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Synthesis of New bis-Heterocyclic Hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions 通过 Hantzsch、Michael 和 Biginelli 反应合成由异丙醇单元连接的新型双杂环杂化物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-06-17 DOI: 10.24820/ark.5550190.p012.209
Ismail A. Abdelhamid, Hadeer M. Diab, Nesma E. Mahmoud, Ahmed H. M. Elwahy, Ibrahim Fares
{"title":"Synthesis of New bis-Heterocyclic Hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions","authors":"Ismail A. Abdelhamid, Hadeer M. Diab, Nesma E. Mahmoud, Ahmed H. M. Elwahy, Ibrahim Fares","doi":"10.24820/ark.5550190.p012.209","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.209","url":null,"abstract":"Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3-diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1 H NMR, 13 C NMR, IR, and MS spectra.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis of 1,4-benzoxazinones using a choline chloride based deep eutectic solvent 使用基于氯化胆碱的深共晶溶剂绿色合成 1,4-苯并恶嗪酮类化合物
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-06-17 DOI: 10.24820/ark.5550190.p012.149
A. Sharifi, Marzieh Sharifi, M. S. Abaee, M. Mirzaei
{"title":"Green synthesis of 1,4-benzoxazinones using a choline chloride based deep eutectic solvent","authors":"A. Sharifi, Marzieh Sharifi, M. S. Abaee, M. Mirzaei","doi":"10.24820/ark.5550190.p012.149","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.149","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A convenient synthetic approach to 11H-indolo[3,2-c]quinoline framework via Friedlander condensation and Cadogan cyclization 通过弗里德兰德缩合和卡多根环化合成 11H-吲哚并[3,2-c]喹啉框架的简便方法
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-06-11 DOI: 10.24820/ark.5550190.p012.176
Sheng Liu, Ru Li
{"title":"A convenient synthetic approach to 11H-indolo[3,2-c]quinoline framework via Friedlander condensation and Cadogan cyclization","authors":"Sheng Liu, Ru Li","doi":"10.24820/ark.5550190.p012.176","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.176","url":null,"abstract":"Indolo[3,2-c ]quinolines bearing various substituents have been prepared from o-aminobenzaldehydes and 2-nitrophenyl substituted ketones through a two-step sequence involving Friedlander condensation and Cadogan cyclization.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trisodium citrate dihydrate catalyzed one-pot four component synthesis of spiropyrano-indenoquinoxaline derivatives and their molecular docking analysis on the anti-cancer efficacies 二水柠檬酸钠催化一锅四组分合成螺吡喃-茚喹喔啉衍生物及其抗癌功效的分子对接分析
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-06-09 DOI: 10.24820/ark.5550190.p012.203
Bubun Banerjee, Aditi Sharma, Pooja A. Chawla, K. Jha, Kinkar Biswas, Mayukh Dev, M. Kaur, A. Priya, Arvind Singh
{"title":"Trisodium citrate dihydrate catalyzed one-pot four component synthesis of spiropyrano-indenoquinoxaline derivatives and their molecular docking analysis on the anti-cancer efficacies","authors":"Bubun Banerjee, Aditi Sharma, Pooja A. Chawla, K. Jha, Kinkar Biswas, Mayukh Dev, M. Kaur, A. Priya, Arvind Singh","doi":"10.24820/ark.5550190.p012.203","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.203","url":null,"abstract":"A efficient, simple and facile protocol has been developed for the synthesis of a series of spiropyrano-indenoquinoxaline derivatives via one-pot four component reactions of ninhydrin, o -phenylenediamines, malononitrile and various C-H activated acids using a catalytic amount of trisodium citrate dihydrate as catalyst in an aqueous ethanol under refluxed conditions. The docking analysis revealed promising anti-cancer activities of these synthesized compounds.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Developments in Synthetic Strategies, Reactions and Biological Importance of Thieno[2,3-c]Pyrazoles 噻吩并[2,3-c]吡唑的合成策略、反应和生物学意义的最新进展
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-06-01 DOI: 10.24820/ark.5550190.p012.187
Abdel-Rahman Ali Hassan Farghaly, Abdullah A. Alamria
{"title":"Recent Developments in Synthetic Strategies, Reactions and Biological Importance of Thieno[2,3-c]Pyrazoles","authors":"Abdel-Rahman Ali Hassan Farghaly, Abdullah A. Alamria","doi":"10.24820/ark.5550190.p012.187","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.187","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Xanthate Radical Addition Route to Sulfur Heterocycles 硫杂环的黄原酸盐自由基加成途径
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-05-25 DOI: 10.24820/ark.5550190.p012.199
S. Zard, B. Quiclet-Sire
{"title":"The Xanthate Radical Addition Route to Sulfur Heterocycles","authors":"S. Zard, B. Quiclet-Sire","doi":"10.24820/ark.5550190.p012.199","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.199","url":null,"abstract":".","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel bis([triazolo[3,4-b]thiadiazoles and bis([triazolo[3,4-b][thiadiazines) with antioxidant activity 具有抗氧化活性的新型双([三唑并[3,4-b]噻二唑和双([三唑并[3,4-b]噻二嗪))
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-05-21 DOI: 10.24820/ark.5550190.p012.181
Mostafa E. Salem, Ahmed H. M. Elwahy, Ahmed R. S. Ginidi, Mohamed R. Shaaban, Akram H. Mohamed, Hatem M. Gaber, Laila I. Ibrahim, Ahmed M. Farag
{"title":"Novel bis([triazolo[3,4-b]thiadiazoles and bis([triazolo[3,4-b][thiadiazines) with antioxidant activity","authors":"Mostafa E. Salem, Ahmed H. M. Elwahy, Ahmed R. S. Ginidi, Mohamed R. Shaaban, Akram H. Mohamed, Hatem M. Gaber, Laila I. Ibrahim, Ahmed M. Farag","doi":"10.24820/ark.5550190.p012.181","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.181","url":null,"abstract":"A novel bis-triazole was synthesized in this context, and its potential usage as a flexible precursor for new bis-triazolothiadiazines and bis-triazolothiadiazoles with antioxidant properties was reported. The novel compounds' structures were determined using elemental analysis and spectrum data. According to the DPPH assay results, the newly synthesized compounds have noteworthy antioxidant characteristics","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141115038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syntheses of Tricyclic Fused Quinoxaline Ring Systems: Furoquinoxalines 三环融合喹喔啉环系统的合成：呋喃喹喔啉
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-05-16 DOI: 10.24820/ark.5550190.p012.177
Abdel-Rahman Ali Hassan Farghaly, Sameh Elgogary, Nasser Amri, E. M. El-Telbani
{"title":"Syntheses of Tricyclic Fused Quinoxaline Ring Systems: Furoquinoxalines","authors":"Abdel-Rahman Ali Hassan Farghaly, Sameh Elgogary, Nasser Amri, E. M. El-Telbani","doi":"10.24820/ark.5550190.p012.177","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.177","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereospecific cyclization of a pseudo-C2-cymmetric unsaturated diol 伪 C2-对称不饱和二元醇的立体特异性环化
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-05-12 DOI: 10.24820/ark.5550190.p012.179
N. Maulide, Bogdan R Brutiu, Phillip S. Grant, Daniel Kaiser
{"title":"Stereospecific cyclization of a pseudo-C2-cymmetric unsaturated diol","authors":"N. Maulide, Bogdan R Brutiu, Phillip S. Grant, Daniel Kaiser","doi":"10.24820/ark.5550190.p012.179","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.179","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An application of triflic anhydride as an acid activator: Synthesis of N?-protected amino hydroxamic acids 三酸酐作为酸活化剂的应用：合成 N?-保护氨基羟肟酸
IF 0.9 4区 化学
Arkivoc Pub Date : 2024-05-09 DOI: 10.24820/ark.5550190.p012.173
V. Sureshbabu, Eti Chetan kumar, Srinivasulu Chinthaginjala
{"title":"An application of triflic anhydride as an acid activator: Synthesis of N?-protected amino hydroxamic acids","authors":"V. Sureshbabu, Eti Chetan kumar, Srinivasulu Chinthaginjala","doi":"10.24820/ark.5550190.p012.173","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.173","url":null,"abstract":"A One-step synthesis of N α -protected amino hydroxamic acids using triflic anhydride as an acid activator is demonstrated. The reaction can be executed under simple and mild conditions with good yields and purity. This method provides compatibility to Fmoc, Cbz and Boc protecting groups and the reaction is racemization-free which adds an advantage.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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