揭示异硫脲催化剂骨架中 CF2 主题的影响：评估 C(3)-F2-HBTM 及其催化活性

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Arkivoc Pub Date : 2024-01-15 DOI:10.24820/ark.5550190.p012.093

Andrew D Smith, Matthew T Westwood, Kevin Kasten, Lotte Stockhammer, R. D. Río-Rodríguez, Jose A. Fernández‐Salas, Andreas Eitzinger, Alexandra M. Z. Slawin, Mario Waser, José Alemán, Armin Ofial

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引用次数: 0

摘要

众所周知，在有机结构中加入 CF 2 基团会影响官能团对氧化的敏感性，并改变构象和反应活性。在本手稿中，报告了在异硫脲催化剂骨架中加入 CF 2 功能基团以得到 C(3)-F 2 -HBTM。该研究开发了外消旋和对映体纯杂环路易斯碱的有效克级路线，并对其催化和动力学活性进行了初步评估。

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Unveiling the Impact of a CF2 motif in the Isothiourea Catalyst Skeleton: Evaluating C(3)-F2-HBTM and its Catalytic Activity

The incorporation of the CF 2 motif within organic structures is known to affect the susceptibility of functional groups to oxidation, as well as altering conformation and reactivity. In this manuscript, the incorporation of the CF 2 functional group within an isothiourea catalyst skeleton to give C(3)-F 2 -HBTM is reported. Effective gram-scale routes to both racemic and enantiopure heterocyclic Lewis bases are developed, with preliminary catalytic and kinetic activity evaluated

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来源期刊

Arkivoc 化学-有机化学

CiteScore

1.10

自引率

11.10%

发文量

120

审稿时长

3.1 months

期刊介绍： Arkivoc publishes full papers (not accounts) describing sound original work that is of interest to organic chemists (in areas of synthetic organic chemistry, bio-organic, organometallic, theoretical, and physical organic chemistry: General Papers describing sound original work Reviews and Accounts of selected topics Honorary Issues - Pay tribute to distinguished organic chemists (invited contributions) Thematic Issues - Cover important current topics in organic chemistry Regional Issues - Recognize organic chemistry in various countries.