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The American journal of cancer最新文献

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The effect of androgens and estrogens on spontaneous benign mammary tumors in the rat. 雄激素和雌激素对大鼠自发性良性乳腺肿瘤的影响。
The American journal of cancer Pub Date : 1940-11-01
J Heiman
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引用次数: 0
The effect of androgens and estrogens on spontaneous benign mammary tumors in the rat. 雄激素和雌激素对大鼠自发性良性乳腺肿瘤的影响。
The American journal of cancer Pub Date : 1940-11-01 DOI: 10.1158/AJC.1940.343
J. Heiman
{"title":"The effect of androgens and estrogens on spontaneous benign mammary tumors in the rat.","authors":"J. Heiman","doi":"10.1158/AJC.1940.343","DOIUrl":"https://doi.org/10.1158/AJC.1940.343","url":null,"abstract":"\u0000 This article studies spontaneous benign mammary tumors in 97 female and male rats. All animals were observed until death and in every instance the tumors were examined and measured. In the 1st series of experiments autotransplants and homotransplants were done on 38 female rats by removing the original tumor and inserting fragments in the axillae and groins of the same animal; such serial autotransplantations were repeated from 2 to 5 times until the animal died. With minor variations such autotransplant tumors retained the structural identity of the original tumor. The 2nd series of experiments comprised 18 female rats injected with estrogen; large, spontaneous tumors showed no changes in morphology, but autotransplants and homotransplants grew more rapidly, and the latent period was reduced. A 3rd series of experiments was carried out with 16 female rats treated with androgens, which appeared to inhibit the epithelial components of adenofibromata. In a last series of experiments on 12 rats treated with estrogens and androgens together or in sequence, estrogen seemed to overcome the inhibiting action of androgens and exerted a stimulating effect on growing specific epithelium. Connective-tissue elements of the tumors did not appear to be directly affected by estrogens and to be moderately inhibited by androgens.\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"28 1","pages":"343-54"},"PeriodicalIF":0.0,"publicationDate":"1940-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80111911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. 性激素对大鼠移植乳腺腺纤维瘤生长的影响。
The American journal of cancer Pub Date : 1940-02-01 DOI: 10.1158/AJC.1940.212
F. Mohs
{"title":"The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats.","authors":"F. Mohs","doi":"10.1158/AJC.1940.212","DOIUrl":"https://doi.org/10.1158/AJC.1940.212","url":null,"abstract":"\u0000 This study reports on an experiment involving normal female rats, castrates of both sexes, and estrogen-injected castrates to determine whether or not estrogenic hormones are capable of influencing transplanted adenofibroma. A total of 469 normal and castrated rats were given injections of estrogen and testosterone after tumor implantation in the region of the right inguinal mammary gland. The injection of estrogen raised the growth rate of tumors in castrates to 2.0 mm/week. Castration does not appreciably affect the number of successful implants in males, the takes in the normal males being 24.3% and in the castrates 22.2%. Injection of testosterone propionate in a small group of castrate females resulted in successful growth in 40%; in castrated males there was a 46.1% take. These results do not indicate any inhibitory effect of testosterone on adenofibroma. Estrogenic hormone is the important endocrine factor determining the successful transplantation of mammary adenofibroma in rats. The stimulatory effect of estrogenic hormone upon mammary adenofibroma is probably exerted indirectly through the \"mammogenic hormone\" of the anterior pituitary. The transplantibility and growth rate of adenofibromas may be altered by hormonal means since this tumor responds like the normal mammary gland to the ovarian and pituitary hormones.\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"37 1","pages":"212-6"},"PeriodicalIF":0.0,"publicationDate":"1940-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85493780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. 性激素对大鼠移植乳腺腺纤维瘤生长的影响。
The American journal of cancer Pub Date : 1940-02-01
F E Mohs
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引用次数: 0
Observations on rats treated with the sex hormones estrin and testosterone. 用雌二醇和睾酮治疗大鼠的观察。
The American journal of cancer Pub Date : 1939-08-01 DOI: 10.1158/AJC.1939.551
C. Mceuen
{"title":"Observations on rats treated with the sex hormones estrin and testosterone.","authors":"C. Mceuen","doi":"10.1158/AJC.1939.551","DOIUrl":"https://doi.org/10.1158/AJC.1939.551","url":null,"abstract":"The occurrence of 3 tar cancers of the skin, 1 uterine cancer, and 1 gastric cancer are reported in rats fed with an estrin product obtained from pregnancy urine. A tar cancer is recorded in 1 control rat. Whereas in rats injected with estrone for long periods, carcinoma of the genital tract and breast occurred accompanied by other usual estrin effects, it appears that with prolonged injection of testosterone, the females went into permanent vaginal diestrus, the pituitary weights were not above normal limits, somatic growth was not inhibited, and the predominant neoplastic lesions were fibrous tissue tumors in injected areas, some of which became sarcomatous.","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"1 1","pages":"551-66"},"PeriodicalIF":0.0,"publicationDate":"1939-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89433198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Observations on rats treated with the sex hormones estrin and testosterone. 用雌二醇和睾酮治疗大鼠的观察。
The American journal of cancer Pub Date : 1939-08-01
C S Mceuen
{"title":"Observations on rats treated with the sex hormones estrin and testosterone.","authors":"C S Mceuen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The occurrence of 3 tar cancers of the skin, 1 uterine cancer, and 1 gastric cancer are reported in rats fed with an estrin product obtained from pregnancy urine. A tar cancer is recorded in 1 control rat. Whereas in rats injected with estrone for long periods, carcinoma of the genital tract and breast occurred accompanied by other usual estrin effects, it appears that with prolonged injection of testosterone, the females went into permanent vaginal diestrus, the pituitary weights were not above normal limits, somatic growth was not inhibited, and the predominant neoplastic lesions were fibrous tissue tumors in injected areas, some of which became sarcomatous.</p>","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"36 4","pages":"551-66"},"PeriodicalIF":0.0,"publicationDate":"1939-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22005124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation of nursing to the extra-chromosomal theory of breast cancer in mice. 护理与小鼠乳腺癌染色体外理论的关系。
The American journal of cancer Pub Date : 1939-01-01 DOI: 10.1158/AJC.1939.90
J. J. Bittner
{"title":"Relation of nursing to the extra-chromosomal theory of breast cancer in mice.","authors":"J. J. Bittner","doi":"10.1158/AJC.1939.90","DOIUrl":"https://doi.org/10.1158/AJC.1939.90","url":null,"abstract":"This study investigates the effect of nursing on the incidence of breast tumors in mice. The A inbred high-cancer line was used as control and newborn young of A stock mothers were removed and fostered by females of the low-tumor C57 Black or CBA lines. It was apparent that the fostered mice and the progeny of the noncancerous fostered animals lived considerably longer than did mice from the other 2 classes. Controls had a tumor incidence of 83.6% as compared to only 7.4% of the fostered mice. Little variation was observed in the average breast tumor age of the various classes. This experiment demonstrates that the source of milk exerts a decided influence on the development of breast tumors, since mice nursed by low-tumor stock females show a low percentage of tumors, while mice nursed by high-tumor stock females have a high ratio. In general, if the mother had a breast tumor the incidence among its progeny was nearly as high as for the control stock, while young descended from noncancerous mothers usually have a low ratio. These findings, however, do not entail definite conclusions, since exceptions are rather common.","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"49 1","pages":"90-7"},"PeriodicalIF":0.0,"publicationDate":"1939-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82114739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Relation of nursing to the extra-chromosomal theory of breast cancer in mice. 护理与小鼠乳腺癌染色体外理论的关系。
The American journal of cancer Pub Date : 1939-01-01
J J Bittner
{"title":"Relation of nursing to the extra-chromosomal theory of breast cancer in mice.","authors":"J J Bittner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"35 1","pages":"90-7"},"PeriodicalIF":0.0,"publicationDate":"1939-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22024409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth processes induced by estrogenic hormones in the uterus of the mouse. 小鼠子宫内雌激素诱导的生长过程。
The American journal of cancer Pub Date : 1938-11-01 DOI: 10.1158/AJC.1938.413
Leo Loeb, V. Suntzeff, E. L. Burns
{"title":"Growth processes induced by estrogenic hormones in the uterus of the mouse.","authors":"Leo Loeb, V. Suntzeff, E. L. Burns","doi":"10.1158/AJC.1938.413","DOIUrl":"https://doi.org/10.1158/AJC.1938.413","url":null,"abstract":"\u0000 The growth processes induced by estrogenic hormones which take place in the uterus of the mouse are investigated. The uterus and other sex organs were studied in 501 mice including 177 control mice which were not subjected to sex hormones. 3 different strains of mice of ages ranging from 1-20 months were used. Mice were variously injected with 1-100 rat units of estrogen, estrogen and acid extract of cattle anterior pituitary gland, acid extract alone, estrogen and corpus luteum extract (Proluton), and corpus luteum alone. Changes which may take place in the uterus of mice under the influence of estrogen include: 1) the normal one-layered cylindrical epithelium may change into several rows of cylindrical cells or into a partly cylindrical and partly squamous epithelium, or a typical squamous epithelium; 2) gland ducts may become cystically dilated and filled with colloid material; 3) the uterine glands may proliferate and penetrate into and through the muscle tissue; 4) infection may take place; and 5) parts of the pancreas may become adherent to the uterus. In none of the test cases were cancerous changes or even precancerous proliferations found. Reactivity of the uterine epithelial structures to growth stimulation is less than that of the compounding tissues in the vagina, cervix, and mammary gland. Cancerous transformation depends, among other factors, on the product of the intensity of growth stimuli acting on a tissue and the responsiveness of the affected tissue. In a minority of the mice certain changes were observed such as a penetration of the uterine glands into or through the musculature of the uterus and a metaplasia of the cylindrical surface epithelium. In a considerable number of cases, the squamous epithelium owed its origin to regenerative processes which led to an extension of the cervix epithelium into the uterus. Under the influence of estrogen these changes are produced more readily the greater the dosage used and the more continuous the action.\u0000","PeriodicalId":85625,"journal":{"name":"The American journal of cancer","volume":"1 1","pages":"413-27"},"PeriodicalIF":0.0,"publicationDate":"1938-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90204267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Growth processes induced by estrogenic hormones in the uterus of the mouse. 小鼠子宫内雌激素诱导的生长过程。
The American journal of cancer Pub Date : 1938-11-01
L Loeb, V Suntzeff, E L Burns
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引用次数: 0
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