Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)最新文献_第9页

Blistering Digital Dactylitis Complicated by Osteomyelitis and Amputation in an HIV-Positive Infant. 1例hiv阳性婴儿的水泡性指指炎并发骨髓炎和截肢。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-09-01 Epub Date: 2011-04-18 DOI: 10.1177/1545109711399444

Olusola A Oyedeji, Kehinde S Oluwadiya, Ademola A Aremu

引用次数: 2

Substance Abuse, Acculturation, and HIV Risk among Caribbean-Born Immigrants in the United States. 美国加勒比裔移民的药物滥用、文化适应和艾滋病风险。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-09-01 Epub Date: 2011-04-21 DOI: 10.1177/1545109711401749

Gilbert Saint-Jean, Jessy Dévieux, Robert Malow, Hayley Tammara, Kimberly Carney

{"title":"Substance Abuse, Acculturation, and HIV Risk among Caribbean-Born Immigrants in the United States.","authors":"Gilbert Saint-Jean, Jessy Dévieux, Robert Malow, Hayley Tammara, Kimberly Carney","doi":"10.1177/1545109711401749","DOIUrl":"https://doi.org/10.1177/1545109711401749","url":null,"abstract":"US immigrants of Caribbean origin are overrepresented in the HIV/AIDS prevalence statistics. Bidirectional travel between the United States and the Caribbean region by providing opportunities for sexual mixing may contribute to these high HIV rates. Caribbean immigrants face further risk because of limited health care access, social isolation, and stigma. Additionally, although substance abuse may not represent a major health issue in their countries of origin, Caribbean immigrants are composed disproportionately of adolescents who are at greatest risk of substance abuse. There is little information on the health care characteristics of these migrants, especially regarding HIV care. This article describes how the social and economic circumstances that surround the lives of people from the Caribbean and the challenges of the acculturation process have placed these individuals at risk of substance abuse and HIV infection. The article draws on findings from the literature and analysis of data from several sources.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"10 5","pages":"326-32"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711401749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29831642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults. 在I期临床研究中，KP-1461的安全性、耐受性和药代动力学:一项针对非hiv感染成人的单次口服剂量研究，以及一项针对高度抗逆转录病毒感染成人的14天剂量递增研究

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-05-18 DOI: 10.1177/1545109711406442

Patrick G Clay, Marypeace McRae, Jean-Pierre Laurent

{"title":"Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults.","authors":"Patrick G Clay, Marypeace McRae, Jean-Pierre Laurent","doi":"10.1177/1545109711406442","DOIUrl":"https://doi.org/10.1177/1545109711406442","url":null,"abstract":"Background: KP-1461 is a prodrug to KP-1212. KP-1212 is a viral mutagen designed to increase viral error rate.Methods: We describe 2 phase I studies: KP1461-101 (double-blind, placebo-controlled, single, escalating doses, 100 to 1600 mg study in 42 non-HIV-infected participants) and KP-1461-102 (double-blind placebo-controlled dose escalation 14-day study in HIV-infected participants, 400-3200 mg). Primary objectives were safety/tolerability. Secondary objectives included pharmacokinetic analysis with exploratory objective to characterize KP-1212 effects on viral load.Results: KP-1461 was well tolerated. Majority of adverse events were grade 1 (neurological, gastrointestinal, cardiovascular). Four participants experienced grade 3 and 1 experienced a grade 4 event. Analysis demonstrated no difference in pharmacokinetic parameters at day 1 or 14. Linear pharmacokinetics found in 1600 mg arm. Compared to placebo, only at the 3200 mg dose demonstrated a marginally statistically significant virologic response.Conclusions: These studies provide safety/tolerability information and suggest virologic efficacy. KP-1212, a first-in-class antiretroviral, demonstrates the ability to induce viral eradication in vitro. Viral reduction in vivo may foretell a paradigm shift in HIV pharmacotherapy.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":" ","pages":"232-8"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711406442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40093328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pandemic Influenza A (H1N1) Infection among HIV-Infected Adults in France. 法国成人艾滋病病毒感染者感染甲型H1N1流感

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-05-12 DOI: 10.1177/1545109711407504

Mathieu Tourdjman, Sokéo Chea, Jérome Le Goff, Nathalie Colin De Verdiere, Anne Scemla, Juliette Pavie, François Simon, Jean-Michel Molina

引用次数: 0

HIV-Testing Practices and a History of Substance Use among Women Living in Public Housing in Puerto Rico. 波多黎各居住在公共住房中的妇女的艾滋病毒检测做法和药物使用史。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-04-20 DOI: 10.1177/1545109710393310

Lisa R Norman, Jessy G Dévieux, Rhonda Rosenberg, Robert M Malow

引用次数: 5

An Increase in Serum Creatinine after Initiation of Fenofibrate in an HIV-Infected Individual: A Case Report and Review of the Literature. hiv感染者服用非诺贝特后血清肌酐升高：一例报告和文献回顾。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-04-25 DOI: 10.1177/1545109711404945

Christine B Bruno, Jeffrey M Schapiro, Parya Saberi

引用次数: 0

HIV and Drug Use in Puerto Rico: Findings from the ARIBBA Study. 波多黎各的艾滋病毒和药物使用:来自ARIBBA研究的发现。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-03-25 DOI: 10.1177/1545109710397768

Milton Mino, Sherry Deren, Hector M Colón

{"title":"HIV and Drug Use in Puerto Rico: Findings from the ARIBBA Study.","authors":"Milton Mino, Sherry Deren, Hector M Colón","doi":"10.1177/1545109710397768","DOIUrl":"https://doi.org/10.1177/1545109710397768","url":null,"abstract":"This paper presents findings from the Alliance for Research in El Barrio and Bayamón (ARIBBA) research study, which compared HIV-related risk behaviors, HIV infection rates, and mortality rates of 800 Puerto Rican injection drug users and crack smokers in East Harlem, New York, with 399 of their counterparts in Bayamón, Puerto Rico. The study was conducted from 1996 to 2004 and is among the most comprehensive ever undertaken on HIV risk behaviors of drug users in Puerto Rico. This paper presents the main findings, many of which have been published in scientific journals. The study found that drug users in Puerto Rico became infected with HIV at a rate almost 4 times higher than Puerto Rican drug users in New York, and they died at a rate that was more than 3 times as high. The findings indicate that drug users in Puerto Rico are more likely than Puerto Rican drug users in New York to engage in injection drug use and sexual behaviors that put them at risk of becoming infected with HIV. In addition, they have fewer prevention resources available to them. HIV prevention programs are scarce in Puerto Rico and the availability of drug treatment programs in Puerto Rico declined by over one third during the period examined. Additionally, significantly fewer HIV-positive drug users in Puerto Rico were taking HIV-related medications than in New York. The paper concludes with recommendations and lessons learned from the study.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"10 4","pages":"248-59"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109710397768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29772753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Clinical Outcomes and Hospitalizations among Children Perinatally Infected with HIV-1 in Baja California, Mexico. 墨西哥下加利福尼亚州围产期感染HIV-1儿童的临床结果和住院情况

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-06-20 DOI: 10.1177/1545109711409942

Rolando M Viani, Maria Rosario G Araneta, Graciano Lopez, Enrique Chacón-Cruz, Stephen A Spector

{"title":"Clinical Outcomes and Hospitalizations among Children Perinatally Infected with HIV-1 in Baja California, Mexico.","authors":"Rolando M Viani, Maria Rosario G Araneta, Graciano Lopez, Enrique Chacón-Cruz, Stephen A Spector","doi":"10.1177/1545109711409942","DOIUrl":"https://doi.org/10.1177/1545109711409942","url":null,"abstract":"This study characterizes temporal trends in HIV disease progression among perinatally infected children at a clinic in Baja California, Mexico. A total of 73 children were followed, 52% were categorized under US Centers for Disease Control and Prevention (CDC) classification group C with a mean age of 2.3 years (SD ± 3.16) at HIV diagnosis. For the years 1998 to 2001, 2002 to 2003, 2004 to 2005, and 2006 to 2007, highly active antiretroviral therapy (HAART) use increased to 60%, 75%, 83%, and 94% (P < .001) as did mean CD4 percentage of 23.4%, 23.2%, 26.9%, and 29.0%, respectively (P = .009), while HIV plasma RNA log(10) decreased significantly (4.49, 4.23, 4.00, and 3.79, respectively; P = .019). Overall mortality was 31% (23 of 73), with pneumonia being the most common cause of death (43% of all deaths) followed by tuberculosis (22%). Mortality rates declined from 30.4% to 25%, 8.9%, and 9.3% (p = 0.035) for the years 1998 to 2001, 2002 to 2003, 2004 to 2005, and 2006 to 2007, respectively. Kaplan-Meier survival analysis showed that median survival was 11.2 years; 1-, 2-, and 5-year survival was 87%, 83%, and 67%, respectively. These findings document a high but improving trend in morbidity and mortality of children perinatally infected with HIV in Tijuana, Baja California, Mexico.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"10 4","pages":"223-8"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711409942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29950528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Behind the Bars of Paradise: HIV and Substance Use among Incarcerated Populations in Puerto Rico. 天堂的铁栏后面:波多黎各被监禁人群中的HIV和药物使用。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-04-01 DOI: 10.1177/1545109711398664

Carlos E Rodríguez-Díaz, Michael Reece, Begoña Rivera-Alonso, Idamar Laureano-Landrón, Brian Dodge, Robert M Malow

{"title":"Behind the Bars of Paradise: HIV and Substance Use among Incarcerated Populations in Puerto Rico.","authors":"Carlos E Rodríguez-Díaz, Michael Reece, Begoña Rivera-Alonso, Idamar Laureano-Landrón, Brian Dodge, Robert M Malow","doi":"10.1177/1545109711398664","DOIUrl":"https://doi.org/10.1177/1545109711398664","url":null,"abstract":"For those who are incarcerated in jails and prisons, the correctional setting represents a unique context for health care access and utilization. In Puerto Rico, over 16 000 persons pass each year through a correctional facility, approximately 6.9% of the incarcerated population present HIV infection, and 73.8% and 27.1% evidence a previous history of drug and alcohol use, respectively. In addition, HIV-infected populations have comorbidity with other diseases that are associated with substance use. Several approaches have been considered to prevent, treat, and provide a continuum of care for HIV and substance disorders among incarcerated populations. Nearly 30 years of legally regulated practices for correctional health care have produced recommendations for addressing the needs of those with HIV and substance disorders within the correctional facilities in Puerto Rico. These recommendations include making prevention services available, building capacity among health care providers, and understanding the cultural and political contexts.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"10 4","pages":"266-72"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711398664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29788980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Vitamin D Deficiency in HIV-Infected Women on Antiretroviral Therapy Living in the Tropics. 生活在热带地区接受抗逆转录病毒治疗的艾滋病毒感染妇女维生素D缺乏

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2011-07-01 Epub Date: 2011-04-26 DOI: 10.1177/1545109711399657

Tereza Conrado, Demócrito de Barros Miranda-Filho, Ricardo Arraes de Alencar Ximenes, Maria de Fátima Albuquerque, Heloísa Ramos Lacerda, Regina Coeli F Ramos, Paulo Sérgio Ramos de Araújo, Ulisses Montarroyos, Francisco Bandeira

{"title":"Vitamin D Deficiency in HIV-Infected Women on Antiretroviral Therapy Living in the Tropics.","authors":"Tereza Conrado, Demócrito de Barros Miranda-Filho, Ricardo Arraes de Alencar Ximenes, Maria de Fátima Albuquerque, Heloísa Ramos Lacerda, Regina Coeli F Ramos, Paulo Sérgio Ramos de Araújo, Ulisses Montarroyos, Francisco Bandeira","doi":"10.1177/1545109711399657","DOIUrl":"https://doi.org/10.1177/1545109711399657","url":null,"abstract":"The effects of HIV/AIDS and antiretroviral drugs on vitamin D metabolism are still mostly unknown. This was a cross-sectional study to estimate the prevalence of vitamin D deficiency and identify its association with the clinical and metabolic parameters among 214 HIV-positive female patients on antiretroviral therapy (ART) in Brazil. The prevalence of vitamin D deficiency (< 30 ng/ml) was 40.65% (87/214). Hypercholesterolemia, high LDL-c, duration of use of current antiretroviral regimen, hypertriglyceridemia, body mass index, age, hypertension, time with AIDS ≥ 10 years and hyperglycemia were selected for multivariate analysis (p < 0.20). After this analysis, hypercholesterolemia and use of current antiretroviral regimen ≥ 3 years remained independently associated with vitamin D deficiency. There was an inverse statistically significant correlation between total cholesterol and serum 25(OH)D levels. High prevalence of vitamin D deficiency was found among HIV-positive women on ART and was independently associated with its prolonged use and with hypercholesterolemia.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"10 4","pages":"239-45"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711399657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29841328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20