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Bromination of (E)-1-(5-methyl-1-(aryl)-1H-1,2,3-triazol-4-yl)-3-arylprop-2-en-1-ones using N-bromosuccinimide under acidic conditions 在酸性条件下使用 N-溴代丁二酰亚胺溴化 (E)-1-(5-甲基-1-(芳基)-1H-1,2,3-三唑-4-基)-3-芳基丙-2-烯-1-酮
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-08-13 DOI: 10.24820/ark.5550190.p012.214
Gamal A. El‐Hiti, Bakr F. Abdel-Wahab, H. Mohamed, Ehab M. Zayed, B. Kariuki
{"title":"Bromination of (E)-1-(5-methyl-1-(aryl)-1H-1,2,3-triazol-4-yl)-3-arylprop-2-en-1-ones using N-bromosuccinimide under acidic conditions","authors":"Gamal A. El‐Hiti, Bakr F. Abdel-Wahab, H. Mohamed, Ehab M. Zayed, B. Kariuki","doi":"10.24820/ark.5550190.p012.214","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.214","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bromination of (E)-1-(5-methyl-1-(aryl)-1H-1,2,3-triazol-4-yl)-3-arylprop-2-en-1-ones using N-bromosuccinimide under acidic conditions 在酸性条件下使用 N-溴代丁二酰亚胺溴化 (E)-1-(5-甲基-1-(芳基)-1H-1,2,3-三唑-4-基)-3-芳基丙-2-烯-1-酮
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-08-13 DOI: 10.24820/ark.5550190.p012.214
Gamal A. El‐Hiti, Bakr F. Abdel-Wahab, H. Mohamed, Ehab M. Zayed, B. Kariuki
{"title":"Bromination of (E)-1-(5-methyl-1-(aryl)-1H-1,2,3-triazol-4-yl)-3-arylprop-2-en-1-ones using N-bromosuccinimide under acidic conditions","authors":"Gamal A. El‐Hiti, Bakr F. Abdel-Wahab, H. Mohamed, Ehab M. Zayed, B. Kariuki","doi":"10.24820/ark.5550190.p012.214","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.214","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An alternative synthetic strategy to construct apixaban analogues 构建阿哌沙班类似物的另一种合成策略
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-27 DOI: 10.24820/ark.5550190.p012.151
R. Dandela, Dattatray Gaikwad, Rana Chatterjee, Sujeet A. Gaware, Achyuta Nanda Acharya
{"title":"An alternative synthetic strategy to construct apixaban analogues","authors":"R. Dandela, Dattatray Gaikwad, Rana Chatterjee, Sujeet A. Gaware, Achyuta Nanda Acharya","doi":"10.24820/ark.5550190.p012.151","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.151","url":null,"abstract":"An alternate synthetic approach has been described to access novel apixaban analogues. The present strategy offers a practical and cost-effective synthetic procedure to construct the privileged scaffold and its amide derivatives that may exhibit promising anticoagulant potency. Moreover, the method was performed by using less expensive reagents, easily achievable precursors","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex-assisted PtZn alloy formation for propane dehyrogenation 用于丙烷脱氢的络合物辅助铂锌合金形成
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-20 DOI: 10.24820/ark.5550190.p012.190
Qian He, Chaokai Xu, Bingqing Yao
{"title":"Complex-assisted PtZn alloy formation for propane dehyrogenation","authors":"Qian He, Chaokai Xu, Bingqing Yao","doi":"10.24820/ark.5550190.p012.190","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.190","url":null,"abstract":"This work","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrazolidines: synthesis, reactivity, physical and biological properties 吡唑烷：合成、反应性、物理和生物特性
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-14 DOI: 10.24820/ark.5550190.p012.223
Rosa M. Claramunt, D. Sanz, J. Elguero, I. Alkorta
{"title":"Pyrazolidines: synthesis, reactivity, physical and biological properties","authors":"Rosa M. Claramunt, D. Sanz, J. Elguero, I. Alkorta","doi":"10.24820/ark.5550190.p012.223","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.223","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TosMIC-free synthesis of bempedoic acid, a hypercholesterolemia drug 不含 TosMIC 的高胆固醇血症药物鱼藤酸的合成
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-12 DOI: 10.24820/ark.5550190.p012.204
B.V. Subba reddy, Rachel Gundamalla, Rajashaker Bantu
{"title":"TosMIC-free synthesis of bempedoic acid, a hypercholesterolemia drug","authors":"B.V. Subba reddy, Rachel Gundamalla, Rajashaker Bantu","doi":"10.24820/ark.5550190.p012.204","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.204","url":null,"abstract":"A novel concise and convergent approach for the preparation of bempedoic acid, a new group of non-statin LDL-lowering drug has been developed starting from pentane-1,5-diol in 8 steps with an overall yield of 20%. Result: The synthesis of a key precursor i.e. 1,11-dihydroxyundecan-6-one, has been accomplished through the ring opening of  - caprolactone with alkyl Grignard reagent. This method doesn’t require the use of p - toluenesulfonylmethylisocyanaide (TosMIC) for the construction of dihyroxyketone, a key intermediate of bempedoic acid. The key steps involved in this approach are the bromination of dihydroxyketone and base-catalyzed alkylation of methyl isobutyrate with 1,11-dibromoundecan-6-ol followed by the hydrolysis of dimethyl ester into bempedoic acid.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An efficient synthesis of new pyrazolone-substituted C-acylimine derivatives by three-component reaction between arylglyoxal derivatives, arylamines and pyrazolone 通过芳基乙二醛衍生物、芳基胺和吡唑酮的三组分反应高效合成新的吡唑酮取代的 C-酰亚胺衍生物
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-11 DOI: 10.24820/ark.5550190.p012.219
M. Anary‐Abbasinejad, Maryam Oudi
{"title":"An efficient synthesis of new pyrazolone-substituted C-acylimine derivatives by three-component reaction between arylglyoxal derivatives, arylamines and pyrazolone","authors":"M. Anary‐Abbasinejad, Maryam Oudi","doi":"10.24820/ark.5550190.p012.219","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.219","url":null,"abstract":"An effective protocol for synthesis of some new pyrazolone-substituted C-acylimine derivatives is reported through a one-pot three-component reaction between arylglyoxals, aniline derivatives and pyrazolone. All reactions were conducted in ethanol/acetic acid mixture as solvent and the stable products were obtained by simple filtering off the precipitated solids in high yields. The structures of all products were proved by 1 H and 13 C NMR and IR spectral and elemental analysis data","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cycloaddition chemistry of 3-oxidopyraziniums. Dimerisation of 3-oxido-1-(4-methoxybenzyl)-5,6-dimethylpyrazinium 3-oxidopyraziniums 的环加成化学。3-氧代-1-(4-甲氧基苄基)-5,6-二甲基吡嗪的二聚化反应
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-06 DOI: 10.24820/ark.5550190.p012.217
M. Planas, Gerard Riesco-Llach, L. Feliu, J. Joule
{"title":"The cycloaddition chemistry of 3-oxidopyraziniums. Dimerisation of 3-oxido-1-(4-methoxybenzyl)-5,6-dimethylpyrazinium","authors":"M. Planas, Gerard Riesco-Llach, L. Feliu, J. Joule","doi":"10.24820/ark.5550190.p012.217","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.217","url":null,"abstract":"3-Oxidopyraziniums are accessed from 2(1 H )-pyrazinones via N-alkylation and then exposure of the resulting pyrazinium salts to mild base at room temperature. 3-Oxidopyraziniums react with acrylates in a 1,3-dipolar cyclisation producing 3,8-diazabicyclo[3.2.1]octanes. 3-Oxido-1-(4-methoxybenzyl)-5,6-dimethylpyrazinium (C 14 H 16 N 2 O 2 ) dimerises at room temperature, forming a tetracyclic alcohol C 28 H 34 N 4 O 5 , the structure of which was elucidated using spectroscopic and X-ray analyses.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of Benzyne from Aryl Benziodoxaborole Triflate under Aqueous Conditions and its Reactions with Alkyl Aryl Sulfides 水溶液条件下从苯齐碘氧硼酸芳基酯生成苄炔及其与烷基芳基硫化物的反应
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-06 DOI: 10.24820/ark.5550190.p012.213
V. Zhdankin, A. Yoshimura, Kim Ngo, I. Mironova, Zachary S. Gardner, Nami Ogura, Akiharu Ueki, M. Yusubov, Akio Saito
{"title":"Generation of Benzyne from Aryl Benziodoxaborole Triflate under Aqueous Conditions and its Reactions with Alkyl Aryl Sulfides","authors":"V. Zhdankin, A. Yoshimura, Kim Ngo, I. Mironova, Zachary S. Gardner, Nami Ogura, Akiharu Ueki, M. Yusubov, Akio Saito","doi":"10.24820/ark.5550190.p012.213","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.213","url":null,"abstract":"Mesityl benziodoxaborole triflate is a unique benzyne precursor under aqueous conditions in the presence of NaHCO 3 at room temperature. Reactions of alkyl aryl sulfides with benzyne generated under these conditions selectively afford the corresponding sulfonium salts. In contrast, the previously reported reactions of alkyl aryl sulfides with common benzyne precursors under strongly basic anhydrous conditions lead to various products of cyclization, rearrangement","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A DFT Study of Mono-, Bi- and Tricyclic Examples of Semi-conjugated Heterocyclic Mesomeric Betaines 半共轭杂环中生甜菜碱的单环、双环和三环实例的 DFT 研究
IF 0.8 4区 化学
Arkivoc Pub Date : 2024-07-06 DOI: 10.24820/ark.5550190.p012.224
Christopher A. Ramsden, W. P. Oziminski
{"title":"A DFT Study of Mono-, Bi- and Tricyclic Examples of \u0000Semi-conjugated Heterocyclic Mesomeric Betaines","authors":"Christopher A. Ramsden, W. P. Oziminski","doi":"10.24820/ark.5550190.p012.224","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.224","url":null,"abstract":"The properties of heterocyclic mesomeric betaines (HMBs) are determined by the connectivity between the ring 2 π heteroatoms and the odd conjugated fragments that complete the ring. In contrast to conjugated HMBs (1,3-dipoles) and cross-conjugated HMBs (1,4-dipoles), semi-conjugated HMBs are a class of heterocycle that is unexplored. The only known example is 1,4-dimethyl-1,2,4,5-tetrazinium-3,6-diolate. In this study density functional theory (DFT) methodology is employed to further investigate the structures and properties of examples of mono- bi-and tricyclic semi-conjugated HMBs. A common feature associated with the ‘semi - conjugation’ is a small energy gap between the frontier orbitals","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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