被忽视的恙虫病:以组学技术为重点的最新综述

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Asian Pacific journal of tropical medicine Pub Date : 2022-12-01 DOI:10.4103/1995-7645.364003

D. Sharma, Ankita Sharma, Birbal Singh, S. Sushanth Kumar, S. Verma

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引用次数: 0

摘要

斑疹伤寒是一种被忽视的疾病，也是亚太地区最严重的健康问题之一。这种疾病是由一种专性细胞内细菌恙虫病东方体引起的，这种细菌通过恙虫叮咬或幼虫螨叮咬传播。丛林斑疹伤寒对全世界数十亿人构成威胁，在婴儿和成长中的儿童中造成不同的健康并发症和急性脑炎。这种疾病会导致多器官衰竭，由于缺乏适当的医疗保健，死亡率可能高达70%。目前可用的基因组和蛋白质组数据库以及生物信息学方法是开发遏制病原体的新疗法的宝贵工具。这篇综述讨论了关于恙虫病东方体介导的恙虫病的最新信息，并描述了组学技术在开发抗该病原体药物中的作用。蛋白质组在鉴定治疗靶点的计算机方法中的作用也得到了强调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neglected scrub typhus: An updated review with a focus on omics technologies

Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.

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来源期刊

Asian Pacific journal of tropical medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TROPICAL MEDICINE

CiteScore

4.00

自引率

9.70%

发文量

1936

审稿时长

3-8 weeks

期刊介绍： Asian Pacific Journal of Tropical Medicine (ISSN 1995-7645 CODEN: APJTB6), a publication of Editorial office of Hainan Medical University,is a peer-reviewed print + online Monthly journal. The journal''s full text is available online at http://www.apjtm.org/. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. APJTM aims to provide an academic communicating platform for international physicians, medical scientists, allied health scientists and public health workers, especially those of the Asia-Pacific region and worldwide on tropical medicine, infectious diseases and public health, and to meet the growing challenges of understanding, preventing and controlling the dramatic global emergence and re-emergence of infectious diseases in the Asia-Pacific. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on tropical medicine, infectious diseases and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. The APJTM will allow us to seek opportunities to work with others who share our aim, and to enhance our work through partnership, and to uphold the standards of our profession and contribute to its advancement.