT and adapted to inpatient MT. As MT was refined, a standard training system for therapists was established, adaptations to modern conditions were made and expanded, and comparisons to and dialogs with other psychotherapeutic concepts such as mindfulness became possible. To better evaluate MT, further work should be conducted on its effectiveness of from a clinical epidemiological perspective.</p>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"15 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/appy.12511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international medical education perspective on training in child and adolescent psychiatry","authors":"Branko Aleksic MD, PhD,&nbsp;Hideki Kasuya MD, PhD","doi":"10.1111/appy.12509","DOIUrl":"10.1111/appy.12509","url":null,"abstract":"Martine Stecher Nielsen and colleagues' article ( 2021) in the Asia Pacific Psychiatry, which is the official journal of the Pacific Rim College of Psychiatrists and the Asian Federation of Psychiatric Associations, compared the status of child and adolescent psychiatry training programs and the workforce in child and adolescent mental health services in three geographical regions, namely South East Europe, the Middle East, and the Far East, to identify similar problems, highlight success stories, and to make recommendations for future regional studies. The study (Stecher-Nielsen et al., 2021) used data from the World Psychiatric Association, Child and Adolescent Psychiatry Section's regional projects including data from 44 countries. The study (Stecher-Nielsen et al., 2021) is extremely important, because it shows there is an urgent need for more qualified child and adolescent psychiatrists and allied professionals in a very large group of countries in South East Europe, the Middle East, and the Far East, with great differences in religion, culture, and economy. The aforementioned lack of qualified child and adolescent psychiatrists and allied professionals may result in various problems, which, in turn can lead to delayed identification, diagnosis, and treatment of child and adolescent mental disorders that can have lifelong consequences, due to the temporally regulated modifications brain undergoes during this neurodevelopmental period (Kieling et al., 2011). This (Skokauskas et al., 2019) is in line with the United Nations' Sustainable Development Goals (United Nations, 2015), adopted in 2015, which contributed to the greater recognition of both the current global mental health epidemic, and the urgent need for countries to allocate more resources. Martine Stecher Nielsen and colleagues (2021) in their article suggested, among other things that the future increase of the child and adolescent mental health workforce size, would inevitably mandate the implementation of other strategies such as advocating for child and adolescent psychiatry or child and adolescent mental health as a focus for both undergraduate and postgraduate trainees to ensure the long term expansion of training positions. This is very salient observation considering recent advances in genetics of childhood neurodevelopmental disorders, such as attention deficit hyperactivity disorder, autism spectrum disorder and intellectual disability (Parenti et al., 2020). Specifically, rare variants frequently affect protein function directly, providing a promising chance to discover the molecular mechanisms of neurodevelopmental disorders, such as autism spectrum disorder (Sanders et al., 2019). Various functional studies, using disease models such as induced pluripotent stem cells and genome-edited animals, with deleterious rare variants have been done to clarify the mechanism of pathogenesis and facilitate novel drug discovery. The aforementioned is conceptually in line with the Rese","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"14 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}