{"title":"Phytochemical and Pharmacological Review of Sesbania grandiflora","authors":"Shamali Dange, R. Jadhav, S. Vikhe","doi":"10.52711/2231-5713.2022.00004","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00004","url":null,"abstract":"There are around 60 global species including genus Sesbania, which are commonly available. The leaves of Sesbania grandiflora is used as local traditional medicine. Most of all parts of plant of S. grandiflora are used in traditional medicine as well as phytochemical investigations, seeds and roots of Sesbania grandiflora to provide scientific validation of its properties. The family of Sesbania grandiflora is fabaceae and is widely used as a traditional Indian medicine. The common name of plant Sesbania grandiflora is Agate, as well as crook wood. Various chemical constituents present in plant contain tannins, coumarone, steroids, tri-terpenes, iosflavanoids, isovestitol, and sativan and betulinic acid, flavanoid and medicarpin. The plant mainly use for colic disorder, jaundice, small pox, catarrh, headache, epilepsy. Flower juice is mainly used for eye disease.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80366114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mufliha Murtaza, Affifa Tajammal, Muhammad Ashfaq, Waqar Mirza, Ansa Nazir, I. Hanif
{"title":"A Short Review on Synthetic Methodologies of Flavonoids","authors":"Mufliha Murtaza, Affifa Tajammal, Muhammad Ashfaq, Waqar Mirza, Ansa Nazir, I. Hanif","doi":"10.52711/2231-5713.2022.00010","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00010","url":null,"abstract":"Flavonoids are the pigments present in plants which mostly found in terrestrial plants. Flavonoids are indeed a naturally present group of polyphenolic compounds present in plants. They were driven by the term \"flavus,\" which means \"yellow.\" It is a 15-carbon skeleton compound. They have fused aromatic ring and benzopyran heterocyclic ring having oxygen atom in it along with phenyl substituent. They are synthesized from Phenylalanine. In cereals and Herbs, they are mainly found. Flavonoids are compounds that are biologically active. They provide color and protection from ultraviolet rays. They have many classes based upon oxidative status, number, and types of substituents present. Flavonoids exist naturally in the form of polymers, most commonly in dimers form. They occur primarily in β-glycosides form except for Catechins. They can help in the inhibition of enzymes and stimulate some hormones along with some neurotransmitters. They also show the properties of scavenging free radicals. They can inhibit or kill many bacterial strains, viral enzymes, and pathogenic protozoans. There are various techniques and methods for the synthesis of natural products artificially. In the present study, we have attempted to cover different synthetic methods for flavonoid synthesis to find its best way to synthesize. It was concluded that Baker & Venkatraman synthesis and Claisen-Schmidt condensation are well-known methods used to synthesize flavonoids.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89589196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunomodulatory activity of Cestrum nocturnum. - A Comprehensive review","authors":"Abhijit Sasmal, Deeparani K. Urolagin","doi":"10.52711/2231-5713.2022.00006","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00006","url":null,"abstract":"Immunomodulatory treatment is more often than not required beneath the conditions of impeded safe responsiveness and when the resistance components of have got to be actuated. In spite of the fact that customary immunomodulatory chemotherapy is accessible but it is so costly that it isn't more often than not reasonable to standard individuals with the socio-economic status. Subsequently, the balance of safe framework by conventional restorative plant items has gotten to be a subject matter for current logical examinations around the world. Night blossoming jasmine, botanically known as Cestrum nocturnum is an evergreen shrub that grows in tropical and sub-tropical locales all through the world. Cestrum nocturnum could be a most widespread plant due to its scent from the white blossoms. It is additionally developed as a therapeutic plant. The therapeutic properties of night sprouting jasmine incorporate antioxidant, anti-hyperlipidaemic, hepatoprotective, pain relieving, antibacterial, antifungal, anti-convulsant, anti-HIV and larvicidal exercises. The present paper reviews the immunomodulatory activity of the plant.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74499939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salman Mohd, Majaz Qazi, Abrarul Haq, N. Khan, S. Siraj
{"title":"Formulation, Optimization and Evaluation of Drotaverine HCl Mini Tablet","authors":"Salman Mohd, Majaz Qazi, Abrarul Haq, N. Khan, S. Siraj","doi":"10.52711/2231-5713.2022.00002","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00002","url":null,"abstract":"The aim of present research was to develop a mini tablet of Drotaverine hydrocholoride. Mini tablets of Drotaverine hcl were prepared by using various polymers, such as gellan gum and carbopol 940. Mini tablets were evaluated for weight variation, hardness, thickness, friability, drug content, and in-vitro dissolution studies. The prepared mini tablets exhibited satisfactory physic-chemical characteristics. All prepared batches shown good in-vitro dissolution studies. The best result from optimized batches is of F5 which gives drug release 97.72% in 12 h time periods.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91545033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone","authors":"D. Nirmala, V. Harika, M. Sudhakar","doi":"10.52711/2231-5713.2022.00003","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00003","url":null,"abstract":"The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85080282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation development and in vitro Evaluation of sustained release matrix tablets of Cefpodoxime proxetil","authors":"A. Bhavani, B. Hemalatha, K. Padmalatha","doi":"10.52711/2231-5713.2021.00045","DOIUrl":"https://doi.org/10.52711/2231-5713.2021.00045","url":null,"abstract":"The present focus is on the development of sustained release formulations due to its inherent boons. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance, reduction in fluctuation and increased safety margin of potent drug. The present study was aimed to prepare a sustained drug delivery system to design a controlled release oral dosage form of Cefpodoxime proxetil. The sustained release matrix tablets of Cefpodoxime proxetil were prepared by wet granulation and evaluated for different parameters such as weight variation, drug content, thickness, hardness, friability and In vitro release studies. The in vitro dissolution study was carried out for 12 hours using USP (Type- II) paddle apparatus in hydrochloride (0.1N) as dissolution media for first 2 hours and phosphate buffer (pH 6.8) for next 10 hours. Based on the in vitro dissolution data, formulation F8 was selected as the best formulation from Cefpodoxime proxetil formulations (F1 – F9) as the drug release was retarded up to 12 hours with 96.29 % and followed zero order release kinetics & drug release mechanism was diffusion.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83844039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemical Composition of Oroxylum indicum: A Review","authors":"Y. Chowdhary","doi":"10.52711/2231-5713.2021.00050","DOIUrl":"https://doi.org/10.52711/2231-5713.2021.00050","url":null,"abstract":"Root bark of sonapatha is an astringent, tonic, anti-diarrhoeal, diuretic, anodyne, and is used to cure dropsy. It is an ingredient of ‘dashamoolarishta’ of Ayurvedic medicine. Stem bark is anti-rheumatic. An infusion of bark powder is diaphoretic. Tender fruits have spas- molytic, carminative, and stomachic properties, while seeds are purgative.it is a medium-sized, soft-wooded tree attaining a height of 10–16 m. Stem bark is dull brown in colour; leaves are broad, 60–120 cm in length and pinnately compound. Leaflets are ovate, wavy, and acuminate. Leaf fall occurs during winter season (January) each year. The tree is recognized by ternately bipinnate leaves. The root bark contains chrysin, baicalein, dehydrobaicalein, and orozylin. Stem bark possesses flavonoids such as oroxylin, baicalein, scutelarin and 7-rutinoside, chrysin, and p-coumaric acid. Heartwood yields β-sitosterol and isoflavone-prunetin. Root bark of sonapatha is an astringent, tonic, anti-diarrhoeal, diuretic, anodyne, and is used to cure dropsy. It is an ingredient of ‘dashamoolarishta’ of Ayurvedic medicine. Stem bark is anti-rheumatic. An infusion of bark powder is diaphoretic. Tender fruits have spas- molytic, carminative, and stomachic properties, while seeds are purgative. It is a medium-sized, soft-wooded tree attaining a height of 10–16 m. Stem bark is dull brown in colour; leaves are broad, 60–120 cm in length and pinnately compound. Leaflets are ovate, wavy, and acuminate. Leaf fall occurs during winter season (January) each year. The tree is recognized by ternately bipinnate leaves. The root bark contains chrysin, baicalein, dehydrobaicalein, and orozylin. Stem bark possesses flavonoids such as oroxylin, baicalein, scutelarin.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83144172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aman Yadav, Dinesh Kumar Mishra, P. Paliwal, N. Farooqui, Arpit Gawshinde
{"title":"Formulation and Evaluation of Polyherbal Antiaging Cream","authors":"Aman Yadav, Dinesh Kumar Mishra, P. Paliwal, N. Farooqui, Arpit Gawshinde","doi":"10.52711/2231-5713.2021.00047","DOIUrl":"https://doi.org/10.52711/2231-5713.2021.00047","url":null,"abstract":"Moringa oleifera family Moringaceae and Ocimum sanctum family Labiatae has been reported to possess antioxidant, antimicrobial, antiinflammatory, antibacterial and antifungal properties. Moringa oleifera and Ocimum sanctum extracts have been used to treat antimicrobial infections. The aim of this present study is to formulate and evaluate of polyherbal anti-aging cream by combining the extract of Moringa oleifera with Ocimum sanctum to achieve multipurpose skin effects such as anti-aging, fairness, softening and antiseptic effects.The polyherbal anti-aging cream formulations comprising of hydroalcoholic extract of Moringa oleifera and Ocimum sanctum, carbapol 940, xanthan gum, stearic acid, glycerol monostearate and cetyl alcohol were prepared and evaluated for physicochemical parameters and the results showed the production of stable polyherbal anti-aging cream. The formulated polyherbal anti-aging cream (O/W) was subjected to characterize like visual inspection, pH, viscosity, good spreadability, good consistency, homogeneity, no evidence of phase separation and ease to washable from skin. Formulation (F4) exhibited fulfilled the objectives of the current research and % drug release is 98.78 and exhibit good anti-microbial activity.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74425613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Prajapati, S. Shende, V. Jain, A. Gupta, Manoj Kumar Goyal
{"title":"Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel","authors":"M. Prajapati, S. Shende, V. Jain, A. Gupta, Manoj Kumar Goyal","doi":"10.52711/2231-5713.2021.00044","DOIUrl":"https://doi.org/10.52711/2231-5713.2021.00044","url":null,"abstract":"The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83362406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dabeer, Dinesh Kumar Mishra, N. Farooqui, Arpit Gawshinde
{"title":"Formulation and Evaluation of Orodispersible Tablet of poorly water Soluble Drug ‘Fenofibrate’ by Using Solubility Enhancement Technique","authors":"A. Dabeer, Dinesh Kumar Mishra, N. Farooqui, Arpit Gawshinde","doi":"10.52711/2231-5713.2021.00046","DOIUrl":"https://doi.org/10.52711/2231-5713.2021.00046","url":null,"abstract":"In the recent years scientific and technological advancements have been made in the research and development of oral drug delivery systems. The aim of this study was to formulate and evaluate of orodispersible tablets by direct compression for fenofibrate by using super fast disintegrating agents like croscarmellose sodium. The use of super disintegrant and excipient for preparation of fast disintegrating is highly effective and commercially feasible. In the present investigation poorly water soluble drug is one of the most important parameters of oral formulations sucessfully developed fenofibrate was using solvent evaporation method drug: PEG 6000 in (1:5 w/w). The formulation F7 was the optimized formula that showed satisfactory results with various physicochemical evaluation parameters like thickness, hardness, weight variation, friability, drug content, % drug release almost 79.98% within 15 min. and it was follow the maximum higuchi release kinetics that regression coefficient values ‘r2’= 0.995.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89387849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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