Arquivos brasileiros de endocrinologia e metabologia最新文献_第6页

The prevalence of glucose metabolism disturbances in Chinese Muslims and possible risk factors: a study from northwest China. 中国穆斯林糖代谢紊乱的患病率及其可能的危险因素:来自中国西北地区的研究

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-10-01 DOI: 10.1590/0004-2730000002654

Wei Liu, Lin Hua, Wan-Fu Liu, Hui-Ling Song, Xin-Wen Dai, Jin-Kui Yang

{"title":"The prevalence of glucose metabolism disturbances in Chinese Muslims and possible risk factors: a study from northwest China.","authors":"Wei Liu, Lin Hua, Wan-Fu Liu, Hui-Ling Song, Xin-Wen Dai, Jin-Kui Yang","doi":"10.1590/0004-2730000002654","DOIUrl":"https://doi.org/10.1590/0004-2730000002654","url":null,"abstract":"Objective: To survey the prevalence of diabetes mellitus (DM) and pre-diabetes mellitus (PDM) in the Muslim population in northwest China, and discuss the risk factor.Materials and methods: According to the income and the population, we randomly selected 3 villages with stratified and cluster sampling. The subjects were residents ≥ 20 years of age, and were from families which have been local for > 3 generations. The questionnaire and oral glucose tolerance test (OGTT) were completed and analyzed for 660 subjects.Results: The prevalence of DM and PDM between the Han and Muslim populations were different (P = 0.041). And the prevalence were also different with respect to age in the Han (P < 0.001) and Muslim population (P < 0.001) respectively. Except for the 20-year-old age group the prevalence of DM and PDM within the Muslim population was higher than the Han (P = 0.013), we did not find any significant difference for other age groups (P > 0.05). The intake of salt (P < 0.001) and edible oil (P < 0.001) in the Muslim population was higher than the Han, while cigarette smoking (P < 0.001) and alcohol consumption (P < 0.001) was lower. BMI (P < 0.001), age (P = 0.025), and smoking cigarettes (P = 0.011) were risk factors for DM and PDM, but alcohol consumption (P < 0.001) was a protective factor.Conclusions: In northwest China, the prevalence of DM was higher in the Muslim population, and it was special higher on the 20-year-old age compared to the Han. This might be explained by the potential genetic differences and poor dietary habits.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32793764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

[Thyrotoxic hypokalemic periodic paralysis in patients of African descent]. [非洲裔患者甲状腺毒性低钾血症性周期性麻痹]。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-10-01 DOI: 10.1590/0004-2730000003215

Morgana Lima e Maia, Paula Grasiele Carvalho Trevisam, Marcos Minicucci, Glaucia M F S Mazeto, Paula S Azevedo

引用次数: 2

Obesity, insulin resistance and comorbidities? Mechanisms of association. 肥胖、胰岛素抵抗和合并症?联想机制。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000003223

Ana Valeria B Castro, Cathryn M Kolka, Stella P Kim, Richard N Bergman

{"title":"Obesity, insulin resistance and comorbidities? Mechanisms of association.","authors":"Ana Valeria B Castro, Cathryn M Kolka, Stella P Kim, Richard N Bergman","doi":"10.1590/0004-2730000003223","DOIUrl":"https://doi.org/10.1590/0004-2730000003223","url":null,"abstract":"Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non-metabolic derangements. On the other hand, observations suggest that individuals who present peripheral adiposity, characterized by large hip and thigh circumferences, have better glucose tolerance, reduced incidence of T2DM and of metabolic syndrome. Insulin resistance (IR) is one of the main culprits in the association between obesity, particularly visceral, and metabolic as well as non-metabolic diseases. In this review we will highlight the current pathophysiological and molecular mechanisms possibly involved in the link between increased VAT, ectopic fat, IR and comorbidities. We will also provide some insights in the identification of these abnormalities.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 196

Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study. UBASH3A基因多态性与自身免疫性甲状腺疾病之间缺乏关联:一项病例对照研究

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000003209

TianTian Cai, Xuan Wang, Fatuma-Said Muhali, RongHua Song, XiaoHong Shi, WenJuan Jiang, Ling Xiao, DanFeng Li, JinAn Zhang

{"title":"Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study.","authors":"TianTian Cai, Xuan Wang, Fatuma-Said Muhali, RongHua Song, XiaoHong Shi, WenJuan Jiang, Ling Xiao, DanFeng Li, JinAn Zhang","doi":"10.1590/0004-2730000003209","DOIUrl":"https://doi.org/10.1590/0004-2730000003209","url":null,"abstract":"Objective: The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population.Subjects and methods: A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform.Results: Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group.Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

3β-hydroxysteroid dehydrogenase type II deficiency on newborn screening test. 新生儿筛查试验中3β-羟基类固醇脱氢酶II型缺乏。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000003098

Vitor Guilherme Brito de Araújo, Renata Santarem de Oliveira, Kallianna Paula Duarte Gameleira, Cátia Barbosa Cruz, Adriana Lofrano-Porto

{"title":"3β-hydroxysteroid dehydrogenase type II deficiency on newborn screening test.","authors":"Vitor Guilherme Brito de Araújo, Renata Santarem de Oliveira, Kallianna Paula Duarte Gameleira, Cátia Barbosa Cruz, Adriana Lofrano-Porto","doi":"10.1590/0004-2730000003098","DOIUrl":"https://doi.org/10.1590/0004-2730000003098","url":null,"abstract":"3β-hydroxysteroid dehydrogenase II (3β-HSD) deficiency represents a rare CAH variant. Newborns affected with its classic form have salt wasting in early infancy and genital ambiguity in both sexes. High levels of 17-hydroxypregnenolone (Δ517OHP) are characteristic, but extra-adrenal conversion to 17-hydroxyprogesterone (17OHP) may lead to positive results on newborn screening tests. Filter paper 17OHP on newborn screening test was performed by immunofluorometric assay, and serum determinations of 17OHP and Δ517OHP, by radioimmunoassay. A 46,XY infant with genital ambiguity and adrenal crisis at three months of age presented a positive result on newborn screening for CAH. Serum determinations of 17OHP and Δ517OHP were elevated, and a high Δ517OHP/cortisol relation was compatible with the diagnosis of 3β-HSD deficiency. Molecular analysis of the HSD3B2 gene from the affected case revealed the presence of the homozygous p.P222Q mutation, whereas his parents were heterozygous for it. We present the first report of 3β-HSD type II deficiency genotype-proven detected at the Newborn Screening Program in Brazil. The case described herein corroborates the strong genotype-phenotype correlation associated with the HSD3B2 p.P222Q mutation, which leads to a classic salt-wasting 3β-HSD deficiency. Further evaluation of 17OHP assays used in newborn screening tests would aid in determining their reproducibility, as well as the potential significance of moderately elevated 17OHP levels as an early indicator to the diagnosis of other forms of classic CAH, beyond 21-hydroxylase deficiency.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

[Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence]. [胰岛素抵抗与代谢综合征成分，按性别和青春期阶段分析]。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000002613

Eliane Rodrigues de Faria, Franciane Rocha de Faria, Sylvia do Carmo Castro Franceschini, Maria do Carmo Gouveia Peluzio, Luciana Ferreira da Rocha Sant Ana, Juliana Farias de Novaes, Sônia Machado Rocha Ribeiro, Andréia Queiroz Ribeiro, Silvia Eloiza Priore

{"title":"[Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence].","authors":"Eliane Rodrigues de Faria, Franciane Rocha de Faria, Sylvia do Carmo Castro Franceschini, Maria do Carmo Gouveia Peluzio, Luciana Ferreira da Rocha Sant Ana, Juliana Farias de Novaes, Sônia Machado Rocha Ribeiro, Andréia Queiroz Ribeiro, Silvia Eloiza Priore","doi":"10.1590/0004-2730000002613","DOIUrl":"https://doi.org/10.1590/0004-2730000002613","url":null,"abstract":"Objective: To analyze the influence of metabolic syndrome components in insulin resistance, by gender and adolescence phase.Subjects and methods: We evaluated biochemical, clinical, lifestyle and body composition data of 800 adolescents from 10 to 19 years old, from both genders, from Viçosa, MG/Brasil, and there was the division by stage: early (10 to 13 years), intermediate (14 to 16 years) and late (17 to 19 years).Results: 10.3 and 3.4% had, respectively, insulin resistance and metabolic syndrome. In the initial phase there was a higher prevalence of dyslipidemia and intermediate hyperuricemia and excess body fat. Females had a higher prevalence of dyslipidemia, excess body fat and insulin resistance and higher male prevalence of low HDL, hyperuricemia and blood pressure changes. Those from the initial phase had higher levels of total cholesterol, LDL, HDL, triglycerides, fasting glucose and waist/hip ratio, stayed less time sitting and had more meals (p < 0.05) in relation to other phases. The final model, adjusted for gender, was different for each phase of adolescence.Conclusions: Insulin resistance is associated with inadequate body composition, in biochemical levels and lifestyle, being the factors associated different in each phase of adolescence.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000002613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion. 阴茎鳞状细胞癌与甲状旁腺相关肽(PTH-rP)分泌的罕见关联。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000002880

Rogelio Trejo-Rosales, Maria J Nevarez-Barragan, Mercedes G Rosas-Jurado, Ivan Perez-Diaz, Ana Paula Piana Bezaury

引用次数: 1

Aggressive pituitary lesion with a remarkably high Ki-67. 侵袭性垂体病变Ki-67异常高。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000003116

Pedro Marques, Manuela Mafra, Carlos Calado, Anabela Martins, Joaquim Monteiro, Valeriano Leite

{"title":"Aggressive pituitary lesion with a remarkably high Ki-67.","authors":"Pedro Marques, Manuela Mafra, Carlos Calado, Anabela Martins, Joaquim Monteiro, Valeriano Leite","doi":"10.1590/0004-2730000003116","DOIUrl":"https://doi.org/10.1590/0004-2730000003116","url":null,"abstract":"The uncommon aggressive pituitary tumors are named carcinomas when metastases are detected, either in the central nervous system and/or systemically. Some cases are associated with hormonal overproduction, but most are diagnosed because of local symptoms. These neoplasias are generally refractory to current treatments. A 51 year-old woman presented sudden onset of headache, left arm paresis and left facial hypoesthesia. Computed tomography scan and magnetic resonance imaging revealed a pituitary tumor invading the left sphenoidal and cavernous sinuses. Laboratory data excluded hormonal hypersecretion. The patient underwent transsphenoidal surgery and histological findings showed a neoplasia with Ki-67 estimated at 75%. Medical imaging excluded both a primary occult tumor and central nervous system or systemic dissemination. Three weeks postoperatively, neurological condition worsened, with new onset of ataxia, bilateral ptosis, ophthalmoplegia and an increase in the size of the lesion, leading to surgical intervention by craniotomy, followed by only a few sessions of radiotherapy, because of severe disease progression. Patient died nearly 2 months after the initial manifestations. This case illustrates the aggressiveness of some pituitary lesions, the limited efficacy of current treatment modalities such as surgery or radiotherapy and the pitfalls of the current pituitary tumors classification. To our knowledge, this case corresponds to one of the most aggressive pituitary neoplasms reported so far, with a very high Ki-67 index (75%) and short survival (2 months). Ki-67 index could be of prognostic value in pituitary tumors. Pituitary tumors World Health Organization (WHO) classification could be revisited. ","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts. 锂盐对精神病患者甲状旁腺功能和矿物质代谢的影响。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI: 10.1590/0004-2730000002983

Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira

{"title":"Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts.","authors":"Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira","doi":"10.1590/0004-2730000002983","DOIUrl":"https://doi.org/10.1590/0004-2730000002983","url":null,"abstract":"Objective: To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.Materials and methods: We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).Results: The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.Conclusion: Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000002983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Persistence of intrasellar trigeminal artery and simultaneous pituitary adenoma: description of two cases and their importance for the differential diagnosis of sellar lesions. 鞍内三叉动脉持续存在并并发垂体腺瘤:两例描述及其对鞍区病变鉴别诊断的重要性。

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01

Marcio Carlos Machado, Sergio Kodaira, Nina Rosa Castro Musolino

{"title":"Persistence of intrasellar trigeminal artery and simultaneous pituitary adenoma: description of two cases and their importance for the differential diagnosis of sellar lesions.","authors":"Marcio Carlos Machado, Sergio Kodaira, Nina Rosa Castro Musolino","doi":"","DOIUrl":"","url":null,"abstract":"Persistent trigeminal artery (PTA) is the most frequent embryonic communication between the carotid and vertebrobasilar systems. However, hormonal changes or the association of PTA with other sellar lesions, such as pituitary adenomas, are extremely rare. The aim of the present study was to report two patients with intrasellar PTA and simultaneous pituitary adenoma in order to emphasize the importance of differential diagnoses for sellar lesions. Case 1. A female patient, 41 years old, was admitted with a history of chronic headache (> 20 years). Pituitary magnetic resonance imaging (MRI) showed a rounded lesion in the left portion of the pituitary gland suggestive of adenoma (most likely clinically non-functioning adenoma). In addition to this lesion, the MRI demonstrated ecstasy of the right internal carotid artery and imaging suggestive of an intrasellar artery that was subsequently confirmed by an angio-MRI of the cerebral vessels as PTA. Case 2. A female patient, 42 years old, was admitted with a history of amenorrhea and galactorrhea in 1994. Laboratorial investigation revealed hyperprolactinemia. Pituitary MRI showed a small hyposignal area in the anterior portion of pituitary gland suggestive of a microadenoma initiated by a dopaminergic agonist. Upon follow-up, aside from the first lesion, the MRI showed a well delineated rounded lesion inside the pituitary gland, similar to a vessel. Angio-MRI confirmed a left primitive PTA. Failure to recognize these anomalous vessels within the sella might lead to serious complications during transsphenoidal surgery. Therefore, although their occurrence is uncommon, a working knowledge of vascular lesions in the sella turcica or pituitary gland is important for the differential diagnosis of pituitary lesions, especially pituitary adenomas.","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32660545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0