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Investigations into the radical cascade route to a spiro-azaindane 螺旋氮杂茚的自由基级联途径研究
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-15 DOI: 10.24820/ark.5550190.p012.115
John A. Murphy, Chelsea D Grace, Simon Nicolle
{"title":"Investigations into the radical cascade route to a spiro-azaindane","authors":"John A. Murphy, Chelsea D Grace, Simon Nicolle","doi":"10.24820/ark.5550190.p012.115","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.115","url":null,"abstract":"The combination of modern radical generation strategies and the radical C-H functionalisation of heteroaromatics (the Minisci reaction) offers attractive routes to the preparation of complex fused heteroaromatic compounds. In this work, the one-step preparation of a trifunctionalised spiro-azaindane was investigated through a radical cascade route. In an effort to determine the most efficient approach, this cascade was initiated by 4 different radical precursors, in varying yields, adapting recently developed protocols. The best results were achieved using a triphenylpyridinium salt (Katritzky salt) under visible light irradiation","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"45 3","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Impact of a CF2 motif in the Isothiourea Catalyst Skeleton: Evaluating C(3)-F2-HBTM and its Catalytic Activity 揭示异硫脲催化剂骨架中 CF2 主题的影响：评估 C(3)-F2-HBTM 及其催化活性
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-15 DOI: 10.24820/ark.5550190.p012.093
Andrew D Smith, Matthew T Westwood, Kevin Kasten, Lotte Stockhammer, R. D. Río-Rodríguez, Jose A. Fernández‐Salas, Andreas Eitzinger, Alexandra M. Z. Slawin, Mario Waser, José Alemán, Armin Ofial
{"title":"Unveiling the Impact of a CF2 motif in the Isothiourea Catalyst Skeleton: Evaluating C(3)-F2-HBTM and its Catalytic Activity","authors":"Andrew D Smith, Matthew T Westwood, Kevin Kasten, Lotte Stockhammer, R. D. Río-Rodríguez, Jose A. Fernández‐Salas, Andreas Eitzinger, Alexandra M. Z. Slawin, Mario Waser, José Alemán, Armin Ofial","doi":"10.24820/ark.5550190.p012.093","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.093","url":null,"abstract":"The incorporation of the CF 2 motif within organic structures is known to affect the susceptibility of functional groups to oxidation, as well as altering conformation and reactivity. In this manuscript, the incorporation of the CF 2 functional group within an isothiourea catalyst skeleton to give C(3)-F 2 -HBTM is reported. Effective gram-scale routes to both racemic and enantiopure heterocyclic Lewis bases are developed, with preliminary catalytic and kinetic activity evaluated","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"41 7","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-component reaction of triphenylphosphine, dialkyl acetylenedicarboxylates, and 2-nitrocyclohexanone 三苯基膦、乙炔二甲酸二烷基酯和 2-硝基环己酮的三组分反应
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-09 DOI: 10.24820/ark.5550190.p012.028
Mohammad Piltan, Hadis Bahrami
{"title":"Three-component reaction of triphenylphosphine, dialkyl acetylenedicarboxylates, and 2-nitrocyclohexanone","authors":"Mohammad Piltan, Hadis Bahrami","doi":"10.24820/ark.5550190.p012.028","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.028","url":null,"abstract":"An efficient, one – pot three component synthesis of novel stable phosphorus ylides has been developed from the reaction between triphenylphosphine and dialkyl acetylenedicarboxylates in the presence of 2-nitrocyclohexanone. The resulting phosphorus ylides when heated in toluene afforded dialkyl 2-(2-nitrocyclohex-1-enyl)fumarate derivatives through intramolecular Wittig reaction.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"48 12","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139380035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RhIII-catalyzed synthesis and investigation of the DNA-binding properties of 11- and 13-substituted berberine derivatives RhIII 催化合成 11 和 13 取代小檗碱衍生物并研究其 DNA 结合特性
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-09 DOI: 10.24820/ark.5550190.p012.110
Heiko Ihmels, Philip N. Gross, P. M. Pithan
{"title":"RhIII-catalyzed synthesis and investigation of the DNA-binding properties of 11- and 13-substituted berberine derivatives","authors":"Heiko Ihmels, Philip N. Gross, P. M. Pithan","doi":"10.24820/ark.5550190.p012.110","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.110","url":null,"abstract":"The Rh-catalyzed annulation reaction of 2-(ethynylaryl)ethaneamines was used as key step to synthesize two berberine derivatives with hydroxy and phenyl substituents in 11-and 13-position. These compounds showed absorption and emission properties comparable to the parent alkaloid berberine. The fluorescence of the hydroxy-substituted berberine (p K a = 6.3) is efficiently quenched under acidic conditions, whereas a fluorescence light-up effect was observed with increasing pH values. The interactions of the berberine derivatives with duplex DNA and quadruplex DNA were investigated with absorption, circular dichroism (CD), and linear dichroism (LD) spectroscopy. The 13-phenyl-substituted berberine binds to duplex DNA with a binding constant of K b = 1.2  10 5 M −1 and to quadruplex DNA with K b = 1.9  10 5 M −1 . The CD-and LD-spectroscopic studies showed that the 11-hydroxy-13-phenyl-substituted berberine binds to duplex DNA by intercalation and to quadruplex DNA by terminal π stacking.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"53 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139379905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Adventures with Oximes 肟的化学探险
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-07 DOI: 10.24820/ark.5550190.p012.112
Samir Z. Zard
{"title":"Chemical Adventures with Oximes","authors":"Samir Z. Zard","doi":"10.24820/ark.5550190.p012.112","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.112","url":null,"abstract":"This account is a collection of vignettes describing new reactions discovered in the author ’ s group revolving around the chemistry of oximes. They range from ionic transformations, including reduction to unsubstituted imines and the formation of  -electrophiles, to the generation and capture of iminyl radicals, to a general synthesis of alkynes. The mechanistic reasonings and occasional serendipitous observations underlying these discoveries are discussed briefly","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"7 6","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139380299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature 十二烷基硫酸钠催化在水介质中于室温一锅三组分合成结构多样的 2-氨基-3-氰基-4-取代基-4H-色烯衍生物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-03 DOI: 10.24820/ark.5550190.p012.116
Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur
{"title":"Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature","authors":"Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur","doi":"10.24820/ark.5550190.p012.116","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.116","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"27 4","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature 十二烷基硫酸钠催化在水介质中于室温一锅三组分合成结构多样的 2-氨基-3-氰基-4-取代基-4H-色烯衍生物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-03 DOI: 10.24820/ark.5550190.p012.116
Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur
{"title":"Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature","authors":"Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur","doi":"10.24820/ark.5550190.p012.116","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.116","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"27 4","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139114256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation 通过氧烯丙基阳离子制备环丙酮 2,2,2-三氟乙氧基半乙酸酯
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-03 DOI: 10.24820/ark.5550190.p012.123
R. Saicic, Milena Veselin Trmcic, Bojan Zoran Vulovic, Matija Sergio Zlatar
{"title":"Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation","authors":"R. Saicic, Milena Veselin Trmcic, Bojan Zoran Vulovic, Matija Sergio Zlatar","doi":"10.24820/ark.5550190.p012.123","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.123","url":null,"abstract":"Hemiacetals of cyclopropanone can be isolated and stocked, contrary to their highly reactive parent ketone. However, they are not readily converted to cyclopropanone, which limits their use as its synthetic equivalents. 2,2.2-trifluoroethoxy hemiacetals are expected to be better cyclopropanone surrogates, however, they have never been prepared, so far. We show that oxyallyl cations with a heteroatom in the  -position can be intercepted with 2,2.2-trifluoroethanol, with formation of cyclopropanone trifluoroethoxy hemiacetals stable enough to be isolated, purified and characterized. These species can serve as synthetic equivalents of cyclopropanone under mild conditions.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"38 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139114838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature 十二烷基硫酸钠催化在水介质中于室温一锅三组分合成结构多样的 2-氨基-3-氰基-4-取代基-4H-色烯衍生物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-03 DOI: 10.24820/ark.5550190.p012.116
Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur
{"title":"Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature","authors":"Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur","doi":"10.24820/ark.5550190.p012.116","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.116","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"27 4","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139115805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature 十二烷基硫酸钠催化在水介质中于室温一锅三组分合成结构多样的 2-氨基-3-氰基-4-取代基-4H-苯并吡喃衍生物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-01-03 DOI: 10.24820/ark.5550190.p012.116
Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur
{"title":"Sodium dodecyl sulphate catalyzed one-pot three component synthesis of structurally diverse 2-amino-3-cyano-4-substitued-4H-chromene derivatives in aqueous medium at room temperature","authors":"Bubun Banerjee, A. Priya, Aditi Sharma, Arvind Singh, M. Kaur","doi":"10.24820/ark.5550190.p012.116","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.116","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":"27 4","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139116517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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