Asian Journal of Pharmaceutical Research and Development最新文献_第2页

New Insights in Topical Drug Delivery for Skin Disorders: A Review 皮肤病局部给药的新见解：综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1323

Madhurima Saini, Dr. Shiv Garg, Dr. Piush Sharma, Dr. Shailendra Bhatt

{"title":"New Insights in Topical Drug Delivery for Skin Disorders: A Review","authors":"Madhurima Saini, Dr. Shiv Garg, Dr. Piush Sharma, Dr. Shailendra Bhatt","doi":"10.22270/ajprd.v12i2.1323","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1323","url":null,"abstract":"Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs. The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. To address some of the limitations posed by conventional dermatotherapy, nano-based technologies have been developed and have demonstrated a significant improvement in dermatotherapy. Their distinct physicochemical properties demonstrate their overall superior therapeutic efficacy in providing sustained and effective targeted drug release, as well as improved solubility of hydrophobic actives with optimized drug formulations. These nanocarriers are commonly classified as polymeric, lipid-based, metallic, and vesicular nanocarriers, including nanoemulsions, nanofibers, and microneedles.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Approch for Nasal Drug Delivery System 鼻腔给药系统的新方法

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1383

Avinash Jadhav, Prof.Vishweshwar Dharashive, Dr.Sameer Shafi, Saiprasad Chavan, Madhav Honrao, Rahul Inje, Akshay Biradar

{"title":"A Novel Approch for Nasal Drug Delivery System","authors":"Avinash Jadhav, Prof.Vishweshwar Dharashive, Dr.Sameer Shafi, Saiprasad Chavan, Madhav Honrao, Rahul Inje, Akshay Biradar","doi":"10.22270/ajprd.v12i2.1383","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1383","url":null,"abstract":"The oral route is the most favored technique for administering the drug orally in the body. As a result of certain limitations such as drug absorption, poor bioavailability, first-pass hepatic metabolism and medicine target to particular organs, may cause problems for administration via oral route. Therefore parenteral route, transmucosal route and transdermal route are preferred over oral route. Intranasal route is deemed to be a desirable route because of the time profile of concentration a drug is close to that of the intravenous route. The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system .The in-situ gelling system is a process in which is in a solution form before the administration in the body but it converts in to a gel form after administration . The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. Therefore this review focuses on nasal drug delivery, a variety of aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review: A Comparative Study of Branded and Generic Anti-Hypertensive Drugs 综述：品牌和非专利抗高血压药物的比较研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1359

Anuksh Telrandhe, Ketakee Phadnis, Nilakshi Dhoble, Nitin Padole, Jagdish Baheti

{"title":"A Review: A Comparative Study of Branded and Generic Anti-Hypertensive Drugs","authors":"Anuksh Telrandhe, Ketakee Phadnis, Nilakshi Dhoble, Nitin Padole, Jagdish Baheti","doi":"10.22270/ajprd.v12i2.1359","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1359","url":null,"abstract":"This comprehensive review investigates the market landscape of antihypertensive medications, undertaking a detailed comparative analysis of branded and generic options. In the face of rising global prevalence of hypertension, the study aims to provide a holistic perspective on the efficacy, safety, and market dynamics shaping the use of branded and generic drugs in the management of these chronic conditions.\u0000Utilizing data derived from market trends, sales analytics, and consumer preferences, the review scrutinizes the market behaviors and forces influencing the adoption of branded and generic antihypertensive drugs. Factors such as cost-effectiveness, patient adherence, and healthcare provider preferences are explored to shed light on the complexities associated with medication selection in the context of chronic disease management.\u0000Through an in-depth examination of industry strategies, regulatory frameworks, and the role of healthcare policies, the review aims to uncover the interplay between market dynamics and clinical considerations. It seeks to inform healthcare professionals, policymakers, and industry stakeholders about the evolving landscape of choices in antihypertensive therapies, fostering a nuanced understanding that can guide optimal decision-making in patient care and resource allocation.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Effectiveness of Pre-Exposure Prophylaxis (PrEP) Use for HIV Prevention among High-Risk Populations 探索在高危人群中使用暴露前预防疗法 (PrEP) 预防艾滋病毒的有效性

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1333

Pallav Dave

{"title":"Exploring the Effectiveness of Pre-Exposure Prophylaxis (PrEP) Use for HIV Prevention among High-Risk Populations","authors":"Pallav Dave","doi":"10.22270/ajprd.v12i2.1333","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1333","url":null,"abstract":"Addressing the global burden of HIV requires effective preventative measures that have been shown to have high efficacy rates. PrEP is one of the preventative measures that is effective in preventing HIV. Different clinical trials and population studies have shown PrEPto have an efficacy rate of 40% to 90% when it comes to preventing HIV. Due to its high efficacy, PrEPcan reduce new HIV infections populations considered to be high risk. However, for efficacy to be high, there is a need to increase medication adherence and address the existing barriers that limit uptake. Some of these barriers are lack of knowledge, inadequate access, stigma,lack of trust in service providers, low perception of HIV risk, cost, and fear of side effects. Addressing these barriers can increase PrEP uptake and help in reducing HIV’s risk among high-risk populations. Some of the measures that can be put in place to address these barriers are providing education and training, allocating enough resources, leveraging technology, lowering PrEP costs, increasing insurance coverage, and improving communication among the targeted population.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, NMR and Mass Characterization of Ducose - A Novel Tetrasaccharide from Goat Milk 山羊奶中的一种新型四糖--杜酮糖的分离、核磁共振和质量特性分析

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1370

Pushpraj Singh

{"title":"Isolation, NMR and Mass Characterization of Ducose - A Novel Tetrasaccharide from Goat Milk","authors":"Pushpraj Singh","doi":"10.22270/ajprd.v12i2.1370","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1370","url":null,"abstract":"Milk is an excellent source of all the necessary nutrients in the proper proportions. Besides the other regular constituents it has oligosaccharides in it which are indigestible by the infant yet are consumed by the microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal micro biota, often associated with bifidobacteria. Goat milk is a rich source of oligosaccharides that have enormous biological activities such as anti-bacterial, immunological, anti-inflammatory, hypoallergenic and therapeutic properties. It is used against tuberculosis in folk medicine and also helps in the enhancement of platelet count during dengue fever. Goat milk oligosaccharides have anti-inflammatory properties and are involved in the repairing process after a dextran sodium sulphate-induced colitis. Keeping in mind the biological importance of goat milk and the role of oligosaccharides, in the present studies, goat milk was analyzed for its oligosaccharide content which led to the isolation of a novel tetrasaccharide, ducose, C28H48O21N2. The structure of the isolated oligosaccharide was elucidated by chemical transformation, chemical degradation, 1H, 13C, 2D-NMR (COSY, TOCSY, HMBC and HSQC) and mass spectrometry as under.\u0000The geometry of compound ducose was optimized by B3LYP method and 6-31 G (d,p) basis set.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble Epoxide Hydrolase 可溶性环氧化物水解酶

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1369

Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive

引用次数: 0

A Case study- Jalaukavacharan-Leech Therapyin management of Vranagranthi (Keloid) 病例研究--Jalaukavacharan-Leech疗法在治疗瘢痕疙瘩（Vranagranthi）中的应用

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1377

Dr. Sejal B.Padvi, Dr. Rajesh Kumar Sharma

{"title":"A Case study- Jalaukavacharan-Leech Therapyin management of Vranagranthi (Keloid)","authors":"Dr. Sejal B.Padvi, Dr. Rajesh Kumar Sharma","doi":"10.22270/ajprd.v12i2.1377","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1377","url":null,"abstract":"Keloid is a type of scar that results from the overgrowth of dense fibrous tissue which is usually develops after healing of a skin injury. In other words, it represents an abnormal scar formation. The tissue extends beyond the borders of the original wound and does not usually regress spontaneously. It causes cosmetic deformity, itching, pain, and stress ultimately resulting in compromised quality of life and diminished functional performance. The treatment of Keloid is often difficult because there is an associated high risk of recurrence. Vrana represents a vast part of Shalyatantra and the pathogenesis of Keloid is similar to Vrana granthi which has been explained as a growth of mass at the site of Vrana following dietetic complications or any physical irritation in a Vrana patient. Jalaukavacharana (leech therapy) is a parasurgical type of Raktamokshana and is considered as the most unique and effective method of bloodletting. Leeches are widely used in most disorders ranging from skin disease with evidence of successful results. In the present paper, an effort has been made to case of keloid that have been conducted in Ayurveda as para surgical procedure.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Concise Review on Contemporary and Novel Treatments Addressing the Prevention and Control of Hyperpigmentation 预防和控制色素沉着的当代新型疗法简明综述

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1363

Jagdale Onkar Nandraj, Khule Ashwini Gajanan, Dr. K.M. Karande

{"title":"A Concise Review on Contemporary and Novel Treatments Addressing the Prevention and Control of Hyperpigmentation","authors":"Jagdale Onkar Nandraj, Khule Ashwini Gajanan, Dr. K.M. Karande","doi":"10.22270/ajprd.v12i2.1363","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1363","url":null,"abstract":"Hyperpigmentation is a common skin condition characterized by the darkening of certain areas of the skin due to an excess production of melanin. This condition can be caused by a variety of factors, including sun exposure, hormonal changes, inflammation, and skin injuries. Hyperpigmentation can have a significant impact on a person's self-esteem and quality of life. Hormonal changes, such as those experienced during pregnancy or menopause, can also lead to hyperpigmentation. Inflammation from conditions like acne or eczema can cause the skin to produce excess melanin, resulting in dark spots or patches. Additionally, skin injuries, such as cuts or burns, can trigger the body to produce more melanin as part of the healing process, leading to hyperpigmentation. Creams containing ingredients like hydroquinone, retinol, or vitamin C can help lighten dark spots and even out skin tone. Medications containing corticosteroids, may be recommended for more severe cases of hyperpigmentation. In addition, novel drug delivery systems such as liposomes, Transferosomes, Niosomes etc. have shown better penetration topically hence they can be used to treat pigmentation. Understanding the causes of hyperpigmentation and seeking appropriate treatment can help improve the overall health and appearance of the skin. By addressing the underlying factors contributing to hyperpigmentation and using targeted skincare products or treatments, individuals can achieve a more even complexion and feel more confident in their skin.\u0000Background: The topic of hyperpigmentation is of significant interest in dermatology and cosmetology due to its widespread prevalence and impact on individuals' skin health and appearance.several traditional treatments such as topical hydroquinone and retinoids have been utilized for managing hyperpigmentation, there is an increasing recognition of the need for more effective and targeted intervention.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Child maltreatment and mental health- Ayurveda perspective 虐待儿童与心理健康--阿育吠陀的观点

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1361

Preetha Karuvanthodi, Jithesh M

{"title":"Child maltreatment and mental health- Ayurveda perspective","authors":"Preetha Karuvanthodi, Jithesh M","doi":"10.22270/ajprd.v12i2.1361","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1361","url":null,"abstract":"Child maltreatment is a pervasive and complex societal issue that encompasses various forms of abuse and neglect, posing significant threats to the well-being and development of children worldwide. The World Health Organization (WHO) defines child maltreatment as “all forms of physical and emotional ill-treatment, sexual abuse, neglect, and exploitation that results in actual or potential harm to the child’s health, development or dignity.” Abuse of children can have serious short and long term effects on physical, sexual, and mental health. These include physical harm, such as concussions and severe disabilities, especially in young children, as well as anxiety, sadness, and post-traumatic stress disorder. Child abuse has a strong correlation with alcohol and drug usage and can impact cognitive and academic performance.Priority must be for protecting and preserving the safety of abused children. The goals of ongoing treatment are to lessen the long-term psychological and physical effects of abuse as well as preventing reoccurrence.\u0000Child maltreatment is a global concern with profound implications for the physical, emotional, and psychological well-being of children. While conventional approaches in the field of child protection have made significant strides, there is growing interest in exploring complementary practices, such as Ayurveda, to enhance the overall well-being of maltreated children. The potential role of Ayurveda in addressing child maltreatment, considering its ancient roots in promoting holistic health and balance is to be highlighted.\u0000Ayurveda also proposes the principles for taking care of childhood and preventing maltreatment for them. Therapies, including herbal remedies, massage, and meditation is having the potential in managing and rehabilitating the children affected by maltreatment. Ayurveda focuses in addressing not only physical symptoms but also mental and emotional aspects that aligns with the comprehensive needs of maltreated children.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Jatyadi Taila Uttarbasti in the Management of Urethral Stricture a Single Case Study Jatyadi Taila Uttarbasti 在治疗尿道狭窄方面的疗效--单个病例研究

Asian Journal of Pharmaceutical Research and Development Pub Date : 2024-04-15 DOI: 10.22270/ajprd.v12i2.1366

D. Varsadiya, Dr.Rajeshkumar Sharma, D. Kanani

{"title":"Efficacy of Jatyadi Taila Uttarbasti in the Management of Urethral Stricture a Single Case Study","authors":"D. Varsadiya, Dr.Rajeshkumar Sharma, D. Kanani","doi":"10.22270/ajprd.v12i2.1366","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1366","url":null,"abstract":"In Ayurveda, Acharya Sushrut mentioned an excellent treatment named Uttarbasti for urethral stricture known as Mutrakruccha in classical scriptures. Mutrakruccha translates to difficulty in micturition. It can be associated with urethral stricture due to the similarity of symptoms. Urethral stricture disease is often seen in patients with recurrent urinary tract infections, urethral injuries, or post-surgical procedures conducted through the urethra. The most common causes of urethral stricture today are traumatic or iatrogenic. Inflammatory or infectious, malignant, and congenital aetiologies are less common. There is a low success rate of Western medical science treatment for urethral stricture disease. Surgical treatment of urethral stricture disease is indicated when the patient has severe voiding symptoms, bladder calculi, increased postvoid residual, urinary tract infection, or when conservative management fails. Urinary tract infections (UTIs) should be adequately treated before surgical intervention. In this case study, a 39-year-old male patient complained of suffering from symptoms like the strangury of urine, pain during micturition, the flow of urine is very poor, frequent micturition and occasionally burning micturition. After clinical examination and radiological testing, the patient was identified as having urethral stricture and treated with Jatyadi Taila Uttarbasti for 21 days at Shalyatantra OPD, Government Akhandanand Ayurved College and Hospital, Ahmedabad. After completion of treatment, the patient felt 75% relief in symptoms. So, we can conclude that non-invasive treatment such as Uttarbasti is highly advisable in patients having Urethral stricture.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0