Artificial organs最新文献

{"title":"Recent progress in the field of Artificial Organs","authors":"","doi":"10.1111/aor.14928","DOIUrl":"10.1111/aor.14928","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 2","pages":"179-180"},"PeriodicalIF":2.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineered vessels used for vascular repairs in trauma","authors":"Donald D. Chang MD, PhD","doi":"10.1111/aor.14929","DOIUrl":"10.1111/aor.14929","url":null,"abstract":"<div>\u0000 \u0000 <p>Clinical trials demonstrate favorable outcomes of bioengineered vessels as graft conduits for reparation of traumatic vascular injuries compared with benchmarked synthetic conduits.</p>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 2","pages":"181-182"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemofiltration system for the post traumatic treatment of hyperkalemia in austere conditions","authors":"Meredith Haanstad,&nbsp;Leslie D. Seeley,&nbsp;Tara Srinivas,&nbsp;Matthew Chamot,&nbsp;Trevor Haanstad,&nbsp;Christopher Marotta,&nbsp;Palaniappan Sethu,&nbsp;Ambalavanan Jayaraman","doi":"10.1111/aor.14919","DOIUrl":"10.1111/aor.14919","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyperkalemia, the buildup of serum potassium to levels &gt;6 mEq L⁻¹, has been a recognized complication of combat injuries such as acute kidney injury since World War II. Currently, renal replacement therapy (RRT) serves as the standard of care for hyperkalemic patients who fail to respond to medical management. However, RRT is difficult to administer in combat settings, and the time between evacuation and RRT is critical in preventing post-traumatic hyperkalemia. Therefore, the need for portable, easily operable hemofiltration technology is pressing to improve the survival of hyperkalemic patients in austere settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this manuscript, we present extra-corporeal direct contact and hemodialysis filtration systems for treating severe hyperkalemia and tested the efficacy, biocompatibility, and performance of a zeolite-based renal RRT. We tested the uptake capacity of an adsorbent zeolite optimized for the selective binding and removal of potassium in various mediums, including dialysate, bovine serum, and whole bovine sodium heparinized blood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Conclusions</h3>\u0000 \u0000 <p>Our results show that we can restore physiological normokalemic levels within just 2 h of testing and maintain these levels for 6 h. Furthermore, calcium and sodium levels were maintained within normal physiological ranges, confirming the selectivity of our sorbent material for potassium binding.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"670-680"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based functional electrical stimulation protocol for people with chronic stroke. Efficacy and usability of a single-center cohort.","authors":"F Covarrubias-Escudero, F Balbontín-Miranda, B Urzúa-Soler, R Ciuffardi, M Muñoz, V Hernández, J P Appelgren-González","doi":"10.1111/aor.14922","DOIUrl":"https://doi.org/10.1111/aor.14922","url":null,"abstract":"<p><strong>Background: </strong>Stroke survivors often face challenges in recovery and reintegration after acute care. Home-based rehabilitation, incorporating advanced technologies like Functional Electrical Stimulation (FES), shows promise for improving long-term outcomes by providing more accessible, high-intensity, and task-oriented rehabilitation outside traditional clinical settings.</p><p><strong>Method: </strong>This study assessed efficacy and usability of a 10-week home-based rehabilitation protocol for 52 individuals with chronic stroke. The intervention featured a cloud-based platform, a mobile application, and functional electrical stimulation devices. Participants were categorized into groups for tailored exercise training and received both synchronous and asynchronous sessions. Efficacy was measured through standardized motor function tests, while usability was evaluated based on adherence, patient satisfaction, and the frequency of technical support requests.</p><p><strong>Results: </strong>High adherence (74.03%) and a satisfaction of 73% were observed. On average, patients performed on average 414 min of unsupervised exercise per week. Significant improvement, including a median decrease of 6.08 s (22%) in Timed Up and Go (TUG) [z (24) = 4.17, p < 0.001], a median decrease of 4.04 s (17%) in Five Times Sit to Stand (5STS) [z (28) = 3.96, p < 0.001], Motor Assessment Scale (MAS) showed a mean increase of 3.2 ± 2.8 points, paired t-test [t (20) = -5.01 p < 0.001] and an increase of 0.095 m/s (28%) in 10-Meter Walk Test (10MWT) [z (24) = 3.71, p < 0.001]. Clinical relevance was observed in all outcome measures compared with the reported Minimum Detectable Change.</p><p><strong>Conclusion: </strong>This evaluation of a home-based physiotherapy protocol indicates that integrating FES devices with virtual platforms and mobile applications can sustain high adherence while improving functional outcomes in chronic stroke rehabilitation. The prescription of high-intensity training, significant improvements in balance, gait, and overall functionality were observed, highlighting the viability of this approach for home-based programs.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of a hemoadsorption filter on cytokine levels during 1 hour of thoraco-abdominal normothermic regional perfusion for donation after circulatory death heart donation in a porcine model","authors":"Katrien Vandendriessche,&nbsp;Vincent van Suylen,&nbsp;Janne Brouckaert,&nbsp;Patrick Matthys,&nbsp;Dieter Dauwe,&nbsp;Bart Meyns,&nbsp;Michiel Erasmus,&nbsp;Arne Neyrinck,&nbsp;Steffen Rex,&nbsp;Filip Rega","doi":"10.1111/aor.14924","DOIUrl":"10.1111/aor.14924","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Both global ischemia caused by circulatory arrest and extracorporeal circulation circuits have been shown to trigger cytokine release. We hypothesized that inserting a hemoadsorption device during thoraco-abdominal normothermic regional perfusion (TA-NRP) in the donation after circulatory death setting would mitigate the inflammatory response, potentially resulting in improved cardiac allograft function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 15 pigs, circulatory arrest was induced by hypoxia. After a 15-min no-touch-period, TA-NRP was performed for 60 min. Eight pigs had a hemoadsorption device incorporated in the ECC, while seven did not. Plasma concentrations of IFN-α, IFN-γ, TNF-α, IL-1β, IL-4, IL-6, IL-8, IL-10, and IL-12p40 were assessed by ELISA at baseline, immediately at start of TA-NRP, 60 min after start of TA-NRP (just before weaning from ECC), and at 30 and 60 min after weaning from ECC. Cardiac function was assessed with pressure–volume loop analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Hemoadsorption had no relevant effects on systemic cytokine levels post TA-NRP. IL-6 plasma levels gradually rose throughout the procedure for both groups. Hemoadsorption did not affect systolic or diastolic left ventricular function, nor were global hemodynamics improved by hemoadsorption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The insertion of a hemoadsorption device did not significantly affect plasma cytokine levels or cardiac function. Further research is necessary to assess the role of the inflammatory response in DCD heart transplantation and its modulation by TA-NRP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"615-626"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study","authors":"Masaki Anraku,&nbsp;Ryo Yokoi,&nbsp;Shintaro Hara,&nbsp;Yuya Nobori,&nbsp;Keita Nakao,&nbsp;Kento Fukumoto,&nbsp;Toshiya Ono,&nbsp;Kazuaki Sato,&nbsp;Fumikazu Watanabe,&nbsp;Takashi Isoyama,&nbsp;Hiroaki Oshiyama,&nbsp;Minoru Ono,&nbsp;Jun Nakajima,&nbsp;Madoka Takai","doi":"10.1111/aor.14927","DOIUrl":"10.1111/aor.14927","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study was designed to evaluate the long-term durability, oxygenation, and pressure loss of newly developed, methacryloyloxyethyl phosphorylcholine (MPC)-polymer-coated, nonporous silicone hollow fiber-membrane lungs in vivo using a pulmonary artery-to-left-atrium paracorporeal configuration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An extracorporeal circuit from the pulmonary artery (device inflow) to the left atrium (device outflow) was established using dedicated composite vascular grafts in three healthy female goats for the prototype lung testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Duration of testing the prototype lungs was 52, 57, or 100 days. Averages of oxygen transfer rates (ml/min) at the beginning of the evaluation were 77.6 ± 17.5 at 1 L/min blood flow, 137.1 ± 58.0 at 2 L/min, and 188.9 ± 86.4 at 3 L/min. Consistent oxygen transfer performance was maintained throughout the experiments. Electron microscopy revealed minimal thrombus formation on the hollow fiber membranes inside the lungs. Native lungs were maintained in good condition without appreciable congestion in all three subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The longevity of the hollow fibers documented here is a key requirement for the development of a device for long-term respiratory support. The pulmonary artery-to-left-atrial configuration established with our composite vascular grafts could maintain long-term functionality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 5","pages":"842-851"},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of concomitant aortic valve replacement in patients with mild-to-moderate aortic valve regurgitation undergoing left ventricular assist device implantation: EUROMACS analysis","authors":"Gregorio Gliozzi,&nbsp;Gaik Nersesian,&nbsp;Guglielmo Gallone,&nbsp;Felix Schoenrath,&nbsp;Ivan Netuka,&nbsp;Daniel Zimpfer,&nbsp;Theo M. M. H. de By,&nbsp;Gloria Faerber,&nbsp;Antonio Spitaleri,&nbsp;Igor Vendramin,&nbsp;Jan Gummert,&nbsp;Volkmar Falk,&nbsp;Bart Meyns,&nbsp;Mauro Rinaldi,&nbsp;Evgenij Potapov,&nbsp;Antonio Loforte","doi":"10.1111/aor.14926","DOIUrl":"10.1111/aor.14926","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Left ventricular assist device (LVAD) therapy may lead to an aortic regurgitation, limiting left ventricular unloading and causing adverse events. Whether concomitant aortic valve replacement may improve outcomes in patients with preoperative mild-to-moderate aortic regurgitation remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective propensity score-matched analysis of adult patients with preoperative mild-to-moderate aortic regurgitation undergoing durable LVAD implantation between 01/01/2011 and 30/11/2021 was performed. Patients undergoing concomitant valve surgery other than biological aortic valve replacement were excluded, resulting in 77 with concomitant biological aortic valve replacement and 385 without.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Following 1:1 propensity score matching, two groups of 55 patients with and without biological aortic valve replacement were obtained, (mean age 59 ± 11 years, 92% male, 59.1% HeartWare). Aortic regurgitation was mild in 72.7% and 76.4% and moderate in 27.3% and 23.6% in non-replacement and replacement cohorts respectively. The 30-day survival was 89.1% vs. 85.5% (<i>p</i> = 0.59), 1-year survival 69.1% vs. 56.4% (<i>p</i> = 0.19), and 2-year survival 61.8% vs. 47.3% (<i>p</i> = 0.10) in the non-replacement and replacement groups, respectively. After a mean follow-up of 1.2 years, non-replacement patients had a higher incidence of pump thrombosis (11 [20%] vs. 3 [5.5%], <i>p</i> = 0.022) and fewer major bleedings (2 [3.6%] vs. 11 [20%], <i>p</i> = 0.008).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared with those treated conservatively, patients with mild-to-moderate aortic regurgitation undergoing concomitant aortic valve replacement during LVAD implantation have a similar survival up to 2 years on support. Patients with concomitant valve replacement had a higher risk of bleeding complications but fewer pump thromboses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"691-704"},"PeriodicalIF":2.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortex kidney tissue partial oxygen pressure depends on percentage of active oxygenation during oxygenated hypothermic machine perfusion","authors":"Thomas Prudhomme,&nbsp;Tom Darius,&nbsp;Stephan Levy,&nbsp;Emma Loiseau,&nbsp;Stéphanie Le Bas-Bernardet,&nbsp;Jérémy Hervouet,&nbsp;David Minault,&nbsp;Gilles Blancho,&nbsp;Sarah Bruneau,&nbsp;Lionel Badet,&nbsp;Philipp Kron,&nbsp;Benoit Mesnard,&nbsp;Julien Branchereau","doi":"10.1111/aor.14916","DOIUrl":"10.1111/aor.14916","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preclinical and clinical studies have demonstrated the advantages of oxygenated hypothermic machine perfusion (HMPO₂) during kidney preservation. However, the optimal oxygenation levels during HMPO₂ remain undetermined. The aim of this study was to compare different levels of oxygenation (0%, 21%, 50%, and 100%) during 22 h of active oxygenated HMP (HMPO₂) using oxygen preloading by bubbling oxygenation in the preservation solution and continuous surface oxygenation during MP in a porcine DCD model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After 60 min of warm ischemia time, both kidneys of an 80 kg pig were procured and randomized to one of the following groups: (1) 22-h static cold storage (<i>n</i> = 6), (2) 22-h HMP without active oxygenation (<i>n</i> = 6), (3) 22-h HMPO₂ 21% O₂ (<i>n</i> = 6), (4) 22-h HMPO₂ 50% O₂ (<i>n</i> = 6), and (5) 22-h HMPO₂ 100% O₂ (<i>n</i> = 6). The primary outcome measure was to compare the different oxygen levels among the different groups assessed by cortex kidney tissue oxygen partial pressures (tpO₂).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Continuous HMPO₂ resulted in a significant modification of cortex kidney tpO₂. In addition, tpO₂ was dependent on the percentage of oxygenation. One hundred percent oxygen resulted in a significantly higher tpO₂ compared to all other study groups. In line with that, ATP resynthesis was significantly higher in the HMPO₂ 100% group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates that continuous HMPO₂ results in a significant modification of tpO₂ compared with SCS, and the degree of tpO₂ is positively correlated with the percentage of active oxygenation during HMP. Metabolic profile analyses (ATP resynthesis) suggest that the aerobic mechanism is better supported with higher oxygen levels (50% and 100% oxygenation).</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"600-614"},"PeriodicalIF":2.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curricular Self-management for patients on ventricular assist device support decreases depression: A multicenter randomized controlled trial","authors":"Christiane Kugler,&nbsp;Hannah Spielmann,&nbsp;Fabian Richter,&nbsp;Volker Lauenroth,&nbsp;Sandra Semmig-Könze,&nbsp;Christine Spitz-Köberich,&nbsp;Tim Bertsche,&nbsp;Paulina Staus,&nbsp;Susanne Weber,&nbsp;Wolfgang Albert,&nbsp;Katharina Tigges-Limmer,&nbsp;the Selma Study Group","doi":"10.1111/aor.14918","DOIUrl":"10.1111/aor.14918","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Utilization of ventricular assist device (VAD) support in patients with end-stage heart failure is well advanced. Recent studies emphasize the need to develop and evaluate evidence-based psychosocial support interventions for patients following VAD implantation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A national, multi-center study in four established German heart centers was initiated. An evidence-based VAD curriculum was developed; a randomized controlled trial evaluated the impact of the interprofessional intervention over time. Primary combined endpoint was the occurrence of adverse events (thromboembolic events, driveline infections, bleeding, rehospitalization, and death); secondary endpoints were psychosocial outcomes (anxiety, depression [HADS], quality of life [QoLVAD], social support [FSoZu], and self-management [SELMA]). A total of 140 patients were randomized block-wise to intervention (IG <i>n</i> = 70) or control (CG n = 70). Center-effects were considered. Instruments were completed at four time points (T0-T3).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At baseline, intervention group (IG) patients were 19% female (control group [CG] 19%; <i>p</i> = 0.982); 58 ± 11 years. (CG 58 ± 11 years.; <i>p</i> = 0.966); 80% were implanted electively (CG 79%; <i>p</i> = 0.968). No significant difference in primary endpoint was found between IG versus CG (<i>p</i> &gt; 0.05). For secondary endpoints, mixed linear regression revealed a significant reduction in depression scores in IG compared to CG (est. 1.18; 95% CI −2.17 to −0.18; <i>p</i> = 0.021). Clinically significant reductions in anxiety were greater in IG patients between T0 and T3 (IG 51.9%; CG 40.7%); increased anxiety was reported in 3.7% IG (11.1% CG). Mixed linear regression analyses favored IG (all &gt;0.05) for QoL, social support, and self-management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A comprehensive curricular VAD intervention has potential to decrease depression levels and improve psychosocial outcomes of patients on VAD support.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 3","pages":"373-389"},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14918","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on a novel flexible bionic artificial anal sphincter","authors":"Minghui Wang,&nbsp;Wei Zhou,&nbsp;Yunlong Liu,&nbsp;Hongliu Yu","doi":"10.1111/aor.14917","DOIUrl":"10.1111/aor.14917","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Artificial anal sphincter is a novel method for the treatment of fecal incontinence. Aiming at the problems of complex mechanical structure, high mechanical failure rate, large volume and poor biocompatibility of existing artificial anal sphincters, this article proposes a novel flexible artificial anal sphincter with bionic structure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A novel flexible artificial anal sphincter was proposed with bionic structure by analogy with the puborectalis, flexible transmission by flexible tendons, good biocompatibility by using thermoplastic urethane and medical silicone, small size and lightweight. The interaction between the rectum and the artificial anal sphincter is simulated by the finite element analysis, and the changes of the anorectal angle and the stress during the traction process of the rectum are analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results suggest that the formed anorectal angle of &lt;90° may effectively control defecation, so the effectiveness of the artificial anal sphincter is preliminarily verified. When the traction angle was 71° and the intestinal tube was basically closed, the maximum equivalent stress was 148.45 kPa, the maximum and minimum principal stress were 88.37 and 82.74 kPa, which were all below the safety pressure that initially verified the safety of the artificial anal sphincter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The novel flexible artificial anal sphincter may effectively reduce the stress between the device and the rectum and improve the biomechanical compatibility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"571-581"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}