Asian Journal of Pharmaceutical Analysis最新文献_第8页

GC- MS Analysis of Ethylacetate extract of leaves of Clitoria ternatea Linn 阴蒂叶乙酸乙酯提取物的GC- MS分析

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00009

Drisya M. K, S. Shrikumar

引用次数: 1

An Accurate and Precise Analytical Method for Estimation of Active Sulfur Trioxide and Sulfuric acid in Triethylamine Sulfur Trioxide Complex 三乙胺三氧化硫配合物中活性三氧化硫和硫酸的精确分析方法

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00004

V. Ahirrao, Rajiv A. Jadhav, K. More, Rahul B Kale, V. Rane, Jaydeo T. Kilbile, M. Rafeeq, R. Yeole

{"title":"An Accurate and Precise Analytical Method for Estimation of Active Sulfur Trioxide and Sulfuric acid in Triethylamine Sulfur Trioxide Complex","authors":"V. Ahirrao, Rajiv A. Jadhav, K. More, Rahul B Kale, V. Rane, Jaydeo T. Kilbile, M. Rafeeq, R. Yeole","doi":"10.52711/2231-5675.2022.00004","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00004","url":null,"abstract":"Triethylamine sulfur trioxide complex (TEA-SO3) is an important sulfating agent used in the synthesis of various drug substances, dyes and other chemicals. Quality of TEA-SO3 is very crucial because it provides the active sulfur trioxide (SO3) in the sulfation reaction. We developed an accurate, precise and robust analytical method for determination of quality of TEA-SO3. The potentiometric titrimetry methods are capable to estimate SO3 as well as degradation product sulfuric acid (H2SO4) present in the TEA-SO3. Estimation of SO3 involves hydrolysis of the complex using H2SO4 under reflux condition and titrating excess H2SO4 against alkali solution. H2SO4 is quantified by direct titration against alkali solution. Both assay and impurity quantification methods were validated as per the ICH guideline. Accuracy of H2SO4 determination was 102.80% with precision of 0.75% and could be detected as low as 0.01%. Method to estimate SO3 was accurate with recovery of 99.92% and precision of 0.25%. The developed methods were employed for quality check of the reagent.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"238 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75751402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

QbD Approached in Method Development, Validation and Degradation Profiling of Aripiprazole a Antidepressent Agent 抗抑郁药阿立哌唑的QbD方法开发、验证及降解分析

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00006

D. D. Masne, R. Chakole, M. Charde

{"title":"QbD Approached in Method Development, Validation and Degradation Profiling of Aripiprazole a Antidepressent Agent","authors":"D. D. Masne, R. Chakole, M. Charde","doi":"10.52711/2231-5675.2022.00006","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00006","url":null,"abstract":"The aim of present research work was to develop simple, precise and rapid RP-HPLC method for analysis of Aripiprazole in tablet dosage form using QbD Method. RP-HPLC method was developed for the estimation of Aripiprazole in tablet dosage form with the help of QbD approaches. The proposed methods were applied for the determination of drug in tablet dosage form. In this method concentration of each drug was obtained by using the absorptivity values calculated for drug wavelength 254nm and solving the equation. A rapid and reliable RP-HPLC method was developed and validated estimation of Aripiprazole in tablet dosage form. The RP-HPLC method was performed C18 (100mm x 4.6 mm,)2.5 μm particle size in gradient mode, and the sample was analyzed using methanol 80 ml and 20 ml (pH 3.3 0.05% OPA with TEA) as a mobile phase at a flow rate of 0.7 ml/min and detection at nm. By the retention time for Aripiprazole found 3.29 min respectively. The method was applied to marketed tablet formulations. The tablet assay was performed for combination was validated for accuracy, precision, linearity, specificity, and sensitivity in accordance with ICH guidelines. Validation related the method is specific, rapid, accurate, precise, reliable, and reproducible. Calibration plots by both HPLC were linear over the 10-50μg/ml for Aripiprazole respectively, and recoveries from tablet dosage form were between 99.48 and 100.02 %. The method can be used for routine of the quality control in pharmaceuticals. The RP-HPLC method was found to be simple, economical and rapid as compared to MS method was found to be more accurate, precise and robust. Both these methods can be used for routine analysis of Aripiprazole in tablet dosage form.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83660464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A New Validated Spectroscopic Method for the estimation of Sodium Benzoate in Soft drinks 一种新的测定软饮料中苯甲酸钠的有效光谱方法

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00003

Manda Pravalika, Jorige Archana

引用次数: 3

Development and Validation of RP-HPLC Method for Estimation of Lacosamide in Bulk and Its Pharmaceutical Formulation 反相高效液相色谱法测定原料药拉科沙胺及其制剂含量的建立与验证

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00005

J. Sonawane, Sonali Rathod, Sonali Suryawanshi, Durgesh Kale, A. Chaudhari

{"title":"Development and Validation of RP-HPLC Method for Estimation of Lacosamide in Bulk and Its Pharmaceutical Formulation","authors":"J. Sonawane, Sonali Rathod, Sonali Suryawanshi, Durgesh Kale, A. Chaudhari","doi":"10.52711/2231-5675.2022.00005","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00005","url":null,"abstract":"Objective - The present paper describes a simple, accurate, and precise reversed-phase high-performance liquid chromatography (HPLC) method for rapid and simultaneous quantification of Lacosamide in bulk and pharmaceutical dosage form. Methods: The chromatographic separation was achieved on C18 (250mmx4.6mm, 5µ id). Mobile phase contained a mixture of methanol: phosphate buffer in the ratio of 35:65(PH 3) v/v, flow rate 1.0 ml/min and ultraviolet detection at 210 nm. Results: The retention time Locosamide was 0.21 min. The proposed method shows a good linearity in the concentration range of 02 to 12μg/ml for locosamide under optimized conditions. Precision and recovery study results are in between 95.37 to 97.95 % w/w.. In the entire robustness conditions, percentage relative standard deviation is. Conclusion: This method is validated for different analytical performance parameters like linearity. Precision, accuracy, limit of detection, limit of quantification, robustness, and pharmacokinetic study were determined according to the International Conference of Harmonization (ICH) Q2B guidelines. All the parameters of validation were found in the acceptance range of ICH guidelines.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78641240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Green Analytical Methods based on Chemometrics and UV spectroscopy for the simultaneous estimation of Empagliflozin and Linagliptin 基于化学计量学和紫外光谱同时测定恩格列净和利格列汀的绿色分析方法

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00008

Ceema Mathew, S. Varma

{"title":"Green Analytical Methods based on Chemometrics and UV spectroscopy for the simultaneous estimation of Empagliflozin and Linagliptin","authors":"Ceema Mathew, S. Varma","doi":"10.52711/2231-5675.2022.00008","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00008","url":null,"abstract":"Empagliflozin and Linagliptin are used together as a fixed dose combination for type II diabetes. It is available as fixed-dose combination tablets in 10:5 and 25:5 (amount in milligrams) of EMPA and LINA, respectively. Two simple chemometrics methods were developed, namely ratio mean centering method and difference between adjacent data point method for the simultaneous estimation of Empagliflozin and Linagliptin in marketed formulation. For the data processing, a simple software program written with Python and MATPLOTLIB was used. Beer’s law is valid in the range of 2-10 µg/ml for Empagliflozin and Linagliptin. The assay results obtained for the marketed formulation were found to be in the range of 98.08 – 99.25% for Empagliflozin and 98.40 – 99.86% for Linagliptin by Ratio mean centering method: Assay results were in the range of 99.90 – 100.92% for Empagliflozin and 99.12 – 102.40% for Linagliptin by Difference between adjacent data point method. The new methods can be successfully employed for the assay of the marketed formulation. To the best of our understanding, this is the first reported green method for analysing Empagliflozin and Linagliptin.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75943549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

DOE Assisted RP-HPLC Method Development and Validation for Estimation of L-Cysteine and Cystine with Dansyl Chloride derivatization in Presence of Amino Acid Mixture DOE辅助反相高效液相色谱(RP-HPLC)在氨基酸混合物存在下用氯化丹酰衍生法测定l -半胱氨酸和胱氨酸的方法建立和验证

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00007

Suneetha A., B. C. Sekhar, K. Babu

{"title":"DOE Assisted RP-HPLC Method Development and Validation for Estimation of L-Cysteine and Cystine with Dansyl Chloride derivatization in Presence of Amino Acid Mixture","authors":"Suneetha A., B. C. Sekhar, K. Babu","doi":"10.52711/2231-5675.2022.00007","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00007","url":null,"abstract":"The aim of the present study is to apply Design of Experiments (DoE), to develop an assay and optimize the derivatization reaction. DoE study type is Response Surface, Sub type is Split-plot, Design is D-optimal method was used in the study for the separation of L-Cysteine and L-Cystine in presence of amino acids by RP-HPLC. DoE Response Surface Split-plot method was used in this study. DoE allows to interpret the results with better outcome and enhanced understanding. Pre-column derivatizing agent Dansyl Chloride was used for dansylation of amino acids; 10mm Ammonium Acetate buffer PH 6.3, Acetonitrile was used as mobile phase in Eclipce XDB C18 column (150mm × 4.6mm, 5μm). Derivatizing reagent volume, derivatization reaction heating time, and temperature was evaluated as variables in the DoE. The wavelength for all amino acids is 222nm. Conclusively DoE as an efficient tool for optimization of dansylation reaction for the separation of L-Cysteine and L-Cystine in presence of amino acids. Method development was established and the design is validated. The proposed method has adequate reproducibility, specificity and accurate for the estimation of L-Cystine and L-Cystine in the presence of amino acids in routine analysis.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73402721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Applications of GC-MS used in Herbal plants 气相色谱-质谱法在中草药研究中的应用

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00010

K. Pawar, P. Sankpal, S. Patil, Pranali Patil, A. Pawar, Prathamesh Shinde

引用次数: 6

Development and Validation of Stability Indicating Method of UV-Spectrophotometry for the Estimation of Flavoxate in Bulk and Tablet Dosage form 紫外分光光度法测定黄酮酸原料药和片剂含量稳定性指示方法的建立与验证

Asian Journal of Pharmaceutical Analysis Pub Date : 2022-03-05 DOI: 10.52711/2231-5675.2022.00002

Faizan Dosani, Nawaz Hakam, AM. Vyawahare, S. Patharkar, K. Gajbhiye

{"title":"Development and Validation of Stability Indicating Method of UV-Spectrophotometry for the Estimation of Flavoxate in Bulk and Tablet Dosage form","authors":"Faizan Dosani, Nawaz Hakam, AM. Vyawahare, S. Patharkar, K. Gajbhiye","doi":"10.52711/2231-5675.2022.00002","DOIUrl":"https://doi.org/10.52711/2231-5675.2022.00002","url":null,"abstract":"Literature survey reveals that few spectrophotometric, high performance liquid chromatographic (HPLC) and High Performance Thin Layer Chromatographic (HPTLC) methods were reported for the estimation of Flavoxate HCl in single and in combined dosage forms. But there is no any stability indicating UV spectroscopic study is reported for Flavoxate in single dosage form. So the present study was aimed to development of simple, accurate, rapid and economical UV-spectrophotometric stability indicating assay method were established for the determination of Flavoxate HCl in bulk and tablet formulation. The solvent was selected for stock solution preparation is water and required concentrations were prepared by using the same solvent. The λmax for detection of Flavoxate HCl is 211nm. In this method Flavoxate followed linearity in the concentrations of 1, 3, 5, 7, 9µg/ml with regression coefficient (r2) 0.999. The percent drug content was found to be 98.81±0.39 for FLV in tablet formulation. Recovery study results of FLV ranges from 99.11 to 100.49%. The method was found to be accurate and precise, as indicate by recovery studies as recoveries were close to 100% and %RSD is less than 2. Inter-day and intraday variation was found to be 0.75 and 0.45%, respectively. The LOD and LOQ values were found to be 0.719µg/ml and 2.186µg/ml, respectively. The stability study of Flavoxate was investigated when the drug was subjected to hydrolytic, peroxide, heat and photolytic (UV and sunlight) degradation. The results express that the Flavoxate is under thermal and photolytic (sunlight and UV light) conditions are more stable. In acidic, basic and hydrogen peroxide conditions Flavoxate is degraded in higher amount.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77671370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Review on Role of Pharmacist in Current Healthcare Scenrio 药师在当前医疗保健中的作用综述

Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00048

Thorat D B

引用次数: 1