Asian journal of anesthesiology最新文献_第5页

Comparison of Caudal Dexmedetomidine and Midazolam as an Adjuvant to Ropivacaine for Postoperative Pain Relief in Children Undergoing Infra-Umbilical Surgeries: A Randomized Controlled Trial. 比较腹腔注射右美托咪定和咪达唑仑作为罗哌卡因的辅助药物为接受腹腔内手术的儿童术后止痛：随机对照试验。

Asian journal of anesthesiology Pub Date : 2023-06-01 Epub Date: 2023-01-01 DOI: 10.6859/aja.202306_61(2).0006

Arunima M Mohan, Ankur Sharma, Shilpa Goyal, Nikhil Kothari, Raksha Vyas, Akhil Dhanesh Goel, Priyanka Sethi, Kamlesh Kumari, Pradeep Bhatia

{"title":"Comparison of Caudal Dexmedetomidine and Midazolam as an Adjuvant to Ropivacaine for Postoperative Pain Relief in Children Undergoing Infra-Umbilical Surgeries: A Randomized Controlled Trial.","authors":"Arunima M Mohan, Ankur Sharma, Shilpa Goyal, Nikhil Kothari, Raksha Vyas, Akhil Dhanesh Goel, Priyanka Sethi, Kamlesh Kumari, Pradeep Bhatia","doi":"10.6859/aja.202306_61(2).0006","DOIUrl":"10.6859/aja.202306_61(2).0006","url":null,"abstract":"Background: We explored the analgesic efficacy of two non-opioid adjuvants (midazolam and dexmedetomidine) with ropivacaine in children undergoing infraumbilical surgeries.Methods: In this parallel group randomized controlled trial, 135 children aged between 2 and 8 years were recruited. Children were randomly allocated to one of three groups: RD received 1 mL/kg of ropivacaine (0.2%) with dexmedetomidine 1 μg/kg, RM received 1 mL/kg of ropivacaine (0.2%) with midazolam 30 µg/kg, and R received 1 mL/kg of ropivacaine (0.2%) with 1 mL normal saline. The primary outcome of the present study was to determine the duration of postoperative analgesia. Secondary outcomes were assessing postoperative face, leg, activity, cry, consolability (FLACC) pain score, rescue analgesics, hemodynamics, sedation scores, and adverse effects.Results: The analgesia duration was significantly prolonged in the RD and RM group (600.0 [480.0-720.0] minutes and 600.0 [480.0-720.0] minutes, respectively) compared to the R group 360.0 (300.0-480.0) minutes (P < 0.001). The FLACC score was comparatively higher in the R group compared to the RD and RM groups postoperatively. Time for the first rescue analgesia was more prolonged in RD and RM groups when compared with the R group. Postoperative sedation was higher in the RM group up to 120 minutes postoperatively compared to the RD and R groups.Conclusion: The combination of dexmedetomidine or midazolam with local anesthetics significantly increases the analgesia duration while minimizing adverse effects.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"61 2","pages":"89-101"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10209689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Intravenous Dexmedetomidine on Hemodynamic Responses to Pneumoperitoneum During Laparoscopic Cholecystectomy. 静脉注射右美托咪定对腹腔镜胆囊切除术中气腹血流动力学反应的影响。

Asian journal of anesthesiology Pub Date : 2023-06-01 DOI: 10.6859/aja.202306_61(2).0004

Rashna Shakya, Shyam Krishna Maharjan

{"title":"Effects of Intravenous Dexmedetomidine on Hemodynamic Responses to Pneumoperitoneum During Laparoscopic Cholecystectomy.","authors":"Rashna Shakya, Shyam Krishna Maharjan","doi":"10.6859/aja.202306_61(2).0004","DOIUrl":"https://doi.org/10.6859/aja.202306_61(2).0004","url":null,"abstract":"Background: Dexmedetomidine is a potent α_2 agonist which has been used for blunting the stress responses during critical events such as laryngoscopy, endotracheal intubation, pneumoperitoneum creation, and extubation. The purpose of this study was to see the efficacy of intravenously administered dexmedetomidine at a dose of 0.5 mcg/kg in attenuating the hemodynamic responses due to pneumoperitoneum during laparoscopic cholecystectomy under general anesthesia.Methods: Sixty patients, ASA-PS class I (American Society of Anesthesiologist physical status class I), aged between 18 and 60 years, of either sex with weight ranging from 50 to 80 kg, scheduled for laparoscopic cholecystectomy were randomized into two groups (groups A and B) in a double-blinded fashion. Both groups were pre-medicated with an injection glycopyrrolate. Group A received 100 mL normal saline (NS) over 10 minutes while group B received dexmedetomidine 0.5 mcg/kg diluted in 100 mL NS over 10 minutes before induction of general anesthesia. Heart rate, systolic, diastolic, and mean arterial pressures were noted.Results: Following pneumoperitoneum, there was no statistically significant difference in the hemodynamic parameters between the two groups (P > 0.05).Conclusion: Administration of dexmedetomidine at a dose of 0.5 mcg/kg before induction did not blunt the hemodynamic responses to pneumoperitoneum during laparoscopic cholecystectomy.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"61 2","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10607245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Styletubation: The Paradigmatic Role of Video-Assisted Intubating Stylet Technique for Routine Tracheal Intubation. 样式插管:视频辅助插管样式技术在常规气管插管中的典范作用。

Asian journal of anesthesiology Pub Date : 2023-06-01 DOI: 10.6859/aja.202306_61(2).0007

Hsiang-Ning Luk, Jason Zhensheng Qu, Alan Shikani

引用次数: 0

Truncal Blocks for Emergency Laparotomy in a High-Risk Patient: A Case Report and Literature Review. 高危病人急诊剖腹手术的截骨阻滞:1例报告及文献复习。

Asian journal of anesthesiology Pub Date : 2023-05-04 DOI: 10.6859/aja.202305/PP.0002

Y. Koyama, Kei Morita, Yoriko Murase, Haruko Nishikawa, K. Tsuzaki

引用次数: 0

Injection Site Reactions Before and After Intramuscular Injection Technique Revision: A Postmarketing Analysis of NALDEBAIN® From 2017 to 2022. 肌内注射技术修订前后注射部位反应:2017 - 2022年NALDEBAIN®上市后分析

Asian journal of anesthesiology Pub Date : 2023-05-04 DOI: 10.6859/aja.202305/PP.0001

K. Man, Sing-Ong Lee, Chueng-He Lu, Chih-Shung Wong, Wei-Zen Sun

{"title":"Injection Site Reactions Before and After Intramuscular Injection Technique Revision: A Postmarketing Analysis of NALDEBAIN® From 2017 to 2022.","authors":"K. Man, Sing-Ong Lee, Chueng-He Lu, Chih-Shung Wong, Wei-Zen Sun","doi":"10.6859/aja.202305/PP.0001","DOIUrl":"https://doi.org/10.6859/aja.202305/PP.0001","url":null,"abstract":"BACKGROUND\u0000The NALDEBAIN® has been available since 2017, and high incidence of injection reactions in the phase 3 study has been reported. Since the first year in the market, the injection site reactions were still the majority of adverse drug reactions (ADRs) in pharmacovigilance reports. The new intramuscular (IM) instruction and package was introduced in the middle of 2018. In this retrospective study, we analyzed the pharmacovigilance data and published postmarketing studies to investigate the impact of IM injection-related reactions in Taiwan between the period of 2017-2022.\u0000\u0000\u0000METHODS\u0000Individual case safety reports (ICSRs) and ADRs were classified by system organ class and preferred term. The reporting rate of ICSRs was used to evaluate the impact of the new IM instruction and package.\u0000\u0000\u0000RESULTS\u0000A total of 37 ICSRs were identified from pharmacovigilance reports. Among them, 51% of IM injection-related reactions were reported after one single dose of NALDEBAIN administration. The reporting rate of IM injection-related reactions in pharmacovigilance data dropped from 125.00 to 3.56 per ten thousand exposures after IM instruction and package revision in 2018. In addition, the percentage of IM injection-related reactions also reduced in postmarketing studies from 27.5% to 4.5%. There were no serious IM injection-related reactions found in the pharmacovigilance and postmarketing dataset.\u0000\u0000\u0000CONCLUSION\u0000Injection site reactions were common after intramuscularly administered oil-based agents during the first year which is later markedly reduced by changing the length of the needle and injection education.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42810094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Styletubation: The Paradigmatic Role of Video-Assisted Intubating Stylet Technique for Routine Tracheal Intubation. 触针插管：视频辅助插管触针技术在常规气管插管中的示范作用。

Asian journal of anesthesiology Pub Date : 2023-04-20 DOI: 10.6859/aja.202304/PP.0001

H. Luk, J. Qu, A. Shikani

引用次数: 2

Truncal Blocks for Emergency Laparotomy in a High-Risk Patient: A Case Report and Literature Review. 高危病人急诊剖腹手术的截骨阻滞:1例报告及文献复习。

Asian journal of anesthesiology Pub Date : 2023-03-01 DOI: 10.6859/aja.202303_61(1).0004

Yukihide Koyama, Kei Morita, Yoriko Murase, Haruko Nishikawa, Koichi Tsuzaki

{"title":"Truncal Blocks for Emergency Laparotomy in a High-Risk Patient: A Case Report and Literature Review.","authors":"Yukihide Koyama, Kei Morita, Yoriko Murase, Haruko Nishikawa, Koichi Tsuzaki","doi":"10.6859/aja.202303_61(1).0004","DOIUrl":"https://doi.org/10.6859/aja.202303_61(1).0004","url":null,"abstract":"In critically ill patients undergoing laparotomy, both general anesthesia (GA) and central neuraxial block (CNB) may pose significant risks. Peripheral truncal blocks have been reported to provide effective postoperative analgesia following laparotomy. However, there are a limited number of reports describing this technique as surgical anesthesia for laparotomy. An 86-year-old man with non-specific interstitial pneumonia under home oxygen therapy and aortic valve stenosis was diagnosed with an incarcerated inguinal hernia. Because of these comorbidities, both GA and CNB were considered relatively contraindicated. Thus, we chose an ultrasound-guided transverse abdominis plane block and ilioinguinal/iliohypogastric block supplemented with neuroleptanesthesia as surgical anesthesia for emergency laparotomy. The surgery was uneventful using this technique. Truncal blocks supplemented with titrated intravenous sedatives/analgesics could be an alternative in high-risk patients undergoing laparotomy in whom both GA and CNB are considered relatively contraindicated.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"61 1","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10261314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injection Site Reactions Before and After Intramuscular Injection Technique Revision: A Postmarketing Analysis of NALDEBAIN® From 2017 to 2022. 肌内注射技术修订前后注射部位反应:2017 - 2022年NALDEBAIN®上市后分析

Asian journal of anesthesiology Pub Date : 2023-03-01 DOI: 10.6859/aja.202303_61(1).0002

Kee-Ming Man, Sing-Ong Lee, Chueng-He Lu, Chih-Shung Wong, Wei-Zen Sun

{"title":"Injection Site Reactions Before and After Intramuscular Injection Technique Revision: A Postmarketing Analysis of NALDEBAIN® From 2017 to 2022.","authors":"Kee-Ming Man, Sing-Ong Lee, Chueng-He Lu, Chih-Shung Wong, Wei-Zen Sun","doi":"10.6859/aja.202303_61(1).0002","DOIUrl":"https://doi.org/10.6859/aja.202303_61(1).0002","url":null,"abstract":"Background: The NALDEBAIN® has been available since 2017, and high incidence of injection reactions in the phase 3 study has been reported. Since the first year in the market, the injection site reactions were still the majority of adverse drug reactions (ADRs) in pharmacovigilance reports. The new intramuscular (IM) instruction and package was introduced in the middle of 2018. In this retrospective study, we analyzed the pharmacovigilance data and published postmarketing studies to investigate the impact of IM injection-related reactions in Taiwan between the period of 2017-2022.Methods: Individual case safety reports (ICSRs) and ADRs were classified by system organ class and preferred term. The reporting rate of ICSRs was used to evaluate the impact of the new IM instruction and package.Results: A total of 37 ICSRs were identified from pharmacovigilance reports. Among them, 51% of IM injection-related reactions were reported after one single dose of NALDEBAIN administration. The reporting rate of IM injection-related reactions in pharmacovigilance data dropped from 125.00 to 3.56 per ten thousand exposures after IM instruction and package revision in 2018. In addition, the percentage of IM injection-related reactions also reduced in postmarketing studies from 27.5% to 4.5%. There were no serious IM injection-related reactions found in the pharmacovigilance and postmarketing dataset.Conclusion: Injection site reactions were common after intramuscularly administered oil-based agents during the first year which is later markedly reduced by changing the length of the needle and injection education.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"61 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10126370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Risks to Pregnant Anesthesia Trainees and Physicians: Are We Ignoring Something Important? 怀孕麻醉培训生和医生的职业风险:我们是否忽视了一些重要的事情?

Asian journal of anesthesiology Pub Date : 2023-03-01 DOI: 10.6859/aja.202303_61(1).0001

Mishu Mangla, Deepak Singla

引用次数: 0

Low Versus High Stroke Volume Variation-Guided and Reduction of Postoperative Complications After Liver Resection: A Randomized Clinical Trial. 肝脏切除术后，低冲程量与高冲程量变化引导并减少术后并发症：随机临床试验。

Asian journal of anesthesiology Pub Date : 2023-03-01 Epub Date: 2023-01-01 DOI: 10.6859/aja.202303_61(1).0003

Kai-Wei Hsieh, Wei-Yu Chen, Yuan-Yi Chia

{"title":"Low Versus High Stroke Volume Variation-Guided and Reduction of Postoperative Complications After Liver Resection: A Randomized Clinical Trial.","authors":"Kai-Wei Hsieh, Wei-Yu Chen, Yuan-Yi Chia","doi":"10.6859/aja.202303_61(1).0003","DOIUrl":"10.6859/aja.202303_61(1).0003","url":null,"abstract":"Background: Liver surgery is a major abdominal operation associated with a dramatic change in intraoperative hemodynamics; thus, the infusion strategy is challenging for anesthesiologists. Studies have demonstrated that stroke volume variation (SVV) can be used to predict fluid responsiveness during major abdominal surgery. SVV can be used as a guide for the administration of intraoperative fluids to improve postoperative prognosis. In the present study, we planned to investigate whether high- or low-SVV in liver surgery is associated with fewer postoperative complications.Methods: This study was a prospective randomized trial of 74 patients who underwent hepatectomy. The patients were divided into two groups for SVV-guided infusion during tumor resection surgery using a low-SVV (≤ 10%, n = 37) or high-SVV (> 10%, n = 37) strategy. The primary outcome was postoperative complications, namely infection, pleural effusion, and atelectasis. The secondary outcomes were differences in perioperative physiological variables and postoperative pain.Results: No differences in postoperative complications within 30 days of surgery were observed between the low-SVV and high-SVV groups. However, we observed lower estimated glomerular filtration rates (eGFRs) and higher alanine transaminase (ALT) levels in the high-SVV group after surgery.Conclusion: Patients who underwent major liver tumor resection with the low-SVV or high-SVV strategy exhibited no differences in postoperative complications (48.6% vs. 45.9%; P > 0.999). However, in the high-SVV group, postoperative eGFRs were lower and ALT levels were higher.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"61 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0