Marina Ayres Delgado, Paul Holzmann Neto, André Luis Vieira Drumond, Geovana Torres de Souza, André Dos Santos Mendonça, Camila Gomes Dall'Aqua, Bruna Carvalho Oliveira, Bruno Vinícius Castello Branco, Samuel Loureiro Gontijo, David Ribeiro do Nascimento
{"title":"Adverse Effects of Chemotherapy and the Interaction With Anesthesia: A Narrative Review.","authors":"Marina Ayres Delgado, Paul Holzmann Neto, André Luis Vieira Drumond, Geovana Torres de Souza, André Dos Santos Mendonça, Camila Gomes Dall'Aqua, Bruna Carvalho Oliveira, Bruno Vinícius Castello Branco, Samuel Loureiro Gontijo, David Ribeiro do Nascimento","doi":"10.6859/aja.202403_62(1).0003","DOIUrl":"https://doi.org/10.6859/aja.202403_62(1).0003","url":null,"abstract":"<p><p>Many cancer patients have their main tumors surgically removed with the goal of curing them, or as part of palliative care. When a patient receives general anesthesia, the side effects of the administered chemotherapy regimens must be considered, especially those that may have significant repercussions during anesthetic care. The aim of this study is to review the existing literature to identify adverse effects of chemotherapy and known interactions between chemotherapy and anesthetic drugs, analyze the mechanisms underlying these interactions, and discuss relevant clinical implications. This integrative review searched for articles using the search terms: chemotherapy, anesthetic drugs, interaction, adverse effects, and drug combination. Negative perioperative outcomes may be related to the chemotherapy. Regarding the type of oncological surgery, factors such as blood loss, hypothermia, and extended operative time influence the increase in morbimortality. Many anesthetic drugs are related to immunomodulation and interact with chemotherapy, which may get better or worse cancer patients. It is crucial for anesthetists to have a comprehensive understanding of the potential adverse effects of chemotherapy drugs and their interactions with anesthetics.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"62 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association Between Long- Versus Short-Acting Angiotensin II Receptor Antagonists and Hypotension During Anesthesia Induction: A Retrospective Study.","authors":"Masahiro Kuroki, Hiroto Suzuki, Yu Onodera, Masaki Nakane, Kaneyuki Kawamae","doi":"10.6859/aja.202403_62(1).0004","DOIUrl":"10.6859/aja.202403_62(1).0004","url":null,"abstract":"<p><strong>Background: </strong>The withdrawal or continuation of angiotensin II receptor blockers (ARBs) before surgery continues to be debated. We hypothesized that this is because ARBs with different half-lives have not been studied individually. This retrospective study aimed to clarify whether the degree of hypotension during anesthesia induction differs among ARBs with different half-lives.</p><p><strong>Methods: </strong>We included patients who received general anesthesia with regular oral administration of telmisartan (group T) or valsartan (group V), which have half-lives of approximately 24 and 6 hours, respectively. The frequency of hypotension and vasopressor frequency and dose during anesthesia induction were compared between the two groups. At our hospital, ARBs were withdrawn on the day of surgery in all patients.</p><p><strong>Results: </strong>Groups T and V included 190 and 132 patients, respectively. Patient backgrounds in group V were significantly more strongly associated with the use of calcium channel blockers. No significant differences were observed in the use of other concomitant antihypertensive medications, cardiovascular complications, or renal function. The time during which the mean arterial blood pressure was < 60 mmHg during anesthesia induction was significantly greater in group T than in group V (11 min vs. 7 min, P=0.030). The proportion of patients who used vasopressors was significantly higher in group T than that in group V (74.2% vs. 56.0%, P < 0.001).</p><p><strong>Conclusion: </strong>Patients taking telmisartan showed more hypotensive during the induction of general anesthesia than those taking valsartan, even after withdrawal on the day of surgery.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"28-38"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Practice Algorithm of Rotational Thromboelastometry-Guided (ROTEM-Guided) Bleeding Management in Liver Transplantation.","authors":"Min-Yi Tsai, Shun-Ming Chan, Nan-Kai Hung, Hou-Chuan Lai, Yao-Chia Liu, Wei-Lin Lin, Wei-Cheng Tseng, Chueng-He Lu","doi":"10.6859/aja.202403_62(1).0001","DOIUrl":"10.6859/aja.202403_62(1).0001","url":null,"abstract":"<p><p>Liver transplantation (LT) is frequently complicated by coagulopathy associated with end-stage liver disease, which is often multifactorial and associated with hemostatic disturbances affecting both the procoagulant and anticoagulant systems. This rebalanced coagulation system may lead to bleeding diathesis or increased clot formation. Conventional coagulation tests cannot reflect these complex changes because they can only illustrate deficiencies in the procoagulant system. Viscoelastic tests such as rotational thromboelastometry (ROTEM) have been used in LT and have shown useful for detecting coagulopathy and guiding transfusions. Implementation of ROTEM-guided bleeding management algorithms has proven effectiveness in reducing bleeding, transfusion needs, complication rates, and healthcare costs in LT. This document is intended to provide a practice algorithm for the management of major bleeding and coagulopathy during LT and to encourage adaptation of the guidelines to individual institutional circumstances and resources.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Efficacy and Factors Associated With Epidural Injections in the Management of Lumbar Spinal Stenosis and in Terms of Delaying Laminectomy: A Retrospective Study.","authors":"Yara Bou Sleiman, Souheil Hallit, Souheil Chamandi","doi":"10.6859/aja.202403_62(1).0005","DOIUrl":"https://doi.org/10.6859/aja.202403_62(1).0005","url":null,"abstract":"<p><strong>Background: </strong>Lumbar epidural injections have been studied as symptomatic treatments for lumbar spinal stenosis (LSS). However, results about their efficacy have been controversial, and data regarding their use is scarce. Our purpose in this article is to study the efficacy of epidural injections in the management of pain and disability in patients suffering from spinal stenosis, to study the factors which can affect their efficacy, and to discuss whether they could replace surgery or not.</p><p><strong>Methods: </strong>A retrospective study between 2021 and 2022 took place in a Pain Clinic located in Notre-Dame des Secours University Hospital-Lebanon. The study was done on 128 patients, of whom 18 were excluded because they underwent laminectomy before taking the transforaminal lumbar epidural injections. Medical records were viewed. Outcome measures were checked before and after epidural injections using the numerical pain scale and the Oswestry Disability Index (ODI) scale. Physical activity was assessed with a physical activity index.</p><p><strong>Results: </strong>Back pain scores (9.46 ± 1.07 vs. 3.91 ± 3.13; P < 0.001), leg pain scores (9.31 ± 1.41 vs. 3.75 ± 3.17; P < 0.001), and ODI scores (27.45 ± 8.97 vs. 9.40 ± 9.42; P < 0.001) decreased after the injection compared to before it. A higher physical activity index was significantly associated with a decrease in back pain, leg pain, and ODI scores after epidural injection. In 57.8% of the patients, epidural injections were sufficient for pain management without the need for surgery.</p><p><strong>Conclusion: </strong>Epidural injections are effective in the management of back and leg pain associated with LSS and in improving patients' disability. Engaging in activities like walking and swimming is associated with better results. In some cases, epidural injections may replace surgery.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"62 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypovolemic Shock and Changes in Density Spectral Array of BIS During Hepatectomy.","authors":"Tsai-Shan Wu, Zhi-Fu Wu, Hou-Chuan Lai","doi":"10.6859/aja.202403_62(1).0007","DOIUrl":"10.6859/aja.202403_62(1).0007","url":null,"abstract":"","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"63-65"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative Cognitive Dysfunction: A Review.","authors":"Neelesh Anand, Reetika Gupta, Shashi Prakash Mishra, Manjaree Mishra","doi":"10.6859/aja.202403_62(1).0001","DOIUrl":"10.6859/aja.202403_62(1).0001","url":null,"abstract":"<p><p>Elderly patients are more vulnerable to cognitive dysfunction in the postoperative period. Patients who are apparently well in cognitive functions in the preoperative period after undergoing anesthesia in noncardiac surgery will develop symptoms of cognitive dysfunction. Postoperative cognitive dysfunction (POCD) doesn't continue for a long duration and usually undergoes self-resolution. Proper definitions and congruous tests for diagnosis are absent. Rigorous preoperative assessment of cognitive function and distinguishing risk factors are indispensable for recognizing the range of POCD and its association with surgery and anesthesia. Recent studies haven't revealed any anesthesia technique or drug which can significantly reduce the incidence of POCD. Therefore, giving accurate information to patients can be challenging.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lawrence Huang, Steven H Hsu, Yi Ting Chuang, Yu Hsuan Tang, Hsien Yung Lai
{"title":"Top 100 Most-Cited Articles on Difficult Airway Management From 2011 to 2022: A Bibliometric Analysis.","authors":"Lawrence Huang, Steven H Hsu, Yi Ting Chuang, Yu Hsuan Tang, Hsien Yung Lai","doi":"10.6859/aja.202403_62(1).0006","DOIUrl":"https://doi.org/10.6859/aja.202403_62(1).0006","url":null,"abstract":"<p><strong>Background: </strong>Difficult airway management (DAM) presents a complex array of challenges inherent in establishing and maintaining a patient's airway during medical procedures or emergencies. Consequences of compromised DAM are profound, ranging from hypoxia, and aspiration, to cardiac arrest. Despite the ongoing progress and innovation in airway management, DAM remains a significant clinical challenge. Performing a bibliometric analysis of the most cited articles in this domain offers quantitative and qualitative insights into the landscape and trend of key research; our analysis revealed an increasing focus on video laryngoscopy research over the past decade, with a notable surge in studies related to airway management during infectious disease outbreaks in recent years.</p><p><strong>Methods: </strong>We performed a bibliometric analysis of the 100 most-cited articles on DAM (Top100DAM) published between 2011 and 2022, sourced from both PubMed and Web of Science databases. Employing social network analysis, we identified key associated topics and cluster terms. Cluster terms are broad categories encompassing related topic terms. Topic terms are specific keywords or phrases found in the articles. Citation counts were estimated for each article, and cluster-specific reviews were generated using the Medical Query Expert software.</p><p><strong>Results: </strong>The Top100DAM comprised 53 topic terms spanning 11 cluster terms. \"Anesthesiology\" stood out as the most frequently featured cluster, and \"betacoronavirus\" had the highest Impact Factor. There was a significant correlation between the counts between the inferred citation based on cluster terms and the observed citation (Pearson's R = 0.06, P = 0.02). To visualize, the network visualization and Sankey diagrams were used to illustrate the characteristics of the articles. The generated summary, utilizing natural language processing techniques, underscored the role of fiber-optic technology and video laryngoscopy in addressing DAM. During the COVID-19 pandemic, experts recommended the provision of supplemental oxygen and the prioritization of video laryngoscopy for anticipated DAM scenarios. Notably, the most cited articles predominantly concentrated on the importance of practice driven by guidelines and protocols for clinicians and anesthesiologists to manage difficult airways effectively.</p><p><strong>Conclusion: </strong>DAM plays a central role in anesthesiology research, with a significant emphasis on guideline development, technological advancements like video laryngoscopy, and adapting practices for infectious disease scenarios. The increased publication volume and high citation rates during the COVID-19 pandemic underscore how ongoing research and innovation have accelerated, refining DAM practices. Articles with high citation rates mostly pertain to guidelines, illustrating their substantial impact on clinical practice and the necessity for studies to base their discus","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"62 1","pages":"46-62"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen-Ying Lin, Yu-Hsin Huang, Chen-Tung Yen, Wei-Zen Sun
{"title":"The Role of PET Scan in Conscious Rats With Neuropathic Pain: Differential Changes in Brain Glucose Metabolic Activity in Spontaneous Versus Allodynia Pain.","authors":"Wen-Ying Lin, Yu-Hsin Huang, Chen-Tung Yen, Wei-Zen Sun","doi":"10.6859/aja.202409_62(3).0004","DOIUrl":"10.6859/aja.202409_62(3).0004","url":null,"abstract":"<p><strong>Background: </strong>Neuropathic pain is caused by lesions in the somatosensory nervous system. Pain occurs spontaneously, and responses to noxious and innocuous stimuli are pathologically amplified. Despite the abundant functional magnetic resonance imaging studies in awake human subjects, there is no available report on the behavioral correlate of differential brain areas involved in spontaneous and evoked pain symptoms in a conscious animal model. We investigated whether positron emission tomography (PET) imaging could depict the spatial changes in glucose metabolic activity in the awake male rat brain during spontaneous- and evoked-pain conditions on a spared nerve injury (SNI) model of neuropathic pain.</p><p><strong>Methods: </strong>Two major branches of the sciatic nerve, the tibial and common peroneal nerves, were transected under anesthesia. Two PET experiments were performed. In the spontaneous pain behavior group, abnormal paw-lifting behaviors were recorded during fluorodeoxyglucose (FDG) uptake. In the allodynia group, the ipsilateral side of the lesion hindpaw was stimulated with a 6-g von Frey fi lament once every 5 seconds for 20 minutes during FDG uptake. Each rat was scanned twice in both experiments: once before and once from 3 to 7 days after SNI surgery. Nerves were isolated but not transected in the sham-operated control group.</p><p><strong>Results: </strong>After SNI surgery, rats displayed spontaneous jerky paw lifting and mechanical sensitization lasting at least 4 weeks. In the spontaneous pain behavior group, glucose metabolic activity in the SNI condition significantly increased in the ipsilateral posterior insular cortex (PIC) compared to pre-surgery and the sham-operated controls. The glucose metabolic activity of the PIC was linearly correlated with the frequency of spontaneous paw lifting. In the allodynia group, changes in glucose metabolic activities in the SNI condition significantly increased in the bilateral primary somatosensory cortex, contralateral secondary somatosensory cortex, contralateral primary motor cortex, ipsilateral secondary motor cortex, ipsilateral rostral insular cortex, PIC, hypothalamus, medial thalamus (including the medial dorsal nucleus and anterior periventricular thalamic nucleus), and medial cerebellum.</p><p><strong>Conclusions: </strong>Differential brain areas in rats with peripheral neuropathic pain were activated between mechanical hypersensitivity and spontaneous pain-related behaviors. The data suggest that PET is a useful imaging technique to establish the link between behavioral correlates and topographical representation in awake rats suffering from spontaneous pain and allodynia of neuropathic pain.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"62 3","pages":"140-152"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fong-Sheng Lin, Chih-Peng Lin, Ya-Jung Cheng, Wei-Zen Sun
{"title":"Effect of Sedation/Analgesia During Colonoscope on Abdominal Pain After Examination.","authors":"Fong-Sheng Lin, Chih-Peng Lin, Ya-Jung Cheng, Wei-Zen Sun","doi":"10.6859/aja.202409_62(3).0002","DOIUrl":"10.6859/aja.202409_62(3).0002","url":null,"abstract":"<p><strong>Background: </strong>Sedation/analgesia (S/A) is widely used to relieve patients' anxiety and discomfort during colonoscopy. Their effects on abdominal pain after colonoscopy have never been fully investigated.</p><p><strong>Methods: </strong>The prospective study consecutively recruited 494 healthy patients having a screen colonoscopy examination as part of their health checkup. They were divided into two groups based on individuals' decision to receive sedation and analgesia or not. In the S/A group, 374 patients received midazolam and alfentanil during colonoscopy with standard monitoring, while in the non-sedation/analgesia (NSA) group, 120 patients received no analgesics. Severity and duration of abdominal pain (ordinal scale: 1 = none, 4 = severe) were assessed at the end of stay in the postanesthetic care unit (the S/A group) or examination room (the NSA group) and before discharge. Side effects S/A during (hypotension, hypoxemia) and after (nausea, vomiting, dizziness) colonoscopy were also recorded. All patients were closely monitored during the whole course of the health check-up package.</p><p><strong>Results: </strong>The mean doses of midazolam and alfentanil were 4.06 mg and 813.12 μg, respectively. Patients in the NSA group had two-fold risks of moderate to severe abdominal pain compared to those in the S/ A group (16.67% vs. 9.36%, odds ratio = 1.937, 95% confidence interval: 1.010-3.625). The NSA group also had a higher incidence of abdominal pain 120 minutes after examination (33.33% vs. 16.04%, P < 0.001). Duration of abdominal pain in those patients who did have abdominal pain was longer in the S/ A group than in the NSA group (153.3 ± 49.9 vs. 118.7 ± 47.5 minutes, P < 0.001). The incidence of hypotension and hypoxemia in the group S/A was 5.6% and 2.9%, respectively. More patients in the S/ A group felt dizzy or sleepy than those in the NSA group (14.7% vs. 3.3%, P < 0.001). The incidence of nausea and vomiting was similar between the two groups.</p><p><strong>Conclusion: </strong>Optimal S/A with midazolam and alfentanil decreases the severity and duration of postcolonoscopic abdominal pain.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developing and Validating a Nationwide Risk-Stratification Prediction Model for Post-General Anesthetic Mortality-The Potentially Protective Effects of Anti-Lipid, Hypoglycaemic, and Anti-Hypertensive Agents in Taiwanese Geriatric Group.","authors":"Feng-Fang Tsai, Chih-Fan Chen, Jou-Wei Lin, Sheng-Nan Chang, Chun-Lin Chu, Ling-Ping Lai, Juey-Jen Hwang, Huei-Ming Yeh","doi":"10.6859/aja.202409_62(3).0006","DOIUrl":"10.6859/aja.202409_62(3).0006","url":null,"abstract":"<p><strong>Background: </strong>This study used the National Taiwan Health Insurance database, including prescribed medications, underlying systemic diseases, and surgical types, to evaluate the relationship between those factors and mortality after general anesthesia.</p><p><strong>Method: </strong>This retrospective, population-based study was retrieved from the National Health Insurance Research Database in Taiwan between January 1, 2005, and December 31, 2013. We proposed a logistic regression model that can significantly predict postanesthesia mortality, which was validated in another set of databases. Moreover, we subgroup the study population into four major comparison groups, which include major organ transplantation, cardiovascular (CV) surgery, major neurosurgery, and others according to the diagnostic codes of the International Classification of Diseases, ninth revision, clinical modification codes.</p><p><strong>Results: </strong>A total of 681,779 subjects were analyzed in this study, and the most common comorbidity was hypertension. Age was an important determinant associated with postoperative mortality among different surgical types. Perioperative prescription could reduce the risks of the operation. The major surgeries (major organ transplantation, CV surgery, and neurosurgery) were associated with increasing postoperative mortality. The prediction model performed well in the validation group (area under receiver operating characteristic curve [AUROC] = 0.8753 for in-hospital mortality; AUROC = 0.8767 for 30-day mortality).</p><p><strong>Conclusions: </strong>The prediction model that we proposed from this nationwide study could identify the predictors for postoperative mortality. The potentially protective effects of anti-lipid, hypoglycemic, and anti-hypertensive agents were encouraging in the geriatric preoperative group. It is expected that applying this prediction model and prescription into clinical practice could improve surgical risk stratification and further improve patient outcomes.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":"62 3","pages":"162-178"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}