Arthritis Care & Research最新文献

{"title":"The prevalence of pincer morphology in early adolescents from the general population: a population-based study (Generation R).","authors":"Delong Chen, Fleur Boel, Suzanne de Vos-Jakobs, Pim van Klij, Michiel M A van Buuren, Sita M A Bierma-Zeinstra, Rintje Agricola","doi":"10.1002/acr.25601","DOIUrl":"https://doi.org/10.1002/acr.25601","url":null,"abstract":"<p><strong>Objective: </strong>Pincer morphology can lead to femoroacetabular impingement syndrome (FAIS) and may be a modifiable risk factor for hip osteoarthritis (OA). Currently, no studies investigate the prevalence of pincer morphology in early adolescence-the period when this bony shape likely develops. The purpose of this study was to estimate the prevalence and birth-assigned sex distribution of pincer morphology in early adolescents from the general population in the Netherlands.</p><p><strong>Methods: </strong>This study was embedded in the Generation R study, a population-based prospective cohort in Rotterdam, the Netherlands. Around the age of 13 years, participants underwent high-resolution dual-energy x-ray absorptiometry (DXA) of their full-body and right hip. The lateral center edge angle (LCEA) was automatically determined based on landmarks outlining the hip contour, and pincer morphology was defined as a LCEA ≥ 40°. The overall and birth-assigned sex-specific prevalence was presented as a percentage with 95% confidence interval (CI).</p><p><strong>Results: </strong>A total of 3,986 adolescents (median age 13.5 years [2.5th - 97.5th percentile, 13.2 - 14.6]; 46.8% males) were included. The overall prevalence of pincer morphology was 3.1% (95% CI 2.6% - 3.6%). The prevalence in male and female adolescents was 3.0% (95% CI 2.2% - 3.7%) and 3.3% (95% CI 2.5% - 4.0%), respectively.</p><p><strong>Conclusion: </strong>Among early adolescents from the general population in the Netherlands, the estimated prevalence of pincer morphology was 3.1%. Male and female adolescents had a similar prevalence of pincer morphology. These findings could inform the timing of prevention strategies for pincer morphology, potentially reducing the risk of FAIS and hip OA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of Sjögren's disease in Alaska Native and American Indian peoples of Alaska.","authors":"Tessalyn Morrison, Peter Holck, Tammy L Choromanski, Amy Wilson, Flora Lee, Elizabeth D Ferucci","doi":"10.1002/acr.25600","DOIUrl":"10.1002/acr.25600","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to determine the prevalence, incidence, and clinical characteristics of Sjögren's disease in Alaska Native and American Indian (AN/AI) peoples of Alaska.</p><p><strong>Methods: </strong>We identified adults with Sjögren's disease by querying electronic health records from participating tribal health organizations within the Alaska Tribal Health System (ATHS). Medical records were abstracted for adults with diagnostic codes for Sjogren's disease. Individuals were included if they were diagnosed with Sjogren's disease by a rheumatologist). Prevalence and incidence were calculated using the ATHS user population in 2019 (point prevalence) and from 2012-2019 (incidence), with direct age-adjustment to the U.S. 2000 standard population. We evaluated whether adults met modified criteria (positive Ro/SSA antigen with sicca symptoms), 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR), and 2012 ACR criteria.</p><p><strong>Results: </strong>The age-adjusted prevalence of Sjögren's disease was 199 per 100,000 adults (95% confidence interval 170, 231); for primary Sjögren's disease it was 129 (106, 155), and for secondary Sjögren's disease it was 70 (54, 91). The age-adjusted incidence over the period was 16.6 (13.7, 20.0) per 100,000 person years. Two-thirds (66%) of adults met modified criteria. Only 5% had a salivary gland biopsy performed and only 3% met 2016 ACR/EULAR or 2012 ACR criteria. The most common associated conditions in secondary Sjögren's disease were rheumatoid arthritis and systemic lupus erythematosus.</p><p><strong>Conclusion: </strong>The prevalence and incidence of Sjögren's disease in AN/AI peoples is higher than other populations. These results may help clinicians to identify and treat this condition.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Still's Lung Disease: Time to Recognize This Complication in Adults","authors":"Lauren A. Henderson","doi":"10.1002/acr.25598","DOIUrl":"10.1002/acr.25598","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":"77 10","pages":"1180-1183"},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of rheumatology fellows' skills as clinical teachers through self-assessment and direct observation.","authors":"David Leverenz, Marcy B Bolster, Lisa Criscione-Schreiber, Jon Golenbiewski, Faye Hant, Rumey Ishizawar, Jennifer Schmidt, Amanda Snyder, Rachel Wolfe, Eli M Miloslavsky","doi":"10.1002/acr.25593","DOIUrl":"https://doi.org/10.1002/acr.25593","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to assess rheumatology fellows' teaching skills through an Observed Structured Teaching Exercise (OSTE), self-assessment, and a survey of fellows' teaching experiences.</p><p><strong>Methods: </strong>Rheumatology fellows from 5 institutions participated in an in-person OSTE, involving a simulated teaching encounter with a standardized learner. Trained faculty observers rated each OSTE encounter to assess the fellows' proficiency as a clinical teacher in the following domains: learning environment, learner assessment, presenting material, feedback, and overall teaching ability. Prior to the OSTE, fellows completed a self-assessment of their teaching skills according to those same five domains. In addition, they completed a post-OSTE survey assessing their experience with teaching during rheumatology fellowship training and their experience with the OSTE station itself.</p><p><strong>Results: </strong>A total of 25 fellows completed the OSTE and self-assessment. According to preceptor ratings on the OSTE, the domain with the highest average proficiency was presenting material (4.16, SD 0.46) and the lowest was learner assessment (3.06, SD 1.56). There was no significant correlation between OSTE ratings and fellow self-assessment in any domain. Of the 23 (92%) fellows who completed the post-OSTE survey, only 57% agreed they had received high-quality feedback on their teaching skills during fellowship training, and 100% agreed they received effective feedback during the OSTE.</p><p><strong>Conclusion: </strong>Fellows' self-assessed teaching ability does not correlate with direct observation. Interventions such as this OSTE are useful for providing high-quality feedback on fellows' teaching skills.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proportion of Acceptable Symptom State Nearly Tripled With Improvements in Patient-Reported Outcomes for All Symptom State Subgroups: A Registry Study of More Than 15,000 Patients With Osteoarthritis in Digital Education and Exercise Therapy.","authors":"Ali Kiadaliri, L Stefan Lohmander, Amanda E Nelson, Leif E Dahlberg","doi":"10.1002/acr.25594","DOIUrl":"10.1002/acr.25594","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated trajectories of patient acceptable symptom state (PASS) among participants of digital education and exercise therapy for knee and hip osteoarthritis.</p><p><strong>Methods: </strong>A longitudinal observational study among individuals aged at least 40 years who participated in the digital program. Participants completed PASS (yes/no) at enrollment and at least one follow-up during 1 year after enrollment (N = 15,253). Group-based trajectory modeling was used to identify groups with distinct PASS trajectories. We used multinomial logistic regression and linear random intercept models to explore predictors and compare changes in patient-reported outcome measures (PROMs) across trajectory subgroups.</p><p><strong>Results: </strong>The proportion of participants reporting acceptable symptom state rose from 17.4% (95% confidence interval [CI] 16.8%-18.1%) at enrollment to 42.4% (95% CI 41.6%-43.1%) and 48.9% (95% CI 47.5%-50.2%) at 3- and 12-month follow-ups, respectively. We identified four PASS trajectories: (1) \"persistently not achieving PASS\" (PNAP) (45.1%), (2) \"early sustained PASS\" (ESP) (34.8%), (3) \"gradually increasing satisfaction\" (GIS) (10.8%), and (4) \"early PASS, later unacceptable PASS\" (9.3%). Among baseline variables, female sex, older age, nonmetropolitan residence, lower education, knee osteoarthritis, fear of movement, no walking difficulties, no wish for surgery, and better PROMs were generally associated with higher odds of following trajectories other than the PNAP. All trajectories experienced improvements in PROMs, with generally larger improvements in the ESP and GIS groups than the other two groups.</p><p><strong>Conclusion: </strong>The percentage of participants achieving PASS almost tripled at 12 months. Improvements in PROMs across all PASS trajectories highlights the importance of distinction between \"feeling better\" and \"feeling good.\"</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Matthew Lammi, Kathleen D Kolstad, Lesley Ann Saketkoo, Avani Khatri, Paul J Utz, Lorinda Chung, Virginia Steen","doi":"10.1002/acr.25589","DOIUrl":"10.1002/acr.25589","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Risk in Patients With Systemic Sclerosis: A Nationwide Cohort Study in South Korea 2004 to 2021.","authors":"Jihyun Na, Su Jin Choi, Sojeong Park, Minae Park, Doo-Ho Lim","doi":"10.1002/acr.25595","DOIUrl":"10.1002/acr.25595","url":null,"abstract":"<p><strong>Objective: </strong>Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site-specific cancer risks in patients with SSc compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore potential associations with immunosuppressive agent use.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, we identified 6,386 patients newly diagnosed with SSc between 2004 and 2020. Standardized incidence ratios (SIRs) were calculated to compare the risk of cancer between patients with SSc and the general population. Subgroup analyses were performed based on age at diagnosis, follow-up duration, and immunosuppressive agent use.</p><p><strong>Results: </strong>Most patients (80.2%) were women, with a mean ± SD age at diagnosis of 53.1 ± 13.4 years. Patients with SSc had higher risks of overall cancer (SIR 3.12; 95% confidence interval [CI] 2.92-3.33), solid cancer (SIR 3.07; 95% CI 2.86-3.28), and hematologic cancer (SIR 5.70; 95% CI 4.50-7.11) compared to the general population. Myelodysplastic syndrome (SIR 12.52; 95% CI 7.00-20.65) had the highest risk, followed by multiple myeloma, eye, Hodgkin lymphoma, and larynx cancers. Cancer risk peaked among patients aged 20 to 39 years (SIR 5.27; 95% CI 4.31-6.38) and during the first year after diagnosis (SIR 4.44; 95% CI 3.81-5.14).</p><p><strong>Conclusion: </strong>In this study, we revealed that the incidence of cancer is higher in patients with SSc in South Korea compared to the general population. The strong association between SSc and cancer occurrence prompts clinicians to conduct careful cancer screening for patients with SSc.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns regarding pentraxin-3 specificity and receiver operating characteristic curve interpretation in the study on endothelial biomarkers of systemic sclerosis-associated pulmonary hypertension: comment on the article by Lammi et al.","authors":"Ashwant Kumar, Sabarinath Mahadevan","doi":"10.1002/acr.25586","DOIUrl":"10.1002/acr.25586","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Wenyan Sun, Lingling Cui, Changgui Li","doi":"10.1002/acr.25590","DOIUrl":"10.1002/acr.25590","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.","authors":"Katie J McMenamin, Thomas R Riley, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R England, Brian Sauer, Katherine D Wysham, Rui Xiao, Michael March, Grant W Cannon, Sylvanus Toikumo, Henry R Kranzler, Rachel L Kember, Ted R Mikuls, Joshua F Baker","doi":"10.1002/acr.25588","DOIUrl":"10.1002/acr.25588","url":null,"abstract":"<p><strong>Objective: </strong>Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training data set) and the Veterans Affairs Rheumatoid Arthritis Registry (VARA; validation data set). Multivariable linear regression was used to estimate the relationship between cross-sectional pain scores and 36 fibromyalgia (FM)-associated SNPs in FORWARD. SNP alleles were summed and weighted by these regression coefficients to generate a genetic risk score (GRS) for pain for each participant in both cohorts. Linear regressions and generalized estimating equations were used to determine the relationship between this GRS, an existing pain intensity GRS, and pain and self-reported disease activity.</p><p><strong>Results: </strong>The sample comprised 756 participants from FORWARD (mean age 56.8 years, 89.4% female) and 2,176 participants from VARA (mean age 64.3 years, 11.0% female) who had pain and genotyping data. Participants in the validation data set (VARA) with FM GRS in the highest quartile had more baseline pain than those in the lowest quartile (+0.55 [95% confidence interval 0.16-0.93], P = 0.006). This was also true for the existing pain intensity GRS. VARA participants in the highest quartile of both GRS had more pain throughout follow-up and higher disease activity scores.</p><p><strong>Conclusion: </strong>GRS based on pain-related SNPs were associated with RA pain and disease activity, suggesting that the genetic risk of pain may have clinical impacts in RA, such as the likelihood of achieving remission.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}