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Two Dimensional Gas Chromatography- A Review 二维气相色谱-综述
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00050
K. B. Sri, G. Shailaja, M. Sumakanth
{"title":"Two Dimensional Gas Chromatography- A Review","authors":"K. B. Sri, G. Shailaja, M. Sumakanth","doi":"10.52711/2231-5675.2021.00050","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00050","url":null,"abstract":"The birth of two-dimensional gas chromatography is assumed to be the ninetieth year of the last century. Two-dimensional gas chromatography is a rapidly developing analytical technique. GCxGC is a truly hyphenated chromatographic technique which employs a pair of GC column. GCxGC analyses, such as the identification of trace compounds that would not be perceived by 1D-GC. The use of 2D-GC compared to that of 1D-GC has been discussed. The paper presents the introduction, principle of operation, working, uses, application, case studies has been discussed.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74185096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Degradation Profiling of Lisinopril and Hydrochlorothiazide by RP- HPLC method with QbD Approach QbD法反相高效液相色谱法分析赖诺普利和氢氯噻嗪的降解特性
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00046
Kalleshvar P. Jatte, R. Chakole, M. Charde
{"title":"Degradation Profiling of Lisinopril and Hydrochlorothiazide by RP- HPLC method with QbD Approach","authors":"Kalleshvar P. Jatte, R. Chakole, M. Charde","doi":"10.52711/2231-5675.2021.00046","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00046","url":null,"abstract":"RP-HPLC method was developed for the estimation of Lisinopril and Hydrochlorothiazide in tablet dosage form with the help of Quality by Design (QbD) approaches. In this method concentration of each drug was obtained by using the absorptivity values calculated for drug wavelength 226.0 nm and solving the equation. The RP-HPLC method was performed C18-(100mm x 4.6 mm,)2.5 μm particle size in gradient mode, and the sample was analysed using methanol 45.0 ml and 55.0 ml (pH 3.3 0.05% OPA with TEA) as a mobile phase at a flow rate of 0.8 ml/min and detection at nm. By the retention time for Lisinopril and Hydrochlorothiazide found 3.39 and 4.59 min respectively. Validation related the method is specific, rapid, accurate, precise, reliable, and reproducible. Calibration plots by both HPLC were linear over the 5-25 and 12.5-62.5 μg/ml for Lisinopril and Hydrochlorothiazide respectively, and recoveries from tablet dosage form were between 99.02 and 100.00 %. The method can be used for routine of the quality control in pharmaceuticals. The degradation profiling of Lisinopril and Hydrochlorothiazide were also carried out.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78642659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial Activity of Synthesized Zinc Oxide Nanoparticles using Ajuga bracteosa Leaf Extract 小苞草叶提取物合成氧化锌纳米颗粒的抗菌活性研究
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00047
M. Purohit, Anuj Kandwal, Reena Purohit, A. R. Semwal, Parveen Shama, A. Khajuria
{"title":"Antimicrobial Activity of Synthesized Zinc Oxide Nanoparticles using Ajuga bracteosa Leaf Extract","authors":"M. Purohit, Anuj Kandwal, Reena Purohit, A. R. Semwal, Parveen Shama, A. Khajuria","doi":"10.52711/2231-5675.2021.00047","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00047","url":null,"abstract":"Nanoscience and nanotechnology has attracted a lot of attention because of its wide variety of applications. Plant based metallic nanoparticles revolutionized the health sector with targeting nano drug to cure different ailments. Living beings are known to be susceptible to microbial attack followed by multidrug resistance of microorganism put the necessitates for searching more efficient methods of drug delivery or drug production. In the present study, we report the green synthesis of stable hexagonally shaped zinc oxide nanoparticles from leaf extract of Ajuga bracteosa and their antimicrobial efficacy against the selected bacterial (Streptococcus pneumonia, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa) and fungal (Aspergillus fumigates and Trichoderma viride) strains by using agar well diffusion method. Initial colour change and surface-plasmon-resonance (SPR) absorbance bands between 349 nm gave support to the synthesis of zinc oxide nanoparticles. These nanoparticles were further characterized by XRD, EDX, TEM and FTIR techniques. XRD analysis showed that nanoparticles are crystalline in nature. TEM measurements showed that nanoparticles are hexagonally shaped with their average size less than 27 nm. FTIR spectra confirms the presence of phytochemicals which were responsible for reducing, capping and stabilizing the nanoparticles. Antimicrobial results of the synthesized ZnO nanoparticles has indicated the good potential of nanoparticles against all tested microorganism in the present study.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86714516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A Review on GC-MS Hyphenated Technique GC-MS联用技术研究进展
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00049
P. Thakur, U. Thakur, Pooja Kaushal, A. Ankalgi, Pramod Kumar, Aman Kapoor, Mahendra Singh Ashawat
{"title":"A Review on GC-MS Hyphenated Technique","authors":"P. Thakur, U. Thakur, Pooja Kaushal, A. Ankalgi, Pramod Kumar, Aman Kapoor, Mahendra Singh Ashawat","doi":"10.52711/2231-5675.2021.00049","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00049","url":null,"abstract":"The hyphenated technique is developed from the coupling of a separation technique and an on-line spectroscopic detection technology, GCMS, LC-MS, LC-FTIR, LC-NMR, and CE-MS. Gas chromatography combined with mass spectrometry is an important technique for identification and quantification of analytes in multifactor systems. GC-MS is highly effective and versatile analytical techniques with numerous scientific applications to cater the field of applied Sciences and Technology. This review elaborates the significant uses of this technique. It includes a brief discussion of the instrumental set-up and theory for the comprehensive GC × GC hyphenated with different detection techniques. It is fast and sensitive, provides a high peak capacity, and allows determination of thermally stable and volatile compounds.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91078177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Bioanalysis - Method Development, Validation, Sample Preparation, its Detection Techniques and its Application 生物分析-方法发展，验证，样品制备，其检测技术及其应用
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00051
Seema R. Nikam, Amol S. Jagdale, S. Boraste, Shrikant B Patil
{"title":"Bioanalysis - Method Development, Validation, Sample Preparation, its Detection Techniques and its Application","authors":"Seema R. Nikam, Amol S. Jagdale, S. Boraste, Shrikant B Patil","doi":"10.52711/2231-5675.2021.00051","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00051","url":null,"abstract":"Quantitatively measurements of chemical and biological drugs and their metabolites in the biological sample. This used in clinical and non-clinical studies. Non clinical including Pharmacokinetic and Toxic kinetic study, and clinical including Bioavailability, Bioequivalence study. This are play significant role and help in improvement in technology and analytical methods. Recent years have witnessed the introduction of several high- quality review articles into the literature covering various scientific and technical aspects of bioanalysis. Method validation and development use for the purpose of suitability of method for their intended purpose, this are important in Drug Discovery and Development. It including a validation parameters are Accuracy, Precision, Range, Calibration Curve, Recovery, Limit of Detection, Limit of Quantitation, Specificity, Selectivity and Stability, Ruggedness. This applicable in bio analysis, FDA and EMA guidelines. There are 3 main Extraction techniques used in sample preparation in bioanalysis is precipitation, liquid –liquid extraction, solid phase extraction. Detection of analyte by using hyphenated and chromatographic techniques like LC-MS/MS, HPLC, GC-MS. This LC-MS/MS is commonly used in a bioanalysis. This bio analysis study used in Pharmaceutical, Biomedical research purpose. Many challenges in pharmaceutical industry that fulfill by the utilization of analytical technologies and high-throughput automated platforms has been employed; in order to perform more experiments in a shorter time frame with increased data quality.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76614884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Quality Evaluation of Generic Products of Metformin and Vildagliptin Tablets 二甲双胍和维格列汀片仿制药质量评价
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00043
Bhavana Habib, Jyoti Mittha
{"title":"Quality Evaluation of Generic Products of Metformin and Vildagliptin Tablets","authors":"Bhavana Habib, Jyoti Mittha","doi":"10.52711/2231-5675.2021.00043","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00043","url":null,"abstract":"The aim of the present study was the evaluation and comparison between four different Metformin and Vildagliptin tablets which are commercially available in Indian market. These tablets were assessed for various pharmacopoeial quality control tests. Parameters including weight variation, hardness, friability, drug content, and disintegration time were evaluated. Results were within acceptable limits for all selected products (three generic and an innovator). These results show that the tested generic products were biopharmaceutically similar to the innovator formulation. Therefore, the consumer can select any one of these equivalent products as a substitute for innovator product in case of cost concern or unavailability.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91554080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Method Development and Validation for the Estimation of Etizolam and Propranolol Hydrochloride in bulk and Combined Dosage Forms by Simultaneous and Derivative Spectroscopic Methods 同时光谱法和导数光谱法测定盐酸安替唑仑和普萘洛尔原料药和复方药的含量
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-11-27 DOI: 10.52711/2231-5675.2021.00045
Susmeena Tabassum Kapatrala, Vinod Kumar Kondreddy, Swapna Kandlapalli, Tejaswi Male
{"title":"Method Development and Validation for the Estimation of Etizolam and Propranolol Hydrochloride in bulk and Combined Dosage Forms by Simultaneous and Derivative Spectroscopic Methods","authors":"Susmeena Tabassum Kapatrala, Vinod Kumar Kondreddy, Swapna Kandlapalli, Tejaswi Male","doi":"10.52711/2231-5675.2021.00045","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00045","url":null,"abstract":"Accurate, simple, sensitive and rapid economic UV spectroscopic methods were developed for the estimation of Etizolam and Propranolol Hydrochloride in bulk and combined dosage form. The present study deals with the UV spectroscopic method development and validation for the Simultaneous Equation method and First Derivative method of Etizolam and Propranolol Hydrochloride in bulk and combined dosage form at determined wavelength of Etizolam and Propranolol Hydrochloride at 244nm and 288nm for Simultaneous Equation method and 234nm and 289nm for First Derivative Method. The linearity range for Etizolam and Propranolol Hydrochloride was 1-5µg/ml and 10-50µg/ml, and exhibit good correlation coefficient of Etizolam and Propranolol Hydrochloride was 0.9877 and 0.9977 for Simultaneous Equation method and 0.9872 and 0.9977 for First Derivative method, respectively and excellent mean recovery (98-102%). The precision was found to be within limit (%RSD <2). Comparatively First Derivative method is more sensitive than Simultaneous Equation method. The methods were validated statistically and parameters like linearity, precision, accuracy, specificity and assay was studied according to ICH guidelines and can be applicable in determination of both drugs in routine quality control analysis of drugs in bulk and combined dosage form.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88906637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An Overview on Estimation of Lacidipine from Bulk and Formulation 拉西地平原料药和制剂评价综述
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-08-16 DOI: 10.52711/2231-5675.2021.00039
N. Dighe, Mayur Bhosale, Pallavi B. Gaikwad
{"title":"An Overview on Estimation of Lacidipine from Bulk and Formulation","authors":"N. Dighe, Mayur Bhosale, Pallavi B. Gaikwad","doi":"10.52711/2231-5675.2021.00039","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00039","url":null,"abstract":"Lacidipine is a calcium channel blocker used in treatment of cardiac arrhythmia. Several methods had been reported for the estimation of lacidipine from bulk and formulations. Here in this an attempt is made to summarize the different methods used along with their specifications. Every method reported for the analysis had its own advantages over the other methods. As per the industrial scalability HPLC is the most useful and effective method for the estimation of Lacidipine from bulk and formulations.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89204977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of RP-HPLC Method for Determation of Acyclovir in Ointment 反相高效液相色谱法测定软膏中阿昔洛韦含量的建立与验证
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-08-16 DOI: 10.52711/2231-5675.2021.00035
Ajay B. Bedadurge, Kadare Mahesh, Vinod Matole, Parikshit D. Shirure, Sainath Suryawanshi, Ghodake Kajal
{"title":"Development and Validation of RP-HPLC Method for Determation of Acyclovir in Ointment","authors":"Ajay B. Bedadurge, Kadare Mahesh, Vinod Matole, Parikshit D. Shirure, Sainath Suryawanshi, Ghodake Kajal","doi":"10.52711/2231-5675.2021.00035","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00035","url":null,"abstract":"The analytical method was developed and validated for determination of acyclovir in ointment by High performance liquid chromatography. The separation was carried out on Luna C18 column (250 × 4.6mm × 5µ). The mobile phase consists of water: acetonitrile in the ratio 88:12 at flow rate 0.8ml/min with diode array detector wavelength at 254nm.The column temperature was adjusted at 30ºC±40ºC with injection volume 20µl.The retention time of acyclovir was 4.747min. The linearity of the calibration curve was linear over the concentration range 80-120µg/ml (r2=0.9996). The validation was carried out as per ICH guidelines. The development method was easy, rapid, linear, precise, accurate and consistent.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90627416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analytical Method Validation and Quantitative Analysis for Active Pharmaceutical Ingredient and Marketed Formulation of Teneligliptin Hydrobromide by UV Spectroscopy 氢溴酸替尼格列汀有效成分及市售制剂的紫外光谱分析方法验证及定量分析
Asian Journal of Pharmaceutical Analysis Pub Date : 2021-08-16 DOI: 10.52711/2231-5675.2021.00034
Kalyani Farkade, M. Tawar
{"title":"Analytical Method Validation and Quantitative Analysis for Active Pharmaceutical Ingredient and Marketed Formulation of Teneligliptin Hydrobromide by UV Spectroscopy","authors":"Kalyani Farkade, M. Tawar","doi":"10.52711/2231-5675.2021.00034","DOIUrl":"https://doi.org/10.52711/2231-5675.2021.00034","url":null,"abstract":"A Dipeptidyl peptidase-4 inhibitor teneligliptin hydrobromide is used for lowering blood glucose levels in people with diabetes mellitus. A very straight forward, quick, responsive and accurate UV- Spectrophotometric method of analysis have been developed for assessment of Teneligliptin Hydrobromide in pharmaceutical formulation. Since teneligliptin hydrobromide only absorbs UV in the low wavelength area, it cannot be identify with high sensitivity. Teneligliptin Hydrobromide has shown successful results for various analytical instruments only in the permutation of Taurine and Sodium periodate. The API was derivatives using Taurine and Sodium periodate in water and methanol. Drug exhibited distinct λmax in methanol at 281nm. Linearity was observed in the concentration range 10-80 μg/ml. The method was validated by recovery studies. The methods used are inexpensive and sensitive for the inference of teneligliptin hydrobromide in bulk drug and tablet dosage forms.","PeriodicalId":8547,"journal":{"name":"Asian Journal of Pharmaceutical Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79097601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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