Arthritis Research & Therapy最新文献

{"title":"No major effect of age (< 40 vs. ≥ 40 years) on response to secukinumab in patients with axSpA: a post hoc analysis of six phase 3 trials.","authors":"Sofia Ramiro, Corine Gaillez, Uta Kiltz, Lianne S Gensler, Chaitali Pisal, Jurgen Braun, Alexis Ogdie","doi":"10.1186/s13075-026-03804-y","DOIUrl":"https://doi.org/10.1186/s13075-026-03804-y","url":null,"abstract":"<p><strong>Background: </strong>Secukinumab is an interleukin (IL)-17 inhibitor approved to treat patients with axial spondyloarthritis (axSpA), including radiographic (r)-axSpA and non-radiographic (nr)-axSpA. Treatment recommendations highlight the importance of individualized treatment of patients with axSpA according to symptoms, extra-musculoskeletal manifestations, and comorbidities. The objective of this post hoc analysis was to compare clinical responses to secukinumab treatment through Week 16 between younger and older patients with r-axSpA and nr-axSpA from six placebo-controlled phase 3 clinical studies.</p><p><strong>Methods: </strong>This post hoc analysis evaluated data pooled from 1427 patients with axSpA from the MEASURE 1-5 trials (NCT01358175, NCT01649375, NCT02008916, NCT02159053, and NCT02896127) and the PREVENT trial (NCT02696031). All patients were randomized to secukinumab 150 mg, 300 mg, or placebo through Week 16. Patient subgroups were defined based on median age at baseline (18 to < 40 years vs. ≥ 40 years). Treatment effect (secukinumab 150/300 mg vs. placebo) within each age subgroup and the difference in treatment effect between younger vs. older age subgroups were assessed.</p><p><strong>Results: </strong>Secukinumab treatment demonstrated clinical efficacy and improvements in patient-reported outcomes vs. placebo at Week 16 in patients with r-axSpA or nr-axSpA irrespective of age. No difference in treatment effect of ASAS20, ASAS40, or ASDAS response was observed between younger vs. older patients with r-axSpA or nr-axSpA (all P>.05). Among patients with r-axSpA, younger patients experienced a larger treatment effect of secukinumab on SF-36 than older patients (difference in least-squares mean [LSM]: 2.2; P < .05). Among patients with nr-axSpA, younger patients experienced a larger treatment effect of secukinumab on the Berlin SIJ total edema score (difference in LSM: - 1.2; P < .05) and Total ASspi-MRI-a score (LSM, - 0.4; P<.05).</p><p><strong>Conclusion: </strong>Clinical efficacy of secukinumab vs. placebo at Week 16 was generally similar between older and younger patients with either r-axSpA or nr-axSpA.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic and genetic landscape of Still's disease across ages, with new insights into age-related IL-18 patterns.","authors":"Greta Rogani, Haeja Kessler, Bella Mehta, Elizabeth Baker, Helen Leavis, Sebastiaan Vastert, Grant Schulert","doi":"10.1186/s13075-026-03808-8","DOIUrl":"https://doi.org/10.1186/s13075-026-03808-8","url":null,"abstract":"<p><p>Still's disease (SD) is now widely recognized as a single disease spectrum encompassing both childhood- and adult-onset forms. While most comparative studies so far have focused on clinical manifestations and treatment responses, aspects related to the pathophysiology of the disease including molecular mechanisms and genetic predisposition have remained less deeply explored.In this review, we provide an integrated overview of current knowledge on the pathogenic pathways driving SD. We summarize evidence supporting their contribution across the age spectrum from children to adults, and discuss age-related trends in IL-18 and S100 proteins, recognized key-mediators of systemic inflammation.To complement the existing literature, we present novel data on IL-18 measurements collected in the context of cohort studies and clinical practice in three tertiary centers involved in SD care across the ages, showing a modest but significant age-related decline in patient IL-18 levels across sJIA and AOSD cohorts.Finally, we emphasize that both sJIA and AOSD share convergent genetic associations within the HLA class II region, although specific variants may exert different functional effects. In particular, HLA-DRB1*15 has been linked to disease susceptibility in the adult spectrum, whereas in children this specific HLA background appears to predispose to lung involvement and features of hypersensitivity.Altogether, the data presented collectively support the view that SD represents a single acquired and complex autoinflammatory disease in which both pediatric and adult forms share core pathogenic mechanisms as well as genetic associations within the HLA class II region. Nevertheless, we observed some differences between children and adults that remain difficult to interpret, as it remains unclear whether they reflect true biological variation or result from differences in study design or methodology. Further comparative, cross-cohort and longitudinal studies will be needed to resolve these uncertainties.</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-related composite indices and their association with osteoporosis and fragility fractures in rheumatoid arthritis.","authors":"Yutong Jiang, Lingmin Su, Xiaoyi Zhao, Xinlei Jia, Wenyu Xu, Bojin Chen, Lingying Xu, Baolin Zheng, Jieruo Gu, Mingcan Yang, Qihong Guo, Weifeng Ni","doi":"10.1186/s13075-026-03797-8","DOIUrl":"https://doi.org/10.1186/s13075-026-03797-8","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-2: a promising topical treatment for Sjögren's disease-related dry eye disease.","authors":"Bo Huang, Shiyu He, Gong Cheng, Kai Zhang, Junru He, Jing He","doi":"10.1186/s13075-026-03806-w","DOIUrl":"https://doi.org/10.1186/s13075-026-03806-w","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RBP4-a risk factor in lipid metabolism-serves as an early diagnostic and prognostic marker of knee osteoarthritis progression.","authors":"Zheng Zhu, Zhengming Zhu, Ya Li, Lingchao Kong, Wenwei Dong, Rende Ning","doi":"10.1186/s13075-026-03805-x","DOIUrl":"https://doi.org/10.1186/s13075-026-03805-x","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma exosomal fibroblast activation protein: a novel biomarker links fatty acid metabolic dysregulation to systemic lupus erythematosus.","authors":"Jin Zhang, Meiyan Chen, Chunjuan Yang, Jie Zang, Wenchang Sun, Hui Wang, Mengyao Zhang, Jiamei Sun, Haibo Li, Donghua Xu","doi":"10.1186/s13075-026-03801-1","DOIUrl":"10.1186/s13075-026-03801-1","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color Doppler carotid resistance, pulsatility, and aortic oscillometry indices in giant cell arteritis: insights from the VASCARD cohort.","authors":"Konstantinos Triantafyllias, Anna-Lena Zang, Andreas V Goules, Elena K Joerns, Muthuraman Muthuraman, Andreas Schwarting","doi":"10.1186/s13075-026-03779-w","DOIUrl":"10.1186/s13075-026-03779-w","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work productivity and activity impairment in patients under 18 with juvenile idiopathic arthritis (JIA): the international UCAN CAN-DU prospective study.","authors":"Deborah A Marshall, Rodrigo Dal Ben, Gillian R Currie, Rae S M Yeung, Sebastiaan J Vastert, Nico Wulffraat, Joost F Swart, Susanne Benseler","doi":"10.1186/s13075-026-03785-y","DOIUrl":"10.1186/s13075-026-03785-y","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inactivation of NF-κB and MAPKs confers the potent therapeutic effect of carboxyamidotriazole on Blau syndrome.","authors":"Haoxin Song, Yang Li, Yuxin Wang, Mengyuan Duan, Na Wu, Yu Du, Ru Xu, Quanlin Chen, Min Shen, Fang Wei, Lei Zhu","doi":"10.1186/s13075-026-03800-2","DOIUrl":"10.1186/s13075-026-03800-2","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of serious infections, myocardial infarction or stroke, venous thromboembolic events, and malignancy in patients with psoriatic arthritis treated with tofacitinib compared with biologic treatments in the United States.","authors":"Marina Magrey, Milena A Gianfrancesco, Lara Fallon, Arne Yndestad, Ivana Vranic, Yuqin Wei, You-Li Ling, David Gruben, Jeffrey R Curtis","doi":"10.1186/s13075-026-03794-x","DOIUrl":"10.1186/s13075-026-03794-x","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}