Asian Journal of Pharmaceutical Research and Development最新文献_第6页

A Detailed Review on Diabetic Wound Healing Activity 糖尿病伤口愈合活动详述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-08-13 DOI: 10.22270/ajprd.v11i4.1293

Raman S. Bhopale, Rajesh D. Jangam, Harshada M. Dhekale, Prachi P. Aiwale, Vitthal J. Chaware, Vivekkumar K. Redasani

{"title":"A Detailed Review on Diabetic Wound Healing Activity","authors":"Raman S. Bhopale, Rajesh D. Jangam, Harshada M. Dhekale, Prachi P. Aiwale, Vitthal J. Chaware, Vivekkumar K. Redasani","doi":"10.22270/ajprd.v11i4.1293","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1293","url":null,"abstract":"Skin damage is known as a wound. Hemostasis, inflammatory, proliferative, and tissue remodelling or resolution are the four perfectly timed and highly planned phases that make up the normal biological process of wound healing in the human body. There are two basic categories of wounds: acute wounds and chronic wounds. Long-term negative effects on one's health are caused by the chronic metabolic condition known as diabetes mellitus, which is becoming more common. 25 percent of those with diabetes mellitus are thought to have poor wound healing due to their diabetes. Oxygenation, infection, hormones related to ageing and sex, stress, diabetes, and obesity, drugs, alcoholism, smoking, and diet are among the factors that affect wound healing. To address their basic medical needs, According to estimates, 80% of people who live in underdeveloped nations need traditional medicines, which are typically made from medicinal plants. Numerous individuals in Africa and other poor nations employ using medicinal herbs to cure diabetic wounds and associated issues due to the abundant supply With therapeutic herbs and enough conventional wisdom regarding wounds healing. Recent developments in functional genomics, nanotechnology, wound healing in diabetics, along with a better knowing the pathophysiology of chronic wounds. In the following review, detailed information about healing of diabetic wounds with mechanism, factors affecting, impairment of wound healing with its pathophysiology, herbal treatments and current advances when treating diabetic wounds are examined.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol 利用 3-氨基苯酚开发估算泛昔洛韦的新型灵敏分光光度法

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-08-13 DOI: 10.22270/ajprd.v11i4.1280

N. R. Babu, A. Divya, Y. Padmavathi, T. Vinoda, M. S. Sree, A.G.Prasanna Lakshmi

{"title":"Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol","authors":"N. R. Babu, A. Divya, Y. Padmavathi, T. Vinoda, M. S. Sree, A.G.Prasanna Lakshmi","doi":"10.22270/ajprd.v11i4.1280","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1280","url":null,"abstract":"The study aims to find out the effectiveness of the combination of citral and curcumin as antifungal compounds. Lemongrass (Cymbopogon citratus) is a valuable family of grass known due to its flavoring, medicinal, and fragrance application. Haldi (Turmeric) scientifically known as Curcuma longa belongs to familthey Zingiberaceae. Its polyphenolic compound curcumin has been showing a variety of antifungal investigations due to extensive traditional uses and very low side effects.Turmeric has beenutilized in traditional medicine for various diseases counting diabetes, hepatitis, hemorrhoids, hysteria, indigestion, skin disease, inflammation, anorexia, hepatic disorders, cough, and sinusitis. In this formulation substudy combination of two bioactive oils is considered to form an effective antifungal spray preparation. The spray preparation is helpful to achieve fast absorption of the drugs through the transdermal way of drug administration. The effectiveness and activity rate of spray preparation is more beneficial. Lemongrass oil and curcumin are dissolved in ethanol to form a stable, safe, and effective spray formulation.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Study of Agnikarma Therapy in the Management of Gridhrasi w.s.r. to Sciatica 阿格尼卡玛疗法治疗坐骨神经痛的病例研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-08-13 DOI: 10.22270/ajprd.v11i4.1306

Divyabahen S. Ninama, Jigna Patel, Sonal Panchal, Damini Parmar

{"title":"A Case Study of Agnikarma Therapy in the Management of Gridhrasi w.s.r. to Sciatica","authors":"Divyabahen S. Ninama, Jigna Patel, Sonal Panchal, Damini Parmar","doi":"10.22270/ajprd.v11i4.1306","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1306","url":null,"abstract":"Gridhrasi is a Shulpradhana Nanatmaja Vatavyadhi. According to Acharya Charaka, Stambha (stiffness), Ruka (pain), Toda (pricking sensation) and Spandana (twitching) are the signs and symptoms of Vataja Gridhrasi. Aruchi (anorexia), Tandra (drowsiness) and Gaurava (heaviness) are the additional symptoms of Vatakaphaja Gridhrasi. Sciatica is a major cause of illness among the working population in a developing country.It starts from hip and gradually comes down to waist, back, thigh, knee, shank and foot and affects these parts with stiffness, distress, piercing pain and with frequent quivering.In Ayurveda science, various modalities of treatment are explained for the management of Gridhrasi. Agnikarma Chikitsa is said to be superior.In modern medicine for the management of sciatica various modalities are available such as Conservative treatment, Epidural steroid injection, Peri-radicular infiltration and Surgical treatment.Purpose of the study was to evaluate the efficacy of Agnikarma therapy performed by Panch Dhatu Shalaka (five types of metals) in case of Sciatica. After giving Agnikarma sitting, we have got marked improvement in symptoms of Sciatica and also found moderately improvement in various clinical examinations of Sciatica like SLR, Cross SLR, Local tenderness etc.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H2 Production From Wastewaters Containing Sulphur via Photocatalysis Using TiO2-N-GO Nanocomposite TiO2-N-GO纳米复合材料光催化含硫废水制氢研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-07-24 DOI: 10.47485/2694-5614.1019

D. Sponza

引用次数: 0

Phosphorylated P53 (TP53) in Cancer Patients Undergoing Radiotherapy 肿瘤放疗患者的磷酸化P53 (TP53

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-07-20 DOI: 10.47485/2694-5614.1018

Amna A. Ali, O. Abdalla, Nuha M. Hassan, Amna A. Yousif, Ammar ME. Hassan, Alkhansa Mahmoud

{"title":"Phosphorylated P53 (TP53) in Cancer Patients Undergoing Radiotherapy","authors":"Amna A. Ali, O. Abdalla, Nuha M. Hassan, Amna A. Yousif, Ammar ME. Hassan, Alkhansa Mahmoud","doi":"10.47485/2694-5614.1018","DOIUrl":"https://doi.org/10.47485/2694-5614.1018","url":null,"abstract":"Introduction: Cancer is a common disease worldwide, and radiotherapy is an important option for cancer treatment. P53 tumour suppressor has a role in apoptosis and cancer treatment response. P53 is phosphorylated in response to ionizing radiation by kinases of the ataxia telangiectasia mutation family (ATM). The aim of this study was to detect the DND damage response in cancer patients before and after radiation therapy through measurements the expression levels of phosphorylated P53 on T18.\u0000Material and Methods: Total of 28 cancer patients on radiotherapy were participate in this study to collect blood samples pre and post radiotherapy compared to 28 healthy people matched in age and sex as control group. P53 antibody used against Phospho-p53 (T18) was obtained from CUSABIO using enzyme linked immunosorbent assay (ELISA).\u0000Results: 21 of patients were breast cancer, and 7 of patients were Head and Neck. 6 male and 22 female. Median of age was 44 years old. Median of body mass index (BMI) for breast cancer patients was 30 while BMI for head and neck was 23. The absorbed dose for breast cancer was 40.5Gy. While the doses for Head and neck cancers were between 20Gy- 66Gy. Phosphorylated P53 expression increased significantly (P= <0.0001) in the patients preradiotherapy compared to the control group. While no significant difference observed between preradiotherapy and postradiotherapy groups (P=0.7). Individually, 19 patients showed increased in phosphorylated P53 expression postradiotherapy, while, nine patients were showed low P53 postradiotherapy, 8 of them diagnosed with breast cancer and 1 diagnosed with Oesophagus.\u0000Conclusion: phosphorylated on T18 can be consider a predictive marker for cancer. Phosphorylated P53 can be indict the DNA damage and response through its activation and proapoptotic effects. Protein expression such as P53 can be use as biomarker to demonstrate individual radiation sensitivity in cancer patients.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80749983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on a Oral Mucoadhesive Drug Delivery System 口腔黏胶给药系统综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-07-03 DOI: 10.22270/ajprd.v11i3.1277

Dr R.A.Mahadik, Dr V. K. Redasani, P. D. Jadhav, P.D.Bhagat

引用次数: 0

An Overview on Antifungal Drug Therapy 抗真菌药物治疗概述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-07-02 DOI: 10.22270/ajprd.v11i3.1270

Mayuri More, Prakash Jadhav, Ashish Bhongale, A. Velhal, Vivek Kumar Redasani, Nishigandha Naikawadi

引用次数: 0

An Overview on Microemulsion as a Topical Drug Delivry System 作为外用给药系统的微乳液概述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-06-30 DOI: 10.22270/ajprd.v11i3.1275

Naikawadi Nishigandha, Jadhav Prakash, Bhagwat Avinash, Velhal Atish, Redasani Vivek Kumar, More Mayuri

引用次数: 0

A Review on Pharmaceutical Emulsion 药用乳剂综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-06-30 DOI: 10.22270/ajprd.v11i3.1181

Rakesh Thakur, Anjali Sharma, Preeti Verma, Asha Devi

引用次数: 0

On Overview of Fast dissolving tablet 速溶片剂概述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-06-30 DOI: 10.22270/ajprd.v11i3.1276

Chavan Achal, Bharatee Chaudhary, V. Redasani, P. Bhagat, R. Mahadik

{"title":"On Overview of Fast dissolving tablet","authors":"Chavan Achal, Bharatee Chaudhary, V. Redasani, P. Bhagat, R. Mahadik","doi":"10.22270/ajprd.v11i3.1276","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1276","url":null,"abstract":"Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for paediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route is the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery in spite of various disadvantages. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0