Asian Pacific journal of tropical medicine最新文献

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Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam 文莱达鲁萨兰国结核病发病率及与死亡率相关的危险因素
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2023-01-01 DOI: 10.4103/1995-7645.368018
Liling Chaw, Nurul Jeludin, Kyaw Thu
{"title":"Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam","authors":"Liling Chaw, Nurul Jeludin, Kyaw Thu","doi":"10.4103/1995-7645.368018","DOIUrl":"https://doi.org/10.4103/1995-7645.368018","url":null,"abstract":"Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were collected. Overall tuberculosis mortality and the proportion of tuberculosis-related deaths were calculated. Logistic regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis treatment. Results: Of 1 107 tuberculosis cases, 99 died, giving an overall tuberculosis mortality rate of 8.9% (95% CI 7.4%-10.8%). Significant risk factors associated with tuberculosis mortality were age ⩾40 years (adjusted OR for 40-59 years was 3.89; 95% CI 1.13-1.69; adjusted OR for ⩾60 years was 22.3; 95% CI 7.27-91.9, using 20-39 years as reference), female sex (adjusted OR 1.74; 95% CI 1.09-2.79), having renal disease (adjusted OR 25.7; 95% CI 2.82-191.50) and having any cancers (adjusted OR 3.61; 95% CI 1.26-10.00). The majority (75.8%) of the recorded deaths were not related to tuberculosis. Conclusions: Tuberculosis patients who were older than 40 years, female, and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis mortality. Clinicians should also focus on other non-tuberculosis aspects of the patient’s medical history.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"16 1","pages":"9 - 15"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45826520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to stimulate Plasmodium vivax research in India: A way forward 是时候刺激印度间日疟原虫研究了:前进的道路
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2023-01-01 DOI: 10.4103/1995-7645.368016
Himanshu Gupta, S. Nema, Praveen Bharti
{"title":"Time to stimulate Plasmodium vivax research in India: A way forward","authors":"Himanshu Gupta, S. Nema, Praveen Bharti","doi":"10.4103/1995-7645.368016","DOIUrl":"https://doi.org/10.4103/1995-7645.368016","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"16 1","pages":"1 - 2"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44916741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel markers in predicting Brucella sacroiliitis: The platelet large cell ratio and basal immature reticulocyte fraction 预测布氏菌性骶髂炎的新标志物:血小板大细胞比率和基底未成熟网状细胞分数
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2023-01-01 DOI: 10.4103/1995-7645.368022
N. Çelik, E. Laloğlu, H. Aslan
{"title":"Novel markers in predicting Brucella sacroiliitis: The platelet large cell ratio and basal immature reticulocyte fraction","authors":"N. Çelik, E. Laloğlu, H. Aslan","doi":"10.4103/1995-7645.368022","DOIUrl":"https://doi.org/10.4103/1995-7645.368022","url":null,"abstract":"Objective: To present platelet large cell ratio (P-LCR), reticulocyte, and immature reticulocyte fraction (IRF) values as novel parameters in diagnosis and response to treatment in patients developing sacroiliitis. Methods: Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination (Wright) or Brucella Coombs agglutination test titers ≥1:160 were included in the study. Two groups were established, one developing sacroiliitis and another with no sacroiliitis development. P-LCR, reticulocyte, and IRF levels were measured using a Sysmex XN-9000 device (Japan). These were then compared between the two groups. Results: Reticulocyte (P=0.037) and IRF (P=0.026) levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group, while P-LCR (P=0.003) levels were significantly higher. P-LCR had the most powerful correlation with sacroiliitis development. Significant negative correlation was observed between reticulocyte, IRF levels and sacroiliitis. Conclusions: Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis, while low reticulocyte and IRF levels secondary to bone marrow involvement were detected. These three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in brucellosis. These are presented as inexpensive, and easily accessible novel parameters.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"16 1","pages":"39 - 44"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41857256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic dilemma in a patient with chronic non–healing ulcer on leg: A case report 诊断困境的患者慢性不愈合的溃疡在腿:一个病例报告
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.359790
M. Vibhu, Meena Amit, S. Smita
{"title":"Diagnostic dilemma in a patient with chronic non–healing ulcer on leg: A case report","authors":"M. Vibhu, Meena Amit, S. Smita","doi":"10.4103/1995-7645.359790","DOIUrl":"https://doi.org/10.4103/1995-7645.359790","url":null,"abstract":"Rationale: Though cutaneous tuberculosis accounts for a small proportion of all tuberculosis cases, it becomes an important health issue considering its high prevalence in tropical countries. Due to its myriad clinical manifestations, it becomes difficult to diagnose and may pose a great diagnostic dilemma. Patient concerns: A 17-year-old male complaint of ulcerproliferative lesion on the left lower leg for 5 years. There was no history suggestive of tuberculosis. On cutaneous examination, single well-defined erosiocrustive plaque of size 14 cm × 13 cm with yellowish adherent crust presented over the left lower leg. The underlying surface shows ulceration after removing the crust. Diagnosis: Ulcerative Lupus vulgaris. Interventions: Anti-tubercular drug therapy (isoniazid, rifampicin, pyrazinamide and ethambutol). Outcomes: Lesion showed dramatic improvement after one month of anti-tubercular therapy. Lessons: Dermatologists should be aware of variable clinical presentations of cutaneous tuberculosis so as to diagnose it timely and correctly.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"568 - 570"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48674897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neglected scrub typhus: An updated review with a focus on omics technologies 被忽视的恙虫病:以组学技术为重点的最新综述
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.364003
D. Sharma, Ankita Sharma, Birbal Singh, S. Sushanth Kumar, S. Verma
{"title":"Neglected scrub typhus: An updated review with a focus on omics technologies","authors":"D. Sharma, Ankita Sharma, Birbal Singh, S. Sushanth Kumar, S. Verma","doi":"10.4103/1995-7645.364003","DOIUrl":"https://doi.org/10.4103/1995-7645.364003","url":null,"abstract":"Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"531 - 541"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48632533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awareness and perceived barriers in practicing healthy living to prevent hypertension among young adults in Malaysia 马来西亚年轻人在实践健康生活以预防高血压方面的认识和感知障碍
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.364001
Lee Siew-Keah, K. Hann, S. Hoe, Lai En, Lim Chin, Master Chan, Tee Kang, Chua Ang-Lim
{"title":"Awareness and perceived barriers in practicing healthy living to prevent hypertension among young adults in Malaysia","authors":"Lee Siew-Keah, K. Hann, S. Hoe, Lai En, Lim Chin, Master Chan, Tee Kang, Chua Ang-Lim","doi":"10.4103/1995-7645.364001","DOIUrl":"https://doi.org/10.4103/1995-7645.364001","url":null,"abstract":"Objective: To investigate the knowledge, attitude, and practice levels and perceived barriers towards healthy living to prevent hypertension among young adults in Malaysia. Methods: Adults aged 18-25 years reside in Malaysia were recruited via convenience sampling. Sociodemographic characteristics, medical knowledge on hypertension (K1), knowledge (K), attitude (A), practice (P) and perceived barriers in practising healthy living to prevent hypertension were assessed. Average scores were categorised into good (80%-100%), upper-moderate (70%-79%), lower-moderate (60%-69%) and poor (<60%). Multivariate analysis was performed to test the difference and relationship of variables. Pearson correlation test was used to test the association of two continuous variables. Results: A total of 1 218 respondents participated in this survey. The mean score of K1 was 54.1%, while the knowledge, attitude, and practice towards healthy living were 82.7%, 78.2%and 68.5% respectively. The prevalence of high salt intake, high fat intakes, low fibre intake, sedentary lifestyle and lack of annual health screening was 83.2%, 81.4%, 70.3%, and 73.2%, respectively. Abnormal BMI was associated with low P scores, while lower socio-economic status, unawareness of self-blood pressure reading and those without family history of hypertension were associated with lower scores in K1, K, A, and P. K1, K, A and P are significantly inter-related. The main perceived barriers included self-proclaimed good fit status, frequent consumption of out-of-home food, and addiction to high salt/fat food. Conclusions: The national strategies for health management should be prioritized in reducing salt and fat, promoting annual health screening, physical activities and fibre intake in this age group.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"542 - 550"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48419174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019 2011-2019年伊朗德黑兰地区人类囊性包虫病的临床与分子特征
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.364002
Narges Hamedani, M. Pirestani, A. Dalimi
{"title":"Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019","authors":"Narges Hamedani, M. Pirestani, A. Dalimi","doi":"10.4103/1995-7645.364002","DOIUrl":"https://doi.org/10.4103/1995-7645.364002","url":null,"abstract":"Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findings, and laboratory data were collected. Formalin-fixed, paraffin-embedded and fresh tissue samples of 175 cystic echinococcosis patients were evaluated for molecular characterization. The samples’ isolated DNA was used to amplify cytochrome c oxidase I and NADH dehydrogenase subunit I genes. Also, the morphological features of fresh samples were examined. Results: In total, 175 patients with a mean age of 45 (9-98) years were admitted to Tehran’s hospitals diagnosed with cystic echinococcosis. Moreover, the highest (26.9%) and the lowest (2.9%) prevalence of cystic echinococcosis cases were in the 16-30 and 1-15 years range, respectively. Male/female ratio was 0.96 (49.1% vs. 50.9%). The liver was affected in 92 patients (52.6%), and two or more organs were infected in 7 patients (4.0%). The cysts’ diameter varied from 1 to 25 cm, and 96.0% of the patients had a single hydatid cyst. All patients underwent radical surgery and the PAIR technique was applied for all cases. No significant difference was observed between the protoscolex hooks of pulmonary and hepatic cysts. G1-G3 had the highest percentage (99.4%) over other identified G6 genotypes (0.6%). Conclusions: The sheep-dog cycle plays an important role in transmitting the human cystic echinococcosis infection in Tehran.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"558 - 567"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42331980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of monkeypox information in Wikipedia across multiple languages 维基百科中多种语言猴痘信息的质量
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.361856
E. Ornos, J. G. D. Dela Rosa, J. G. Solidum, Jervy P. Garcia, Erika P. Ong, R. Valenzuela, O. Tantengco
{"title":"Quality of monkeypox information in Wikipedia across multiple languages","authors":"E. Ornos, J. G. D. Dela Rosa, J. G. Solidum, Jervy P. Garcia, Erika P. Ong, R. Valenzuela, O. Tantengco","doi":"10.4103/1995-7645.361856","DOIUrl":"https://doi.org/10.4103/1995-7645.361856","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"571 - 572"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43923768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul 伊斯坦布尔奥密克戎变异株传播前后新冠肺炎感染儿童的血液学特征
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.364004
B. Akbeyaz, A. Karaaslan, C. Çetin, M. Köle, Z. Altaş, Y. Akın
{"title":"Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul","authors":"B. Akbeyaz, A. Karaaslan, C. Çetin, M. Köle, Z. Altaş, Y. Akın","doi":"10.4103/1995-7645.364004","DOIUrl":"https://doi.org/10.4103/1995-7645.364004","url":null,"abstract":"Objective: To examine the effect of the COVID-19 virus, especially the Omicron variant, on hematological parameters of hospitalized pediatric patients during the COVID-19 pandemic. Methods: Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr. Lütfi Kirdar City Hospital in Istanbul, Turkey, between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics, SARS-CoV-2 infection polymerase chain reaction (PCR) test results, reverse-transcriptase (RT)-PCR for other respiratory agents, duration of hospital stay, and hematological and biochemical laboratory findings. Results: Out of 467 children with a confirmed diagnosis of SARS-CoV-2 infection, 94 (20.1%) had Omicron infection and 373 (79.9%) were infected with other variants; the Omicron group had younger patients than the remaining samples (P<0.001). The most frequent clinical symptoms in all children were cough (53.5%) and fever (32.3%), followed by vomiting (20.8%). Lung involvement in the Omicron group (10.6%) was significantly lower than in the remaining samples (29.8%) (P<0.001). Hemoglobin and lymphocyte levels were lower in the Omicron-infected group (both P<0.001), while prothrombin time, activated partial thromboplastin time, international normalized ratio, and D-dimer levels were significantly higher in this group (P<0.001, P<0.001, P<0.001, and P=0.023, respectively). In terms of lung involvement, those with lung involvement were significantly older (P<0.001). Conclusions: Although lung involvement was less common with Omicron infection, this group had greater hematological system involvement, such as anemia, lymphopenia, D-dimer elevation, and coagulation disorders.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"551 - 557"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45704814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dengue epidemic in Pakistan: Strategic management, efforts, and recommendations 巴基斯坦登革热疫情:战略管理、努力和建议
IF 3.1 4区 医学
Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI: 10.4103/1995-7645.364005
Abdullah Nadeem, Khulud Qamar, A. Sahito
{"title":"Dengue epidemic in Pakistan: Strategic management, efforts, and recommendations","authors":"Abdullah Nadeem, Khulud Qamar, A. Sahito","doi":"10.4103/1995-7645.364005","DOIUrl":"https://doi.org/10.4103/1995-7645.364005","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"529 - 530"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45986012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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