Artificial organs最新文献

{"title":"Machine Learning-Based Prediction of Life-Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions","authors":"Naotaka Kato,&nbsp;Takeshi Goto,&nbsp;Tomoyuki Ohira,&nbsp;Hirotaka Kinoshita,&nbsp;Kugo Kurokawa,&nbsp;Kouhei Naganuma,&nbsp;Chikako Ohminato,&nbsp;Junko Ogasawara,&nbsp;Shingo Hatakeyama,&nbsp;Yoshihiro Sasaki,&nbsp;Kazuyoshi Hirota,&nbsp;Chikara Ohyama","doi":"10.1111/aor.70008","DOIUrl":"10.1111/aor.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients undergoing hemodialysis (HD) face a significantly elevated risk of cardiovascular mortality, with sudden events during treatment posing a critical threat to survival. These risks are particularly pronounced in high-risk populations, such as patients recovering from cardiovascular surgery or those being treated for sepsis. Therefore, the development of effective preventive strategies is essential for improving patient outcomes. This study aimed to develop a machine learning model that uses pretreatment patient characteristics to predict sudden adverse events during HD and within 24 h after treatment in high-risk inpatients at acute care hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>His retrospective study analyzed data from 739 patients who underwent HD at Hirosaki University Hospital between 2018 and 2021. Sudden events were defined as fatal arrhythmia, refractory intradialytic hypotension, or respiratory arrest. A logistic regression model was constructed using backward stepwise selection from 51 patient characteristics (demographic data, clinical parameters, laboratory data, and HD-related information).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 739 patients, 17 (2.3%) experienced sudden events. The model identified 23 pre-HD covariates and achieved an area under the receiver operating characteristic curve (AUC) of 0.889. Key covariates included emergency hospitalization (present in 71% of patients with sudden events), recent surgery (76%), shorter HD history, elevated pre-HD heart rate, lower serum albumin levels, and higher C-reactive protein concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our model enables the early identification of high-risk inpatients receiving hemodialysis using pre-dialysis data, thereby supporting timely clinical interventions, optimized resource allocation, and improved patient safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"139-149"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart in Continuous and Pulsatile Flow","authors":"Antony P. McNamee,&nbsp;Daniel Timms,&nbsp;Frank Nestler,&nbsp;Nicole Bartnikowski,&nbsp;Amanda Smith,&nbsp;Geoff D. Tansley,&nbsp;Michael J. Simmonds","doi":"10.1111/aor.70009","DOIUrl":"10.1111/aor.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heart transplantation is curative for advanced heart failure; however, the limited availability of suitable donor organs makes mechanical circulatory support devices a crucial alternative. BiVACOR's total artificial heart (TAH) is a new device that provides full replacement of the organic failing heart to support systemic and pulmonary circulation using a single, magnetically levitated centrifugal rotor. The aim of this study was to assess the in vitro hemocompatibility of the TAH operating in either continuous flow (CF) or pulsatile flow (PF) mode.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cattle blood was circulated in an in vitro blood loop at 5 L/min against 100 mmHg for 6 h using the TAH in CF (<i>n</i> = 6) or PF (<i>n</i> = 6), which were compared with a reference pump (CentriMag; <i>n</i> = 6). Blood analysis included hematology, plasma free-hemoglobin, and von Willebrand factor (vWF) multimers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The normalized indexes of hemolysis were 0.004 ± 0.003 g/100 L for CF, 0.004 ± 0.003 g/100 L for PF, and 0.003 ± 0.002 g/100 L for reference. Basic hematology and vWF multimers were affected in a linear manner, but did not vary between flow regimes or devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BiVACOR's TAH operated in a manner requisite of complete heart support, generated comparable in vitro blood compatibility to the clinically approved reference pump, as evidenced by hematological parameters and vWF analyses. The presence of a large pulse pressure did not impact hemocompatibility, which is a positive sign for future applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"84-93"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on Machine Perfusion for Organ Preservation: Highlights From the World Transplant Congress 2025","authors":"Kathryn White,&nbsp;Harshini Maheswaran,&nbsp;Isabella Faria,&nbsp;Narendra R. Battula,&nbsp;Paulo N. Martins,&nbsp;Maheswaran Pitchaimuthu","doi":"10.1111/aor.70040","DOIUrl":"10.1111/aor.70040","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"156-160"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Surgical Closure of Post-Infarct Ventricular Septal Defect With Transaxillary Microaxial Flow Pump Bridging","authors":"Sarah Madira,&nbsp;Mehran Rahimi,&nbsp;Sophia Roberts-Pyeatte,&nbsp;Aaron Guo,&nbsp;Takuya Wada,&nbsp;John M. Lasala,&nbsp;Justin Vader,&nbsp;Jonathan Moreno,&nbsp;Joel Schilling,&nbsp;Michael Pasque,&nbsp;Kunal Kotkar,&nbsp;Muhammad F. Masood,&nbsp;Ralph J. Damiano,&nbsp;Tsuyoshi Kaneko,&nbsp;Amit Pawale","doi":"10.1111/aor.70043","DOIUrl":"10.1111/aor.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ventricular septal defects are catastrophic complications of acute myocardial infarction associated with poor prognosis and high in-hospital mortality. Transaxillary microaxial flow pump (tMAFP) support may provide hemodynamic stabilization and serve as an effective bridge to delayed surgical repair with improved survival outcomes. We aimed to describe perioperative management and outcomes of surgical post-infarct ventricular septal defects (PIVSD) repair with and without tMAFP bridging, hypothesizing that tMAFP support would facilitate delayed repair with favorable operative and survival outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed 34 patients diagnosed with PIVSD at a single tertiary center between January 2018 and May 2025, stratified by the use of tMAFP. This report focuses on the surgical repair subgroup, describing perioperative management and outcomes with or without tMAFP bridging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 20 surgical patients, nine were bridged with tMAFP. These patients had a longer stabilization period before repair (median 14 vs. 3 days), shorter cardiopulmonary bypass times, higher preoperative mobility, and no in-hospital mortality, compared with five deaths among 11 patients repaired without tMAFP bridging. None in the tMAFP group required postoperative VA-ECMO, and no device-related complications were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this retrospective cohort study, tMAFP support allowed delayed surgical repair in PIVSD with favorable perioperative outcomes and survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"112-118"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145487552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quasi Ischemia-Free Liver Procurement: A Novel Technique to Decrease Graft Injury With Normothermic Machine Perfusion","authors":"Cristiano Quintini,&nbsp;Teresa Diago Uso,&nbsp;Koji Hashimoto,&nbsp;Beatrice Cazzaniga,&nbsp;Qiang Liu,&nbsp;Luca Del Prete","doi":"10.1111/aor.15068","DOIUrl":"10.1111/aor.15068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Normothermic machine perfusion has emerged as a valuable technique for organ preservation, enabling liver viability assessment and reducing the discard rates of marginal grafts. However, the standard protocol involves two cooling/rewarming phases, which can result in a double ischemia/reperfusion injury that increases the risk of graft dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We describe a novel surgical technique, named quasi ischemia-free liver procurement, which circumvents cold ischemia during liver procurement, thereby minimizing ischemia–reperfusion injury.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, we applied quasi-ischemia-free liver procurement to an orphan liver graft from a 43-year-old deceased brain donor. The liver was subsequently transplanted into a 66-year-old male recipient with alcoholic liver cirrhosis and hepatocellular carcinoma. The technique was successful, with ex-situ normothermic perfusion beginning within 3 min of graft disconnection without graft cooling and lasting for nearly 4 h. The graft exhibited excellent viability, evidenced by immediate lactate clearance, stable transaminase levels, and good bile production during machine perfusion. The recipient experienced an uneventful postoperative course with immediate graft function and was discharged on postoperative day 8.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Quasi ischemia-free liver procurement represents a simpler alternative to ischemia-free liver transplantation, potentially simplifying the implantation phase. This technique holds promise for improving outcomes in liver transplantation, particularly in cases involving marginal grafts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"150-155"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Artificial Lung-Kidney Assist Device","authors":"Brett F. Curran","doi":"10.1111/aor.70094","DOIUrl":"https://doi.org/10.1111/aor.70094","url":null,"abstract":"<div>\u0000 \u0000 <p>The RenOx platform integrates lung and kidney support within a single extracorporeal device designed to reflect the clinical realities of multiorgan failure. Early preclinical work demonstrates the feasibility of combined gas exchange and renal support, suggesting that a unified lung–kidney device could reduce the burden of multi-device management, streamline intensive care workflows, and potentially improve outcomes in patients with combined organ failure.</p>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"6-7"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in the Field of Artificial Organs","authors":"","doi":"10.1111/aor.70084","DOIUrl":"https://doi.org/10.1111/aor.70084","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 1","pages":"3-5"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Decannulation Using the Purse-String Technique in Venoarterial Extracorporeal Membrane Oxygenation Patients.","authors":"Siwon Oh, Ilkun Park, Suk Kyung Lim, Jun Ho Lee, Suryeun Chung, Dong Seop Jeong, Kiick Sung, Wook Sung Kim, Yang Hyun Cho","doi":"10.1111/aor.70058","DOIUrl":"10.1111/aor.70058","url":null,"abstract":"<p><strong>Background: </strong>Surgical femoral arterial decannulation following venoarterial extracorporeal membrane oxygenation (V-A ECMO) can lead to serious vascular complications. Among surgical options, the purse-string method has gained attention as a potentially simpler and less invasive alternative. However, clinical data evaluating its safety and feasibility remain limited.</p><p><strong>Methods: </strong>We retrospectively analyzed 325 adult patients who underwent femoral arterial decannulation following V-A ECMO support from 2012 to 2023 at a single tertiary center. Of these, 87 patients received decannulation using the purse-string technique. Propensity score matching was used to contextualize outcomes relative to the conventional cross-clamp method.</p><p><strong>Results: </strong>The purse-string technique significantly reduced operative time (132.9 ± 88.5 vs. 74.1 ± 36.9 min; p < 0.001) without increasing reintervention rates. Most reinterventions in the purse-string group were detected by early imaging surveillance, while cross-clamp patients more frequently presented with symptomatic complications such as acute ischemia. Vessel injuries and late vascular complications occurred exclusively in the cross-clamp group. No patient in the purse-string cohort experienced permanent limb loss or amputation.</p><p><strong>Conclusion: </strong>The purse-string technique enables efficient and safe decannulation after V-A ECMO, offering a less invasive alternative to cross-clamp repair. This less invasive method may be particularly advantageous in critically ill patients or bedside settings where minimizing operative time and vascular trauma is essential.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":"428-439"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipocyte Mesenchymal Stem Cells Derived Exosomes Improve Bleomycin-Induced Lung Fibrosis in Rat.","authors":"Atefeh Ashtari, Maryam Radan, Dian Dayer, Maryam Zohour Soleimani, Vahid Bayati, Fereshteh Nejaddehbashi","doi":"10.1111/aor.70052","DOIUrl":"10.1111/aor.70052","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease with limited treatment options. Although extracellular vesicles (EVs), such as exosomes, have shown therapeutic potential, their effectiveness and the best method of delivery are still under investigation. This study explored the therapeutic impact of exosomes derived from adipose-derived mesenchymal stem cells (ADMSCs-Exo) in a rat model of bleomycin-induced pulmonary fibrosis.</p><p><strong>Methods: </strong>Thirty Wistar rats were randomly divided into six groups: (1) Healthy control (Co), (2) Fibrosis control (Co/F), (3 and 4) Exosome inhalation groups treated with 250 or 500 μg/kg doses, and (5 and 6) Exosome injection groups receiving the same doses. Treatment effects were evaluated through lung tissue histopathology and analysis of key inflammatory biomarkers.</p><p><strong>Results: </strong>The inhalation of ADMSCs-Exo at both doses significantly reduced levels of C-reactive protein (CRP), fibrinogen, pro-inflammatory cytokines, and histopathological signs of lung fibrosis compared to the fibrosis control group (p < 0.05). Notably, the inhalation route showed better therapeutic outcomes than systemic injection.</p><p><strong>Conclusion: </strong>The results suggest that inhalation delivery of ADMSCs-derived exosomes may provide a more effective and targeted strategy for treating pulmonary fibrosis compared to systemic administration.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":"381-392"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decellularized Human Sclera; an Optimized Biomaterial for Scleral Reconstruction.","authors":"Fateme Naghibi Nasab, Saman Behboodi Tanourlouee, Mahsa Atarmoghadam, Ashkan Azimzadeh, Parviz Kokhaei, Ahmad Masoumi, Abdol-Mohammad Kajbafzadeh","doi":"10.1111/aor.70053","DOIUrl":"10.1111/aor.70053","url":null,"abstract":"<p><strong>Background: </strong>The sclera, a dense tissue that provides structural support to the eye, can be damaged by various factors, necessitating surgical repair. Decellularization techniques, which preserve the essential extracellular matrix (ECM) while removing cells, offer a promising solution. This study aimed to develop an optimized decellularization protocol for human sclera and evaluate its effectiveness using a rabbit model for scleral defects.</p><p><strong>Methods: </strong>Twelve New Zealand white rabbits underwent lamellar sclerectomy. The right eye was grafted with human native sclera (HNS), while the left eye received human acellular sclera (HAS) patches prepared by methods A, B, and C. Method A used sodium dodecyl sulfate (SDS); Method B combined SDS with Triton X-100; and Method C used a mix of SDS, EDTA, Triton X-100, and trypsin. Outcomes were assessed through cell nucleus visualization, cytotoxicity tests, SDS residue checks, structural assessments, slit lamp evaluations, AS-OCT scans, and histopathological reviews.</p><p><strong>Results: </strong>All protocols successfully decellularized tissues, confirmed by DAPI staining. With 80% cell viability, cytotoxicity was minimal and SDS residues were safely reduced. Method C best preserved collagen structures and ECM integrity. Slit lamp tests showed distinctions between HNS and HAS patches for Methods A and B, while Method C had superior biodegradability. All rabbits displayed conjunctival congestion, more so with HNS patches. AS-OCT showed the thinnest grafts with Method C. By the study's end, all patches had effectively healed the defects. Despite evident inflammation, especially in HNS patches, inflammation levels across HAS patches remained consistent.</p><p><strong>Conclusion: </strong>The decellularized human sclera emerges as an ideal material for reconstructing the sclera. The proposed decellularization processes efficiently retained ECM while eliminating cells, making them robust and safe choices for mending damaged scleral tissue. This optimized biomaterial holds the potential to improve surgical outcomes in scleral reconstruction procedures.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":"371-380"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145861916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}