Laboratory hematology : official publication of the International Society for Laboratory Hematology最新文献_第2页

Platelet hyperreactivity: report of a case with catastrophic arterial thrombosis in a child. 血小板高反应性:儿童灾难性动脉血栓形成1例报告。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-12-01 DOI: 10.1532/LH96.12006

Elizabeth F Plocharczyk, Sarah H O'Brien, Jill L Crumbacher, Samir B Kahwash

引用次数: 0

Infantile pyknocytosis: an under-recognized form of neonatal hemolytic anemia? 婴儿红细胞增多症:一种未被认识的新生儿溶血性贫血?

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-12-01 DOI: 10.1532/LH96.12005

Maria Coutinho, Emília Costa, Tânia Monteiro, Gisela Silva, Helena Costa, Ana Guedes, Inês Freitas, José Barbot

引用次数: 3

Biology and bioinformatics of myeloma cell. 骨髓瘤细胞的生物学和生物信息学。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-12-01 DOI: 10.1532/LH96.11003

Saeid Abroun, Najmaldin Saki, Rahim Fakher, Farahnaz Asghari

引用次数: 11

Best practices for use of the HEMOX analyzer in the clinical laboratory: quality control determination and choice of anticoagulant. 临床实验室使用haemx分析仪的最佳实践:质量控制测定和抗凝血剂的选择。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-09-01 DOI: 10.1532/LH96.12001

Derek L Vanhille, Roberto H Nussenzveig, Christopher Glezos, Sherrie Perkins, Archana M Agarwal

引用次数: 8

Clinically silent massive fetomaternal hemorrhage: important lessons from an illustrative case. 临床无症状的母婴大出血:一个典型病例的重要教训。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-06-01 DOI: 10.1532/LH96.12002

Ginell R Post, John Lazarchick, Zeba N Singh

引用次数: 0

Reactive hemophagocytic syndrome caused by Rickettsial infection: report of a case. 立克次体感染致反应性噬血细胞综合征1例报告。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-06-01 DOI: 10.1532/LH96.11008

S Anoun, Y Traoue, A Ouled Lahcen, K Gamraoui, S Faez, B Oukkache

引用次数: 3

Study of survivin and X-linked inhibitor of apoptosis protein (XIAP) genes in acute myeloid leukemia (AML). 急性髓性白血病(AML)中survivin和X-linked inhibitor of apoptosis protein (XIAP)基因的研究。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2012-03-01 DOI: 10.1532/LH96.11005

Azza Mostafa Ibrahim, Iman Maher Mansour, Manal Michel Wilson, Doha Abdel-Hamid Mokhtar, Amani Mohamed Helal, Hanan Mohamed Al Wakeel

{"title":"Study of survivin and X-linked inhibitor of apoptosis protein (XIAP) genes in acute myeloid leukemia (AML).","authors":"Azza Mostafa Ibrahim, Iman Maher Mansour, Manal Michel Wilson, Doha Abdel-Hamid Mokhtar, Amani Mohamed Helal, Hanan Mohamed Al Wakeel","doi":"10.1532/LH96.11005","DOIUrl":"https://doi.org/10.1532/LH96.11005","url":null,"abstract":"Apoptosis deregulation is important for cancer development, chemotherapy response, and prognosis. Survivin and X-linked inhibitor of apoptosis protein (XIAP) are 2 members of the inhibitor of apoptosis proteins family (IAP). We used semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to determine the levels of expression of survivin and XIAP in 30 patients with de novo acute myeloid leukemia (AML) and 20 age- and sex-matched healthy volunteers. Survivin and XIAP overexpression were detected in 36.7% and 43.3% of cases, respectively. Patients with overexpression of either survivin or XIAP showed unfavorable response to chemotherapy in 81.2% and 91.7%, respectively. Also, these cases showed shorter median survival time (30 days) compared to patients with normal expression of either survivin or XIAP (150 days and 180 days). Patients with overexpression of both survivin and XIAP showed unfavorable response to induction therapy in 100% of the patients and the shortest median survival (30 days). These findings suggest that survivin and XIAP may have a role in leukemogenesis and provide prognostic information.","PeriodicalId":85078,"journal":{"name":"Laboratory hematology : official publication of the International Society for Laboratory Hematology","volume":"18 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30538973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Burkitt's leukemia with an atypical immunophenotype: report of a case and review of literature. 伯基特白血病伴非典型免疫表型:1例报告及文献复习。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2011-12-01 DOI: 10.1532/LH96.11004

Neil J Rawlinson, Peter Baker, Samir B Kahwash

{"title":"Burkitt's leukemia with an atypical immunophenotype: report of a case and review of literature.","authors":"Neil J Rawlinson, Peter Baker, Samir B Kahwash","doi":"10.1532/LH96.11004","DOIUrl":"https://doi.org/10.1532/LH96.11004","url":null,"abstract":"Burkitt's leukemia (BL) constitutes a small but important fraction of acute leukemias in children. It is an aggressive type of leukemia that is responsive to high-intensity, short-duration chemotherapy with complete remission possible in 75% to 90% of cases. The recognition and proper designation of BL is important because treatment differs from that of precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Burkitt's leukemia is separated by its typical morphologic features (blasts with typical French-American-British [FAB] L-3 morphology compared to FAB L-1/L-2 morphology in pre-B ALL) and a classic immunophenotype (blast positivity for CD45 [bright], CD20 [bright], CD10, CD19, surface immunoglobulin [SIg], Ig light chain restriction, and negative terminal deoxynucleotidyl transferase [TdT]) compared to pre-B ALL blasts (which are positive for CD45 [dim], CD10, CD19, and TdT and negative for CD20 and SIg). The diagnosis of Burkitt's leukemia is confirmed by the characteristic cytogenetic findings.The combination of Burkitt's morphology with precursor B-cell immunophenotype may present a diagnostic pitfall, resulting in delay of proper management.We describe such an atypical case in a 12-year-old girl and emphasize that correct classification and treatment starts with proper morphologic/immunophenotypic correlation, and the awareness of the overlapping features in some cases.","PeriodicalId":85078,"journal":{"name":"Laboratory hematology : official publication of the International Society for Laboratory Hematology","volume":"17 4","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30341855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Detection of morphologic changes in peripheral mononuclear cells in hepatitis B virus infection using the beckman coulter LH 750. 利用beckman coulter lh750检测乙型肝炎病毒感染外周血单核细胞形态学变化。

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2011-09-01 DOI: 10.1532/LH96.09013

Y Zhu, X Cao, D Xu

{"title":"Detection of morphologic changes in peripheral mononuclear cells in hepatitis B virus infection using the beckman coulter LH 750.","authors":"Y Zhu, X Cao, D Xu","doi":"10.1532/LH96.09013","DOIUrl":"https://doi.org/10.1532/LH96.09013","url":null,"abstract":"The Beckman Coulter LH 750 with VCS technology can determine intrinsic biophysical properties of peripheral leukocytes in their \"near native state.\" We investigated the possibility of the LH 750 to detect morphologic changes in lymphocytes/monocytes in hepatitis B virus (HBV) infection. The VCS data from 37 active HBV patients, 140 HBV carriers, and 655 controls were analyzed. We observed significant increases in lymphocyte volume (LV) and the lymphocyte volume SD (LV-SD), and a significant decrease in lymphocyte conductivity (LC) in HBV infection, compared with controls. Similar changes in monocyte volume and conductivity were also observed. A simplified parameter, the Lymph-Index (calculated as [LV LV-SD]/LC]) is proposed. The Lymph-Index was significantly increased in HBV carriers compared with controls (13.86 ± 2.73 versus 11.83 ± 1.36; P < .001). The increase was more pronounced in patients with active HBV infection (18.84 ± 3.88 versus 11.83 ± 1.36; P < .0001). With a cutoff value of 18.2 for the Lymph-Index, a 91.7% sensitivity and a 95.7% specificity were achieved in diagnosing active HBV infection. This overall sensitivity and specificity were superior to those of the individual lymphocyte/monocyte VCS parameters. In conclusion, VCS parameters can reflect the morphologic changes of lymphocytes/monocytes in HBV infection and may be useful clinically to aid in identifying HBV infection in a population with a high HBV prevalence.","PeriodicalId":85078,"journal":{"name":"Laboratory hematology : official publication of the International Society for Laboratory Hematology","volume":"17 3","pages":"22-6"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30156207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Laboratory hematology : official publication of the International Society for Laboratory Hematology Pub Date : 2011-06-01 DOI: 10.1532/LH96.11-001

A Girolami, G Berti de Marinis, E Bonamigo, S Vettore

{"title":"Similarities and discrepancies in homozygous factor VII defects due to mutations in the region of residues Met298 to Cys310 (exon 8) in the catalytic domain of factor VII.","authors":"A Girolami, G Berti de Marinis, E Bonamigo, S Vettore","doi":"10.1532/LH96.11-001","DOIUrl":"https://doi.org/10.1532/LH96.11-001","url":null,"abstract":"Patients with the Arg304Gln mutation in factor VII Padua (FVII Padua) show discrepant activity levels that depend on the thromboplastin used in the assay system. This report investigates the possibility that residues close to Arg304 (exon 8) show the same discrepant behavior. All available homozygous patients with a mutation in a 13-residue region (preceding and following Arg304) have been evaluated. Only the Arg304Trp mutation showed a discrepancy similar to that shown by the Arg304Gln mutation. Other homozygotes failed to show differences, despite their all being positive for cross-reacting material. Another FVII amino acid residue involved in tissue factor binding and activation is Arg79 (exon 4). No comparison could be carried out because no homozygotes for deficiency in this region have ever been described. The relationship between these 2 residues involved in tissue factor binding and activation has not yet been completely clarified; however, Arg residues 79 and 304 are the only 2 residues definitely shown thus far to be involved in this important function.","PeriodicalId":85078,"journal":{"name":"Laboratory hematology : official publication of the International Society for Laboratory Hematology","volume":"17 2","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29963111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2