The American journal of cancer最新文献

{"title":"Occurrence of cancer in rats treated with oestrone.","authors":"C. Mceuen","doi":"10.1158/AJC.1938.184","DOIUrl":"https://doi.org/10.1158/AJC.1938.184","url":null,"abstract":"Rats of relatively low susceptibility to spontaneous carcinoma were studied. The estrone used was crystalline folliculin. Experiment 1 inv olved 12 rats, of which half were ovariectomized at the age of 58 days. All animals received daily vaginal application of a solution of estrone in corn oil from the age of 62 days until death. Hysterectomy was done on some to remove pyometra. Some were painted on the interscapular region 3 times a week with tar. In 2 cases, 3 mg of dry kieselguhr were inserted into 1 mammary gland. In this series, 1 rat killed on the 964th day of life had squamous carcinoma of the vagina, a precancerous lesion of the cervix, and a mammary adenofibroma. Another rat, at the age of 751 days, had a large abscess adherent to the descending colon. In the wall of the abscess a squamous cell carcinoma was found. In other rats of this group, a cervical papilloma and an ileo-caecal lymphosarcoma were found. In the 2nd series, 10 rats were ovariectomized at 106 days of age and silk threads placed in 1 or both uterine horns. All of these rats received daily sc injections of 30 gamma of estrone in corn oil. Some also had silk threads or kieselguhr placed in 1 mammary gland. A rat in this group, killed on Day 293 of life, had a precancerous lesion of the cervix and an abdominal lymphosarcoma. Another rat at the age of 624 days had an adenocarcinoma of the breast and 49 days later an abscess in the lower abdomen. In the wall of the abscess squamous pearls of doubtful malignancy were found. In the same rat there was an area of squamous metaplasia in a breast where kieselguhr had been injected. In a control series of 12 rats injected with corn oil alone or not treated, squamous lesions were found in abscesses of uterine horns of 2 at 753 days. A 3rd series consisted of 12 female rats of which 6 were ovariectomized at the age of 116 days. All received daily injections of 30 gamma estrone. Kieselguhr, 15 mg, was placed in the uterine horns of each animal and 35 mg in the peritoneal cavity of some. A malignant breast tumor developed in 1 rat at the age of 553 days. When estrone injections were stopped, the tumor ceased to grow. Another rat in this group died of abdominal lymphosarcoma. Of 12 rats in the 3 series which survived 500 days or longer and were treated with estrone, 4 developed cancer while of 18 control rats from Series 2 and 3 living 500 days or more only 1 had cancer. Fistulas between the uterus or vagina were found only in estrone-treated rats. In this colony of 121 rats kept without treatment, 55 female and 27 males survived 500 or more days. A submaxillary gland cancer was found in 1 but no other malignant tumors occurred among them. It is concluded that rats treated for long periods with estrone, often toghether with various forms of local irritation, developed malignant tumors more frequently than others of the same colony subjected to other procedures or untreated.","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"92 1","pages":"184-95"},"PeriodicalIF":0.0,"publicationDate":"1938-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85674351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the proliferative changes taking place in the epithelium of vagina and cervix of mice with advancing age and under the influence of experimentally administered estrogenic hormones.","authors":"V Suntzeff, E L Burns, M Moskop, L Loeb","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"32 2","pages":"256-89"},"PeriodicalIF":0.0,"publicationDate":"1938-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22003812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the proliferative changes taking place in the epithelium of vagina and cervix of mice with advancing age and under the influence of experimentally administered estrogenic hormones.","authors":"V. Suntzeff, E. L. Burns, M. Moskop, L. Loeb","doi":"10.1158/AJC.1938.256","DOIUrl":"https://doi.org/10.1158/AJC.1938.256","url":null,"abstract":"\u0000 This study describes the gradual changes which take place in the epithelium of vagina and cervix of mice from early to advanced age, with and without the stimulation of estrogen and other hormones, and the eventual transition from normal growth processes to precancerous and cancerous proliferation. With advancing age the average depth of the epithelial processes extending from the surface epithelium into the underlying connective tissue in the vagina and cervix of mice increases. Estrogenic substances injected into these animals causes these processes to reach a greater depth (10.7%) than in noninjected controls (0.8%). Injection of estrogenic substances over long periods of time causes these processes to pass into a precancerous and into a carcinoma-like growth. Mechanical factors may lead to partial erosion of the surface epithelium. Under the influence of intense stimulation leading in the end to carcinoma-like growth processes in the vagina and cervix, morphological potentalities of the tissues may be revealed which under ordinary conditions would remain hidden. These observations confirm that the transitions in the epithelial tissue of vagina, cervix, and uterus are gradual. Further research is needed to investigate the occurrence of spontaneous carcinoma, which is a condition analagous to that seen in the mammary gland.\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"1 1","pages":"256-89"},"PeriodicalIF":0.0,"publicationDate":"1938-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90104598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of cancer in rats treated with oestrone.","authors":"C S Mceuen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"34 ","pages":"184-95"},"PeriodicalIF":0.0,"publicationDate":"1938-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22022494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophyseal tumors induced by estrogenic hormone.","authors":"B Zondek","doi":"10.1158/ajc.1938.555","DOIUrl":"https://doi.org/10.1158/ajc.1938.555","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"33 ","pages":"555-9"},"PeriodicalIF":0.0,"publicationDate":"1938-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1158/ajc.1938.555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22003325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaplasia of uterine epithelium produced in rats by prolonged administration of oestrin.","authors":"C S Mceuen","doi":"10.1158/ajc.1936.91","DOIUrl":"https://doi.org/10.1158/ajc.1936.91","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"27 1","pages":"91-4"},"PeriodicalIF":0.0,"publicationDate":"1936-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1158/ajc.1936.91","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22034255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma mammae occurring in a male mouse under continued treatment with oestrin.","authors":"H. Burrows","doi":"10.1158/AJC.1935.613","DOIUrl":"https://doi.org/10.1158/AJC.1935.613","url":null,"abstract":"\u0000 Several studies have proven the connection between ovarian activity, or treatment with estrogens, and breast cancer in laboratory animals. This article presents the results of an experiment conducted on 130 male mice of no particular strain, of which 20 had been castrated. The mice were treated with a solution of estrin in benzene for prolonged periods. Only 1 of the mice, a castrated male, developed breast cancer 175 days after the beginning of treatment. The tumor was removed, and an autograft was made in the right groin; 58 days after the autograft the mouse was killed. The grafted tumor had penetrated the abdominal wall and numerous metastases were present. On the other hand, grafts from the original tumor given to 10 young mice did not give rise to any additional tumors.\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"50 1","pages":"613-6"},"PeriodicalIF":0.0,"publicationDate":"1935-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85712970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma mammae occurring in a male mouse under continued treatment with oestrin.","authors":"H Burrows","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"24 3","pages":"613-6"},"PeriodicalIF":0.0,"publicationDate":"1935-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22003731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumors of the breast related to the oestrin hormone.","authors":"C. F. Geschickter, D. Lewis, C. Hartman","doi":"10.1158/AJC.1934.828","DOIUrl":"https://doi.org/10.1158/AJC.1934.828","url":null,"abstract":"\u0000 47 figures and 2 tables are the core of evidence presented in this discussion of the relatedness of estrogen to breast tumors. A pathologic study of 95 cases of gynecomastia, 25 cases of virginal hypertrophy, and 450 cases of fibroadenoma shows the similarity of these lesions, characterized by a developmentally responsive fibroepithelial growth occurring in both males and females under normal and abnormal conditions. That prolonged (developmental) and uninterrupted stimulation by estrogen rather than brief high concentrations is necessary for production of these conditions is supported by the following: 1) these hypertrophies are easily produced in male animals when pathologic concentrations of estrogen are present; 2) these conditions are prevalent in prepuberty in girls, when small but steady estrogen breast secretions occur for 3-5 years before menstrual onset; 3) these conditions occur or are exacerbated during the latter 2 trimesters of pregnancy; 4) experimental injection of repeated small doses of estrogen into monkeys is more efficacious in reproducing the diseases than high doses given over short periods; and 5) the bio-assay of these pathologic tissues demonstrates that affected tissue has a marked capacity to concentrate the hormone. Cystic disease and fibrosarcoma receive similar histological treatment in the text, and the frozen sections suggest that the involutional changes in fibroadenomatous lesions may give rise to cystic disease and the proliferative changes in fibroadenoma may be responsible for fibrosarcoma development. Nonsurgical attempts to involute these lesions are described, and their advancement is recommended (e.g., treatment of gynecomastia by prolactin).\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"19 1","pages":"828-59"},"PeriodicalIF":0.0,"publicationDate":"1934-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76942957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumors of the breast related to the oestrin hormone.","authors":"C F Geschickter, D Lewis, C G Hartman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"21 ","pages":"828-59"},"PeriodicalIF":0.0,"publicationDate":"1934-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22033614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}