Arthritis Research & Therapy最新文献

{"title":"Outcomes in JIA have greatly improved, but we can still do better","authors":"Stephanie Shoop-Worrall,Kirsten Minden","doi":"10.1186/s13075-026-03775-0","DOIUrl":"https://doi.org/10.1186/s13075-026-03775-0","url":null,"abstract":"Abstract Outcomes for children and adolescents with juvenile idiopathic arthritis (JIA) have improved substantially over the past two decades, driven by biologic and targeted synthetic DMARDs, treat-to-target strategies with regular standardized assessments, and multidisciplinary specialist care. These advances have reduced mortality to near-population levels, increased remission rates, and minimized long-term joint damage. Yet progress remains uneven across JIA categories, and many young people still experience persistent pain, fatigue, psychosocial burden, and reduced quality of life despite adequate inflammatory control. Early diagnosis and timely initiation of effective therapy remain critical but remain inconsistent. The lack of reliable biomarkers or predictors of treatment response continues to limit individualized care, reinforcing trial-and-error prescribing. Future priorities include precision medicine approaches, consistent outcome measurement, stronger multidisciplinary models, and structured transition to adult services. Active patient involvement in research and care is essential to ensure equitable, patient-centred progress.","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"47 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared fecal metabolomic signatures define cross-disease subtypes in primary Sjögren’s disease and systemic lupus erythematosus","authors":"Nan Wang,Lili Shang,Le Qiang,Yaping Zhang,Zhaojun Liang,Chong Gao,Jing Luo","doi":"10.1186/s13075-026-03887-7","DOIUrl":"https://doi.org/10.1186/s13075-026-03887-7","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"37 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic concentrations of cartilage oligomeric matrix protein, neo-epitope of MMP-derived type III collagen fragment, and propeptide of type IV collagen are greater in those at risk of post-traumatic osteoarthritis in comparison to matched controls","authors":"Karl Morgan,Yi He,Lilly Dietel,Antara Jain,Shoji Leach,Zak Sheehy,Molly Robb,James Murray,Sunny Deo,Anne-Christine Bay-Jensen,Dario Cazzola,Jean-Philippe Walhin","doi":"10.1186/s13075-026-03893-9","DOIUrl":"https://doi.org/10.1186/s13075-026-03893-9","url":null,"abstract":"Abstract Background Intra-articular knee injuries substantially increase the risk of post-traumatic osteoarthritis (PTOA). Identifying systemic biomarkers that reflect early joint tissue remodelling may improve detection of PTOA related biological activity following injury. However, no circulating biomarkers have been established for this population. This study examined whether systemic extracellular matrix protein fragments differ in young adults 1–7 years after surgically managed intra-articular knee injury compared with matched uninjured controls. Secondary aims were to evaluate the discriminative performance of a biomarker panel and explore associations with PTOA illness. Methods Thirty-eight individuals with prior surgically managed intra-articular knee injury and 38 matched uninjured controls participated. Groups were matched for sex, age, body composition, and aerobic capacity. After 30 min of non-weight bearing rest, serum and plasma samples were collected and biomarkers reflecting extracellular matrix turnover, inflammation and adiposity were quantified using immunoassay. Multivariate and univariate analyses were performed, and discriminative performance was evaluated using receiver operating characteristic analysis with leave-one-pair-out cross-validation. Results Multivariate analysis demonstrated significant separation between groups (R² = 0.09, p  = 0.0004), driven by biomarkers reflecting cartilage oligomeric matrix protein and type III and type IV collagen turnover. Univariate analyses showed moderate-to-large paired effects for these biomarkers. A combined three-biomarker model demonstrated acceptable discrimination (area under the curve = 0.77, 95% confidence interval 0.66–0.87), which remained robust under cross-validation (area under the curve = 0.73, 95% confidence interval 0.61–0.84). Conclusions Systemic biomarkers of extracellular matrix remodelling differ in young adults following surgically managed intra-articular knee injury. A multivariate biomarker panel may capture early PTOA-related biological activity and support future risk stratification.","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"78 2 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial transcriptomics reveals distinct phenotype of proliferating and interferon-activated T lymphocytes in macrophage activation syndrome driven liver inflammation in systemic juvenile idiopathic arthritis","authors":"Taskin Sabit,Minyi Yu,Lara Berklite,Sarangarajan Ranganathan,Grant S. Schulert,Esraa Eloseily,Alexei A. Grom","doi":"10.1186/s13075-026-03894-8","DOIUrl":"https://doi.org/10.1186/s13075-026-03894-8","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"20 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic CD19 CAR-NK cell therapy for a patient with relapsed and refractory lupus nephritis.","authors":"Yu Tang, Yanru Wang, Wei Shi, Xun Gong, Yingying Qiu, Jialiang Deng, Hailu Li, Ming Sun, Xiaoming Fei","doi":"10.1186/s13075-026-03892-w","DOIUrl":"10.1186/s13075-026-03892-w","url":null,"abstract":"<p><strong>Objective: </strong>To monitor changes in the clinical course and adverse events following allogeneic CD19 CAR-NK cell therapy in a patient with relapsed/refractory lupus nephritis (LN).</p><p><strong>Methods: </strong>This case report depicts a patient with severe LN refractory to available treatments (including prednisone, mycophenolate mofetil and belimumab) was treated with allogenic CD19-CAR NK cells. Prior to infusion with CD19 CAR-NK cells, this patient received condition lymphodepleting chemotherapy with cyclophosphamide 300 mg/m²/d and fludarabine 25 mg/m²/d intravenously on day - 5, - 4, and - 3. The patient's response to CD19 CAR-NK treatment was evaluated by SLEDAI-2 K score, Lupus Low Disease Activity State (LLDAS) and the Definitions of Remission in SLE (DORIS) remission criteria.</p><p><strong>Results: </strong>Clinical symptoms improved rapidly after infusion of CD19-targeted CAR NK cells. Three months after CAR-NK therapy, the patient's SLEDAI-2 K score decreased from 14 to 8. Clinical remission of arthritis and alopecia was achieved one month following CAR-NK cell infusion, while clinical remission of proteinuria was observed six months after the second infusion, at which time the 2021 DORIS remission criteria were also met, and this remission has persisted through the latest follow-up at 20 months.</p><p><strong>Conclusion: </strong>CD19-targeted CAR-NK cell therapy achieved durable remission in a patient with relapsed/refractory LN and showed favorable safety and tolerability.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"28 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic assessment of the distal interphalangeal joints in psoriatic arthritis and osteoarthritis of the hand: definition and prevalence of elementary lesions to support differential diagnosis","authors":"Garifallia Sakellariou,Ilaria Tinazzi,Marco Canzoni,Carmelo Pirri,Alberto Batticciotto,Christian Dejaco,Orazio De Lucia,Georgios Filippou,Nicolò Girolimetto,Luca Idolazzi,Pierluigi Macchioni,Niccolò Possemato,Greta Carrara,Annamaria Iagnocco","doi":"10.1186/s13075-026-03889-5","DOIUrl":"https://doi.org/10.1186/s13075-026-03889-5","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"172 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated pro-BNP and low-grade inflammation are associated with low bone mineral density in systemic sclerosis, a case control study.","authors":"Kerstin Lillpers, Kristofer Andréasson, Seyed Morteza Najibi, Anthony D Woolf, Roger Hesselstrand, Kristina E Åkesson, Meliha C Kapetanovic","doi":"10.1186/s13075-026-03888-6","DOIUrl":"10.1186/s13075-026-03888-6","url":null,"abstract":"<p><strong>Background: </strong>Bone mineral density (BMD) is compromised in patients with systemic sclerosis (SSc) compared to the background population, yet the underlying disease related factors are less known. This study evaluates SSc disease-related features and predictability for BMD along with established risk factors for low BMD in SSc patients compared to controls.</p><p><strong>Methods: </strong>The study includes 211 SSc patients, 182 women and 29 men (mean age 61 yrs, mean disease duration 9 yrs) regularly followed at the Skåne University Hospital, Lund, Sweden and 505 age- and sex-matched controls.</p><p><strong>Data collection: </strong>BMD hip and spine, BMI, SSc-features, biomarkers and potential risk factor questionnaire. Multinomial logistic regression analysis was used to calculate BMD odds ratio (OR); multiple linear regression for associations between T-score and SSc-related variables and lifestyle factors; and machine learning to fit a model to predict total hip T-score in SSc.</p><p><strong>Results: </strong>NT-proBNP and elevated CRP were independently associated with low BMD in SSc patients (p<0.001), as were diffuse cutaneous disease subtype, finger ulcers, vital lung capacity and anti-topoisomerase I antibodies (ATA). BMI, menopausal status, low physical activity and higher medication burden were associated with lower hip T-score. Predictive modeling identified BMI and NT-proBNP as the strongest determinants of hip T-score.</p><p><strong>Conclusion: </strong>This large case-control study finds elevated NT-proBNP, indicators of low-grade inflammation and of disease severity negatively associated with BMD in SSc patients, in addition to several established risk factors. This highlights the importance of BMD assessment to identify at-risk SSc patients beyond traditional risk stratification.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"28 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Sjögren's patient subgroups identified through whole genome DNA methylation profiling.","authors":"Olivia Solomon, Caroline Shiboski, Kimberly E Taylor, Hong Quach, Diana Quach, Lisa F Barcellos, Lindsey A Criswell","doi":"10.1186/s13075-026-03883-x","DOIUrl":"10.1186/s13075-026-03883-x","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"28 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of apremilast on entheseal bone damage in psoriasis patients at risk of developing psoriatic arthritis - data from the prospective, interventional EPOS study","authors":"David Simon, Ioanna Minopoulou, Sara Bayat, Louis Schuster, Koray Tascilar, Frank Roemer, Melek Yalcin Mutlu, Jürgen Rech, Dagmar Werner, Gerhard Krönke, Filippo Fagni, Michael Sticherling, Georg Schett, Arnd Kleyer","doi":"10.1186/s13075-026-03873-z","DOIUrl":"https://doi.org/10.1186/s13075-026-03873-z","url":null,"abstract":"A subset of psoriasis (PsO) patients exhibits subclinical entheseal inflammation and bone remodeling placing them at higher risk of developing psoriatic arthritis (PsA). Whether early pharmacological interventions during this phase can modulate these inflammatory and structural changes remains largely unclear.","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"19 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-driven bone erosion and reactive remodeling in experimental arthritis revealed by cortical bone surface analysis.","authors":"Anders Nguyen, David A McBride, Miriam Bollmann, Liam Davidsson, Nour Dada, Taymaa Sami, Lisi Wagener, Carmen Corciulo, Muhammad Arif, Linda C Johansson, Mattias N D Svensson","doi":"10.1186/s13075-026-03874-y","DOIUrl":"10.1186/s13075-026-03874-y","url":null,"abstract":"<p><strong>Background: </strong>Pre-clinical models of inflammatory arthritis are widely used to investigate mechanisms of disease pathology and evaluate therapeutic interventions. However, the sequence of inflammatory activation, bone erosion and reactive bone remodeling remains incompletely defined. We therefore sought to define the time-dependent relationship between inflammation and structural bone remodeling in experimental arthritis.</p><p><strong>Methods: </strong>K/BxN serum-transfer-induced arthritis was induced in male C57BL/6J mice, with longitudinal assessment of clinical disease, histopathology, joint gene expression and structural bone changes during disease progression. µCT analyses included semi-quantitative scoring, conventional morphometric parameters and BRAVO, our in-house µCT-based cortical surface roughness analysis workflow. Anti-RANKL treatment was used to evaluate therapeutic modulation of structural outcomes.</p><p><strong>Results: </strong>Synovial inflammation preceded histologically detectable cartilage erosion and bone erosion. Transcriptional activation of inflammatory and osteoclastogenic genes defined a pre-erosive molecular phase preceding measurable structural damage, whereas osteoblast- and matrix remodeling-associated genes increased during the reparative phase. Conventional µCT morphometrics and BRAVO both captured the overall erosive trajectory. However, BRAVO demonstrated improved discrimination of disease-associated cortical surface changes together with greater robustness, reduced age dependency, and clearer resolution of erosive and remodeling phases across disease progression. Anti-RANKL treatment significantly reduced cortical bone erosions, and these treatment-associated structural changes were readily detected by BRAVO.</p><p><strong>Conclusion: </strong>By integrating longitudinal gene expression profiling with high-resolution structural analysis, this study defines coordinated phases of inflammation-driven bone damage and reactive bone formation in experimental inflammatory arthritis. BRAVO provides a robust and sensitive approach for quantifying erosion-associated cortical surface changes and evaluating therapeutic effects on structural outcomes.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":"28 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}