Arthritis Research & Therapy最新文献

{"title":"Increased soluble CD200 in serum of SLE patients does not reflect disease activity or affect CD200R1 function in T cells.","authors":"Ellen D Kaan, Fabienne Verburg, Maarten Limper, Linde Meyaard, Michiel van der Vlist","doi":"10.1186/s13075-026-03782-1","DOIUrl":"10.1186/s13075-026-03782-1","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of candidate biomarkers for diagnosis, disease activity, and relapse prediction in IgG4-related disease.","authors":"Qiyuan Hao, Difei Lian, Mingzhu Zhou, Hang Zhou, Xia Zhang, Tianqi Wang, Huilan Liu, Lan Gao, Mingxin Bai, Yuetong Xu, Fan Yang, Guang Yang, Zhitao Ying, Yini Wang, Xiaolin Sun, Yanying Liu","doi":"10.1186/s13075-026-03787-w","DOIUrl":"10.1186/s13075-026-03787-w","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting clinical response in psoriatic arthritis through integrative analysis of transcriptomics and proteomics.","authors":"Mieke L M Bentvelzen, Said El Bouhaddani, Julia Spierings, Arno N Concepcion, Harald E Vonkeman, Shasti C Mooij, Lydia G Schipper, Amin Herman, Simone A Vreugdenhil, Simon C Mastbergen, Paco M J Welsing","doi":"10.1186/s13075-026-03788-9","DOIUrl":"10.1186/s13075-026-03788-9","url":null,"abstract":"<p><strong>Background: </strong>The therapeutic response to disease-modifying antirheumatic drugs (DMARDs) remains relatively low in psoriatic arthritis (PsA), leading to delayed disease control and frequent treatment switches. Predictive biomarkers may enable personalized treatment and earlier disease control. We aimed to identify transcriptomic and proteomic markers for tofacitinib or comparator treatment outcomes and develop a prediction model to support treatment decisions in PsA patients.</p><p><strong>Methods: </strong>Baseline CD4⁺ T-cell transcriptomics and proteomics data from 80 PsA patients in the development cohort of the TOFA-PREDICT trial were analyzed. The TOFA-PREDICT trial is a four-arm randomized trial that was designed to discover profiles of PsA patients that predict response to tofacitinib as compared with methotrexate or etanercept. Forty DMARD-naïve patients were randomized to tofacitinib or methotrexate, and 40 patients who failed DMARD-treatment were randomized to add-on tofacitinib or etanercept. Treatment response was defined as reaching minimal disease activity at 16 weeks. Feature selection was performed in the full cohort and in each treatment subgroup using XGBoost and sPLS-DA. Using different modeling strategies, prediction models were developed that combine clinical variables with transcriptomic, proteomic, or integrated multi-omics predictors. The models were cross-validated and compared using AUC-ROC and their ability to identify the most promising treatment (tofacitinib versus control) per patient.</p><p><strong>Results: </strong>Fifty percent of patients responded to treatment. Eighteen transcriptomic, ten proteomic, and two clinical predictors were selected. The integrated multi-omics model incorporating treatment-predictor interactions achieved the highest performance (AUC = 0.70 ± 0.19; variation (SD) in treatment-effects in patients 15.2% ± 14.8%). The selected proteins were significantly interconnected (p-value = 3.41E-5) and related to immune system processes.</p><p><strong>Conclusions: </strong>Integrated baseline gene and protein expression profiles combined with clinical variables can predict treatment response and identify differential treatment effects between individual patients. These findings demonstrate the potential of omics-guided personalized treatment for patients with PsA.</p><p><strong>Trial registration: </strong>EU Clinical Trials, 2017-003900-28.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.","authors":"Oriana Coquoz, Léa Schlunke, Ilayda Turan, Coralie Hoffmann Schreiner, Isa Uccelli, Cindy Serdjebi, Jimmy Stalin","doi":"10.1186/s13075-026-03777-y","DOIUrl":"10.1186/s13075-026-03777-y","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of glucocorticoid-free clinical remission in patients with newly diagnosed microscopic polyangiitis and granulomatosis with polyangiitis: a retrospective cohort study using a nationwide registry in Japan (J-CANVAS).","authors":"Yusuke Ushio, Risa Wakiya, Hiromi Shimada, Koichi Sugihara, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Makoto Wada, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Hirosuke Takagi, Koji Endo, Shintaro Hirata, Naoto Azuma, Tohru Takeuchi, Shoichi Fukui, Kazuro Kamada, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Tsuyoshi Shirai, Takafumi Ito, Isao Matsumoto, Toshihiko Takada, Toshiko Ito-Ihara, Takashi Kida, Nobuyuki Yajima, Takashi Kawaguchi, Yutaka Kawahito, Hiroaki Dobashi","doi":"10.1186/s13075-026-03780-3","DOIUrl":"10.1186/s13075-026-03780-3","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble factors released from fibroblast-like synoviocytes of JIA patients with future extended course can condition persistent JIA synovial fibroblasts for increased IL-6 production.","authors":"Megan M Simonds, Lina Al-Jaberi, Hermine I Brunner, AnneMarie C Brescia","doi":"10.1186/s13075-026-03783-0","DOIUrl":"10.1186/s13075-026-03783-0","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a risk score for serious infection in patients with rheumatic diseases receiving prolonged high-dose glucocorticoids.","authors":"Se Rim Choi, Ju Yeon Kim, You-Jung Ha, Jin Kyun Park, Eun Ha Kang, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Jun Won Park","doi":"10.1186/s13075-026-03756-3","DOIUrl":"10.1186/s13075-026-03756-3","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interpretable machine learning model integrating clinical and CT radiomic features for the detection of interstitial lung disease in idiopathic inflammatory myopathies.","authors":"Kai Xu, Mengke Zhang, Xiaodi Zhao, Jingjing Dong, Biru Song, Yangyang Li, Wenpeng Ge, Zixun Qin, Xinjun Li, Zhiqiang Zhang, Changhua Liang, Zhixia Wang","doi":"10.1186/s13075-026-03781-2","DOIUrl":"10.1186/s13075-026-03781-2","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality, duration, and multi-trajectories as predictors of rheumatoid arthritis: evidence from the english longitudinal study of ageing.","authors":"Zeping Chen, Wei Zhao, Dong Yang, Rui Xie","doi":"10.1186/s13075-026-03784-z","DOIUrl":"10.1186/s13075-026-03784-z","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib for refractory Behcet's syndrome: a multi-centre, single-arm trial.","authors":"Jiachen Li, Weiyi Xia, Huijuan Ji, Xiaoxin Gong, Qi Dong, Yanan Wu, Longjun Wang, Meixia Peng, Sifan Geng, Jingxuan Liu, Ke Ma, Qi Yu, Xinglei Cui, Yuanyuan Luo, Wenhua Zhu, Shumin Zhang, Shi Chen, Yuhui Li, Zhanguo Li, Tian Liu","doi":"10.1186/s13075-026-03778-x","DOIUrl":"10.1186/s13075-026-03778-x","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}