Asian Journal of Pharmaceutical Research and Development最新文献_第3页

A Review on Green Chemistry and Its Applications 绿色化学及其应用综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1341

Abhishek Yadav, Adarsh Dubey

{"title":"A Review on Green Chemistry and Its Applications","authors":"Abhishek Yadav, Adarsh Dubey","doi":"10.22270/ajprd.v12i2.1341","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1341","url":null,"abstract":"Green Chemistry is most investigated subject these days. It is also known as sustainable chemistry. Green Chemistry and sustainable chemistry are equals that helps to save and conserve resources. It decreases the effect of chemical products on human and atmospheric health. Green Chemistry gives 12 principles that reduce and prevent the utilization and manufacture of hazardous substance. These principles of green chemistry inform about the various issues related to production of chemical compound. Green Chemistry concept started approximately three decades ago. Green chemistry concept for the chemical synthesis and application launched in 1990. This review article purpose to study about Green chemistry and its application and how green chemistry connect to the phytochemistry.\u0000By establishing Green Aspiration Level (GAL) that is a quantifiable descriptor, process greenness becomes measurable. Green house gases and global warming are the problem that affected the human and environment health. Green chemistry is used in daily life mainly in medicines. Tree bark and Pine bark extracts are mostly used in anti-microbial, antioxidant and anticancer drugs. The matter that present in environment gives applicable things to the researchers and engineers for the changing and developing a sustainable culture. The word “Green chemistry” is given by the IUPAC which means: the invention, design and utilization of chemical product and process to reduce or to eliminate the use and production of unsafe substance.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Lubricants on Properties of Conventional Tablets of Antihypertensive Drugs from Different Biopharmaceutical Classification System 润滑剂对不同生物制药分类系统抗高血压药物常规片剂性能的影响

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-11-24 DOI: 10.22270/ajprd.v11i5.1303

Dindawar Kavita, B.M Supriya, Kolageri Shivanand

{"title":"Effect of Lubricants on Properties of Conventional Tablets of Antihypertensive Drugs from Different Biopharmaceutical Classification System","authors":"Dindawar Kavita, B.M Supriya, Kolageri Shivanand","doi":"10.22270/ajprd.v11i5.1303","DOIUrl":"https://doi.org/10.22270/ajprd.v11i5.1303","url":null,"abstract":"Background: Hypertension is a long-term medical condition in which blood pressure in the arteries is elevated. Hypertension causes coronary artery disease, stroke, heartfailure; kidney diseases etc.to over come hypertension, antihypertensive drugs are used. Objectives: The aim of present work was to find out effectsof lubricants on properties of conventionaltablets containing antihypertensive drugs from different BCS class. Antihypertensive drugs suchas Metoprolol succinate, and Atenolol were selected which represented BCS class I, and II respectively. Methods: Lubricants are the essential components of all solid dosage forms. Sodium stearyl fumarate, a hydrophilic lubricant was compared with Magnesium stearate,a conventional hydrophobic lubricant. Uncoatedtabletswereprepared either by direct compression or wet granulation technique employing sodium stearyl fumarate or magnesium stearate as a lubricant at 1% or 2%, mixing time of lubricants was varied as 3 and 6mins. Results: Irrespective of class of drug, concentration, mixing time and processing method sodium stearyl fumarate turned out to be effective as tablet lubricant than Magnesium stearate. Both the Lubricants, when used at lower concentration and shorter mixing time resulted in superior tablets properties.Direc tcompression method gave better results than wet granulation technique. Both Sodium stearyl fumarate and Magnesium stearate (1%, 3min) were subjected to storage at400± 20C/ 75% RH for 90 days to check effect of aging and storage. Conclusion: According to at the end of storage period up on investigating for different tablet properties there were no significan tchanges observed.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cytotoxic Activities of n-Hexane Extract of Pumpkin Seed (Cucurbita moschata) on WiDr Colon Cancer Cell and HeLa Cervical Cancer Cell 南瓜籽（Cucurbita moschata）正己烷提取物对 WiDr 结肠癌细胞和 HeLa 宫颈癌细胞的细胞毒活性

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1284

Annisa Krisridwany, Dhecella Winy Cintya Ningrum, Fitria Susilowati, Rima Octavia, A. Winanta

{"title":"The Cytotoxic Activities of n-Hexane Extract of Pumpkin Seed (Cucurbita moschata) on WiDr Colon Cancer Cell and HeLa Cervical Cancer Cell","authors":"Annisa Krisridwany, Dhecella Winy Cintya Ningrum, Fitria Susilowati, Rima Octavia, A. Winanta","doi":"10.22270/ajprd.v11i5.1284","DOIUrl":"https://doi.org/10.22270/ajprd.v11i5.1284","url":null,"abstract":"Colon cancer and cervical cancer are types of cancer with a high prevalence, contributing 10% and 3.1% respectively of the total new cancer cases. Nutrition and dietary factors play an important role in human carcinogenesis. Natural plants contain substances that can be beneficial to human health. One such plant is the pumpkin (Cucurbita moschata). Pumpkin seeds are thought to have many biological activities for health, such as antioxidant, anticancer, and anti-inflammatory effects. This study aimed to determine the cytotoxic activity of n-hexane extract of pumpkin seed against colon (WiDr) and cervical (HeLa) cancer cells using the MTT Assay method. The method used in this study consisted of the preparation of plant extracts, phytochemical screening, total content of metabolites. The results proved that the n-hexane extract of pumpkin seed was observed containing flavonoids, alkaloids, and steroids. The content of highest total content, namely flavonoid compounds as much as 616.46 mg/L. The n-hexane extract of pumpkin seed showed cytotoxic activity for WiDr cells and HeLa cells with an IC50 value of 193.44 µg/mL and 237.702 µg/mL, respectively. The results of this study can be concluded that n-hexane extract of pumpkin seed can be used as a chemopreventive agent, due to the moderate cytotoxic test results.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139319615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and Future Treatments, Prevention, Diagnosis on Retinoblastoma 视网膜母细胞瘤当前和未来的治疗、预防和诊断方法

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1319

Ashwin Singh Chouhan, Sohail Khan

{"title":"Current and Future Treatments, Prevention, Diagnosis on Retinoblastoma","authors":"Ashwin Singh Chouhan, Sohail Khan","doi":"10.22270/ajprd.v11i5.1319","DOIUrl":"https://doi.org/10.22270/ajprd.v11i5.1319","url":null,"abstract":"The most frequent intraocular cancer in children is retinoblastoma. All pediatric patients with retinoblastoma must undergo genetic testing as a crucial part of their treatment. Retinoblastoma can also extend to the brain and spine, among other parts of the body. MRI and CT scans are two imaging procedures that may be used to detect retinoblastoma. The size and location of the retinoblastoma tumor in your child determine the optimal course of treatment. Chemotherapy is a type of medication that can be used to treat cancer. Chemotherapy can aid in tumor reduction, enabling subsequent therapies like radiation therapy, cryotherapy, or laser therapy to target any remaining cancer cells. Early eye examinations are crucial for diagnosis and care. If detected early, retinal blastoma is frequently treatable. A hereditary mutation may cause retinal tumors (retinoblastoma). External beam radiation therapy, cryotherapy, laser photocoagulation, thermotherapy, brachytherapy, and chemotherapy (intravitreal, intra-arterial, and systemic) are now included in the treatment of retinoblastoma in addition to the damaged globe. Long-term side effects of radiation and chemotherapy in retinoblastoma patients can include secondary cancers.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139319687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Nutrition Intervention on Cognitive Function of Children Aged Between 6 and 12 Years – A Study from South India 营养干预对 6 至 12 岁儿童认知功能的影响 - 印度南部的一项研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1316

Dr. Anitha. R, Dr. Pa. Raajeswari

{"title":"The Effect of Nutrition Intervention on Cognitive Function of Children Aged Between 6 and 12 Years – A Study from South India","authors":"Dr. Anitha. R, Dr. Pa. Raajeswari","doi":"10.22270/ajprd.v11i5.1316","DOIUrl":"https://doi.org/10.22270/ajprd.v11i5.1316","url":null,"abstract":"Nutrition is a fundamental cornerstone of good health, productivity, and overall functional capacity. Food that is safe, plentiful, and nutritious is essential for child growth and development. Children who do not grow properly during childhood may not be able to compensate for the growth loss later in life, even with an adequate diet. This study aimed to evaluate the impact of supplementation of the formulated health mixes which weremade out of selected potential ingredients for undernourished children and nutrition education on child nutrition to their mothers. Based on the inclusion criteria, it is designed as an intervention study with 90 children aged 6 to 12 years. Children were divided into three groups (CG, EGI, and EGII), each with 30 children. The raw materials were obtained, processed, powdered, and blended to create a health mix for three months of supplementation. The children were able to take 50gm of health mix each day as mid-morning and mid-evening snacks in the form of ladoos. The results showed that the children in Experimental Group II who got health mix supplementation as well as health and nutrition education for their mothers improved in nutritional status and cognitive performance. This study provides fresh insights for future policy and intervention programs.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139319699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson Disease: A Review 帕金森病：综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1318

Annu Kumari, Muskan Gupta, Gaurav Rankawat, Abhishek Rankawat

引用次数: 0

Investigation of Anti Inflammatory Activity of Triphala Hydrogels in Carrageenan Induced Paw Edema Model 三叶草水凝胶在卡拉胶诱导的爪水肿模型中的抗炎活性研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1315

Sireesha Kalva, Neha Andhi, Ramya Sree Yenni, P. S. Ganesh, A. Madhu, M. Nihal

{"title":"Investigation of Anti Inflammatory Activity of Triphala Hydrogels in Carrageenan Induced Paw Edema Model","authors":"Sireesha Kalva, Neha Andhi, Ramya Sree Yenni, P. S. Ganesh, A. Madhu, M. Nihal","doi":"10.22270/ajprd.v11i5.1315","DOIUrl":"https://doi.org/10.22270/ajprd.v11i5.1315","url":null,"abstract":"Inflammation is a reaction of a living vascularized tissue to an injury, conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes has serious stroke effects. So, number of herbal medicines are recommended for the treatment of inflammation that has no side effects. Hence our study focused to investigate bioactive compounds for anti-inflammatory activity. Folk medicine and ethnopharmacological data can provide a broad range of plants with promising anti-inflammatory activity. Triphala, an ayurvedic formula composed of three different plants. Terminalia chebula Retz., Terminalia bellerica Roxb(Combretaceae) and Phyllanthus emblica L is widely used for various microbial infections. Triphala is now evaluated for its anti-inflammatory action. Triphala is formulated into a hydrogel of different concentrations and is evaluated for in-vitro anti-inflammatory activity by membrane stabilization method at 100, 250 and 500 mg/ml and in-vivo evaluation is done by Carrageenan -induced paw edema method. The results obtained are compared with standard NSAID diclofenac hydrogel. The prepared hydrogel of triphala showed a dose-dependent anti-inflammatory potential in in-vivo and in-vitro methods which provide scientific basis for anti-inflammatory activity of Triphala.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139319715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes of Abortions Occurring in Red Goats from Maradi, Tessaoua and Madarounfa-Niger 尼日尔马拉迪、泰索瓦和马达伦法红山羊流产的原因

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-13 DOI: 10.22270/ajprd.v11i5.1322

Mama Agnès Tea, L. Soromou, D. Tialla, Fati Mounkaila Moussa

引用次数: 0

The Public Health of Coffee for Wounds 咖啡治疗伤口的公共卫生

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-10-07 DOI: 10.47485/2694-5614.1021

引用次数: 0

Novel Terahertz-Based Radiation Treatment of Alzheimer Disease 新型太赫兹辐射治疗阿尔茨海默病

Asian Journal of Pharmaceutical Research and Development Pub Date : 2023-09-06 DOI: 10.47485/2694-5614.1020

{"title":"Novel Terahertz-Based Radiation Treatment of Alzheimer Disease","authors":"","doi":"10.47485/2694-5614.1020","DOIUrl":"https://doi.org/10.47485/2694-5614.1020","url":null,"abstract":"Alzheimer’s Disease Facts and Figures, an annual report released by the Alzheimer’s Association, reveals the burden of Alzheimer’s and dementia on individuals, caregivers, government and the nation’s health care system. Per the special report, More Than Normal Aging: Understanding Mild Cognitive Impairment (MCI), it is estimated 10% to 15% of individuals with MCI go on to develop dementia each year. Because of the narrow brain-blood barrier every medicine designed to treat Alzheimer’s failed due to inability of complex and large molecules to penetrate this barrier. Four steps of Alzheimer’s treatment by using proprietary Magtera Technology. First step: Detect the THz modes for Aβ42 Oligomer. or any other micro bio structures proven to be responsible for Alzheimer’s. The most probable THz modes would be intermolecular modes: librations, low frequency bond vibrations; hydrogen bond stretches and distortions; molecular rotations. There are plenty of such modes. Second step: detect the THz modes of healthy brain tissue. Third step: Find a THz window of penetration in brain fluids that corresponds to one of these modes by using the highly tunable THz Magnon Laser that bridges the THz Gap and covers the whole THz spectrum. Fourth step: Apply high power THz radiation by using the THz Magnon Laser at resonance frequencies that correspond to Aβ42 Oligomer molecular excitations but do nor coincide with THz modes of healthy brain tissue, and eradicate Aβ42 Oligomer molecules.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0